# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA metabolic process	29	2.651585e-49	1.2031795522413793e-46	2.025782	534	0.02707224	94	1.955556190212766e-20	1.45848	226	259	0.0201175	
GO Biological Process	rRNA processing	30	5.723996e-49	2.5107354454666666e-46	2.040352	521	0.02641318	92	1.338337954423913e-20	1.46583	221	252	0.01967242	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	31	1.119234e-46	4.750967808387098e-44	2.665833	286	0.01449937	168	4.5022719560714284e-12	1.515631	107	118	0.009524657	
GO Biological Process	nuclear-transcribed mRNA catabolic process	35	2.811603e-45	1.0570823964857144e-42	2.095091	451	0.02286439	111	9.400975722792792e-18	1.485728	176	198	0.01566673	
GO Biological Process	mRNA catabolic process	37	5.189043e-43	1.84547613072973e-40	2.003748	477	0.02418251	104	6.9390405733653845e-19	1.483112	189	213	0.01682393	
GO Biological Process	regulation of viral transcription	53	5.549044e-36	1.3777333961509434e-33	2.680696	216	0.01095057	860	0.017711891590697675	1.311441	51	65	0.00453979	
GO Biological Process	viral gene expression	60	3.093232e-34	6.783973314666667e-32	2.304612	273	0.0138403	152	1.0874052194078948e-13	1.526673	116	127	0.0103258	
GO Biological Process	viral transcription	70	7.447553e-32	1.4000335703857141e-29	2.304879	253	0.01282636	153	1.081480585620915e-13	1.553112	105	113	0.009346626	
GO Biological Process	cotranslational protein targeting to membrane	77	1.563603e-30	2.6721366074025973e-28	2.432982	217	0.01100127	151	1.0540655295364238e-13	1.586166	93	98	0.00827844	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	79	3.433394e-30	5.718991347594936e-28	2.478085	207	0.0104943	165	1.5591485013333334e-12	1.580604	87	92	0.007744348	
GO Biological Process	protein localization to endoplasmic reticulum	80	5.369349e-30	8.831907936375e-28	2.14789	277	0.01404309	160	3.7217723065624997e-13	1.523171	113	124	0.01005875	
GO Biological Process	translational initiation	91	2.992348e-27	4.32706673978022e-25	2.003513	296	0.01500634	199	4.197599990100502e-10	1.437675	123	143	0.01094891	
GO Biological Process	protein targeting to ER	92	6.312211e-27	9.028520059673914e-25	2.287973	215	0.01089987	179	1.8303595591061453e-11	1.539052	93	101	0.00827844	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	97	8.47919e-26	1.150285167113402e-23	2.163998	232	0.01176172	181	2.3351154411602206e-11	1.528177	96	105	0.008545487	
GO Biological Process	negative regulation of ubiquitin-protein transferase activity	108	4.574057e-23	5.5731496354629624e-21	2.20126	198	0.01003802	677	0.004088932806351551	1.313277	66	84	0.005875022	
GO Biological Process	mitochondrial translation	142	2.204318e-19	2.0427197578873243e-17	2.031572	198	0.01003802	218	9.386381098623856e-9	1.468371	94	107	0.008367456	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	152	2.165001e-18	1.8742926420394735e-16	2.06754	179	0.009074778	558	0.0009753780954121863	1.380758	57	69	0.005073883	
GO Biological Process	mitochondrial translational elongation	154	2.555023e-18	2.183217380324675e-16	2.17662	158	0.008010139	269	3.599729567695167e-7	1.474803	75	85	0.006676162	
GO Biological Process	mitochondrial translational termination	160	4.827358e-18	3.970200245125e-16	2.154673	159	0.008060837	285	7.465705552280702e-7	1.460112	76	87	0.006765177	
GO Biological Process	positive regulation of viral transcription	162	5.647068e-18	4.587022704444445e-16	2.438552	122	0.006185044	689	0.00501542202394775	1.432666	36	42	0.003204558	
GO Cellular Component	ribosomal subunit	30	2.751972e-33	1.585135872e-31	2.036253	351	0.01779468	42	2.455204114285714e-13	1.436538	159	185	0.01415346	
GO Cellular Component	mitochondrial ribosome	44	9.618234e-21	3.7773428072727275e-19	2.385821	149	0.007553866	84	0.000011962335085714286	1.415811	72	85	0.006409115	
GO Cellular Component	small ribosomal subunit	59	6.295157e-16	1.8437341179661014e-14	2.100177	147	0.007452471	106	0.0002457501283018868	1.39287	60	72	0.005340929	
GO Cellular Component	mitochondrial nucleoid	65	2.379019e-14	6.324530510769231e-13	2.362966	101	0.005120406	124	0.0008358262141935484	1.472462	37	42	0.003293573	
GO Cellular Component	mitochondrial large ribosomal subunit	69	8.704909e-13	2.180011993043478e-11	2.370695	88	0.004461343	118	0.0005505645233898305	1.44203	44	51	0.003916682	
GO Cellular Component	spliceosomal snRNP complex	72	1.481576e-12	3.5557823999999995e-11	2.079493	115	0.005830165	83	0.00001092713499759036	1.482732	55	62	0.004895852	
GO Cellular Component	cytosolic small ribosomal subunit	85	1.02943e-11	2.0927706352941177e-10	2.123421	101	0.005120406	160	0.00518832756	1.405532	37	44	0.003293573	
GO Cellular Component	nuclear ubiquitin ligase complex	86	1.040963e-11	2.091609376744186e-10	2.29484	85	0.004309252	137	0.0016579617635036495	1.462513	35	40	0.003115542	
GO Cellular Component	PRC1 complex	106	1.911694e-9	3.116421916981132e-8	3.665851	31	0.00157161	185	0.01959949907027027	1.671444	12	12	0.001068186	
GO Cellular Component	DNA-directed RNA polymerase III complex	110	3.420545e-9	5.373365236363637e-8	3.26433	35	0.001774398	167	0.008177274711377245	1.583473	18	19	0.001602279	
GO Cellular Component	precatalytic spliceosome	126	2.284975e-8	3.1336799999999995e-7	2.377202	53	0.002686946	99	0.00019369902545454546	1.611749	27	28	0.002403418	
GO Cellular Component	sex chromosome	142	1.599286e-7	0.000001946173385915493	2.030853	66	0.003346008	222	0.048965651027027025	1.414299	22	26	0.001958341	
GO Cellular Component	U2 snRNP	170	0.000003697949	0.000037588563952941177	2.343048	37	0.001875792	167	0.008177274711377245	1.583473	18	19	0.001602279	
GO Cellular Component	INO80-type complex	176	0.000005203352	0.000051087456	2.306597	37	0.001875792	135	0.0015450828799999999	1.598772	22	23	0.001958341	
GO Cellular Component	exosome (RNase complex)	178	0.000005674299	0.00005508532961797753	2.065438	47	0.002382763	209	0.04058255954066986	1.453429	20	23	0.00178031	
GO Cellular Component	U12-type spliceosomal complex	194	0.00001012624	0.0000901966119587629	2.017893	47	0.002382763	142	0.0031548680112676057	1.542871	24	26	0.002136372	
GO Cellular Component	Ino80 complex	225	0.00004819597	0.00037014504960000005	2.443659	26	0.001318124	197	0.027673086700507613	1.566979	15	16	0.001335232	
GO Cellular Component	ER membrane protein complex	281	0.0003862551	0.0023752626790035586	2.356458	21	0.001064639	219	0.04628951408219178	1.671444	10	10	0.0008901549	
GO Molecular Function	rRNA binding	10	1.930901e-23	8.152264022e-21	2.967289	116	0.005880862	78	0.00006301150964102564	1.476442	53	60	0.004717821	
GO Molecular Function	snRNA binding	15	2.097641e-16	5.904160201333334e-14	2.908288	81	0.004106464	140	0.008578856711428572	1.451517	33	38	0.002937511	
GO Molecular Function	mRNA 5'-UTR binding	21	1.269444e-14	2.552186937142857e-12	2.816315	75	0.003802281	132	0.006194057818181818	1.595469	21	22	0.001869325	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	33	3.118233e-11	3.989448401818182e-9	2.185937	90	0.004562738	193	0.04523800810362694	1.4409	25	29	0.002225387	
Human Phenotype	Exercise intolerance	2	1.833368e-14	6.117032332e-11	2.086499	134	0.006793409	156	0.003970541511346153	1.361033	57	70	0.005073883	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	1	2.282088e-28	2.0897079816e-24	2.52545	187	0.009480355	180	0.003992640227222222	1.39287	50	60	0.004450774	
Mouse Phenotype Single KO	early cellular replicative senescence	4	1.202674e-23	2.7532214545e-20	2.465726	161	0.008162231	187	0.005015406422994652	1.414299	44	52	0.003916682	
Mouse Phenotype Single KO	thoracic vertebral transformation	14	4.236249e-14	2.7708094352142857e-11	2.074642	132	0.006692015	325	0.03708066572923077	1.358048	39	48	0.003471604	
Mouse Phenotype	abnormal cellular replicative senescence	1	1.283108e-27	1.2267795588e-23	2.181454	245	0.01242079	244	0.0011259088458196722	1.353074	68	84	0.006053053	
Mouse Phenotype	early cellular replicative senescence	2	1.879749e-26	8.9861400945e-23	2.234068	222	0.01125475	213	0.0004808554577464789	1.396686	61	73	0.005429945	
Mouse Phenotype	thoracic vertebral transformation	11	1.209674e-18	1.0514266467272727e-15	2.165274	163	0.008263625	423	0.014752464780141845	1.348884	46	57	0.004094712	
Mouse Phenotype	decreased cellular sensitivity to ultraviolet irradiation	39	6.051892e-12	1.4836446003076924e-9	3.032976	53	0.002686946	394	0.010889263138324874	1.671444	15	15	0.001335232	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	57	5.117815e-10	8.584461265789473e-8	2.219957	76	0.003852978	354	0.007855125839830508	1.504299	27	30	0.002403418