# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to insulin stimulus	32	2.215528e-14	9.1106665475e-12	2.051161	137	0.02753215	201	0.0038252957676119404	1.592416	58	148	0.0125514	
GO Biological Process	insulin receptor signaling pathway	40	2.107001e-13	6.93150653975e-11	2.3347	95	0.01909164	190	0.0027455173076842104	1.833488	37	82	0.008006925	
GO Biological Process	protein-lipid complex assembly	173	4.065713e-8	0.000003092527015433526	3.348565	29	0.005827974	417	0.04706671358992806	2.101762	15	29	0.003246051	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	190	8.765713e-8	0.000006070948282473684	2.291931	52	0.01045016	354	0.028856854340112995	2.09327	17	33	0.003678857	
GO Biological Process	very-low-density lipoprotein particle assembly	195	1.013597e-7	0.0000068399604733333335	4.536709	19	0.003818328	231	0.006261074986147186	3.324605	9	11	0.00194763	
GO Biological Process	ribonucleoside monophosphate biosynthetic process	214	2.533821e-7	0.000015580631092990654	2.192601	53	0.01065113	402	0.04416101479104478	1.657442	31	76	0.006708505	
GO Biological Process	retrograde transport, endosome to Golgi	226	3.43895e-7	0.000020023514623893804	2.118485	56	0.01125402	356	0.028809579026685392	1.688688	32	77	0.006924908	
GO Biological Process	sulfur amino acid metabolic process	227	3.446409e-7	0.000019978544507048456	2.42613	42	0.008440514	400	0.0428167542	1.976792	18	37	0.003895261	
GO Biological Process	nucleoside monophosphate biosynthetic process	240	5.692918e-7	0.000031213794984166666	2.068252	57	0.01145498	392	0.040870141987244896	1.625362	34	85	0.007357715	
GO Biological Process	fatty acid oxidation	272	0.000001500424	0.00007258852726470589	2.062269	53	0.01065113	402	0.04416101479104478	1.657442	31	76	0.006708505	
GO Biological Process	negative regulation of cyclin-dependent protein kinase activity	281	0.000001990972	0.00009323558913879004	2.754422	29	0.005827974	288	0.014665010997222224	2.344273	15	26	0.003246051	
GO Biological Process	negative regulation of cyclin-dependent protein serine/threonine kinase activity	282	0.000002067646	0.00009648281458865249	2.872561	27	0.005426045	302	0.018991304093377483	2.37032	14	24	0.003029647	
GO Biological Process	negative regulation of organelle assembly	410	0.00002572336	0.0008255943761951218	2.316798	31	0.006229904	336	0.02636216097738095	2.16715	16	30	0.003462454	
GO Biological Process	pyrimidine ribonucleoside biosynthetic process	451	0.00004363392	0.0012731236214634147	2.772338	21	0.004220257	287	0.014295552458536585	2.515442	13	21	0.002813244	
GO Biological Process	pyrimidine ribonucleotide biosynthetic process	481	0.00006056801	0.0016569946852182953	2.634945	22	0.004421222	239	0.006536780049790795	2.585804	14	22	0.003029647	
GO Biological Process	pyrimidine ribonucleotide metabolic process	550	0.0001123704	0.0026885128974545457	2.521452	22	0.004421222	302	0.018991304093377483	2.37032	14	24	0.003029647	
GO Biological Process	UMP biosynthetic process	596	0.0001775783	0.0039207262578859065	2.938183	16	0.003215434	175	0.0019278190660571427	3.657066	9	10	0.00194763	
GO Biological Process	maintenance of protein location in nucleus	623	0.000229058	0.004838160869983949	2.993747	15	0.003014469	409	0.04622528267481663	2.539629	10	16	0.002164034	
GO Biological Process	'de novo' pyrimidine nucleobase biosynthetic process	641	0.000280787	0.005764237336973479	3.43715	12	0.002411576	268	0.01088136368283582	4.063406	6	6	0.00129842	
GO Biological Process	morphogenesis of an endothelium	693	0.0003881101	0.007369611552525252	2.167074	25	0.005024116	409	0.04622528267481663	2.539629	10	16	0.002164034	
GO Cellular Component	catalytic step 2 spliceosome	39	1.571282e-10	6.9619879384615386e-9	2.420855	67	0.01346463	44	0.015088601454545457	1.650759	39	96	0.008439732	
GO Cellular Component	nonhomologous end joining complex	243	0.005471723	0.038910030222222225	2.512228	11	0.002210611	32	0.0050871591	3.611917	8	9	0.001731227	
GO Molecular Function	insulin receptor binding	14	1.970845e-8	0.000005943505421428572	2.261593	59	0.01185691	35	0.035720399879999996	2.22832	17	31	0.003678857	
Human Phenotype	Abnormal CNS myelination	1	2.489755e-11	1.6614135115000001e-7	2.233833	86	0.01728296	9	0.006794901622555556	1.722884	53	125	0.01146938	
Human Phenotype	Hypoglycemia	5	2.985117e-9	0.0000039839371482	2.05535	82	0.0164791	48	0.034088603437500004	1.618171	45	113	0.009738152	
Human Phenotype	Acute encephalopathy	21	0.000001225222	0.00038932887647619044	3.201709	24	0.004823151	62	0.046910307441935487	2.37032	14	24	0.003029647	
Human Phenotype	Hyperammonemia	60	0.00004150206	0.004615720773	2.135812	35	0.007033762	59	0.04593278116779661	2.086614	19	37	0.004111664	
Mouse Phenotype Single KO	abnormal branching of the mammary ductal tree	7	6.753297e-15	8.834277232714285e-12	2.842456	75	0.01507235	199	0.02880780696231156	2.031703	19	38	0.004111664	
Mouse Phenotype Single KO	abnormal mammary gland duct morphology	15	3.28603e-12	2.0060117806666665e-9	2.327337	86	0.01728296	208	0.03577808071826923	1.840033	24	53	0.005193681	
Mouse Phenotype Single KO	pale kidney	59	1.830069e-7	0.00002840329124237288	2.486831	42	0.008440514	221	0.04455315561085972	2.097242	16	31	0.003462454	
Mouse Phenotype Single KO	abnormal kidney inner medulla morphology	90	0.000003970671	0.00040399371496666666	3.165141	22	0.004421222	237	0.04730649157383966	3.48292	6	7	0.00129842	
Mouse Phenotype Single KO	decreased bone stiffness	269	0.0007189599	0.024474036447211897	3.528819	10	0.002009646	213	0.038744814661971834	4.063406	5	5	0.001082017	
Mouse Phenotype	dry eyes	41	2.641033e-9	6.158760125121951e-7	3.438896	33	0.006631833	136	0.0022404684988235296	3.047555	12	16	0.002596841	
Mouse Phenotype	increased liver glycogen level	166	0.00003664108	0.002110393770361446	2.075058	38	0.007636656	305	0.027144453284262297	2.031703	18	36	0.003895261	
Mouse Phenotype	aortic valve stenosis	228	0.000122384	0.005132076421052632	2.259112	27	0.005426045	333	0.030839134702702706	2.483193	11	18	0.002380437	
Mouse Phenotype	calcified aortic valve	278	0.0002798385	0.009624229850719423	2.477208	20	0.004019293	242	0.013516899307438017	3.55548	7	8	0.001514824