# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	13	5.203651e-33	5.2672956545384616e-30	2.432013	234	0.02522639	130	0.0000010912536009230769	1.607074	92	155	0.01326604	
GO Biological Process	cellular response to epidermal growth factor stimulus	20	9.813773e-28	6.4569719453500005e-25	3.142107	127	0.01369125	158	0.000012240401858227848	2.137555	30	38	0.004325883	
GO Biological Process	response to epidermal growth factor	23	7.639041e-26	4.370527848652174e-23	2.957476	129	0.01390686	189	0.00008811774657671958	1.998445	31	42	0.004470079	
GO Biological Process	nuclear-transcribed mRNA catabolic process	35	1.386634e-23	5.213347658857143e-21	2.133715	216	0.0232859	274	0.002959087382262774	1.36746	100	198	0.01441961	
GO Biological Process	protein targeting to ER	40	1.393758e-22	4.5851153804999996e-20	2.783389	123	0.01326003	245	0.0011630907096734694	1.554842	58	101	0.008363374	
GO Biological Process	mRNA catabolic process	43	2.285234e-22	6.993347489767441e-20	2.036647	228	0.02457956	316	0.005860647982594937	1.334718	105	213	0.01514059	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	50	1.965619e-21	5.1731160842e-19	2.596537	131	0.01412247	421	0.02277378432114014	1.399676	61	118	0.008795963	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	57	5.167289e-20	1.1929185254561403e-17	2.374297	144	0.01552393	292	0.004249561601541095	1.526609	53	94	0.007642394	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	62	2.175829e-19	4.618021582419355e-17	2.49917	126	0.01358344	243	0.001048142509176955	1.547183	60	105	0.008651766	
GO Biological Process	cotranslational protein targeting to membrane	73	3.951941e-18	7.123779673835616e-16	2.598735	109	0.01175075	263	0.001810723430798479	1.547183	56	98	0.008074982	
GO Biological Process	protein localization to endoplasmic reticulum	75	9.025294e-18	1.5835179166133333e-15	2.275452	138	0.0148771	354	0.011201513253672316	1.419291	65	124	0.009372747	
GO Biological Process	endoplasmic reticulum unfolded protein response	81	2.70132e-17	4.388477762962963e-15	2.251391	137	0.0147693	298	0.004687593477516778	1.472538	62	114	0.008940159	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	84	4.787276e-17	7.49949581952381e-15	2.596584	102	0.01099612	337	0.008793722368249258	1.500936	51	92	0.007354001	
GO Biological Process	regulation of mitochondrial membrane permeability	85	4.893885e-17	7.57630973117647e-15	2.371577	121	0.01304442	174	0.00004014459237068965	1.78032	48	73	0.006921413	
GO Biological Process	viral transcription	103	6.256097e-16	7.99261945854369e-14	2.305318	119	0.01282881	283	0.003506440136466431	1.48557	62	113	0.008940159	
GO Biological Process	DNA-templated transcription, elongation	106	7.529625e-16	9.347390129716981e-14	2.30844	118	0.012721	503	0.04874711000397614	1.378399	56	110	0.008074982	
GO Biological Process	viral gene expression	108	8.110226e-16	9.881709623518519e-14	2.243889	125	0.01347564	370	0.013290170334594596	1.407084	66	127	0.009516943	
GO Biological Process	cellular response to unfolded protein	134	3.317702e-14	3.2580328819402982e-12	2.034375	139	0.01498491	306	0.0051296534209150325	1.45448	65	121	0.009372747	
GO Biological Process	regulation of membrane permeability	144	1.381042e-13	1.2620230331944443e-11	2.102871	122	0.01315222	230	0.0007806879979130435	1.637913	49	81	0.007065609	
GO Biological Process	mitochondrial translational termination	146	1.489353e-13	1.342355899109589e-11	2.478215	86	0.009271238	380	0.01365466490105263	1.493832	48	87	0.006921413	
GO Cellular Component	mitochondrial ribosome	33	1.856844e-20	9.723110400000002e-19	3.132533	92	0.009918068	49	0.00016622845126530614	1.656396	52	85	0.007498198	
GO Cellular Component	ribosomal subunit	37	1.533975e-19	7.164077837837839e-18	2.146496	174	0.01875809	50	0.000201911616	1.43428	98	185	0.01413122	
GO Cellular Component	mitochondrial large ribosomal subunit	43	3.724083e-16	1.496561726511628e-14	3.494452	61	0.00657611	48	0.00015221761200000003	1.858136	35	51	0.005046864	
GO Cellular Component	large ribosomal subunit	44	1.185629e-15	4.656288436363637e-14	2.331598	114	0.01228978	45	0.0000398885376	1.600998	68	115	0.009805335	
GO Cellular Component	catalytic step 2 spliceosome	48	1.7127e-14	6.16572e-13	2.229007	115	0.01239759	134	0.04178040931343283	1.381989	49	96	0.007065609	
GO Cellular Component	spliceosomal snRNP complex	52	2.468723e-13	8.20375643076923e-12	2.730072	71	0.007654161	115	0.020312369530434783	1.528467	35	62	0.005046864	
GO Cellular Component	endopeptidase complex	53	1.060563e-12	3.45783559245283e-11	2.444277	82	0.008840017	103	0.011951795883495145	1.530366	39	69	0.005623648	
GO Cellular Component	proteasome complex	55	2.556003e-12	8.03049669818182e-11	2.415833	81	0.008732212	113	0.0169983512920354	1.513054	38	68	0.005479452	
GO Cellular Component	peptidase complex	56	5.393891e-12	1.6644006514285714e-10	2.164296	99	0.0106727	101	0.00956526872079208	1.476857	48	88	0.006921413	
GO Cellular Component	small nuclear ribonucleoprotein complex	59	8.363617e-12	2.449547487457627e-10	2.433962	76	0.008193187	103	0.011951795883495145	1.530366	39	69	0.005623648	
GO Cellular Component	preribosome	79	2.392822e-9	5.23391951392405e-8	2.113764	78	0.008408797	64	0.0017250942600000002	1.603167	45	76	0.006488825	
GO Cellular Component	prespliceosome	138	0.000006149199	0.00007699866573913043	2.833257	25	0.002695127	117	0.020551960615384616	1.933979	15	21	0.002162942	
GO Cellular Component	90S preribosome	148	0.00001015399	0.00011855469405405407	2.18158	39	0.004204398	72	0.0029430792	1.921502	22	31	0.003172314	
GO Cellular Component	ESCRT complex	180	0.00003742754	0.00035930438400000005	2.345981	29	0.003126348	132	0.03921398836363636	1.740581	18	28	0.00259553	
GO Cellular Component	U2-type prespliceosome	233	0.000335196	0.002485917115879828	2.587062	18	0.001940492	124	0.031015816258064516	2.030678	12	16	0.001730353	
GO Molecular Function	NF-kappaB binding	12	7.147996e-18	2.514903259333333e-15	3.766851	62	0.006683915	56	0.0035120774853571427	2.030678	21	28	0.003028118	
GO Molecular Function	structural constituent of ribosome	16	3.195759e-15	8.432809061249999e-13	2.029948	151	0.01627857	52	0.003034423661153846	1.420639	85	162	0.01225667	
GO Molecular Function	L-serine transmembrane transporter activity	41	6.966885e-10	7.174192309756098e-8	5.287286	22	0.002371712	86	0.041789964753488375	2.436813	9	10	0.001297765	
GO Molecular Function	exonuclease activity	44	9.652967e-10	9.262460607727272e-8	2.051897	88	0.009486848	72	0.022104937755555554	1.531915	43	76	0.006200433	
GO Molecular Function	non-membrane spanning protein tyrosine phosphatase activity	261	0.0002087296	0.0033764611923371647	2.896491	16	0.001724881	71	0.0205359863943662	2.70757	8	8	0.001153569	
Human Phenotype	Increased serum lactate	24	2.271311e-12	6.315190959583334e-10	2.133446	106	0.01142734	53	0.0018082847935849055	1.570391	58	100	0.008363374	
Human Phenotype	Nevus	57	2.150496e-9	2.51758944e-7	2.505292	55	0.00592928	83	0.0076923055738554215	2.005608	20	27	0.002883922	
Human Phenotype	Ectropion	242	0.00003240837	0.0008936407149173553	2.11305	37	0.003988788	144	0.038418031935416666	1.874472	18	26	0.00259553	
Human Phenotype	Increased serum pyruvate	308	0.0001106119	0.0023964714568181817	2.946111	17	0.001832687	147	0.03864168155918367	2.436813	9	10	0.001297765	
Human Phenotype	Abnormality of glycolysis	322	0.0001389738	0.002880037786956522	2.787291	18	0.001940492	110	0.02085791136090909	2.461428	10	11	0.001441961	
Human Phenotype	Facial diplegia	473	0.001094181	0.015436511232558141	2.3288	18	0.001940492	71	0.005159659465633803	2.499296	12	13	0.001730353	
Mouse Phenotype Single KO	pale liver	52	4.443943e-15	7.825612702115384e-13	2.222434	121	0.01304442	69	0.0030074653604347827	1.624542	48	80	0.006921413	
Mouse Phenotype Single KO	absent hypoglossal nerve	89	7.820975e-13	8.04681663764045e-11	4.376788	36	0.003880983	155	0.04960024928064516	2.166056	12	15	0.001730353	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	90	8.785511e-13	8.938769358555554e-11	2.023462	125	0.01347564	92	0.016712560139130438	1.573318	43	74	0.006200433	
Mouse Phenotype	absent hypoglossal nerve	99	7.820975e-13	7.553165856060607e-11	4.376788	36	0.003880983	211	0.038043740097156394	2.166056	12	15	0.001730353	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	380	0.000002310329	0.00005812909360263158	2.36032	38	0.004096593	158	0.014453872006329116	1.895299	21	30	0.003028118	
Mouse Phenotype	decreased abdominal adipose tissue amount	409	0.000003911181	0.00009142983261858189	2.43765	34	0.003665373	182	0.020466076974725276	1.949451	18	25	0.00259553