# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	12	2.075609e-15	2.2760782359166668e-12	2.327109	110	0.04959423	81	0.0005440780249012346	1.65431	80	396	0.03488879	
GO Biological Process	ribonucleoprotein complex biogenesis	16	1.408162e-13	1.1581252348750001e-10	2.037199	128	0.05770965	34	0.00001474506975117647	1.73156	96	454	0.04186655	
GO Biological Process	rRNA processing	19	1.46396e-11	1.0139078757894736e-8	2.472756	71	0.03201082	111	0.0027817817771171173	1.75475	54	252	0.02354993	
GO Biological Process	rRNA metabolic process	21	2.30325e-11	1.4432603214285714e-8	2.429067	72	0.03246168	113	0.0030185465035398235	1.738942	55	259	0.02398604	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	22	2.710012e-11	1.620956723090909e-8	2.651423	61	0.02750225	145	0.019092166220689655	1.849092	35	155	0.01526385	
GO Biological Process	ribosome biogenesis	42	2.023105e-9	6.338580641666667e-7	2.052443	83	0.0374211	116	0.003451058920862069	1.647908	65	323	0.02834714	
GO Biological Process	RNA catabolic process	44	2.82685e-9	8.454208897727273e-7	2.208008	69	0.03110911	146	0.01911032899726027	1.66495	49	241	0.02136939	
GO Biological Process	nuclear-transcribed mRNA catabolic process	50	7.732924e-9	0.00000203515093832	2.354815	57	0.02569883	165	0.03609324688909091	1.695668	41	198	0.01788051	
GO Biological Process	mRNA catabolic process	60	4.091938e-8	0.000008974302023666667	2.204104	59	0.02660054	180	0.04270500504777777	1.653145	43	213	0.01875273	
GO Biological Process	nucleoside triphosphate metabolic process	61	4.419095e-8	0.000009532929689344263	2.053691	69	0.03110911	187	0.04582065835026738	1.580856	50	259	0.02180549	
GO Biological Process	negative regulation of cell cycle G2/M phase transition	76	1.015003e-7	0.00001757424273289474	2.872881	34	0.01532913	109	0.0026249899156880734	2.339667	26	91	0.01133886	
GO Biological Process	DNA replication	80	1.461305e-7	0.00002403664061875	2.010541	67	0.03020739	138	0.012979875496376811	1.738196	45	212	0.01962495	
GO Biological Process	macromolecular complex disassembly	87	2.382697e-7	0.00003603897680804598	2.136138	56	0.02524797	123	0.0049079218585365856	1.84356	43	191	0.01875273	
GO Biological Process	cellular protein complex disassembly	90	3.304936e-7	0.00004832183647111112	2.48612	40	0.01803427	172	0.038737770223255814	1.884732	29	126	0.01264719	
GO Biological Process	DNA-dependent DNA replication	91	3.407416e-7	0.00004927273312527472	2.363086	44	0.01983769	178	0.04135900313707865	1.922596	27	115	0.01177497	
GO Biological Process	negative regulation of G2/M transition of mitotic cell cycle	113	0.000001315437	0.00015318438480530974	2.69755	31	0.01397656	137	0.011679409724087592	2.208225	24	89	0.01046664	
GO Biological Process	protein complex disassembly	129	0.000002688315	0.0002742289696511628	2.136741	46	0.0207394	195	0.04966282179897436	1.751072	34	159	0.01482774	
GO Biological Process	pyridine-containing compound metabolic process	132	0.000002914472	0.0002905419473333333	2.244061	41	0.01848512	169	0.0376403384147929	1.939461	27	114	0.01177497	
GO Biological Process	mitochondrial membrane organization	184	0.00001577689	0.0011283048669021739	2.064164	42	0.01893598	162	0.031026956272839506	1.915131	29	124	0.01264719	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	268	0.00007733681	0.0037972950850373127	2.465287	24	0.01082056	139	0.014254027605035972	2.373576	20	69	0.008722198	
GO Cellular Component	mitochondrial matrix	22	3.342872e-15	2.6256740072727273e-13	2.13475	130	0.05861136	24	0.000010697767199999999	1.695486	94	454	0.04099433	
GO Cellular Component	ribosomal subunit	25	2.212031e-11	1.5289558272000001e-9	2.837545	55	0.02479711	30	0.002620858176	1.859087	42	185	0.01831662	
GO Cellular Component	mitochondrial ribosome	27	4.172922e-10	2.67067008e-8	4.129572	29	0.01307484	56	0.03412550057142857	2.023124	21	85	0.009158308	
GO Cellular Component	mitochondrial large ribosomal subunit	30	3.752629e-9	2.1615143039999997e-7	5.031155	21	0.009467989	49	0.029165367379591835	2.408481	15	51	0.006541648	
GO Cellular Component	spliceosomal complex	33	1.178296e-8	6.169986327272728e-7	2.268273	60	0.0270514	35	0.011554247314285714	1.76104	40	186	0.0174444	
GO Cellular Component	ribosome	34	2.155342e-8	0.0000010954208752941175	2.211811	61	0.02750225	41	0.019351855141463415	1.630827	47	236	0.02049717	
GO Cellular Component	large ribosomal subunit	36	2.505278e-8	0.0000012025334399999999	2.993753	35	0.01577998	44	0.021971425745454545	1.922596	27	115	0.01177497	
GO Cellular Component	methyltransferase complex	40	2.21779e-7	0.0000095808528	2.726973	35	0.01577998	34	0.008979485929411765	2.159693	24	91	0.01046664	
GO Cellular Component	3M complex	79	0.0001049397	0.002295389893670886	11.12419	5	0.002254283	52	0.03326974892307692	6.551068	4	5	0.00174444	
GO Cellular Component	PcG protein complex	87	0.0002163174	0.004296511117241379	2.399963	22	0.009918846	36	0.0115139952	2.670272	15	46	0.006541648	
GO Cellular Component	U2-type spliceosomal complex	100	0.0004999523	0.008639175744000001	2.771294	15	0.006762849	48	0.0285572592	2.729612	12	36	0.005233319	
GO Cellular Component	pyruvate dehydrogenase complex	114	0.00107216	0.01625168842105263	5.34083	6	0.00270514	40	0.01981771056	5.849168	5	7	0.002180549	
GO Cellular Component	endoplasmic reticulum exit site	122	0.001581027	0.022393562754098362	2.966589	11	0.004959423	59	0.04623703322033899	4.094418	6	12	0.002616659	
GO Molecular Function	nuclease activity	16	2.50455e-7	0.000066088813125	2.056196	61	0.02750225	26	0.01078571443769231	1.776823	46	212	0.02006106	
GO Molecular Function	mismatched DNA binding	25	0.000001389352	0.00023463376576	7.5326	10	0.004508566	21	0.003083006934285715	5.459224	8	12	0.003488879	
GO Molecular Function	heat shock protein binding	40	0.000006014839	0.0006348662564499999	2.225932	39	0.01758341	34	0.03617892646470588	2.027712	26	105	0.01133886	
GO Molecular Function	exonuclease activity	46	0.000009357132	0.0008588219848695652	2.632909	27	0.01217313	32	0.028822485725000003	2.262705	21	76	0.009158308	
GO Molecular Function	DNA insertion or deletion binding	130	0.0008987678	0.029189212704615386	6.923323	5	0.002254283	27	0.022804226051851853	6.82403	5	6	0.002180549	
Human Phenotype	Increased serum lactate	3	3.246512e-7	0.0007221324858666667	2.777723	33	0.01487827	21	0.03969338721428571	2.129097	26	100	0.01133886	
Mouse Phenotype Single KO	abnormal amino acid metabolism	54	0.000004065308	0.000689370839925926	11.27928	7	0.003155996	43	0.031056008090697675	6.82403	5	6	0.002180549	
Mouse Phenotype	abnormal amino acid metabolism	14	2.986684e-11	2.0396918374285715e-8	16.11044	12	0.00541028	39	0.005067646248461538	7.019002	6	7	0.002616659	
Mouse Phenotype	abnormal DNA repair	74	0.000010613	0.0013712282837837837	2.31382	34	0.01532913	52	0.021831550626923078	2.013648	30	122	0.0130833	
Mouse Phenotype	disorganized mitochondrial cristae	90	0.00003824438	0.004062827968666667	4.63686	11	0.004959423	44	0.007731756885681817	5.039283	8	13	0.003488879