# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	16	1.485087e-56	1.2213912395625e-53	2.780999	324	0.01920341	487	0.0036718743901437375	1.334134	78	113	0.008028821	
GO Biological Process	regulation of DNA-templated transcription in response to stress	20	7.591161e-52	4.9946043799500006e-49	2.572338	339	0.02009246	420	0.001467470688261905	1.348076	83	119	0.008543489	
GO Biological Process	endoplasmic reticulum unfolded protein response	26	2.77024e-47	1.402061083076923e-44	2.647232	293	0.01736605	334	0.00032383932596706587	1.390248	82	114	0.008440556	
GO Biological Process	mRNA catabolic process	30	8.712369e-44	3.8215354557e-41	2.106844	429	0.02542674	305	0.00014476776775409835	1.297597	143	213	0.01471951	
GO Biological Process	nuclear-transcribed mRNA catabolic process	34	2.00162e-42	7.746858111764705e-40	2.150661	396	0.02347084	309	0.0001501384835080906	1.308046	134	198	0.0137931	
GO Biological Process	cellular response to unfolded protein	40	2.904268e-40	9.554315652999999e-38	2.397876	298	0.0176624	342	0.00041645118394736843	1.373714	86	121	0.00885229	
GO Biological Process	liver regeneration	41	4.559081e-40	1.463242606804878e-37	3.431179	166	0.009838786	315	0.00017989731561904762	1.711895	31	35	0.003190942	
GO Biological Process	cellular response to topologically incorrect protein	44	6.310701e-40	1.887329874068182e-37	2.311811	318	0.0188478	377	0.0008158778955702918	1.334873	96	139	0.009881626	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	52	8.441842e-38	2.136273055346154e-35	2.604445	239	0.01416548	388	0.0009722778120618557	1.359501	83	118	0.008543489	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	54	1.375605e-37	3.3521455916666666e-35	2.102771	368	0.02181128	336	0.0003304902040208333	1.334245	107	155	0.0110139	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	63	4.239306e-36	8.854766294285716e-34	2.402219	265	0.0157065	510	0.005155543968431373	1.357061	66	94	0.006793618	
GO Biological Process	cellular response to epidermal growth factor stimulus	64	1.296407e-35	2.6655343301562497e-33	2.761261	203	0.01203177	692	0.03145031425433526	1.47502	29	38	0.002985075	
GO Biological Process	response to epidermal growth factor	76	6.611551e-34	1.144755258013158e-31	2.634341	209	0.01238739	640	0.020606377171875	1.472598	32	42	0.003293875	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	80	4.147364e-33	6.8218953595e-31	2.597482	209	0.01238739	588	0.012550895307312925	1.362861	55	78	0.005661348	
GO Biological Process	protein targeting to ER	88	6.471498e-32	9.677095702500001e-30	2.562891	206	0.01220958	368	0.0006913263016576088	1.396963	73	101	0.007514153	
GO Biological Process	response to unfolded protein	92	1.503225e-31	2.1501019320652177e-29	2.01257	341	0.020211	363	0.000641668003168044	1.316709	109	160	0.01121976	
GO Biological Process	cotranslational protein targeting to membrane	93	2.076735e-31	2.9384683725806455e-29	2.595343	198	0.01173542	374	0.0007717876645721924	1.400283	71	98	0.007308286	
GO Biological Process	translational elongation	100	1.736926e-30	2.2856209234e-28	2.412632	220	0.01303936	166	2.1596202007228915e-8	1.55313	90	112	0.009264025	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	110	2.444841e-29	2.9246966108181817e-27	2.589215	185	0.01096491	441	0.00209463291015873	1.386563	66	92	0.006793618	
GO Biological Process	multi-organism metabolic process	115	1.006068e-28	1.1512042445217391e-26	2.09823	279	0.01653627	413	0.0013487621331961257	1.314819	100	147	0.01029336	
GO Cellular Component	ribosomal subunit	35	1.852126e-39	9.144210651428572e-38	2.251713	332	0.01967757	56	0.000002650118811428571	1.36862	131	185	0.0134843	
GO Cellular Component	mitochondrial ribosome	43	1.848409e-27	7.428025004651164e-26	2.807975	150	0.008890469	69	0.000018099936	1.50075	66	85	0.006793618	
GO Cellular Component	large ribosomal subunit	44	2.85254e-27	1.1202702545454544e-25	2.338871	208	0.01232812	96	0.0005929383600000001	1.361352	81	115	0.008337622	
GO Cellular Component	catalytic step 2 spliceosome	45	3.182046e-25	1.2219056639999999e-23	2.23783	210	0.01244666	53	7.516092498113208e-7	1.530121	76	96	0.007822954	
GO Cellular Component	proteasome core complex	48	6.146697e-24	2.21281092e-22	5.042588	62	0.003674727	139	0.0166498021294964	1.610654	20	24	0.002058672	
GO Cellular Component	mitochondrial large ribosomal subunit	55	9.674662e-20	3.0396028974545454e-18	2.992037	95	0.005630631	129	0.009796721860465115	1.440114	38	51	0.003911477	
GO Cellular Component	nuclear ubiquitin ligase complex	60	1.560093e-16	4.49306784e-15	2.77758	88	0.005215742	148	0.025915318054054056	1.449588	30	40	0.003088008	
GO Cellular Component	endopeptidase complex	61	1.967983e-16	5.574876432786885e-15	2.212404	135	0.008001422	102	0.0008069324611764706	1.456591	52	69	0.005352548	
GO Cellular Component	proteasome complex	64	9.36516e-16	2.5285932e-14	2.18086	133	0.007882883	107	0.0011324754841121496	1.449588	51	68	0.005249614	
GO Cellular Component	ESCRT complex	71	2.493275e-14	6.068139718309859e-13	2.979857	67	0.003971076	77	0.00007646283303896104	1.794728	26	28	0.002676274	
GO Cellular Component	small ribosomal subunit	72	2.746347e-14	6.591232799999999e-13	2.121255	127	0.007527264	115	0.004622819227826086	1.3959	52	72	0.005352548	
GO Cellular Component	DNA-directed RNA polymerase III complex	76	5.006021e-14	1.1382110905263157e-12	4.361505	40	0.002370792	159	0.03771463245283019	1.627608	16	19	0.001646938	
GO Cellular Component	spliceosomal snRNP complex	119	3.203731e-10	4.652140477310924e-9	2.029463	96	0.0056899	124	0.009014734916129032	1.402827	45	62	0.004632012	
GO Cellular Component	mitochondrial small ribosomal subunit	123	5.122365e-10	7.196298146341464e-9	2.700179	52	0.003082029	95	0.0005260130223157895	1.7257	25	28	0.00257334	
GO Cellular Component	high-density lipoprotein particle	142	3.935884e-9	4.789582783098591e-8	2.652928	48	0.00284495	173	0.04993585387283238	1.503277	21	27	0.002161606	
GO Cellular Component	ESCRT III complex	153	1.157113e-8	1.3068570352941176e-7	3.234707	33	0.001955903	117	0.005416668553846153	1.932784	12	12	0.001235203	
GO Cellular Component	methylosome	184	3.046513e-7	0.0000028610730782608696	3.475329	24	0.001422475	117	0.005416668553846153	1.932784	12	12	0.001235203	
GO Cellular Component	U1 snRNP	239	0.000007362567	0.00005323228358158996	2.189479	40	0.002370792	159	0.03771463245283019	1.627608	16	19	0.001646938	
GO Cellular Component	precatalytic spliceosome	277	0.00004080209	0.0002545343376173285	2.045057	39	0.002311522	156	0.035905824	1.518616	22	28	0.002264539	
GO Cellular Component	platelet dense tubular network	309	0.0001640271	0.000917277763106796	2.117809	30	0.001778094	127	0.00965017927559055	1.932784	11	11	0.00113227	
GO Molecular Function	structural constituent of ribosome	10	9.696163e-36	4.0937200186e-33	2.239468	303	0.01795875	28	0.000010984897610714286	1.3959	117	162	0.01204323	
GO Molecular Function	unfolded protein binding	11	6.476355e-31	2.485742800909091e-28	2.51651	206	0.01220958	94	0.011049903738297872	1.331068	73	106	0.007514153	
GO Molecular Function	rRNA binding	15	1.211238e-23	3.4092312239999996e-21	3.169992	106	0.006282598	119	0.046180697226890756	1.385162	43	60	0.004426145	
GO Molecular Function	alcohol dehydrogenase (NADP+) activity	232	0.000006552505	0.0001192442935775862	2.226388	39	0.002311522	103	0.0171337204	1.811985	15	16	0.001544004	
Human Phenotype	Abnormal CSF metabolite level	35	2.252064e-12	4.2937208777142854e-10	2.136652	106	0.006282598	107	0.028208517205607478	1.411239	46	63	0.004734946	
Human Phenotype	Abnormality of glycolysis	252	0.0000153437	0.00040630361150793647	2.468892	29	0.001718824	113	0.04188302544690265	1.932784	11	11	0.00113227	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	17	2.05105e-31	1.1047920499999998e-28	2.182768	280	0.01659554	177	0.014205926648022598	1.350871	65	93	0.006690685	
Mouse Phenotype Single KO	decreased sensitivity to induced cell death	41	1.868018e-22	4.1720587380487803e-20	2.042305	229	0.01357278	142	0.006042515356267606	1.412419	57	78	0.005867216	
Mouse Phenotype Single KO	increased hepatocyte apoptosis	122	8.130278e-14	6.1023734136065576e-12	2.080746	128	0.007586534	182	0.015501553232967032	1.518616	33	42	0.003396809	
Mouse Phenotype Single KO	cardia bifida	443	0.000001394958	0.0000288343801489842	2.071473	53	0.003141299	110	0.002181900824090909	1.932784	16	16	0.001646938	
Mouse Phenotype	decreased circulating free fatty acid level	19	1.14983e-35	5.786065594736842e-33	2.078909	358	0.02121859	167	0.001190105761257485	1.364318	84	119	0.008646423	
Mouse Phenotype	dry eyes	37	1.062698e-27	2.7460690751351353e-25	3.442206	112	0.006638217	301	0.013277230467109635	1.811985	15	16	0.001544004	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	121	1.264235e-16	9.9895461446281e-15	2.868539	84	0.004978663	394	0.032290117781725886	1.546227	24	30	0.002470407	
Mouse Phenotype	increased liver adenoma incidence	472	4.106768e-7	0.000008318815433898306	2.037128	61	0.003615458	355	0.022800833101690142	1.587644	23	28	0.002367473