# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	17	1.229272e-81	9.515288381176471e-79	2.162332	771	0.02242909	340	0.000022908208957647058	1.217551	139	155	0.01005061	
GO Biological Process	endoplasmic reticulum unfolded protein response	18	3.823302e-80	2.795046167666667e-77	2.496644	563	0.01637818	280	0.0000011845365227857143	1.274333	107	114	0.007736804	
GO Biological Process	cellular response to topologically incorrect protein	25	2.156512e-76	1.13510165632e-73	2.283647	640	0.01861818	249	7.974755640160643e-8	1.269792	130	139	0.009399855	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	26	9.247716e-76	4.6804113401538454e-73	2.405558	571	0.01661091	399	0.0000883816814511278	1.23755	103	113	0.007447578	
GO Biological Process	IRE1-mediated unfolded protein response	36	1.151202e-69	4.207963088333333e-67	3.234737	320	0.009309091	497	0.0008464284486720321	1.287475	55	58	0.003976862	
GO Biological Process	cellular response to unfolded protein	37	1.992705e-69	7.087028404054054e-67	2.286719	579	0.01684364	260	2.245927002346154e-7	1.279156	114	121	0.00824295	
GO Biological Process	regulation of DNA-templated transcription in response to stress	39	8.314282e-68	2.8053240214871795e-65	2.22717	598	0.01739636	348	0.00002698494954597701	1.243608	109	119	0.007881417	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	40	5.531449e-67	1.819708434775e-64	2.349225	528	0.01536	524	0.001127947793091603	1.227708	85	94	0.006146059	
GO Biological Process	liver regeneration	41	1.975893e-65	6.341652679756098e-63	3.155146	311	0.009047273	664	0.005969467388704818	1.318909	34	35	0.002458424	
GO Biological Process	regulation of mitochondrial membrane permeability	79	1.196883e-50	1.9936434679746834e-48	2.263673	428	0.01245091	673	0.006523231099257058	1.22751	66	73	0.004772234	
GO Biological Process	regulation of nuclease activity	88	1.272134e-48	1.9022740120454545e-46	3.517074	197	0.005730909	977	0.048672972526100304	1.305481	25	26	0.001807664	
GO Biological Process	response to epidermal growth factor	93	7.473652e-47	1.0574815770752688e-44	2.319962	375	0.01090909	834	0.026940796220623498	1.260722	39	42	0.002819957	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	104	2.972338e-45	3.7608649751923076e-43	2.31602	363	0.01056	703	0.009854572941820768	1.316558	32	33	0.002313811	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	107	9.377963e-45	1.1533141599719627e-42	2.182234	408	0.01186909	290	0.000002191718117896552	1.265653	110	118	0.007953724	
GO Biological Process	regulation of membrane permeability	111	1.723108e-44	2.0427367722522523e-42	2.088417	449	0.01306182	724	0.01154712973494475	1.206845	72	81	0.005206074	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	136	6.443688e-41	6.234741940588235e-39	2.208202	362	0.01053091	593	0.0025274222794266442	1.235856	71	78	0.005133767	
GO Biological Process	positive regulation of mRNA metabolic process	169	8.20322e-36	6.3873474544378705e-34	2.223928	310	0.009018182	477	0.0006366368339203354	1.305481	50	52	0.003615329	
GO Biological Process	protein targeting to ER	175	2.932473e-35	2.2050521261142856e-33	2.106716	345	0.01003636	254	1.401922558897638e-7	1.30393	97	101	0.007013738	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	177	5.402813e-35	4.0167014840112996e-33	2.154063	325	0.009454545	899	0.033496446741935484	1.200286	61	69	0.004410701	
GO Biological Process	cotranslational protein targeting to membrane	186	2.168147e-34	1.5339057189784945e-32	2.123085	330	0.0096	316	0.000010179086150632911	1.274576	92	98	0.006652205	
GO Cellular Component	nuclear ubiquitin ligase complex	52	2.784629e-31	9.253536369230769e-30	2.757578	178	0.005178182	186	0.025486086193548387	1.255873	37	40	0.002675343	
GO Cellular Component	cleavage furrow	53	3.941368e-31	1.2850346988679245e-29	2.102486	304	0.008843636	157	0.007602400937579618	1.253262	48	52	0.003470716	
GO Cellular Component	PcG protein complex	58	8.846203e-29	2.635558411034483e-27	2.062378	293	0.008523636	154	0.007290874098701299	1.269155	43	46	0.003109183	
GO Cellular Component	mitochondrial ribosome	60	6.185858e-27	1.781527104e-25	2.186769	238	0.006923636	84	0.000023393046857142855	1.277836	80	85	0.005784526	
GO Cellular Component	mitochondrial large ribosomal subunit	101	1.163873e-18	1.9912599445544555e-17	2.272399	147	0.004276364	114	0.0004580382315789474	1.304457	49	51	0.003543022	
GO Cellular Component	DNA-directed RNA polymerase III complex	120	1.954314e-16	2.81421216e-15	3.425155	64	0.001861818	188	0.027459556085106383	1.357701	19	19	0.001373825	
GO Cellular Component	ESCRT complex	182	3.080532e-11	2.9248128e-10	2.117465	97	0.002821818	182	0.019888833758241756	1.309211	27	28	0.001952278	
GO Cellular Component	proteasome accessory complex	265	2.219885e-8	1.447532558490566e-7	2.015541	77	0.00224	217	0.04940068512442397	1.30113	23	24	0.001663051	
GO Molecular Function	snRNA binding	56	2.524298e-17	1.903140385e-15	2.431133	118	0.003432727	106	0.0051647726	1.321972	37	38	0.002675343	
Human Phenotype	Abnormal CSF metabolite level	42	8.674678e-22	1.3782411022380952e-19	2.087537	211	0.006138182	211	0.007073753181990521	1.249947	58	63	0.004193782	
Human Phenotype	Increased CSF lactate	70	1.17859e-17	1.12353301e-15	2.010147	184	0.005352727	255	0.018118158005490194	1.240657	53	58	0.003832249	
Human Phenotype	Abnormality of transition element cation homeostasis	111	8.267472e-15	4.970165824864865e-13	2.498123	94	0.002734545	297	0.03577462704040404	1.310883	28	29	0.002024584