# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of fat cell differentiation 65 8.569641e-9 0.0000017348908602923077 2.584359 47 0.04331797 107 0.03376857660747664 2.423662 19 115 0.01484375 GO Biological Process positive regulation of gliogenesis 107 1.165499e-7 0.000014333459197196264 3.643729 24 0.02211982 126 0.04669501436587302 3.227297 11 50 0.00859375 GO Biological Process metanephric nephron development 110 1.373519e-7 0.00001643103320090909 3.496192 25 0.02304147 102 0.03446142134803922 4.000781 9 33 0.00703125 GO Biological Process striated muscle cell differentiation 152 0.000001042957 0.0000902912576513158 2.103138 51 0.04700461 27 0.00028475486281851853 2.593508 32 181 0.025 GO Biological Process regulation of axon extension involved in axon guidance 185 0.000003224832 0.0002293814285837838 3.720664 18 0.01658986 37 0.0012738861581891893 7.334766 8 16 0.00625 GO Biological Process regulation of axon extension 214 0.000008622012 0.0005301731584485981 2.440808 31 0.02857143 85 0.02498451338352941 2.895302 15 76 0.01171875 GO Biological Process paramesonephric duct development 232 0.00001381386 0.0007835197575 17.1115 5 0.004608295 112 0.03713701257410714 14.66953 3 3 0.00234375 GO Biological Process regulation of lymphocyte differentiation 247 0.0000181679 0.0009679003890688259 2.106736 39 0.0359447 48 0.0037153449575 2.492862 26 153 0.0203125 GO Biological Process myoblast fusion 248 0.00001894679 0.0010053258452016127 4.584068 12 0.01105991 99 0.03148969967070707 5.134336 7 20 0.00546875 GO Biological Process regulation of axon guidance 320 0.00006260877 0.00257459001384375 2.961991 18 0.01658986 62 0.008832647652580645 5.588393 8 21 0.00625 GO Biological Process positive regulation of protein localization to plasma membrane 367 0.0001412009 0.005062840989373297 2.771633 18 0.01658986 68 0.010340661499264705 3.745412 12 47 0.009375 GO Biological Process positive regulation of embryonic development 412 0.0002190711 0.006996982050728155 2.58904 19 0.01751152 102 0.03446142134803922 4.000781 9 33 0.00703125 GO Biological Process nephron tubule morphogenesis 476 0.0004105248 0.011348940847058822 2.016791 29 0.02672811 105 0.034346794662857144 3.027046 13 63 0.01015625 GO Biological Process positive regulation of protein localization to cell periphery 486 0.0004587442 0.012421018369958847 2.507297 18 0.01658986 91 0.02697433043076923 3.321403 12 53 0.009375 GO Biological Process positive regulation of neural precursor cell proliferation 543 0.0006196784 0.015017215590423573 2.441813 18 0.01658986 109 0.03701763118990826 3.361768 11 48 0.00859375 GO Biological Process positive regulation of protein localization to membrane 545 0.000622724 0.015035642414678899 2.051798 26 0.02396313 87 0.0258637724954023 2.511001 19 111 0.01484375 GO Biological Process eye photoreceptor cell differentiation 659 0.001307337 0.026105079792109256 2.348114 17 0.0156682 122 0.04442025385245902 3.492746 10 42 0.0078125 Mouse Phenotype Single KO atelectasis 66 9.285134e-9 0.0000012882420005757574 2.886071 39 0.0359447 38 0.011730317008157895 2.839264 18 93 0.0140625 Mouse Phenotype Single KO abnormal immature B cell number 78 4.231429e-8 0.0000049675891478205126 2.765448 38 0.03502304 94 0.048362091527659565 2.378843 18 111 0.0140625 Mouse Phenotype Single KO abnormal somatic nervous system physiology 105 3.438153e-7 0.00002998396859142857 3.066422 28 0.02580645 39 0.01185407930051282 3.189029 15 69 0.01171875 Mouse Phenotype Single KO increased stomach pH 115 7.721185e-7 0.00006148077482173912 7.053887 11 0.01013825 78 0.03410201807051282 5.867812 6 15 0.0046875 Mouse Phenotype Single KO abnormal gastric parietal cell morphology 187 0.000009965245 0.0004879772645187166 4.897341 12 0.01105991 73 0.029490921305479454 4.513702 8 26 0.00625 Mouse Phenotype Single KO abnormal gastric chief cell morphology 205 0.00001778897 0.0007946029184878048 5.041099 11 0.01013825 55 0.018273059885454548 5.704818 7 18 0.00546875 Mouse Phenotype Single KO abnormal hair cell physiology 217 0.00002362153 0.0009967850240092165 3.199581 18 0.01658986 70 0.028064308192857143 3.761418 10 39 0.0078125 Mouse Phenotype Single KO abnormal susceptibility to hearing loss 294 0.0001489692 0.004639833212244898 2.974877 16 0.01474654 44 0.01258893538090909 4.314568 10 34 0.0078125 Mouse Phenotype Single KO abnormal sensory neuron physiology 307 0.0001766832 0.005269993688599348 2.558464 20 0.01843318 88 0.047309078593181814 3.035075 12 58 0.009375 Mouse Phenotype Single KO abnormal cochlear hair cell physiology 315 0.0002066087 0.0060060821139682535 3.013566 15 0.01382488 68 0.02783042571617647 4.125806 9 32 0.00703125 Mouse Phenotype Single KO abnormal B cell apoptosis 316 0.0002066154 0.005987269676582279 3.013557 15 0.01382488 70 0.028064308192857143 3.761418 10 39 0.0078125 Mouse Phenotype Single KO increased susceptibility to age-related hearing loss 326 0.0002471075 0.0069409919555214715 3.729124 11 0.01013825 84 0.03647046689642858 4.889844 7 21 0.00546875 Mouse Phenotype Single KO abnormal cochlear outer hair cell physiology 348 0.0003321933 0.00874107485086207 3.171673 13 0.01198157 59 0.01941690632881356 4.889844 8 24 0.00625 Mouse Phenotype Single KO abnormal cochlear hair cell number 363 0.0004133432 0.010426952293112949 2.11087 26 0.02396313 14 0.0044260012842142855 3.729542 15 59 0.01171875 Mouse Phenotype Single KO abnormal cochlear outer hair cell number 373 0.000461248 0.01132345291152815 2.260642 22 0.0202765 33 0.01176559898757576 3.826834 12 46 0.009375 Mouse Phenotype Single KO abnormal thymus involution 421 0.0008666934 0.018851096113539193 4.711086 7 0.006451613 56 0.018337497516071426 6.770553 6 13 0.0046875 Mouse Phenotype Single KO decreased neurotransmitter release 465 0.001258678 0.024786482679569892 3.539087 9 0.008294931 45 0.012514196316888888 5.334375 8 22 0.00625 Mouse Phenotype Single KO abnormal thymus physiology 581 0.003152621 0.049687694487091226 2.051411 19 0.01751152 64 0.02689611209375 2.857701 15 77 0.01171875 Mouse Phenotype abnormal male preputial gland morphology 17 1.555861e-15 8.750345306470588e-13 10.35549 22 0.0202765 156 0.03910949113846154 5.177482 6 17 0.0046875 Mouse Phenotype abnormal glans penis morphology 18 1.833989e-15 9.741538238333333e-13 10.27071 22 0.0202765 177 0.048739779510169494 4.889844 6 18 0.0046875 Mouse Phenotype epidermal hyperplasia 20 2.761041e-15 1.31991565005e-12 4.132028 46 0.04239631 176 0.04845959712443182 2.330673 17 107 0.01328125 Mouse Phenotype abnormal preputial gland morphology 25 2.985533e-14 1.14178724052e-11 8.36006 23 0.02119816 108 0.020972991894444442 5.134336 7 20 0.00546875 Mouse Phenotype extramedullary hematopoiesis 26 5.06444e-14 1.862350416923077e-11 3.301898 55 0.05069124 173 0.04543755823526011 2.011821 24 175 0.01875 Mouse Phenotype atelectasis 41 1.414543e-12 3.2986452739024393e-10 3.067728 54 0.04976959 119 0.024727726782352945 2.402768 19 116 0.01484375 Mouse Phenotype abnormal immature B cell number 44 3.197154e-12 6.947270316818182e-10 2.895466 57 0.05253456 107 0.019796398985046728 2.157284 25 170 0.01953125 Mouse Phenotype abnormal immature B cell morphology 47 5.03434e-12 1.0241132923404255e-9 2.861413 57 0.05253456 135 0.03203337270222222 2.060327 25 178 0.01953125 Mouse Phenotype abnormal brown adipose tissue morphology 59 7.650814e-11 1.239820892440678e-8 2.815483 52 0.04792627 32 0.005808421036875 2.494818 25 147 0.01953125 Mouse Phenotype increased thymocyte number 68 2.786982e-10 3.918578662058824e-8 4.637147 26 0.02396313 96 0.01656586665 3.585885 11 45 0.00859375 Mouse Phenotype decreased susceptibility to weight gain 127 5.20551e-8 0.000003918888276377952 2.621529 41 0.03778802 143 0.03570931872587413 2.151531 22 150 0.0171875 Mouse Phenotype abnormal glomerular mesangium morphology 129 5.324007e-8 0.000003945955885813954 3.129398 31 0.02857143 159 0.03923690083018867 2.558639 15 86 0.01171875 Mouse Phenotype abnormal mesangial cell morphology 150 1.316894e-7 0.000008393882356000001 4.22944 20 0.01843318 78 0.012581589569230769 3.520688 12 50 0.009375 Mouse Phenotype abnormal urinary system development 168 2.569295e-7 0.00001462204136607143 2.06858 59 0.05437788 126 0.02509713936190476 2.225722 22 145 0.0171875 Mouse Phenotype abnormal thymus involution 169 2.69721e-7 0.000015259186278106507 6.319201 13 0.01198157 22 0.004576359612272727 5.740251 9 23 0.00703125 Mouse Phenotype increased DN3 thymocyte number 172 3.027905e-7 0.000016831278898255814 6.25382 13 0.01198157 171 0.04313084515789474 6.112305 5 12 0.00390625 Mouse Phenotype abnormal somatic nervous system physiology 177 4.063713e-7 0.000021950937849152544 2.788093 32 0.02949309 50 0.009695075815199999 2.933906 17 85 0.01328125 Mouse Phenotype abnormal stomach pH 185 6.399263e-7 0.000033072082996216214 5.844178 13 0.01198157 92 0.016999811341304346 5.404564 7 19 0.00546875 Mouse Phenotype increased stomach pH 193 9.435392e-7 0.00004674185643108808 6.907851 11 0.01013825 134 0.03125534423955224 5.501074 6 16 0.0046875 Mouse Phenotype mesangial cell hyperplasia 302 0.00003624552 0.0011474947573509933 3.741981 14 0.01290323 146 0.03547819915890411 3.667383 9 36 0.00703125