# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of mRNA catabolic process 150 2.86992e-37 2.517685152e-35 2.651782 229 0.006505682 1233 0.03448781797810219 1.326606 24 25 0.001766264 GO Biological Process posttranscriptional gene silencing 151 3.040247e-37 2.649444388940397e-35 2.291277 303 0.008607955 1310 0.04513894603358779 1.222433 46 52 0.00338534 GO Biological Process paraxial mesoderm development 264 1.428664e-25 7.121132415151515e-24 2.267238 208 0.005909091 1286 0.041761733933125975 1.381881 17 17 0.001251104 GO Biological Process regulation of mRNA catabolic process 266 1.666555e-25 8.244435054511278e-24 2.105631 245 0.006960227 1255 0.037165692425498005 1.292727 29 31 0.002134236 GO Biological Process negative regulation of neural precursor cell proliferation 583 8.878749e-16 2.004038732264151e-14 2.11091 144 0.004090909 1055 0.01926981508625592 1.381881 20 20 0.001471887 GO Biological Process anterograde axonal transport 653 1.564267e-14 3.1522495333843797e-13 2.106021 132 0.00375 1255 0.037165692425498005 1.292727 29 31 0.002134236 GO Cellular Component cleavage furrow 51 2.626001e-27 8.897509270588235e-26 2.005931 297 0.0084375 199 0.03902028928643216 1.222433 46 52 0.00338534 Mouse Phenotype Single KO vertebral transformation 11 2.20378e-62 1.8345466781818183e-59 2.202303 563 0.01599432 432 0.0005005390013425926 1.246697 83 92 0.006108331 Mouse Phenotype Single KO thoracic vertebral transformation 18 1.060551e-49 5.395258615e-47 2.677424 304 0.008636364 757 0.011433310445310436 1.266724 44 48 0.003238151 Mouse Phenotype Single KO abnormal cervical atlas morphology 27 7.341195e-46 2.4897526894444444e-43 2.19289 414 0.01176136 657 0.0062647943033485535 1.289756 42 45 0.003090963 Mouse Phenotype Single KO abnormal vertebral body morphology 34 1.938296e-42 5.220287197647059e-40 2.058121 443 0.01258523 363 0.00014763735241597796 1.3307 52 54 0.003826906 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 35 1.96578e-42 5.143042131428572e-40 2.473141 298 0.008465909 715 0.009044473917342657 1.307185 35 37 0.002575802 Mouse Phenotype Single KO abnormal interventricular septum thickness 47 3.911751e-38 7.621256150425532e-36 2.311272 305 0.008664773 976 0.029353692335040982 1.253334 39 43 0.00287018 Mouse Phenotype Single KO thin interventricular septum 67 7.680272e-35 1.0496753836417911e-32 2.958843 178 0.005056818 905 0.021609781369060773 1.381881 19 19 0.001398293 Mouse Phenotype Single KO small superior cervical ganglion 77 3.791505e-32 4.50893653051948e-30 2.578708 206 0.005852273 446 0.0006500849952017936 1.381881 32 32 0.002355019 Mouse Phenotype Single KO abnormal mesangial cell morphology 79 3.833839e-31 4.4438561674683543e-29 2.360405 236 0.006704545 852 0.017121666170187795 1.300594 32 34 0.002355019 Mouse Phenotype Single KO subcutaneous edema 80 4.694512e-31 5.373455798e-29 2.52125 207 0.005880682 1067 0.0395751894611059 1.289756 28 30 0.002060642 Mouse Phenotype Single KO abnormal fourth pharyngeal arch artery morphology 99 1.07006e-28 9.897514565656566e-27 2.208931 249 0.007073864 1110 0.04654134345135135 1.381881 16 16 0.00117751 Mouse Phenotype Single KO cervical vertebral transformation 104 5.984819e-28 5.269518036826923e-26 2.294637 223 0.006335227 680 0.007231736710147058 1.30915 36 38 0.002649397 Mouse Phenotype Single KO abnormal Mullerian duct morphology 108 7.596515e-28 6.440859986574074e-26 2.083528 276 0.007840909 809 0.013768551223733003 1.302916 33 35 0.002428613 Mouse Phenotype Single KO heterochrony 142 1.656384e-24 1.0681343864788733e-22 2.609071 151 0.004289773 1022 0.03656780750880626 1.381881 17 17 0.001251104 Mouse Phenotype Single KO abnormal pharynx morphology 168 1.233662e-22 6.724192222619048e-21 2.299517 177 0.005028409 737 0.010043587697829037 1.381881 22 22 0.001619076 Mouse Phenotype Single KO abnormal cerebral artery morphology 179 1.37621e-21 7.040198307262569e-20 2.348197 161 0.004573864 1040 0.03791059633653846 1.324303 23 24 0.00169267 Mouse Phenotype Single KO small thyroid gland 242 9.62455e-19 3.6418183615702485e-17 2.209612 157 0.004460227 905 0.021609781369060773 1.381881 19 19 0.001398293 Mouse Phenotype Single KO abnormal stapedial artery morphology 252 2.280708e-18 8.287477442857144e-17 2.514886 118 0.003352273 1022 0.03656780750880626 1.381881 17 17 0.001251104 Mouse Phenotype Single KO absent stapedial artery 274 1.388329e-17 4.639754982846715e-16 2.496607 114 0.003238636 1110 0.04654134345135135 1.381881 16 16 0.00117751 Mouse Phenotype Single KO abnormal transitional stage T2 B cell morphology 391 8.060649e-15 1.887758641764706e-13 2.339836 107 0.003039773 1110 0.04654134345135135 1.381881 16 16 0.00117751 Mouse Phenotype enlarged liver sinusoidal spaces 35 9.22726e-57 2.5206237959999998e-54 2.58531 371 0.01053977 903 0.0024823447707641192 1.314472 39 41 0.00287018 Mouse Phenotype abnormal cervical atlas morphology 41 8.427044e-51 1.965145553268293e-48 2.226576 445 0.01264205 1136 0.009268000798415492 1.251515 48 53 0.003532529 Mouse Phenotype thoracic vertebral transformation 52 2.053132e-47 3.7749990484615385e-45 2.478813 333 0.009460227 981 0.00418435556880734 1.260663 52 57 0.003826906 Mouse Phenotype increased body temperature 75 1.803353e-40 2.2989144043999998e-38 2.471456 284 0.008068182 1539 0.03485550456530214 1.263434 32 35 0.002355019 Mouse Phenotype abnormal mesangial cell morphology 122 1.889788e-31 1.4810051695081967e-29 2.072846 318 0.009034091 1609 0.04057214806650093 1.216055 44 50 0.003238151 Mouse Phenotype subcutaneous edema 125 4.694512e-31 3.59073833856e-29 2.52125 207 0.005880682 1494 0.029511204026104416 1.289756 28 30 0.002060642 Mouse Phenotype absent segment of posterior cerebral artery 165 1.227208e-27 7.111112538181818e-26 2.77934 154 0.004375 1634 0.04452936278151775 1.319068 21 22 0.001545481 Mouse Phenotype cervical vertebral transformation 200 3.59525e-25 1.7187092625000002e-23 2.033415 263 0.007471591 823 0.0015588240459295261 1.317608 41 43 0.003017368 Mouse Phenotype thin hypoglossal nerve 203 4.826132e-25 2.2730368498522167e-23 3.060008 119 0.003380682 1660 0.044916633419277104 1.381881 15 15 0.001103915 Mouse Phenotype heterochrony 215 1.656384e-24 7.365901127441861e-23 2.609071 151 0.004289773 1444 0.02702294820083103 1.381881 17 17 0.001251104 Mouse Phenotype abnormal stapedial artery morphology 232 1.212087e-23 4.995156813362069e-22 2.509564 156 0.004431818 1208 0.012227664208609271 1.381881 20 20 0.001471887 Mouse Phenotype absent ductus venosus valve 242 2.865961e-23 1.1322914512809918e-21 2.30173 182 0.005170455 1634 0.04452936278151775 1.319068 21 22 0.001545481 Mouse Phenotype ruffled hair 243 2.870188e-23 1.1292949575308643e-21 2.208281 199 0.005653409 1160 0.010026027258620689 1.302916 33 35 0.002428613 Mouse Phenotype persistent right dorsal aorta 250 6.448607e-23 2.4662052610800003e-21 2.132168 212 0.006022727 1444 0.02702294820083103 1.381881 17 17 0.001251104 Mouse Phenotype absent stapedial artery 253 7.345219e-23 2.7757960023320158e-21 2.495749 152 0.004318182 1292 0.01580471040789474 1.381881 19 19 0.001398293 Mouse Phenotype delayed hair appearance 255 1.046555e-22 3.923965629411765e-21 2.031235 236 0.006704545 1250 0.0138686052912 1.3307 26 27 0.001913453 Mouse Phenotype abnormal transitional stage T2 B cell morphology 264 3.94167e-22 1.4275116238636363e-20 2.132775 204 0.005795455 1121 0.008636755785013382 1.33423 28 29 0.002060642 Mouse Phenotype increased lactate dehydrogenase level 273 8.469634e-22 2.966233358021978e-20 2.210547 185 0.005255682 1065 0.006783187458591549 1.335818 29 30 0.002134236 Mouse Phenotype abnormal cerebral artery morphology 276 1.37621e-21 4.7673709456521734e-20 2.348197 161 0.004573864 1464 0.02811920141393443 1.324303 23 24 0.00169267 Mouse Phenotype lethality during fetal growth through weaning, incomplete penetrance 297 2.110859e-20 6.795260235353535e-19 2.707601 116 0.003295455 1444 0.02702294820083103 1.381881 17 17 0.001251104