# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	viral life cycle	39	5.657401e-88	1.908865122025641e-85	2.273383	735	0.04481707	240	0.000016928093989583336	1.285648	193	298	0.02040385	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	68	7.499892e-64	1.4513393945294119e-61	2.533636	431	0.02628049	221	0.00000800379800678733	1.408776	110	155	0.01162914	
GO Biological Process	mitochondrial transport	78	4.885669e-60	8.242374150128206e-58	2.177644	549	0.03347561	282	0.00009589569920567375	1.29571	156	239	0.01649223	
GO Biological Process	mRNA catabolic process	83	4.72992e-57	7.498917744578314e-55	2.314	458	0.02792683	200	0.0000032973611656	1.360674	146	213	0.01543504	
GO Biological Process	multi-organism metabolic process	84	3.208598e-56	5.0264215573809523e-54	2.669259	345	0.02103659	258	0.00004581826089534884	1.390916	103	147	0.0108891	
GO Biological Process	regulation of mRNA stability	86	9.352665e-56	1.4310664969186046e-53	2.351614	433	0.02640244	310	0.0002674622781870968	1.35407	103	151	0.0108891	
GO Biological Process	nuclear-transcribed mRNA catabolic process	92	2.854716e-54	4.083174765652174e-52	2.35224	421	0.02567073	218	0.00000707879954266055	1.363499	136	198	0.01437784	
GO Biological Process	cellular response to insulin stimulus	102	4.550621e-52	5.870747229313726e-50	2.171419	478	0.02914634	237	0.000014643457351054852	1.408343	105	148	0.01110054	
GO Biological Process	RNA catabolic process	115	2.802115e-50	3.206350546521739e-48	2.116304	489	0.02981707	249	0.00003246087486746988	1.309668	159	241	0.01680939	
GO Biological Process	regulation of RNA stability	116	3.032969e-50	3.440589575086207e-48	2.227016	436	0.02658537	419	0.0020552203567064434	1.302718	105	160	0.01110054	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	120	8.717872e-50	9.559873137333335e-48	2.917697	263	0.01603659	679	0.029993915293078054	1.282406	73	113	0.007717518	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	124	2.600699e-49	2.7598869468548383e-47	2.666769	302	0.01841463	441	0.002822134043764172	1.352674	77	113	0.008140395	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	125	1.082179e-48	1.13923147688e-46	2.90362	259	0.01579268	290	0.00014710223758275862	1.413117	84	118	0.008880431	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	142	1.685807e-45	1.5622207262676055e-43	2.639222	283	0.0172561	525	0.009310716871619048	1.351553	64	94	0.006766043	
GO Biological Process	viral gene expression	143	2.028747e-45	1.866872851258741e-43	2.721091	268	0.01634146	302	0.00020964788081456954	1.391129	89	127	0.009409028	
GO Biological Process	regulation of DNA-templated transcription in response to stress	151	3.855682e-44	3.360060889933775e-42	2.451211	314	0.01914634	420	0.0020915068121666667	1.351198	81	119	0.008563273	
GO Biological Process	rRNA processing	155	1.480073e-43	1.2565342327096775e-41	2.077204	441	0.02689024	568	0.013229233845774648	1.205235	153	252	0.01617507	
GO Biological Process	rRNA metabolic process	158	2.835121e-42	2.3612251417088608e-40	2.03954	447	0.0272561	558	0.012743248705555555	1.203319	157	259	0.01659795	
GO Biological Process	interaction with host	163	9.232597e-42	7.453481222269938e-40	2.105464	409	0.02493902	726	0.040701657016528926	1.232574	95	153	0.01004334	
GO Biological Process	macroautophagy	165	2.165264e-41	1.726830847030303e-39	2.260108	346	0.02109756	550	0.012043123977636364	1.27046	96	150	0.01014906	
GO Cellular Component	ribonucleoprotein granule	49	3.484397e-42	1.2287832685714286e-40	2.000515	468	0.02853659	53	0.000002024316135849057	1.374296	135	195	0.01427212	
GO Cellular Component	spliceosomal complex	52	8.648381e-41	2.873923532307692e-39	2.086036	408	0.02487805	64	0.000251162262	1.312723	123	186	0.01300349	
GO Cellular Component	ribosomal subunit	66	2.568726e-29	6.725391709090909e-28	2.06533	296	0.01804878	127	0.028517578582677165	1.212517	113	185	0.01194629	
GO Cellular Component	ficolin-1-rich granule lumen	67	5.290097e-29	1.3643712859701492e-27	2.187707	256	0.01560976	89	0.005282709573033708	1.312723	82	124	0.008668992	
GO Cellular Component	catalytic step 2 spliceosome	71	1.960829e-27	4.772271143661971e-26	2.324162	212	0.01292683	119	0.025858067899159665	1.302718	63	96	0.006660324	
GO Cellular Component	high-density lipoprotein particle	74	6.895816e-27	1.610266222702703e-25	4.491941	79	0.004817073	109	0.013572796359633028	1.617484	22	27	0.002325827	
GO Cellular Component	host cell	78	3.739747e-26	8.28497796923077e-25	2.519972	172	0.0104878	137	0.03682236823357664	1.342857	46	68	0.004863093	
GO Cellular Component	endopeptidase complex	79	1.146801e-25	2.5084457316455695e-24	2.630135	156	0.009512195	93	0.007240076593548387	1.409704	49	69	0.005180252	
GO Cellular Component	proteasome complex	81	2.883845e-25	6.152202666666666e-24	2.614752	155	0.00945122	102	0.009433695811764706	1.401243	48	68	0.005074532	
GO Cellular Component	P-body	88	6.646208e-24	1.3050735709090908e-22	2.131704	221	0.01347561	52	0.000001267163003076923	1.578508	66	83	0.006977482	
GO Cellular Component	peptidase complex	90	8.741522e-24	1.678372224e-22	2.299912	186	0.01134146	80	0.00216573696	1.398589	62	88	0.006554604	
GO Cellular Component	cleavage furrow	94	6.437098e-23	1.183330355744681e-21	2.391897	165	0.01006098	121	0.026682490710743804	1.41247	37	52	0.003911619	
GO Cellular Component	cytoplasmic stress granule	101	6.016485e-21	1.0293550574257425e-19	2.544654	133	0.008109756	114	0.016882438736842104	1.477279	32	43	0.003383021	
GO Cellular Component	axon cytoplasm	107	2.31042e-20	3.731220336448598e-19	2.624125	122	0.007439024	94	0.0073073259574468075	1.538448	31	40	0.003277302	
GO Cellular Component	nuclear pore	119	1.333417e-18	1.9362559462184873e-17	2.077244	179	0.01091463	81	0.002357233066666667	1.429267	54	75	0.005708849	
GO Cellular Component	methyltransferase complex	121	2.226039e-18	3.179004456198348e-17	2.01263	191	0.01164634	123	0.026883072	1.308853	60	91	0.006343165	
GO Cellular Component	CCR4-NOT complex	124	3.23373e-18	4.506359225806452e-17	3.691967	65	0.003963415	131	0.030115148702290078	1.736957	14	16	0.001480072	
GO Cellular Component	pre-autophagosomal structure	139	1.310632e-15	1.6293324431654675e-14	2.576887	94	0.005731707	91	0.0058607987340659334	1.612889	26	32	0.002748705	
GO Cellular Component	nuclear inner membrane	143	2.832744e-15	3.4230640783216783e-14	2.120501	137	0.008353659	134	0.03453507295522388	1.382476	39	56	0.004123057	
GO Cellular Component	zonula adherens	196	1.422087e-11	1.2537583346938775e-10	3.853745	37	0.002256098	144	0.049692996	1.985094	8	8	0.0008457554	
GO Molecular Function	cadherin binding	9	3.650505e-85	1.7124924566666665e-82	2.04271	903	0.05506098	15	1.3626108131999999e-11	1.416991	217	304	0.02294111	
GO Molecular Function	thyroid hormone receptor binding	37	1.378071e-35	1.5724907464864866e-33	4.087315	118	0.007195122	101	0.02170699498019802	1.630613	23	28	0.002431547	
GO Molecular Function	phosphotyrosine binding	62	2.4681e-22	1.6806964838709677e-20	2.373201	163	0.009939024	95	0.013118571734736842	1.588075	28	35	0.002960144	
GO Molecular Function	protein phosphorylated amino acid binding	68	1.054525e-20	6.547359632352941e-19	2.178894	180	0.01097561	83	0.003233046350120482	1.579052	35	44	0.00370018	
GO Molecular Function	RNA polymerase core enzyme binding	71	5.753362e-20	3.421224558309859e-18	2.641871	118	0.007195122	95	0.013118571734736842	1.588075	28	35	0.002960144	
GO Molecular Function	RNA polymerase II core binding	86	8.102221e-18	3.977625239767442e-16	2.643944	104	0.006341463	101	0.02170699498019802	1.630613	23	28	0.002431547	
GO Molecular Function	RNA polymerase binding	95	4.804866e-17	2.1353836054736843e-15	2.168595	147	0.008963415	66	0.0009370607457575757	1.588075	40	50	0.004228777	
Human Phenotype	Hypoglycemia	18	1.41345e-25	5.23997325e-23	2.030578	267	0.01628049	62	0.02166332406612903	1.335107	76	113	0.008034676	
Human Phenotype	Increased serum ferritin	68	2.87826e-14	2.824504261764706e-12	3.78613	48	0.002926829	66	0.022820092856060608	1.786584	18	20	0.00190295	
Human Phenotype	Leukodystrophy	141	1.487392e-10	7.039267245390071e-9	2.027009	100	0.006097561	81	0.04575132374074074	1.468969	37	50	0.003911619	
Mouse Phenotype Single KO	glomerulonephritis	92	2.12816e-22	2.1182131652173917e-20	2.029204	232	0.01414634	282	0.03850515252836879	1.33934	56	83	0.005920288	
Mouse Phenotype Single KO	increased fibroblast apoptosis	158	8.279922e-18	4.798686440126582e-16	2.548975	111	0.006768293	206	0.013121332008737864	1.588075	28	35	0.002960144	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	211	4.683448e-15	2.0325276462559245e-13	3.155887	65	0.003963415	252	0.026390117894444443	1.764528	16	18	0.001691511	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	215	6.879853e-15	2.930177391674419e-13	2.24583	117	0.007134146	151	0.005431554597947021	1.746882	22	25	0.002325827	
Mouse Phenotype Single KO	abnormal liver glycogen level	249	1.077675e-13	3.96316063253012e-12	2.015878	137	0.008353659	312	0.04900767701282051	1.465188	31	42	0.003277302	
Mouse Phenotype Single KO	decreased spongiotrophoblast size	442	1.537145e-9	3.1845332047511314e-8	2.507755	56	0.003414634	252	0.026390117894444443	1.764528	16	18	0.001691511	
Mouse Phenotype	decreased circulating free fatty acid level	25	6.144181e-48	2.3497805816400002e-45	2.306017	386	0.02353659	197	0.0014719115820304568	1.36788	82	119	0.008668992	
Mouse Phenotype	decreased fatty acid level	33	2.060257e-43	5.969126417272728e-41	2.072288	442	0.02695122	466	0.03909527779184549	1.234321	97	156	0.01025478	
Mouse Phenotype	decreased fibroblast proliferation	84	3.771385e-32	4.2926442839285715e-30	2.045337	334	0.02036585	421	0.029488031657957246	1.267406	83	130	0.008774712	
Mouse Phenotype	increased fibroblast apoptosis	150	2.47399e-24	1.5769212259999999e-22	2.654036	145	0.008841463	325	0.012511389275076924	1.48882	36	48	0.003805899	
Mouse Phenotype	abnormal hypoglossal nerve topology	314	4.683448e-15	1.4260651696815286e-13	3.155887	65	0.003963415	365	0.019023880564931508	1.764528	16	18	0.001691511	
Mouse Phenotype	abnormal vitelline vein morphology	321	6.879853e-15	2.0491674309345794e-13	2.24583	117	0.007134146	240	0.0035681241673750004	1.746882	22	25	0.002325827	
Mouse Phenotype	ovary hypoplasia	339	3.16258e-14	8.919595097345132e-13	3.597952	51	0.003109756	478	0.04170864237238494	1.985094	9	9	0.0009514748	
Mouse Phenotype	dry eyes	426	6.359154e-12	1.4272270280281688e-10	2.434626	77	0.004695122	487	0.04482155571868584	1.736957	14	16	0.001480072	
Mouse Phenotype	decreased liver cholesterol level	467	2.653184e-11	5.431925529764454e-10	2.121826	97	0.005914634	173	0.0006302384609826589	1.736957	28	32	0.002960144	
Mouse Phenotype	decreased spongiotrophoblast size	610	2.958392e-9	4.6369157232786885e-8	2.460108	56	0.003414634	498	0.046742308289156626	1.671658	16	19	0.001691511	
Mouse Phenotype	microcytic anemia	630	4.751577e-9	7.211083761428572e-8	2.166746	71	0.004329268	423	0.02962235129787234	1.574385	23	29	0.002431547