# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of megakaryocyte differentiation 164 3.719855e-12 2.9847299966463413e-10 2.649779 67 0.01388601 301 0.008788607563787375 1.783283 33 76 0.007217848 GO Biological Process platelet formation 171 7.23897e-12 5.570620247368421e-10 4.488155 32 0.006632124 487 0.04887417425256673 2.377711 11 19 0.002405949 GO Biological Process production of molecular mediator of immune response 178 1.258332e-11 9.302466734831461e-10 2.532943 69 0.01430052 266 0.005172506080451128 1.872288 31 68 0.006780402 GO Biological Process erythrocyte homeostasis 186 1.711691e-11 1.2109753693010753e-9 2.390628 76 0.0157513 383 0.02200158000992167 1.706787 32 77 0.006999125 GO Biological Process erythrocyte differentiation 204 5.992743e-11 3.865612996911765e-9 2.422669 70 0.01450777 338 0.014569088073076924 1.785633 30 69 0.00656168 GO Biological Process positive regulation of T cell differentiation 270 1.716937e-9 8.367842215925925e-8 2.012798 89 0.0184456 365 0.017887198144657536 1.74405 31 73 0.006780402 GO Biological Process gene silencing by miRNA 337 3.128819e-8 0.000001221724902700297 2.696669 41 0.008497409 380 0.021654654710789475 1.960138 21 44 0.004593176 GO Biological Process posttranscriptional gene silencing by RNA 353 5.021942e-8 0.0000018720604752974506 2.514727 45 0.009326425 271 0.005551403353874539 2.013213 25 51 0.005468066 GO Biological Process posttranscriptional gene silencing 362 7.177286e-8 0.000002609002941270718 2.482521 45 0.009326425 293 0.007616159732423208 1.974498 25 52 0.005468066 GO Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 366 8.27437e-8 0.000002974929913387978 2.499453 44 0.009119171 255 0.0041237725803921575 2.295063 19 34 0.004155731 GO Biological Process production of miRNAs involved in gene silencing by miRNA 405 1.796514e-7 0.000005837117957037037 3.043199 30 0.006217617 491 0.049781435014256616 2.129532 14 27 0.003062117 GO Biological Process production of small RNA involved in gene silencing by RNA 477 9.657504e-7 0.000026642158309433962 2.694176 32 0.006632124 377 0.020691375651193635 2.190376 16 30 0.003499563 GO Biological Process cytokine production involved in immune response 482 9.929841e-7 0.00002710928998319502 2.920138 28 0.005803109 420 0.029625718301190474 2.321323 13 23 0.002843395 GO Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activity 487 0.000001177194 0.0000318084103613963 2.962459 27 0.005595855 475 0.04447742 2.224601 13 24 0.002843395 GO Biological Process regulation of extrinsic apoptotic signaling pathway via death domain receptors 511 0.000001561195 0.00004020306263209393 2.043496 54 0.01119171 424 0.029761579951415096 1.801296 25 57 0.005468066 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 581 0.000004533486 0.00010267838601376937 2.813228 26 0.005388601 455 0.038025142947252746 2.566847 10 16 0.002187227 GO Biological Process definitive hemopoiesis 704 0.00001666912 0.0003115752131818182 2.605188 26 0.005388601 364 0.017582726825 2.657442 11 17 0.002405949 GO Biological Process regulation of transforming growth factor beta production 911 0.0001289791 0.001863047175521405 2.087244 32 0.006632124 409 0.026554588524449876 2.200155 15 28 0.00328084 GO Biological Process megakaryocyte development 1104 0.0004395658 0.005239353588949275 2.33054 21 0.004352332 455 0.038025142947252746 2.566847 10 16 0.002187227 GO Biological Process megakaryocyte differentiation 1169 0.0005772919 0.006498361088195039 2.106718 25 0.005181347 319 0.011475242011285266 2.542401 13 21 0.002843395 GO Cellular Component ficolin-1-rich granule lumen 44 8.133482e-12 3.194240203636364e-10 2.352777 81 0.01678756 27 0.0080745856 1.62291 49 124 0.01071741 GO Cellular Component clathrin coat 79 9.997242e-8 0.0000021867385032911394 2.348625 49 0.01015544 56 0.040339080000000006 1.843939 22 49 0.004811899 GO Cellular Component clathrin complex 87 2.834026e-7 0.000005628961986206896 4.452265 18 0.00373057 53 0.03681983275471698 3.194299 7 9 0.001531059 GO Molecular Function RNA polymerase II activating transcription factor binding 45 7.644409e-7 0.00007172154399555555 2.063018 56 0.01160622 35 0.030446892685714287 2.106131 20 39 0.004374453 Mouse Phenotype Single KO abnormal erythropoiesis 32 6.580082e-30 1.8829315898125e-27 2.788586 164 0.03398964 78 0.000005512012712948718 1.978806 53 110 0.0115923 Mouse Phenotype Single KO abnormal T cell activation 35 7.17347e-29 1.8767847082857144e-26 2.141797 261 0.05409326 94 0.00008707522810106384 1.520568 107 289 0.02340332 Mouse Phenotype Single KO decreased erythrocyte cell number 37 2.503052e-28 6.19471544972973e-26 2.364788 208 0.04310881 239 0.007438468645606694 1.501972 64 175 0.01399825 Mouse Phenotype Single KO decreased myeloid cell number 38 2.62893e-28 6.335029476315789e-26 2.003309 299 0.06196891 196 0.003384266018112245 1.400404 104 305 0.02274716 Mouse Phenotype Single KO abnormal platelet activation 44 2.065081e-26 4.2977151629545455e-24 3.27574 113 0.02341969 160 0.0017954416056250003 1.836051 38 85 0.008311461 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 45 1.177461e-25 2.3960023060000004e-23 2.227133 212 0.04393782 140 0.0009658522349285714 1.479133 94 261 0.02055993 Mouse Phenotype Single KO abnormal platelet aggregation 46 1.248696e-25 2.485719406956522e-23 3.285602 109 0.02259067 151 0.0013037257525165564 1.895518 36 78 0.007874016 Mouse Phenotype Single KO autoimmune response 47 1.742102e-25 3.3941336199999996e-23 2.073358 247 0.05119171 148 0.0012650933783108107 1.41448 114 331 0.02493438 Mouse Phenotype Single KO abnormal T cell proliferation 48 6.826965e-25 1.3023858021875e-22 2.095933 235 0.04870466 102 0.00011017136820588236 1.542075 98 261 0.02143482 Mouse Phenotype Single KO abnormal self tolerance 49 8.363593e-25 1.5629677775714287e-22 2.04527 248 0.05139896 143 0.0010523102733566432 1.418318 115 333 0.02515311 Mouse Phenotype Single KO abnormal immune tolerance 50 1.207718e-24 2.2118147452e-22 2.036124 249 0.05160622 149 0.0012780676871140938 1.409488 116 338 0.02537183 Mouse Phenotype Single KO decreased erythroid progenitor cell number 55 2.459622e-23 4.095047028e-21 3.18562 103 0.02134715 89 0.00006993970499550561 2.335328 29 51 0.006342957 Mouse Phenotype Single KO abnormal platelet physiology 59 8.535368e-23 1.3247180470508476e-20 2.698221 130 0.02694301 168 0.0021596468365476192 1.717454 46 110 0.01006124 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 60 2.824373e-22 4.310463926833333e-20 4.511383 64 0.01326425 203 0.003806287934581281 2.407526 17 29 0.003718285 Mouse Phenotype Single KO decreased T cell proliferation 64 9.798769e-22 1.4019894958281252e-19 2.337264 161 0.03336788 161 0.0018303648608695652 1.615402 59 150 0.01290464 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 65 2.362085e-21 3.3276326684615386e-19 4.148619 67 0.01388601 163 0.001882345503190184 2.346832 20 35 0.004374453 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 66 5.395745e-21 7.486187418939394e-19 3.028482 99 0.02051813 254 0.008914768509055118 1.937243 25 53 0.005468066 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 68 3.62317e-20 4.879024660294117e-18 2.26831 158 0.03274611 136 0.0009119792954411765 1.595846 68 175 0.01487314 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 69 8.760666e-20 1.1626292545217391e-17 2.366299 142 0.02943005 372 0.033644762631720435 1.460863 53 149 0.0115923 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 75 6.930908e-19 8.462176607466666e-17 2.422353 129 0.02673575 77 0.000005325851528051948 2.125953 44 85 0.009623797 Mouse Phenotype abnormal erythropoiesis 36 1.602804e-31 4.2567802900000003e-29 2.622892 192 0.03979275 80 0.0000012704405823749999 1.874315 68 149 0.01487314 Mouse Phenotype decreased inflammatory response 44 4.824061e-28 1.04824652775e-25 2.257958 226 0.04683938 282 0.00433067190212766 1.387117 102 302 0.02230971 Mouse Phenotype abnormal platelet aggregation 48 1.434623e-26 2.857589688125e-24 3.209786 117 0.0242487 220 0.0013811303436818182 1.791332 41 94 0.008967629 Mouse Phenotype abnormal platelet activation 50 2.038043e-26 3.8971458246e-24 3.176933 118 0.02445596 253 0.0028234513518972334 1.724921 42 100 0.009186352 Mouse Phenotype decreased erythrocyte cell number 51 2.147494e-26 4.025919634117647e-24 2.137074 239 0.04953368 162 0.00024253188037037037 1.546775 87 231 0.01902887 Mouse Phenotype increased myeloid cell number 53 8.759983e-26 1.5802678766603775e-23 2.014027 268 0.05554404 175 0.0003852671603828572 1.473925 103 287 0.02252843 Mouse Phenotype decreased erythroid progenitor cell number 59 1.893839e-23 3.0689821489830506e-21 2.842144 123 0.02549223 99 0.0000026749901006060604 2.215594 41 76 0.008967629 Mouse Phenotype decreased T cell proliferation 62 4.942725e-23 7.622160278225807e-21 2.098433 216 0.04476684 172 0.00031560855441279073 1.5618 81 213 0.01771654 Mouse Phenotype abnormal platelet physiology 63 8.683085e-23 1.3177615188095236e-20 2.574584 141 0.0292228 177 0.0004507838105593221 1.711231 55 132 0.01202975 Mouse Phenotype abnormal embryonic erythropoiesis 64 1.373162e-22 2.0513752940625e-20 4.266454 69 0.01430052 244 0.002434441804057377 2.384684 18 31 0.003937008 Mouse Phenotype abnormal embryonic erythrocyte morphology 66 3.548932e-22 5.141111947272727e-20 3.942921 74 0.01533679 163 0.00024307323298159507 2.422051 23 39 0.005030621 Mouse Phenotype abnormal mean corpuscular hemoglobin 76 9.846974e-21 1.2387752422894737e-18 2.228312 169 0.03502591 144 0.00008610596762499999 1.65171 74 184 0.01618548 Mouse Phenotype abnormal erythroid progenitor cell morphology 81 6.960144e-20 8.21554775111111e-18 2.308961 150 0.03108808 96 0.000001927354185 1.967197 57 119 0.01246719 Mouse Phenotype abnormal embryonic hematopoiesis 82 8.385993e-20 9.777863301585367e-18 2.801125 105 0.02176166 367 0.013346012327247957 1.817833 27 61 0.005905512 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 95 5.428848e-18 5.463706918736842e-16 2.092419 167 0.0346114 255 0.0028382345918823533 1.5287 67 180 0.01465442 Mouse Phenotype decreased platelet aggregation 105 1.504511e-16 1.3699647305714286e-14 3.011798 77 0.01595855 409 0.0207120737801956 1.711231 30 72 0.00656168 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 109 4.110652e-16 3.605682914862386e-14 2.22463 129 0.02673575 471 0.03236130548407643 1.502545 45 123 0.00984252 Mouse Phenotype increased circulating tumor necrosis factor level 117 1.645567e-15 1.3447235971794871e-13 2.726295 84 0.01740933 304 0.007185336815131579 1.676308 40 98 0.008748906 Mouse Phenotype increased mean platelet volume 137 9.599842e-14 6.699568566569343e-12 3.030661 62 0.01284974 358 0.012626336720111733 1.927755 23 49 0.005030621 Mouse Phenotype abnormal CD4-positive T cell differentiation 154 4.171939e-13 2.5901239466883117e-11 2.163014 109 0.02259067 369 0.013485083141463416 1.642782 38 95 0.008311461