# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 97 1.144962e-25 1.5532530884536082e-23 2.252463 211 0.01225106 744 0.010047388193817204 1.255729 86 118 0.007891356 GO Biological Process cotranslational protein targeting to membrane 118 7.921465e-22 8.83377609618644e-20 2.259956 176 0.01021889 639 0.004638524847574334 1.301023 74 98 0.006790237 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 127 5.712443e-21 5.918900585590551e-19 2.275947 166 0.009638274 829 0.017661441534378767 1.273505 68 92 0.006239677 GO Biological Process protein targeting to ER 145 1.272647e-18 1.1549490946896552e-16 2.108467 173 0.01004471 944 0.029273937952330513 1.24532 73 101 0.006698477 GO Biological Process establishment of protein localization to endoplasmic reticulum 155 5.074595e-18 4.308167458387097e-16 2.008329 188 0.01091564 891 0.023740933169472504 1.247107 76 105 0.006973757 GO Biological Process snRNA metabolic process 189 2.382909e-15 1.6590846312698414e-13 2.069666 146 0.008477037 832 0.018107495724759618 1.282215 64 86 0.005872637 GO Biological Process histone H4-K5 acetylation 216 6.49478e-14 3.956704167592592e-12 3.335579 55 0.003193404 663 0.0056462649108597295 1.722977 15 15 0.001376399 GO Biological Process histone H4-K8 acetylation 216 6.49478e-14 3.956704167592592e-12 3.335579 55 0.003193404 663 0.0056462649108597295 1.722977 15 15 0.001376399 GO Biological Process histone H4 acetylation 220 8.549167e-14 5.1135676615e-12 2.099975 125 0.007257737 625 0.0041823091792 1.418922 42 51 0.003853918 GO Biological Process pyrimidine nucleotide catabolic process 245 6.561488e-13 3.5241885955918365e-11 4.407166 36 0.002090228 793 0.014028536099873897 1.722977 13 13 0.001192879 GO Biological Process gene silencing by miRNA 247 9.887151e-13 5.267409716963563e-11 2.10057 114 0.006619056 525 0.0012521334911809524 1.488025 38 44 0.003486878 GO Biological Process pyrimidine deoxyribonucleotide catabolic process 255 1.30339e-12 6.726003533333334e-11 4.535239 34 0.001974104 869 0.022067143291139242 1.722977 12 12 0.001101119 GO Biological Process positive regulation of mRNA catabolic process 313 5.081683e-11 2.136417463162939e-9 2.153662 91 0.005283632 854 0.019830520548009368 1.516219 22 25 0.002018719 GO Biological Process maintenance of protein location in nucleus 492 2.203445e-8 5.893319665650406e-7 2.594824 45 0.002612785 938 0.02913032240085288 1.615291 15 16 0.001376399 GO Biological Process deoxyribonucleotide catabolic process 500 2.831833e-8 7.4528180894e-7 2.638225 43 0.002496661 723 0.008649265095573996 1.632294 18 19 0.001651679 GO Biological Process deoxyribose phosphate catabolic process 601 1.732782e-7 0.0000037939564622296173 2.465542 43 0.002496661 946 0.029903563207188164 1.550679 18 20 0.001651679 GO Biological Process positive regulation of mitochondrial membrane permeability 660 4.494945e-7 0.000008961966856818182 2.044986 60 0.003483714 946 0.029903563207188164 1.550679 18 20 0.001651679 GO Biological Process negative regulation of appetite 719 0.000001016677 0.000018607027319888732 2.415269 39 0.002264414 869 0.022067143291139242 1.722977 12 12 0.001101119 GO Biological Process cellular response to arsenic-containing substance 858 0.00000436706 0.0000669768561072261 2.19111 42 0.0024386 1024 0.04335191428125 1.608112 14 15 0.001284639 GO Biological Process miRNA mediated inhibition of translation 1079 0.00002554059 0.0003114815790639481 2.164703 36 0.002090228 869 0.022067143291139242 1.722977 12 12 0.001101119 GO Cellular Component cytosolic large ribosomal subunit 66 1.489687e-11 3.9002714181818184e-10 2.000212 115 0.006677118 121 0.021135082314049588 1.327539 47 61 0.004312718 GO Cellular Component endoribonuclease complex 76 8.883386e-11 2.0198014484210525e-9 2.48165 66 0.003832085 153 0.04983097976470588 1.425912 24 29 0.002202239 GO Cellular Component NuRD complex 153 7.288334e-7 0.000008231530164705883 2.136531 52 0.003019218 132 0.027182853818181817 1.615291 15 16 0.001376399 Human Phenotype Flat acetabular roof 124 0.00000164569 0.00008856201104838708 2.365983 39 0.002264414 82 0.01342853361707317 1.722977 16 16 0.001468159 Mouse Phenotype Single KO abnormal fourth pharyngeal arch artery morphology 124 1.135297e-11 8.38380212016129e-10 2.030649 112 0.006502932 654 0.02907372702752294 1.615291 15 16 0.001376399 Mouse Phenotype Single KO retroesophageal right subclavian artery 189 2.082098e-9 1.0087709728042327e-7 2.00219 90 0.00522557 488 0.008917189803893442 1.632294 18 19 0.001651679 Mouse Phenotype Single KO increased embryonic neuroepithelium apoptosis 308 1.490763e-7 0.000004432115841233766 2.181206 56 0.003251466 586 0.01990511469453925 1.621625 16 17 0.001468159 Mouse Phenotype Single KO decreased fertilization frequency 522 0.000008324854 0.00014603580091570882 2.131439 42 0.0024386 597 0.020989071068676715 1.558884 19 21 0.001743439 Mouse Phenotype abnormal third pharyngeal arch artery morphology 180 3.491685e-11 1.8546666824999998e-9 2.042782 105 0.006096499 874 0.014969462979405034 1.558884 19 21 0.001743439 Mouse Phenotype absent teeth 204 1.962493e-10 9.197742927941177e-9 2.049525 96 0.005573942 786 0.00947697389351145 1.627256 17 18 0.001559919 Mouse Phenotype decreased mesenchymal cell proliferation involved in lung development 252 2.129232e-9 8.0784076e-8 2.240543 69 0.004006271 1082 0.038258615428835484 1.722977 10 10 0.0009175996 Mouse Phenotype abnormal pharyngeal pouch morphology 254 2.44224e-9 9.19301442519685e-8 2.003983 89 0.005167509 669 0.004132512871748879 1.636828 19 20 0.001743439 Mouse Phenotype increased embryonic neuroepithelium apoptosis 312 1.945746e-8 5.96258894423077e-7 2.101482 70 0.004064333 863 0.014258098831981458 1.516219 22 25 0.002018719 Mouse Phenotype decreased fertilization frequency 700 0.000008324854 0.00011370561299142857 2.131439 42 0.0024386 874 0.014969462979405034 1.558884 19 21 0.001743439 Mouse Phenotype fusion of atlas and occipital bones 890 0.00005131117 0.000551220333 2.170202 33 0.001916043 1146 0.04555397684816754 1.599907 13 14 0.001192879