# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process DNA replication-dependent nucleosome assembly 4 2.974797e-36 9.78633843075e-33 28.76139 33 0.01149025 103 0.007999110806019418 2.829225 15 32 0.004821601 GO Biological Process chromatin silencing at rDNA 7 1.877896e-28 3.530176209142857e-25 13.76535 36 0.01253482 86 0.0027649675498837207 2.850182 17 36 0.005464481 GO Biological Process chromatin assembly or disassembly 8 1.909348e-27 3.1406387915e-24 3.424389 110 0.03830084 20 0.000070141351905 1.966682 58 178 0.01864352 GO Biological Process nucleosome organization 9 2.482359e-27 3.629484675666667e-24 3.511505 106 0.03690808 14 0.00005319064245071428 2.011893 57 171 0.01832208 GO Biological Process nucleosome assembly 10 3.381499e-27 4.4497145340999994e-24 3.786703 96 0.03342618 3 0.000026554090005333336 2.210249 52 142 0.01671488 GO Biological Process negative regulation of gene expression, epigenetic 11 5.770715e-27 6.903348971363636e-24 4.758168 74 0.02576602 73 0.0015750023323424659 2.011893 38 114 0.01221472 GO Biological Process chromatin assembly 12 1.589941e-26 1.7435028015833333e-23 3.557912 101 0.03516713 11 0.000021272013971818184 2.101028 55 158 0.0176792 GO Biological Process protein-DNA complex subunit organization 13 6.240197e-25 6.316519409461539e-22 2.72699 139 0.04839833 40 0.000126955071225 1.762419 73 250 0.02346512 GO Biological Process regulation of gene expression, epigenetic 14 1.769072e-24 1.662801317714286e-21 2.864327 126 0.04387187 76 0.0017910074264473684 1.654944 68 248 0.02185792 GO Biological Process protein-DNA complex assembly 15 2.83334e-24 2.4855947373333333e-21 2.834032 127 0.04422006 27 0.00008470852817407407 1.846532 67 219 0.02153648 GO Biological Process DNA packaging 21 6.461474e-21 4.0488826840952385e-18 2.89259 105 0.03655989 60 0.0006245605727166667 1.789473 59 199 0.01896496 GO Biological Process chromatin silencing 23 1.468927e-20 8.40417843173913e-18 5.071759 52 0.01810585 100 0.0071883945639 1.991152 32 97 0.01028608 GO Biological Process regulation of megakaryocyte differentiation 24 1.97179e-20 1.0811160254166666e-17 4.185894 63 0.02193593 70 0.0009714293375714286 2.303088 29 76 0.009321761 GO Biological Process DNA conformation change 27 2.613525e-19 1.2737546472222222e-16 2.410256 132 0.045961 87 0.0030296086702298847 1.589467 74 281 0.02378656 GO Biological Process gene silencing 38 6.579112e-16 2.2782772317894734e-13 2.824761 81 0.02820334 96 0.0068306491101041665 1.710109 51 180 0.01639344 GO Biological Process DNA replication-independent nucleosome assembly 40 3.895505e-15 1.281523757375e-12 4.828928 39 0.01357939 125 0.0183770909144 2.277615 20 53 0.006428801 GO Biological Process DNA replication-independent nucleosome organization 42 6.622211e-15 2.0748017749761905e-12 4.747477 39 0.01357939 131 0.023552169055725193 2.235437 20 54 0.006428801 GO Biological Process chromatin remodeling at centromere 75 7.888308e-12 1.3840299329600002e-9 4.465303 32 0.01114206 102 0.007800041113333334 2.492998 19 46 0.006107361 GO Biological Process CENP-A containing nucleosome assembly 90 9.027307e-11 1.3198925868111111e-8 4.424424 29 0.01009749 129 0.020072442777519378 2.443013 17 42 0.005464481 GO Biological Process centromere complex assembly 93 1.243811e-10 1.75992569344086e-8 3.891386 33 0.01149025 104 0.008512301511730769 2.414272 20 50 0.006428801 GO Cellular Component nucleosome 19 3.539415e-26 3.2190048e-24 5.862891 59 0.02054318 15 2.8425323519999994e-7 2.471755 43 105 0.01382192 GO Cellular Component nuclear nucleosome 20 2.89905e-25 2.5047792e-23 12.16009 34 0.01183844 40 0.015294864960000001 2.414272 16 40 0.005143041 GO Cellular Component DNA packaging complex 22 8.17815e-22 6.423565090909091e-20 4.760135 59 0.02054318 18 0.00000236285472 2.31727 43 112 0.01382192 GO Cellular Component protein-DNA complex 39 6.634825e-12 2.939737846153846e-10 2.340707 82 0.02855153 35 0.004200147401142857 1.643378 55 202 0.0176792 GO Cellular Component small ribosomal subunit 53 3.466933e-8 0.0000011303509856603771 3.139939 32 0.01114206 41 0.015843732760975608 2.011893 24 72 0.007714561 GO Cellular Component cytosolic small ribosomal subunit 103 0.00003734799 0.0006265759875728155 2.887867 20 0.006963788 48 0.04364690399999999 2.194793 16 44 0.005143041 Mouse Phenotype Single KO abnormal platelet aggregation 9 4.362438e-17 4.4385383073333335e-14 3.39294 67 0.02332869 129 0.03979845863333334 1.934513 25 78 0.008036001 Mouse Phenotype Single KO abnormal platelet morphology 21 2.417737e-14 1.0542484623333333e-11 2.019849 140 0.04874652 32 0.0013786533105625 1.656408 73 266 0.02346512 Mouse Phenotype Single KO abnormal platelet physiology 32 8.61928e-13 2.4664608425e-10 2.580351 74 0.02576602 139 0.04714275911582733 1.755834 32 110 0.01028608 Mouse Phenotype Single KO abnormal platelet cell number 33 9.013822e-13 2.5011990319393944e-10 2.055425 118 0.04108635 27 0.0012658514706666666 1.748655 62 214 0.01992928 Mouse Phenotype Single KO thrombocytopenia 51 3.513777e-11 6.308952154705883e-9 2.154407 91 0.03168524 58 0.00800309959051724 1.7752 45 153 0.0144648 Mouse Phenotype Single KO decreased erythroid progenitor cell number 57 5.323282e-11 8.551805837543859e-9 2.805843 54 0.01880223 49 0.004957642781836735 2.48528 21 51 0.006750241 Mouse Phenotype Single KO abnormal erythropoiesis 73 1.977048e-10 2.479976511780822e-8 2.228167 78 0.02715877 37 0.0022353521454864865 2.030183 37 110 0.01189328 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 115 1.180519e-8 9.400010854782609e-7 2.145209 68 0.02367688 19 0.0003605345126421052 2.343264 33 85 0.01060752 Mouse Phenotype Single KO increased circulating interleukin-1 beta level 120 1.667389e-8 0.0000012723567560833334 5.099322 19 0.006615599 142 0.04934253319154929 2.766353 11 24 0.003535841 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 151 1.504216e-7 0.000009121924445033112 2.568991 40 0.01392758 123 0.036740444982113825 2.011893 23 69 0.007393121 Mouse Phenotype Single KO abnormal cortical plate morphology 467 0.000729209 0.014298430006423982 2.28892 20 0.006963788 60 0.008004956303833334 3.292189 12 22 0.003857281 Mouse Phenotype abnormal platelet aggregation 11 3.179201e-17 2.763303705545455e-14 3.272363 71 0.02472145 214 0.04471143569158878 1.797862 28 94 0.009000321 Mouse Phenotype decreased inflammatory response 12 3.221601e-17 2.56681059675e-14 2.249184 134 0.04665738 220 0.047575318704545455 1.418984 71 302 0.02282224 Mouse Phenotype abnormal platelet physiology 41 4.871157e-13 1.1359300506585366e-10 2.484768 81 0.02820334 155 0.01867521138580645 1.737544 38 132 0.01221472 Mouse Phenotype abnormal erythropoiesis 71 7.584964e-11 1.0214062085070422e-8 2.111445 92 0.03203343 48 0.0003706678195625 1.94438 48 149 0.01542912 Mouse Phenotype increased circulating tumor necrosis factor level 72 8.356163e-11 1.1096288117083334e-8 2.83537 52 0.01810585 173 0.022389772949132948 1.847657 30 98 0.009643202 Mouse Phenotype abnormal mean corpuscular hemoglobin 73 9.611596e-11 1.2588557446027395e-8 2.082236 94 0.03272981 138 0.012715153115217393 1.64013 50 184 0.016072 Mouse Phenotype decreased erythroid progenitor cell number 80 3.315295e-10 3.9621919368749996e-8 2.445651 63 0.02193593 74 0.0020933538174324326 2.223672 28 76 0.009000321 Mouse Phenotype abnormal erythroid progenitor cell morphology 92 1.429016e-9 1.4850893452173912e-7 2.094707 81 0.02820334 13 0.000046093389780000005 2.23168 44 119 0.01414336 Mouse Phenotype decreased pre-B cell number 129 5.402996e-8 0.000004004499593488372 2.022462 71 0.02472145 186 0.02807393345806452 1.799097 31 104 0.009964642 Mouse Phenotype decreased mean corpuscular hemoglobin 155 3.112484e-7 0.00001919900614451613 2.347657 45 0.01566852 81 0.0025340226522222223 2.194793 28 77 0.009000321 Mouse Phenotype microcytic anemia 252 0.000009351142 0.00035478678040476186 3.311026 19 0.006615599 163 0.01968899662822086 2.70565 13 29 0.004178721 Mouse Phenotype interstitial pneumonia 271 0.00001748493 0.0006168760728044281 3.286042 18 0.006267409 154 0.018540300068181817 3.01784 11 22 0.003535841 Mouse Phenotype thrombocytosis 274 0.00001848197 0.0006449128290875913 2.051964 42 0.01462396 187 0.028665825989839574 1.934513 25 78 0.008036001 Mouse Phenotype hypochromic anemia 448 0.0005961305 0.012722329710937499 2.622671 16 0.005571031 212 0.04191010231132075 2.58672 12 28 0.003857281 Mouse Phenotype abnormal thymus corticomedullary boundary morphology 581 0.00250528 0.04122716364888124 2.20872 17 0.00591922 201 0.03500631242985075 2.531092 13 31 0.004178721 Mouse Phenotype abnormal secondary ovarian follicle number 602 0.002898123 0.04602816279568106 2.238682 16 0.005571031 217 0.047381980824884797 3.01784 9 18 0.00289296