# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	actin filament polymerization	5	5.701505e-205	1.5005220859e-201	7.127454	420	0.01738986	903	0.044740352266888155	1.370817	24	26	0.001898134	
GO Biological Process	actin polymerization or depolymerization	9	2.376174e-176	3.474230407333333e-173	5.185528	474	0.0196257	570	0.007966811815263158	1.346908	39	43	0.003084467	
GO Biological Process	regulation of actin filament polymerization	35	3.693736e-85	1.3887392006857145e-82	2.323385	686	0.02840344	612	0.010878996834313726	1.190148	113	141	0.008937045	
GO Biological Process	regulation of protein polymerization	38	2.424999e-80	8.397516273947369e-78	2.127004	783	0.03241968	427	0.0011205976351756442	1.199465	147	182	0.01162607	
GO Biological Process	regulation of actin polymerization or depolymerization	50	9.697933e-75	2.55230200694e-72	2.127018	728	0.03014243	480	0.0034346689704166664	1.197323	129	160	0.01020247	
GO Biological Process	regulation of actin filament length	55	2.204638e-73	5.274696625818182e-71	2.108839	729	0.03018384	471	0.0028953348180467088	1.19911	130	161	0.01028156	
GO Biological Process	liver development	59	9.458062e-73	2.1094684382711864e-70	2.062129	762	0.03155018	915	0.04660313780327868	1.171139	97	123	0.007671623	
GO Biological Process	hepaticobiliary system development	66	3.193199e-71	6.366561460757575e-69	2.034183	771	0.03192282	792	0.03203136531565656	1.178613	100	126	0.00790889	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	77	1.058767e-63	1.8093915523376624e-61	4.719788	185	0.007659821	691	0.018086824596382056	1.423175	23	24	0.001819045	
GO Biological Process	response to unfolded protein	92	1.020233e-57	1.4592658746739133e-55	2.18105	529	0.02190295	902	0.04458829405764967	1.150915	124	160	0.009807023	
GO Biological Process	response to topologically incorrect protein	93	1.086168e-57	1.5368693238709679e-55	2.128247	559	0.02314508	837	0.035896368497013144	1.14679	139	180	0.01099336	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	146	4.844085e-48	4.365980446232877e-46	2.355717	372	0.01540245	411	0.0008000073281508516	1.279673	81	94	0.006406201	
GO Biological Process	negative regulation of Notch signaling pathway	308	4.436364e-27	1.8953933076623375e-25	2.557787	174	0.007204372	553	0.007161289610488245	1.395049	31	33	0.002451756	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	321	5.593207e-26	2.2928663835825544e-24	2.152156	237	0.009812852	553	0.007161289610488245	1.395049	31	33	0.002451756	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	428	7.955682e-19	2.4460004541588786e-17	2.550691	118	0.004885724	777	0.030170826489060488	1.485052	16	16	0.001265422	
GO Biological Process	virion assembly	788	6.384948e-10	1.06623769964467e-8	2.02742	93	0.003850613	635	0.013233297579055118	1.361298	33	36	0.002609934	
GO Biological Process	maintenance of protein location in nucleus	865	4.671807e-9	7.107087666242774e-8	2.384949	58	0.002401457	777	0.030170826489060488	1.485052	16	16	0.001265422	
GO Biological Process	photoperiodism	882	7.916293e-9	1.1810714238888889e-7	2.078558	76	0.003146737	795	0.0320418505081761	1.41755	21	22	0.001660867	
GO Biological Process	protein localization to chromatin	963	4.285606e-8	5.856104813499481e-7	2.232747	58	0.002401457	721	0.021885242104022193	1.485052	17	17	0.001344511	
GO Biological Process	entrainment of circadian clock by photoperiod	975	5.105604e-8	6.890732619076922e-7	2.085456	67	0.002774097	659	0.01611642634400607	1.485052	18	18	0.0014236	
GO Cellular Component	proteasome regulatory particle	159	7.994624e-9	8.688497026415095e-8	2.291193	61	0.002525671	126	0.037804512	1.414335	20	21	0.001581778	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase activity	73	2.576615e-12	1.4902011684931507e-10	2.076021	113	0.004678702	109	0.03193137721284404	1.386049	28	30	0.002214489	
Mouse Phenotype Single KO	abnormal fibroblast proliferation	12	1.592699e-90	1.2153620619166668e-87	2.325762	728	0.03014243	225	0.0016668576635111112	1.223599	117	142	0.009253401	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	120	7.233182e-27	5.519520631166667e-25	3.182702	121	0.005009937	509	0.034825492223968565	1.41755	21	22	0.001660867	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	167	2.273014e-20	1.2463466585628744e-18	2.614589	123	0.005092746	427	0.020367739251288056	1.423175	23	24	0.001819045	
Mouse Phenotype Single KO	decreased total retina thickness	204	2.52864e-17	1.135037082352941e-15	2.18104	148	0.006127857	475	0.029783730475789475	1.328731	34	38	0.002689022	
Mouse Phenotype Single KO	absent hypoglossal nerve	214	8.059357e-17	3.4485762639719628e-15	3.268577	70	0.002898311	550	0.04406421656	1.485052	15	15	0.001186333	
Mouse Phenotype Single KO	increased lactate dehydrogenase level	431	1.679513e-9	3.568283188167054e-8	2.07915	83	0.003436568	509	0.034825492223968565	1.41755	21	22	0.001660867	
Mouse Phenotype Single KO	abnormal Peyer's patch follicle morphology	454	4.221266e-9	8.514126159030838e-8	2.00721	86	0.003560782	384	0.01582758118984375	1.42565	24	25	0.001898134	
Mouse Phenotype	abnormal fibroblast proliferation	17	5.593835e-96	3.1460386138235295e-93	2.283053	802	0.03320636	178	0.00002818308861235955	1.249191	143	170	0.01130971	
Mouse Phenotype	vertebral transformation	35	2.856083e-71	7.802002732285714e-69	2.327278	571	0.02364193	720	0.025861628574999997	1.193593	86	107	0.006801645	
Mouse Phenotype	absent segment of posterior cerebral artery	169	7.233182e-27	4.092097816686391e-25	3.182702	121	0.005009937	718	0.025777494660167134	1.41755	21	22	0.001660867	
Mouse Phenotype	abnormal cerebral artery morphology	232	2.273014e-20	9.367365023275862e-19	2.614589	123	0.005092746	602	0.015084270584551494	1.423175	23	24	0.001819045	
Mouse Phenotype	absent hypoglossal nerve	304	8.059357e-17	2.5347207985855264e-15	3.268577	70	0.002898311	773	0.03273552818111255	1.485052	15	15	0.001186333	
Mouse Phenotype	increased B-1a cell number	584	3.491371e-9	5.7159243375e-8	2.006691	87	0.003602186	528	0.00983686563352273	1.485052	19	19	0.001502689