# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 1 1.244459e-34 1.6375835981e-30 3.287748 148 0.05035726 51 7.174364205882354e-10 2.074022 87 248 0.02739295 GO Biological Process negative regulation of gene expression, epigenetic 3 2.827975e-31 1.2404441008333332e-27 5.089533 81 0.02756039 87 0.0000012423824820344826 2.333745 45 114 0.01416877 GO Biological Process chromatin silencing 7 3.474164e-29 6.530932010857143e-26 6.099864 64 0.02177611 123 0.00001571464897398374 2.316101 38 97 0.01196474 GO Biological Process gene silencing 10 5.141998e-26 6.766355168199999e-23 3.476016 102 0.03470568 95 0.000002977856767157895 2.003563 61 180 0.01920655 GO Biological Process regulation of megakaryocyte differentiation 11 8.235209e-24 9.851555930090909e-21 4.480037 69 0.02347737 70 1.3446294807428572e-7 2.800494 36 76 0.01133501 GO Biological Process DNA replication-dependent nucleosome assembly 12 2.261973e-23 2.48044189225e-20 20.44053 24 0.008166043 409 0.041330552931540344 2.401812 13 32 0.004093199 GO Biological Process chromatin assembly or disassembly 22 5.821872e-21 3.4822733476363635e-18 3.011691 99 0.03368493 125 0.0000231902530808 1.926432 58 178 0.01826196 GO Biological Process chromatin assembly 30 1.933696e-19 8.481835221333333e-17 3.063717 89 0.03028241 127 0.000026508401404724412 1.983191 53 158 0.01668766 GO Biological Process chromatin silencing at rDNA 31 2.091512e-19 8.878131099354839e-17 10.46231 28 0.00952705 322 0.016386800533850932 2.463397 15 36 0.004722922 GO Biological Process nucleosome organization 35 8.607706e-19 3.236251521542857e-16 2.94587 91 0.03096291 153 0.00014617636447058824 1.866996 54 171 0.01700252 GO Biological Process nucleosome assembly 41 8.909248e-18 2.8594340105365852e-15 3.083649 80 0.02722014 141 0.00006680248477092199 1.998474 48 142 0.01511335 GO Biological Process DNA conformation change 42 9.66145e-18 3.0270242988095237e-15 2.319623 130 0.04423273 144 0.00007488060413541666 1.683175 80 281 0.02518892 GO Biological Process positive regulation of gene expression, epigenetic 45 3.32127e-17 9.712131540000002e-15 4.440506 49 0.01667234 238 0.0038616910067226892 2.069254 28 80 0.008816121 GO Biological Process protein-DNA complex subunit organization 55 7.46681e-16 1.7864682325454545e-13 2.281395 119 0.04048996 146 0.00007808052180342464 1.726349 73 250 0.02298489 GO Biological Process DNA packaging 56 9.035473e-16 2.123174807267857e-13 2.557444 95 0.03232392 171 0.000427070419994152 1.75285 59 199 0.01857683 GO Biological Process protein-DNA complex assembly 67 5.291433e-15 1.0392532365223881e-12 2.333295 107 0.03640694 145 0.00007646402679448276 1.781745 66 219 0.02078086 GO Biological Process platelet aggregation 73 1.76348e-14 3.178853879452055e-12 4.49032 40 0.01361007 350 0.02345235329085714 2.307182 16 41 0.005037783 GO Biological Process regulation of gene silencing 92 9.014823e-13 1.2894136506195653e-10 2.781621 65 0.02211637 281 0.008571903721708187 1.760107 39 131 0.0122796 GO Biological Process regulation of posttranscriptional gene silencing 137 5.50871e-10 5.291176269343066e-8 2.682237 52 0.01769309 377 0.03020490332572944 1.735678 32 109 0.01007557 GO Biological Process regulation of gene silencing by RNA 137 5.50871e-10 5.291176269343066e-8 2.682237 52 0.01769309 377 0.03020490332572944 1.735678 32 109 0.01007557 GO Cellular Component nucleosome 20 3.72959e-24 3.22236576e-22 5.535024 57 0.01939435 25 3.254957568e-7 2.421168 43 105 0.01353904 GO Cellular Component DNA packaging complex 22 2.433873e-21 1.9116966109090908e-19 4.651619 59 0.02007486 24 3.07251432e-7 2.375419 45 112 0.01416877 GO Cellular Component protein-DNA complex 36 1.456261e-12 6.9900528e-11 2.37103 85 0.0289214 31 0.000009503409135483871 1.873158 64 202 0.02015113 GO Cellular Component myelin sheath 53 2.310178e-8 7.532052045283019e-7 2.02286 75 0.02551888 51 0.011951146164705882 1.642265 45 162 0.01416877 GO Cellular Component cortical cytoskeleton 93 0.00001423959 0.00026458076903225806 2.000352 46 0.01565158 59 0.04671012447457627 1.787395 26 86 0.008186398 GO Cellular Component nuclear euchromatin 108 0.00005441625 0.00087066 2.652486 22 0.007485539 58 0.041344992 2.601348 11 25 0.003463476 GO Molecular Function nucleosomal DNA binding 7 9.479526e-17 5.717508396e-14 5.147445 41 0.01395032 28 0.000036883301528571425 2.956077 23 46 0.007241814 GO Molecular Function nucleosome binding 8 1.002998e-16 5.293321945e-14 4.022129 53 0.01803334 37 0.0003908556437837838 2.418608 27 66 0.008501259 GO Molecular Function chromatin DNA binding 18 3.307712e-9 7.758422257777779e-7 2.418572 57 0.01939435 46 0.0022271784260869567 1.989667 35 104 0.01102015 GO Molecular Function RNA polymerase II distal enhancer sequence-specific DNA binding 34 0.000006517605 0.0008093331855882353 2.084529 45 0.01531133 57 0.01432303870877193 2.052831 25 72 0.007871537 GO Molecular Function clathrin heavy chain binding 67 0.00005736768 0.003615020074029851 6.250392 8 0.002722014 54 0.010917794896296296 5.06756 6 7 0.001889169 Mouse Phenotype Single KO abnormal platelet activation 15 5.115234e-19 3.1226798492e-16 3.474174 73 0.02483838 114 0.0009158783205263158 2.156197 31 85 0.009760705 Mouse Phenotype Single KO abnormal platelet aggregation 25 1.102049e-17 4.0365850771999994e-15 3.414565 69 0.02347737 144 0.0026405099763888887 2.122312 28 78 0.008816121 Mouse Phenotype Single KO abnormal T cell activation 28 1.365065e-16 4.464250073214286e-14 2.074705 154 0.05239878 110 0.0008300677317818182 1.595668 78 289 0.02455919 Mouse Phenotype Single KO abnormal platelet physiology 30 2.739885e-16 8.363042315000001e-14 2.8282 83 0.0282409 141 0.002401988905815603 1.934887 36 110 0.01133501 Mouse Phenotype Single KO abnormal platelet morphology 31 3.43332e-16 1.0141584270967741e-13 2.086591 148 0.05035726 161 0.003777635605093168 1.55583 70 266 0.0220403 Mouse Phenotype Single KO decreased erythroid progenitor cell number 32 4.615611e-16 1.32078593521875e-13 3.300409 65 0.02211637 63 0.000017634870368253965 2.898115 25 51 0.007871537 Mouse Phenotype Single KO decreased platelet aggregation 42 1.393674e-14 3.038541147142857e-12 3.659078 51 0.01735284 249 0.019931482918473898 2.069254 21 60 0.006612091 Mouse Phenotype Single KO abnormal T cell proliferation 44 3.686234e-14 7.671555622272727e-12 2.020628 138 0.04695475 160 0.0036611030934374997 1.562983 69 261 0.02172544 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 47 1.061987e-13 2.0690670125531913e-11 2.434832 89 0.03028241 81 0.00015557675170370372 1.944265 49 149 0.01542821 Mouse Phenotype Single KO abnormal platelet dense granule morphology 48 1.532487e-13 2.923538220625e-11 4.890512 34 0.01156856 323 0.03934212913003096 2.601348 11 25 0.003463476 Mouse Phenotype Single KO decreased T cell proliferation 56 2.155569e-12 3.5247402380357146e-10 2.240307 94 0.03198367 172 0.005715511912790698 1.734232 44 150 0.0138539 Mouse Phenotype Single KO extramedullary hematopoiesis 64 6.273349e-12 8.97579012390625e-10 2.610165 67 0.02279687 231 0.01754963627229437 1.763274 34 114 0.01070529 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 67 1.529174e-11 2.089947211641791e-9 2.373757 77 0.02619939 60 0.00001615453521333333 2.434416 35 85 0.01102015 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 68 4.441789e-11 5.981391451911764e-9 2.144788 91 0.03096291 106 0.0007182821637169812 1.790538 53 175 0.01668766 Mouse Phenotype Single KO abnormal erythropoiesis 69 4.571472e-11 6.0668071165217395e-9 2.261117 81 0.02756039 57 0.000012584800856666665 2.257368 42 110 0.01322418 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 71 4.964835e-11 6.403238604929577e-9 3.934652 34 0.01156856 342 0.04347441044152047 2.446408 12 29 0.003778338 Mouse Phenotype Single KO increased spleen germinal center size 86 3.593711e-9 3.8264664682558137e-7 4.814463 22 0.007485539 346 0.044812637754335256 2.687343 10 22 0.003148615 Mouse Phenotype Single KO dilated heart right atrium 90 5.595572e-9 5.693183644888889e-7 5.17428 20 0.006805036 234 0.01870490606880342 4.434115 6 8 0.001889169 Mouse Phenotype Single KO abnormal T-helper 2 physiology 100 1.700809e-8 0.0000015574308013000002 2.715156 42 0.01429058 212 0.013811157552830187 2.140607 21 58 0.006612091 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 107 2.396433e-8 0.000002050853923457944 2.460841 49 0.01667234 165 0.003988458438060605 2.342551 21 53 0.006612091 Mouse Phenotype abnormal platelet activation 27 6.107569e-19 2.1627580447777778e-16 3.359211 76 0.02585914 254 0.002397968060787402 1.951011 33 100 0.01039043 Mouse Phenotype abnormal platelet physiology 30 3.716474e-18 1.1844402638e-15 2.817822 94 0.03198367 212 0.0008496793051415094 1.88114 42 132 0.01322418 Mouse Phenotype abnormal platelet aggregation 33 9.078948e-18 2.630418843272727e-15 3.287841 73 0.02483838 280 0.0036269380328571425 1.949753 31 94 0.009760705 Mouse Phenotype increased myeloid cell number 36 1.271773e-17 3.3776171258333337e-15 2.060367 167 0.05682205 180 0.00040270554871666667 1.606787 78 287 0.02455919 Mouse Phenotype decreased erythroid progenitor cell number 53 5.457173e-15 9.844534160943395e-13 2.845116 75 0.02551888 134 0.000050948528368656716 2.411536 31 76 0.009760705 Mouse Phenotype decreased platelet aggregation 57 6.999685e-14 1.174105057631579e-11 3.403367 53 0.01803334 423 0.029108249773049644 1.888605 23 72 0.007241814 Mouse Phenotype abnormal erythropoiesis 59 1.740457e-13 2.8204253181355934e-11 2.265157 101 0.03436543 93 0.0000029201802477419353 2.102981 53 149 0.01668766 Mouse Phenotype extramedullary hematopoiesis 63 7.934091e-13 1.2040927627142859e-10 2.216313 100 0.03402518 234 0.001574913661153846 1.72297 51 175 0.01605793 Mouse Phenotype abnormal platelet dense granule morphology 64 8.960304e-13 1.33858541475e-10 4.34204 36 0.01224906 361 0.016370214424653737 2.561933 13 30 0.004093199 Mouse Phenotype thrombocytopenia 74 4.214953e-12 5.445833193648648e-10 2.04114 113 0.03844845 395 0.023154711195189873 1.51374 53 207 0.01668766 Mouse Phenotype abnormal erythroid progenitor cell morphology 78 1.556482e-11 1.9078877438461537e-9 2.223851 88 0.02994216 138 0.00006615839952391303 2.086642 42 119 0.01322418 Mouse Phenotype abnormal mean corpuscular hemoglobin 81 3.166446e-11 3.737579037777778e-9 2.099707 97 0.03300442 165 0.00022992043634545455 1.799351 56 184 0.01763224 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 83 4.746741e-11 5.467902494096386e-9 2.056979 100 0.03402518 135 0.00005681843090666666 1.872182 57 180 0.0179471 Mouse Phenotype abnormal embryonic erythropoiesis 88 1.000185e-10 1.0866782710227272e-8 3.654418 36 0.01224906 388 0.022201354146649484 2.47929 13 31 0.004093199 Mouse Phenotype abnormal embryonic erythrocyte morphology 92 4.194484e-10 4.3590719047826084e-8 3.324051 38 0.01292957 403 0.02592219600744417 2.273905 15 39 0.004722922 Mouse Phenotype abnormal pre-B cell morphology 93 5.907726e-10 6.073523471612903e-8 2.043709 90 0.03062266 320 0.0077328979584375 1.733639 39 133 0.0122796 Mouse Phenotype abnormal bone marrow cell physiology 102 6.212244e-9 5.823065184705883e-7 2.572852 49 0.01667234 164 0.00021384645629268293 2.50515 25 59 0.007871537 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 110 1.539871e-8 0.0000013384278755454547 2.066754 73 0.02483838 474 0.03855152532911392 1.634254 34 123 0.01070529 Mouse Phenotype spleen hyperplasia 111 1.635218e-8 0.0000014084972340540541 2.140722 67 0.02279687 340 0.012449482146176472 1.763274 34 114 0.01070529 Mouse Phenotype increased mortality induced by ionizing radiation 117 2.8671e-8 0.0000023429353076923075 2.98058 35 0.01190881 478 0.03967772995606694 2.051155 17 49 0.005352645