# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	19	3.299329e-50	2.2850458058421053e-47	2.540268	336	0.01754111	392	0.0002768918122755102	1.322293	90	113	0.00795756	
GO Biological Process	regulation of DNA-templated transcription in response to stress	29	1.190141e-43	5.400367385862069e-41	2.319221	347	0.01811537	370	0.00013676810206486486	1.325379	95	119	0.008399646	
GO Biological Process	endoplasmic reticulum unfolded protein response	31	4.456812e-42	1.8918448099354838e-39	2.427217	305	0.01592274	468	0.0011121894012179486	1.296131	89	114	0.007869142	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	40	2.264894e-39	7.4509350365e-37	4.149649	129	0.006734534	986	0.04971682398884381	1.452686	21	24	0.001856764	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	43	5.678055e-38	1.7376168777906976e-35	2.03334	404	0.0210911	375	0.0001432769114426667	1.285326	120	155	0.01061008	
GO Biological Process	cellular response to topologically incorrect protein	45	3.413826e-36	9.982785852e-34	2.151537	336	0.01754111	431	0.0006423814680278422	1.278005	107	139	0.009460654	
GO Biological Process	cellular response to unfolded protein	48	2.098541e-35	5.7530627122916666e-33	2.204221	311	0.01623597	511	0.002050464994187867	1.276031	93	121	0.008222812	
GO Biological Process	liver regeneration	52	1.126192e-34	2.849915486153846e-32	3.058644	168	0.008770556	600	0.005176118968	1.470474	31	35	0.002740937	
GO Biological Process	mitochondrial membrane organization	60	4.930057e-33	1.0812436677166668e-30	2.020239	355	0.01853302	210	4.369361356428572e-8	1.419214	106	124	0.009372237	
GO Biological Process	regulation of mitochondrial membrane permeability	74	2.438354e-30	4.335986525135135e-28	2.29692	242	0.01263378	268	0.000002339588692761194	1.478271	65	73	0.005747126	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	75	2.821367e-30	4.950182447066667e-28	2.303632	240	0.01252937	454	0.0009387337855726872	1.294403	92	118	0.008134394	
GO Biological Process	regulation of necrotic cell death	80	5.363228e-29	8.8218396565e-27	4.38005	88	0.004594101	778	0.019358072971722366	1.475744	24	27	0.002122016	
GO Biological Process	regulation of membrane permeability	87	7.048578e-28	1.0661176770344827e-25	2.145184	257	0.01341686	297	0.0000100918542013468	1.434751	70	81	0.006189213	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	93	5.868579e-27	8.303723770000001e-25	2.309794	211	0.0110154	597	0.005123783971859297	1.319656	62	78	0.005481874	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	95	4.109027e-26	5.691651188736842e-24	2.18461	230	0.01200731	775	0.01942529882064516	1.23414	84	113	0.007427056	
GO Biological Process	positive regulation of mRNA catabolic process	98	2.778051e-25	3.7302421539795915e-23	2.851462	134	0.006995563	479	0.001493656112546973	1.593804	24	25	0.002122016	
GO Biological Process	viral gene expression	106	1.357493e-24	1.6852123006603773e-22	2.086322	240	0.01252937	361	0.00009701583927146815	1.320326	101	127	0.00893015	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	112	4.107658e-24	4.826131394821428e-22	3.079819	113	0.005899243	610	0.006448246525245902	1.660212	16	16	0.001414677	
GO Biological Process	mitochondrial transmembrane transport	120	1.044374e-23	1.1452431221666666e-21	2.230847	198	0.01033673	634	0.00756778448659306	1.300166	65	83	0.005747126	
GO Biological Process	positive regulation of mRNA metabolic process	131	5.080572e-23	5.103453965496183e-21	2.304478	179	0.009344819	793	0.021765417442622947	1.340941	42	52	0.003713528	
GO Cellular Component	PcG protein complex	49	9.233788e-21	3.256323604897959e-19	2.210544	175	0.009135996	112	0.004434549428571429	1.407571	39	46	0.003448276	
GO Cellular Component	mitochondrial ribosome	54	1.981249e-18	6.3399968e-17	2.308418	140	0.007308797	105	0.00344369664	1.308638	67	85	0.005923961	
GO Cellular Component	nuclear ubiquitin ligase complex	59	8.144487e-17	2.3853683959322035e-15	2.668945	96	0.005011746	147	0.0262008293877551	1.369675	33	40	0.002917772	
GO Cellular Component	mitochondrial large ribosomal subunit	88	1.13081e-12	2.2204996363636362e-11	2.385757	86	0.004489689	140	0.021968471314285715	1.33468	41	51	0.003625111	
GO Cellular Component	very-low-density lipoprotein particle	125	7.954443e-10	1.09962220032e-8	2.581904	55	0.002871313	166	0.03975494053012048	1.494191	18	20	0.001591512	
GO Molecular Function	rRNA binding	9	1.773688e-28	8.320567484444445e-26	3.266317	124	0.006473506	84	0.0014241283488095238	1.41118	51	60	0.004509284	
GO Molecular Function	5'-3' RNA polymerase activity	47	2.292666e-11	2.059496989787234e-9	2.270235	84	0.004385278	144	0.039926984888888885	1.365063	37	45	0.003271441	
GO Molecular Function	SUMO transferase activity	48	2.578893e-11	2.2683513012499997e-9	2.649918	62	0.003236753	133	0.0280758778	1.572833	18	19	0.001591512	
GO Molecular Function	thyroid hormone receptor binding	51	4.935025e-11	4.0854265784313724e-9	2.313196	78	0.004072044	129	0.025070255637209302	1.482332	25	28	0.002210433	
Human Phenotype	Increased serum lactate	9	1.750847e-26	1.2981557812222221e-23	2.212485	227	0.01185069	58	0.00026860654322413794	1.361374	82	100	0.007250221	
Human Phenotype	Abnormality of mitochondrial metabolism	23	1.419332e-15	4.117914102608696e-13	2.003495	161	0.008405116	156	0.04985244307692308	1.299297	54	69	0.004774536	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	96	6.856469e-13	6.540071524270833e-11	2.553714	77	0.004019838	363	0.04182027125895317	1.509284	20	22	0.001768347	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	192	1.855695e-9	8.8503120390625e-8	2.117368	79	0.00412425	297	0.021857931657239055	1.521861	22	24	0.001945181	
Mouse Phenotype Single KO	gastrointestinal tract polyps	391	0.000002536423	0.00005940159951662404	2.351943	38	0.001983816	346	0.03625420384971098	1.660212	13	13	0.001149425	
Mouse Phenotype	absent segment of posterior cerebral artery	154	6.856469e-13	4.256798708376624e-11	2.553714	77	0.004019838	553	0.0286627887721519	1.509284	20	22	0.001768347	
Mouse Phenotype	abnormal vitelline vein morphology	156	7.659238e-13	4.694229135769231e-11	2.03786	124	0.006473506	610	0.03957191318360656	1.460987	22	25	0.001945181	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	169	4.446076e-12	2.515321457751479e-10	2.406334	80	0.004176455	551	0.028187389687840292	1.438851	26	30	0.002298851	
Mouse Phenotype	abnormal cerebral artery morphology	259	1.855695e-9	6.85030883976834e-8	2.117368	79	0.00412425	461	0.014703295706290672	1.521861	22	24	0.001945181	
Mouse Phenotype	increased liver adenoma incidence	296	1.972347e-8	6.37081407668919e-7	2.088484	71	0.003706604	653	0.05000912529555896	1.423039	24	28	0.002122016	
Mouse Phenotype	decreased type II pneumocyte number	520	0.000005320225	0.00009782052158653848	2.003661	51	0.00266249	596	0.036499374171140936	1.660212	12	12	0.001061008