# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	19	5.73729e-35	3.973526268947368e-32	2.315972	274	0.02795063	124	1.348093917983871e-7	1.52983	125	213	0.01735388	
GO Biological Process	RNA catabolic process	21	1.900679e-33	1.1910016648095237e-30	2.172078	300	0.03060288	129	3.9409215848837214e-7	1.481891	137	241	0.01901985	
GO Biological Process	rRNA processing	23	1.030546e-32	5.896067310434782e-30	2.214276	281	0.02866469	81	1.0522553735802469e-9	1.551685	150	252	0.02082466	
GO Biological Process	nuclear-transcribed mRNA catabolic process	24	1.373984e-32	7.533439773333334e-30	2.336815	250	0.0255024	138	5.398566523115942e-7	1.527234	116	198	0.0161044	
GO Biological Process	rRNA metabolic process	25	6.01964e-32	3.1684977104e-29	2.175476	285	0.02907273	82	1.4713034571585368e-9	1.539942	153	259	0.02124115	
GO Biological Process	liver regeneration	29	5.29783e-30	2.4039360334482756e-27	3.806507	107	0.01091503	275	0.0035223063751999998	1.862022	25	35	0.003470776	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	38	1.363626e-28	4.7220932984210526e-26	2.271767	231	0.02356422	203	0.00033158391760098525	1.463189	87	155	0.0120783	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	56	6.097906e-25	1.4328990188214286e-22	2.700769	144	0.01468938	214	0.00044255481781775704	1.524333	69	118	0.009579342	
GO Biological Process	cellular response to insulin stimulus	57	9.211444e-25	2.126550729754386e-22	2.00634	264	0.02693053	368	0.01715345735978261	1.356256	77	148	0.01068999	
GO Biological Process	regulation of mRNA stability	58	1.526498e-24	3.463308134827586e-22	2.107905	232	0.02366622	283	0.0043279662710954065	1.398366	81	151	0.01124531	
GO Biological Process	mitochondrial translational termination	62	1.069711e-23	2.270375330483871e-21	3.053939	112	0.01142507	153	0.000002046749139869281	1.767851	59	87	0.008191032	
GO Biological Process	mitochondrial translation	68	2.507896e-23	4.853147568235294e-21	2.725204	132	0.01346527	130	3.9739096913076924e-7	1.729766	71	107	0.009857004	
GO Biological Process	protein targeting to ER	69	2.550145e-23	4.863385225362319e-21	2.762232	129	0.01315924	277	0.0036463755268953068	1.496992	58	101	0.0080522	
GO Biological Process	RNA phosphodiester bond hydrolysis	70	2.847639e-23	5.353154514428571e-21	2.378194	169	0.01723962	200	0.000242161853045	1.509218	77	133	0.01068999	
GO Biological Process	mitochondrial translational elongation	72	2.980265e-23	5.446848213194444e-21	3.049132	110	0.01122105	160	0.0000062076028093125	1.74811	57	85	0.007913369	
GO Biological Process	regulation of receptor catabolic process	73	3.336705e-23	6.014753574657534e-21	5.751832	53	0.005406508	314	0.007515180333757963	2.60683	9	9	0.001249479	
GO Biological Process	macromolecular complex disassembly	75	9.026174e-23	1.5836723155466665e-20	2.028204	235	0.02397225	85	2.3567676112941177e-9	1.624151	119	191	0.01652089	
GO Biological Process	regulation of RNA stability	78	1.467062e-22	2.4750088279487182e-20	2.016665	236	0.02407426	352	0.012507850062784091	1.352293	83	160	0.01152298	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	79	1.561566e-22	2.6010945562025314e-20	2.433879	156	0.0159135	298	0.0058276265335570464	1.497541	54	94	0.007496876	
GO Biological Process	cotranslational protein targeting to membrane	82	1.418625e-21	2.276547118902439e-19	2.729748	121	0.01234316	237	0.0012729478024894514	1.542818	58	98	0.0080522	
GO Cellular Component	ribosome	37	8.281209e-24	3.8675484194594593e-22	2.026365	247	0.02519637	43	5.427724353488372e-7	1.469104	133	236	0.01846453	
GO Cellular Component	ribosomal subunit	38	2.218594e-23	1.0088764294736842e-21	2.241216	192	0.01958584	52	0.000019313613415384615	1.465461	104	185	0.01443843	
GO Cellular Component	large ribosomal subunit	42	2.053788e-21	8.44987062857143e-20	2.573962	133	0.01356728	54	0.000064603808	1.564098	69	115	0.009579342	
GO Cellular Component	catalytic step 2 spliceosome	45	3.939363e-19	1.512715392e-17	2.42097	132	0.01346527	32	1.3789763999999998e-9	1.873659	69	96	0.009579342	
GO Cellular Component	mitochondrial ribosome	46	1.777012e-18	6.675384208695652e-17	2.931912	91	0.009282873	50	0.0000084681504	1.717441	56	85	0.007774538	
GO Cellular Component	mitochondrial large ribosomal subunit	48	2.834017e-17	1.02024612e-15	3.523419	65	0.006630623	49	0.000005793335118367346	1.942344	38	51	0.00527558	
GO Cellular Component	methyltransferase complex	52	2.505533e-16	8.326078892307693e-15	2.256448	128	0.01305723	48	0.00000317080152	1.718789	60	91	0.008329863	
GO Cellular Component	peptidase complex	56	4.018561e-14	1.2400131085714285e-12	2.254808	109	0.01111905	131	0.03792850516030535	1.392284	47	88	0.006525059	
GO Cellular Component	MLL1 complex	59	1.755753e-13	5.1422731932203395e-12	3.483756	50	0.005100479	105	0.013397458834285714	1.797814	20	29	0.002776621	
GO Cellular Component	nuclear chromosome, telomeric region	63	1.050478e-12	2.8813110857142856e-11	2.005592	127	0.01295522	104	0.012880314276923075	1.362661	69	132	0.009579342	
GO Cellular Component	histone methyltransferase complex	70	4.828867e-11	1.1920403108571428e-9	2.068959	100	0.01020096	78	0.0027400187076923074	1.586766	42	69	0.005830904	
GO Cellular Component	exosome (RNase complex)	76	3.402573e-10	7.736376505263158e-9	3.360129	38	0.003876364	76	0.0025891033263157896	2.040128	18	23	0.002498959	
GO Cellular Component	PcG protein complex	79	6.77747e-10	1.482464324050633e-8	2.097989	85	0.008670815	124	0.02263981006451613	1.586766	28	46	0.003887269	
GO Cellular Component	spliceosomal snRNP complex	84	1.851874e-9	3.809569371428571e-8	2.328614	64	0.006528614	60	0.0002470826016	1.723872	41	62	0.005692073	
GO Cellular Component	ESCRT complex	88	4.993469e-9	9.80535730909091e-8	2.985333	39	0.003978374	95	0.007184456488421052	1.862022	20	28	0.002776621	
GO Cellular Component	mitochondrial nucleoid	93	1.204603e-8	2.2382300903225807e-7	2.447921	52	0.005304499	100	0.010134616320000001	1.67582	27	42	0.003748438	
GO Cellular Component	small nuclear ribonucleoprotein complex	94	1.324855e-8	2.435478127659574e-7	2.121289	70	0.007140671	64	0.00044625384	1.662327	44	69	0.006108566	
GO Cellular Component	U5 snRNP	121	9.176446e-7	0.00001310487494876033	2.935034	28	0.002856268	115	0.016973783373913042	1.895877	16	22	0.002221297	
GO Cellular Component	Fanconi anaemia nuclear complex	126	0.000001057183	0.000014498509714285713	2.685123	32	0.003264307	107	0.013993389218691588	2.20578	11	13	0.001527141	
GO Cellular Component	methylosome	152	0.000005047914	0.000057386811789473685	3.987606	16	0.001632153	125	0.026687881727999997	2.172359	10	12	0.00138831	
GO Molecular Function	structural constituent of ribosome	9	2.280889e-26	1.0699903731111112e-23	2.404205	189	0.01927981	29	0.000041414748131034486	1.512605	94	162	0.01305012	
GO Molecular Function	ribonuclease activity	15	1.700831e-17	4.787272321333333e-15	2.331703	129	0.01315924	74	0.010052154094594595	1.474571	56	99	0.007774538	
GO Molecular Function	exonuclease activity	39	7.45087e-11	8.066044394871795e-9	2.096034	95	0.009690911	86	0.020839792000000003	1.509218	44	76	0.006108566	
GO Molecular Function	3'-5'-exoribonuclease activity	71	1.751585e-8	0.00000104157631971831	2.52291	48	0.00489646	87	0.02131444671034483	1.824781	21	30	0.002915452	
GO Molecular Function	exoribonuclease activity, producing 5'-phosphomonoesters	85	1.719448e-7	0.00000854059936	2.285769	50	0.005100479	73	0.007128297561643835	1.873659	23	32	0.003193114	
GO Molecular Function	exoribonuclease activity	99	3.988541e-7	0.000017009717274747473	2.180506	52	0.005304499	65	0.002150826450769231	1.916787	25	34	0.003470776	
Human Phenotype	Increased serum lactate	11	2.02304e-15	1.227249629090909e-12	2.266337	119	0.01213914	31	0.000037959877119354836	1.668372	64	100	0.008885187	
Human Phenotype	Elevated hepatic transaminases	14	2.595785e-14	1.2372623789285715e-11	2.024245	142	0.01448536	74	0.0028347895932432435	1.514444	61	105	0.008468694	
Human Phenotype	Exercise intolerance	26	1.495976e-12	3.8394799415384615e-10	2.475132	79	0.008058758	91	0.014305540735164836	1.564098	42	70	0.005830904	
Human Phenotype	Lipid accumulation in hepatocytes	30	5.559129e-12	1.2365355939e-9	2.144555	101	0.01030297	109	0.027968073504587156	1.520651	42	72	0.005830904	
Human Phenotype	Abnormal CSF metabolite level	41	5.927083e-11	9.646688989999999e-9	2.428474	70	0.007140671	76	0.004034534433157895	1.65513	40	63	0.005553242	
Human Phenotype	Increased CSF lactate	48	2.615519e-10	3.6361163097916664e-8	2.451735	64	0.006528614	71	0.002361024882394366	1.707923	38	58	0.00527558	
Human Phenotype	Hepatic failure	51	3.008738e-10	3.936727190980392e-8	2.021552	97	0.00989493	15	0.0000045563955786666666	1.9341	46	62	0.006386228	
Human Phenotype	Leukodystrophy	71	2.398262e-8	0.0000022540284966197185	2.170303	64	0.006528614	58	0.0006471920650172414	1.824781	35	50	0.004859086	
Human Phenotype	Glycosuria	135	0.000001374967	0.00006796410956296297	2.247848	44	0.004488422	125	0.043458937472800004	1.797814	20	29	0.002776621	
Human Phenotype	Progressive macrocephaly	252	0.00009411986	0.0024923088324603176	2.341267	26	0.002652249	97	0.0200615008185567	1.955123	18	24	0.002498959	
Mouse Phenotype Single KO	absent hypoglossal nerve	47	3.932874e-16	7.662410046382979e-14	4.831746	42	0.004284403	69	0.02240891750289855	2.259253	13	15	0.001804804	
Mouse Phenotype Single KO	bowed ulna	277	0.000001682334	0.000055614196527075815	2.185283	46	0.004692441	87	0.04046228850689655	2.234426	12	14	0.001665973	
Mouse Phenotype	absent hypoglossal nerve	54	3.932874e-16	6.963371909999999e-14	4.831746	42	0.004284403	99	0.01630740577878788	2.259253	13	15	0.001804804	
Mouse Phenotype	abnormal Peyer's patch germinal center morphology	355	0.000001841776	0.00004960343756619718	2.527063	34	0.003468326	155	0.04806299279032258	2.027535	14	18	0.001943635	
Mouse Phenotype	abnormal Peyer's patch follicle morphology	360	0.000002143346	0.00005692369751666666	2.144425	47	0.004794451	112	0.01997764974375	1.850009	22	31	0.003054283	
Mouse Phenotype	increased urine magnesium level	442	0.00001392033	0.000301113744638009	2.835765	23	0.002346221	138	0.03413288085217391	2.369846	10	11	0.00138831