# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process DNA replication-dependent nucleosome assembly 1 1.013162e-48 1.3332198758e-44 38.91353 40 0.01554606 135 0.0010840735106666666 3.259896 15 32 0.005555556 GO Biological Process negative regulation of megakaryocyte differentiation 2 2.13624e-44 1.4055391079999999e-40 62.64313 31 0.01204819 180 0.003920956525666666 3.86358 10 18 0.003703704 GO Biological Process chromatin silencing at rDNA 3 5.092489e-40 2.2337354250333335e-36 18.77942 44 0.01710066 187 0.00436155055 2.897685 15 36 0.005555556 GO Biological Process DNA conformation change 4 2.917953e-39 9.59933588175e-36 3.342549 164 0.06373883 51 0.00001067191545745098 1.856168 75 281 0.02777778 GO Biological Process negative regulation of gene expression, epigenetic 5 3.876913e-39 1.0203259633400001e-35 6.172359 86 0.03342402 30 9.198105909333334e-7 2.562164 42 114 0.01555556 GO Biological Process chromatin silencing 6 7.552694e-36 1.6564316724333335e-32 7.403019 68 0.02642829 58 0.00001870423663189655 2.509336 35 97 0.01296296 GO Biological Process nucleosome organization 8 1.300136e-33 2.138561203e-30 4.067474 110 0.04275165 25 4.5827654462800003e-7 2.277479 56 171 0.02074074 GO Biological Process nucleosome assembly 9 2.476703e-33 3.621214975222223e-30 4.402858 100 0.03886514 39 0.000004435865158974359 2.301823 47 142 0.01740741 GO Biological Process regulation of gene expression, epigenetic 10 5.939417e-33 7.8156788303e-30 3.400177 134 0.05207928 33 0.0000016467998028181817 1.99099 71 248 0.0262963 GO Biological Process chromatin assembly 11 2.095958e-31 2.5073373929090905e-28 4.050006 103 0.04003109 44 0.0000072694592675 2.200774 50 158 0.01851852 GO Biological Process chromatin assembly or disassembly 12 2.308839e-31 2.53183436675e-28 3.822326 110 0.04275165 34 0.0000017673945787058821 2.187915 56 178 0.02074074 GO Biological Process protein-DNA complex subunit organization 13 1.873672e-30 1.896588449846154e-27 3.087681 141 0.05479984 17 1.1192704814117647e-7 2.086333 75 250 0.02777778 GO Biological Process regulation of gene silencing 14 4.166249e-30 3.915976470785715e-27 4.399334 90 0.03497862 118 0.000488140353601695 2.070407 39 131 0.01444444 GO Biological Process gene silencing 15 3.198215e-29 2.805687412333333e-26 3.892614 100 0.03886514 77 0.00005916896499090909 2.009062 52 180 0.01925926 GO Biological Process regulation of hematopoietic progenitor cell differentiation 16 9.877622e-29 8.123726743625e-26 5.161921 73 0.02837155 161 0.0029152497639751552 2.030944 33 113 0.01222222 GO Biological Process chromosome organization 17 1.325763e-28 1.0262185480588235e-25 2.224478 232 0.09016712 131 0.000911411726923664 1.455861 121 578 0.04481481 GO Biological Process protein-DNA complex assembly 18 6.011006e-28 4.394379330777777e-25 3.138457 126 0.04897007 38 0.0000034291696050000007 2.032349 64 219 0.0237037 GO Biological Process DNA packaging 19 5.403254e-26 3.7421799676842106e-23 3.320978 108 0.04197435 74 0.000057764560208108104 1.95703 56 199 0.02074074 GO Biological Process regulation of hematopoietic stem cell differentiation 20 6.564336e-26 4.3190048712e-23 5.199077 65 0.02526234 202 0.005443742801386139 2.025566 30 103 0.01111111 GO Biological Process regulation of gene silencing by miRNA 21 9.578998e-25 6.002382603904762e-22 4.40969 73 0.02837155 146 0.0020229871480821914 2.099455 32 106 0.01185185 GO Cellular Component nucleosome 5 1.005399e-42 3.474658944e-40 8.318896 75 0.02914885 8 5.98291056e-11 3.046709 46 105 0.01703704 GO Cellular Component nuclear nucleosome 6 4.5134e-40 1.2998592e-37 17.96449 45 0.01748931 45 0.002471382144 2.781778 16 40 0.005925926 GO Cellular Component DNA packaging complex 7 1.17839e-37 2.908939885714286e-35 6.844245 76 0.0295375 11 1.6439453672727275e-10 2.918383 47 112 0.01740741 GO Cellular Component protein-DNA complex 18 1.22826e-26 1.1791296e-24 3.409272 107 0.0415857 6 2.91709728e-11 2.444384 71 202 0.0262963 GO Cellular Component nuclear chromatin 22 1.904293e-23 1.4957355927272728e-21 2.368359 167 0.06490478 15 2.27017152e-9 2.002704 91 316 0.0337037 GO Cellular Component chromatin 23 1.699792e-22 1.27706112e-20 2.06684 213 0.08278274 7 4.358882468571428e-11 1.874552 131 486 0.04851852 GO Cellular Component ribosomal subunit 46 4.894347e-13 1.8385720904347822e-11 2.846307 64 0.02487369 34 0.00010598855717647059 1.917171 51 185 0.01888889 GO Cellular Component large ribosomal subunit 68 1.304668e-9 3.315391623529412e-8 3.023108 41 0.01593471 49 0.004534726922448979 1.93515 32 115 0.01185185 GO Cellular Component ribosome 73 7.338023e-9 1.7370005128767124e-7 2.156696 69 0.02681695 47 0.0030066718365957448 1.650207 56 236 0.02074074 GO Cellular Component cytosolic large ribosomal subunit 76 3.295624e-8 7.493208252631578e-7 3.376333 29 0.01127089 46 0.0026034592695652176 2.394153 21 61 0.007777778 GO Cellular Component cytosolic ribosome 79 5.920224e-8 0.0000012949553255696203 2.52447 44 0.01710066 38 0.00018265687578947366 2.173264 35 112 0.01296296 GO Molecular Function cadherin binding 6 3.607788e-24 2.538680156e-21 2.407906 167 0.06490478 4 0.000006125358873499999 1.87587 82 304 0.03037037 GO Molecular Function nucleosome binding 8 4.055734e-19 2.1404136184999999e-16 4.594263 53 0.02059852 39 0.02670989841538462 2.212778 21 66 0.007777778 GO Molecular Function nucleosomal DNA binding 9 6.128071e-18 2.8747461957777777e-15 5.736244 40 0.01554606 33 0.015816392430303028 2.570121 17 46 0.006296296 GO Molecular Function phosphotyrosine binding 10 5.960478e-17 2.5165138116e-14 4.454432 48 0.01865527 34 0.022771518429411764 2.781778 14 35 0.005185185 GO Molecular Function protein phosphorylated amino acid binding 13 8.458498e-16 2.747059888923077e-13 3.934938 51 0.01982122 37 0.027569329086486485 2.528889 16 44 0.005925926 GO Molecular Function protein N-terminus binding 30 2.55487e-10 3.595553713333334e-8 2.599153 57 0.02215313 32 0.0162006584 1.986984 30 105 0.01111111 GO Molecular Function structural constituent of ribosome 33 1.578593e-9 2.019642316969697e-7 2.568649 53 0.02059852 28 0.011532855912142858 1.803004 42 162 0.01555556 GO Molecular Function protein phosphatase activator activity 58 1.895657e-7 0.000013799075610344826 5.979071 14 0.005441119 35 0.022862528074285713 5.215833 6 8 0.002222222 GO Molecular Function nerve growth factor binding 75 0.000002722986 0.00015328595856 9.60623 8 0.003109211 17 0.002184878294470588 6.954444 6 6 0.002222222 GO Molecular Function phosphatase activator activity 92 0.00001989402 0.0009129625265217392 3.743333 15 0.005829771 38 0.027122283547368425 4.425556 7 11 0.002592593 Mouse Phenotype Single KO abnormal hemoglobin 27 8.223385e-18 2.7889457942592593e-15 2.030266 174 0.06762534 30 0.0006743843580666667 1.622082 87 373 0.03222222 Mouse Phenotype Single KO extramedullary hematopoiesis 35 5.624545e-16 1.4715416732857144e-13 3.114949 70 0.0272056 48 0.0032053277262500002 2.074133 34 114 0.01259259 Mouse Phenotype Single KO abnormal hemoglobin content 49 1.162892e-12 2.173184090612245e-10 2.10655 110 0.04275165 90 0.012172155913333333 1.65285 53 223 0.01962963 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 55 2.39626e-12 3.989555058181819e-10 3.369342 47 0.01826661 99 0.015855696980808083 2.217359 22 69 0.008148148 Mouse Phenotype Single KO abnormal hemostasis 57 2.63925e-12 4.239931973684211e-10 2.061918 112 0.04352895 134 0.0383520649261194 1.580556 50 220 0.01851852 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 85 5.42013e-10 5.8390741658823533e-8 3.965596 30 0.01165954 82 0.008597867996463414 3.11751 13 29 0.004814815 Mouse Phenotype Single KO abnormal body temperature 106 7.969553e-9 6.884641209528301e-7 2.315179 59 0.02293043 37 0.0008000421402702703 2.249967 33 102 0.01222222 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 108 9.801787e-9 8.310644773981481e-7 3.483433 30 0.01165954 141 0.04690411528652482 2.583079 13 35 0.004814815 Mouse Phenotype Single KO thin ventricular wall 123 2.188098e-8 0.0000016289766980487804 2.196669 62 0.02409639 112 0.02832991024821429 1.955938 27 96 0.01 Mouse Phenotype Single KO decreased body temperature 131 4.535306e-8 0.0000031702135146564885 2.581928 43 0.01671201 64 0.00479318729578125 2.387347 23 67 0.008518519 Mouse Phenotype Single KO abnormal bone marrow morphology 144 1.384214e-7 0.00000880225527638889 2.947287 32 0.01243684 71 0.005890730342957747 2.749432 17 43 0.006296296 Mouse Phenotype Single KO abnormal erythropoiesis 151 1.721273e-7 0.000010438209841721855 2.040693 64 0.02487369 50 0.0035592947662000003 2.086333 33 110 0.01222222 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 161 3.884178e-7 0.000022091563941614905 2.409332 42 0.01632336 39 0.0013505736782307692 2.755535 21 53 0.007777778 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 182 0.000001297034 0.00006525791394505493 2.007151 57 0.02215313 138 0.04497306606231884 1.963608 24 85 0.008888889 Mouse Phenotype Single KO decreased erythroid progenitor cell number 191 0.000001787457 0.00008569499345026178 2.319927 40 0.01554606 127 0.0369261648984252 2.318148 17 51 0.006296296 Mouse Phenotype Single KO abnormal vertebral body morphology 284 0.00004103546 0.001323104602887324 2.160971 34 0.01321415 113 0.028695088311504423 2.318148 18 54 0.006666667 Mouse Phenotype Single KO pale liver 289 0.00004285132 0.0013577492638062285 2.185136 33 0.0128255 107 0.0216553550682243 2.086333 24 80 0.008888889 Mouse Phenotype abnormal hemoglobin 21 9.766135e-20 4.446381749285715e-17 2.016641 197 0.07656432 29 0.00036956331113793106 1.596102 98 427 0.0362963 Mouse Phenotype abnormal hemoglobin content 36 7.718043e-15 2.04978358675e-12 2.093605 133 0.05169063 75 0.005000320138 1.630346 64 273 0.0237037 Mouse Phenotype extramedullary hematopoiesis 51 1.343449e-11 2.518571742941176e-9 2.227787 88 0.03420132 118 0.018866170327118643 1.708806 43 175 0.01592593 Mouse Phenotype decreased hemoglobin content 59 1.047841e-10 1.6980352205084746e-8 2.095753 92 0.03575593 97 0.009483503659484535 1.703839 49 200 0.01814815 Mouse Phenotype decreased mean corpuscular hemoglobin 64 6.689772e-10 9.993892201875e-8 2.795168 48 0.01865527 127 0.027230217342519687 2.077302 23 77 0.008518519 Mouse Phenotype abnormal embryonic erythropoiesis 93 1.010726e-8 0.000001039091536129032 3.478538 30 0.01165954 110 0.015355878640909091 2.91638 13 31 0.004814815 Mouse Phenotype abnormal embryonic erythrocyte morphology 116 7.472213e-8 0.000006158778318362068 3.097459 31 0.01204819 147 0.044174226510204084 2.496467 14 39 0.005185185 Mouse Phenotype abnormal megakaryocyte morphology 133 1.686196e-7 0.000012121593951879699 2.113075 59 0.02293043 107 0.013512275363551401 1.942232 31 111 0.01148148 Mouse Phenotype decreased mean corpuscular volume 139 2.431202e-7 0.000016722821814388487 2.249672 50 0.01943257 126 0.02701380116190476 1.902631 29 106 0.01074074 Mouse Phenotype abnormal bone marrow hematopoietic cell morphology 155 4.702517e-7 0.000029006945185161292 2.005323 62 0.02409639 121 0.023811441352066115 1.854519 32 120 0.01185185 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 156 4.72601e-7 0.00002896498821153846 2.005014 62 0.02409639 115 0.017986693604347827 1.865827 33 123 0.01222222 Mouse Phenotype abnormal fibroblast apoptosis 180 0.000001685555 0.00008953106308333334 2.419082 37 0.0143801 142 0.04047107335563381 2.086333 21 70 0.007777778 Mouse Phenotype abnormal embryonic hematopoiesis 184 0.000002139266 0.00011116044688043477 2.201169 44 0.01710066 43 0.0012587261060930234 2.622168 23 61 0.008518519 Mouse Phenotype decreased body temperature 206 0.000006107368 0.0002834589584854369 2.051289 47 0.01826661 120 0.022942432184999997 1.976526 27 95 0.01