# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	27	3.362203e-50	1.6386381213703706e-47	2.025856	545	0.02444933	173	2.509557453815029e-9	1.338578	175	213	0.01518438	
GO Biological Process	regulation of DNA-templated transcription in response to stress	29	1.051026e-48	4.769121080689656e-46	2.291597	399	0.0178996	760	0.02379564478815789	1.218508	89	119	0.007722343	
GO Biological Process	endoplasmic reticulum unfolded protein response	33	4.025201e-47	1.6050793926969697e-44	2.400317	351	0.01574627	394	0.00023134580731725888	1.314826	92	114	0.007982646	
GO Biological Process	nuclear-transcribed mRNA catabolic process	36	6.952303e-46	2.541259866027778e-43	2.030677	494	0.02216141	207	6.009251238647343e-8	1.324787	161	198	0.01396963	
GO Biological Process	IRE1-mediated unfolded protein response	41	1.410368e-44	4.5265932956097563e-42	3.195626	205	0.009196537	624	0.007713679271153846	1.348337	48	58	0.004164859	
GO Biological Process	cellular response to topologically incorrect protein	44	7.496214e-44	2.2418790915e-41	2.184503	397	0.01780988	425	0.0003967775989647059	1.277606	109	139	0.009457701	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	54	1.014804e-39	2.4729270066666667e-37	2.408448	292	0.01309946	239	0.0000012672353751882846	1.380713	100	118	0.00867679	
GO Biological Process	cellular response to unfolded protein	63	7.591908e-39	1.585744720190476e-36	2.168191	356	0.01597057	442	0.0005144960599547512	1.292621	96	121	0.008329718	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	83	2.644971e-33	4.193394384216867e-31	2.140713	312	0.01399668	427	0.00042084207770491807	1.334591	77	94	0.006681128	
GO Biological Process	cotranslational protein targeting to membrane	85	5.22666e-33	8.09148458117647e-31	2.400944	242	0.0108564	243	0.0000014441450146913581	1.413117	85	98	0.007375271	
GO Biological Process	protein targeting to ER	88	8.540139e-33	1.2770419216022727e-30	2.354182	250	0.01121529	250	0.00000197947784112	1.403405	87	101	0.007548807	
GO Biological Process	liver regeneration	89	1.01775e-32	1.5047833988764044e-30	2.816079	180	0.008075008	510	0.0018330677934509806	1.489592	32	35	0.002776573	
GO Biological Process	regulation of mitochondrial membrane permeability	94	6.682481e-32	9.354762497765957e-30	2.226618	273	0.0122471	473	0.0009101729764270613	1.36142	61	73	0.005292842	
GO Biological Process	RNA phosphodiester bond hydrolysis	110	1.062122e-29	1.2705875816363636e-27	2.005096	324	0.01453501	220	4.2585610383636364e-7	1.371992	112	133	0.009718004	
GO Biological Process	mitochondrial transmembrane transport	117	1.435351e-28	1.6143404964957265e-26	2.265547	234	0.01049751	430	0.00043636284479069766	1.354429	69	83	0.005986985	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	118	3.935931e-28	4.3892301719491523e-26	2.319944	219	0.009824593	282	0.000010010835240425531	1.399022	79	92	0.006854664	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	120	7.681354e-28	8.423244773833333e-26	2.137746	259	0.01161904	223	5.507302909730941e-7	1.412009	91	105	0.007895879	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	128	1.533629e-27	1.576642500859375e-25	2.80395	151	0.006774034	583	0.004618966998284734	1.558404	22	23	0.001908894	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	131	2.491409e-27	2.5026298496946564e-25	2.243281	228	0.01022834	455	0.0006660223957802197	1.530499	31	33	0.002689805	
GO Biological Process	translational elongation	135	3.52887e-27	3.4397333577777784e-25	2.124934	256	0.01148446	254	0.000002441993340629921	1.381945	95	112	0.00824295	
GO Cellular Component	mitochondrial ribosome	43	7.976619e-28	3.205487821395349e-26	2.550419	180	0.008075008	85	0.00004595341552941176	1.380063	72	85	0.006247289	
GO Cellular Component	large ribosomal subunit	45	2.269417e-24	8.71456128e-23	2.06817	243	0.01090126	78	0.000014090096492307692	1.345895	95	115	0.00824295	
GO Cellular Component	mitochondrial large ribosomal subunit	50	5.292589e-22	1.8291187584e-20	2.812953	118	0.005293616	125	0.0045341766144	1.373674	43	51	0.00373102	
GO Cellular Component	spliceosomal snRNP complex	103	1.028974e-12	1.7262787106796116e-11	2.016125	126	0.005652505	198	0.04804058181818182	1.261348	48	62	0.004164859	
GO Cellular Component	CCR4-NOT complex	113	2.34308e-11	3.5830462300884957e-10	2.632687	63	0.002826253	192	0.040300308	1.527413	15	16	0.001301518	
GO Cellular Component	methylosome	141	8.193286e-10	1.0041133480851063e-8	3.616893	33	0.001480418	183	0.026934458754098358	1.629241	12	12	0.001041215	
GO Cellular Component	mitochondrial small ribosomal subunit	213	2.52772e-7	0.000002050657352112676	2.161668	55	0.002467364	161	0.012173996124223603	1.454679	25	28	0.002169197	
GO Cellular Component	DNA-directed RNA polymerase I complex	214	2.714023e-7	0.0000021915101607476634	2.628742	37	0.001659863	157	0.01181748382165605	1.629241	14	14	0.001214751	
GO Cellular Component	U1 snRNP	249	0.000002718282	0.000018864222072289154	2.071514	50	0.002243058	164	0.012751818146341463	1.543491	18	19	0.001561822	
GO Molecular Function	unfolded protein binding	9	5.080424e-32	2.3832833475555555e-29	2.320824	251	0.01126015	137	0.022530887905109487	1.244986	81	106	0.0070282	
GO Molecular Function	ribonuclease activity	13	1.534125e-27	4.982365961538462e-25	2.106487	265	0.01188821	56	0.000020796403410714283	1.382386	84	99	0.007288503	
GO Molecular Function	rRNA binding	16	3.244112e-26	8.56040054e-24	2.965245	131	0.005876811	116	0.00711467418275862	1.357701	50	60	0.004338395	
GO Molecular Function	endoribonuclease activity	26	3.00564e-19	4.880696953846154e-17	2.244252	156	0.00699834	89	0.000717587248988764	1.425586	49	56	0.004251627	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	73	6.793515e-12	3.9290712780821914e-10	2.149229	100	0.004486115	138	0.023574433410144927	1.460699	26	29	0.002255965	
Human Phenotype	Hemolytic anemia	18	1.455018e-21	5.394075063333334e-19	2.156243	193	0.008658203	446	0.04444547161434978	1.262088	55	71	0.004772234	
Human Phenotype	Nevus	33	3.15679e-15	6.383412021212122e-13	2.255661	119	0.005338477	380	0.029214920815789473	1.448214	24	27	0.00208243	
Human Phenotype	Abnormal CSF metabolite level	53	7.776826e-14	9.791464131698113e-12	2.044418	134	0.006011395	261	0.006087333033333333	1.34477	52	63	0.004511931	
Human Phenotype	Atherosclerosis	64	1.587571e-12	1.65529082546875e-10	2.077484	115	0.005159033	409	0.036615403616136924	1.389647	29	34	0.002516269	
Human Phenotype	Abnormality of transition element cation homeostasis	71	2.591127e-12	2.4352944325352114e-10	2.70485	66	0.002960836	460	0.04943078424130434	1.404518	25	29	0.002169197	
Human Phenotype	Abnormality of reticulocytes	127	3.457189e-10	1.8165214328346455e-8	2.110697	87	0.00390292	453	0.046450090119205305	1.382386	28	33	0.002429501	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	413	0.000002558496	0.00004133860486198547	2.382715	37	0.001659863	394	0.03178956228426396	1.538727	17	18	0.001475054	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	7	1.308467e-41	1.711661759857143e-38	2.194975	372	0.01668835	173	0.00269106233583815	1.313904	75	93	0.006507592	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	87	3.941883e-20	4.14894513e-18	2.045616	203	0.009106814	159	0.0017651234769182388	1.404518	50	58	0.004338395	
Mouse Phenotype Single KO	increased incidence of tumors by ionizing radiation induction	158	5.74538e-16	3.329774978481013e-14	3.464764	61	0.00273653	256	0.02356161200546875	1.629241	15	15	0.001301518	
Mouse Phenotype Single KO	spontaneous chromosome breakage	361	4.823329e-9	1.2234687992520775e-7	2.092433	77	0.003454309	186	0.004098368458978495	1.564071	24	25	0.00208243	
Mouse Phenotype	decreased circulating free fatty acid level	17	6.065363e-44	3.4112315084117647e-41	2.043819	465	0.02086044	180	0.0002403715075	1.314346	96	119	0.008329718	
Mouse Phenotype	early cellular replicative senescence	121	4.313496e-21	3.408374814545454e-19	2.003611	225	0.01009376	143	0.00004100377262097902	1.428375	64	73	0.005553145	
Mouse Phenotype	increased cellular sensitivity to oxidative stress	136	3.772368e-20	2.6520301799999997e-18	2.326491	152	0.006818896	537	0.045963074240223466	1.323758	39	48	0.003383948	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	137	3.941883e-20	2.7509739681021896e-18	2.045616	203	0.009106814	244	0.00120097092454918	1.404518	50	58	0.004338395	
Mouse Phenotype	abnormal pharyngeal muscle morphology	200	2.138618e-16	1.0223663349e-14	3.457653	63	0.002826253	553	0.04931667535985534	1.629241	12	12	0.001041215	
Mouse Phenotype	decreased creatinine clearance	263	7.538169e-14	2.7403967227756653e-12	2.881076	68	0.003050559	560	0.04956949962321429	1.533403	16	17	0.001388286	
Mouse Phenotype	heterochrony	274	1.847414e-13	6.44639607810219e-12	2.428355	89	0.003992643	560	0.04956949962321429	1.533403	16	17	0.001388286	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	307	1.31516e-12	4.095845198697068e-11	2.773654	65	0.002915975	289	0.0030859897442906572	1.629241	19	19	0.00164859	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	308	1.320143e-12	4.098015332142857e-11	2.326275	90	0.004037504	198	0.0004143194161363636	1.574933	29	30	0.002516269	
Mouse Phenotype	increased lactate dehydrogenase level	355	4.481275e-11	1.206914655633803e-9	2.018947	107	0.004800144	398	0.012532772601256282	1.466317	27	30	0.002342733	
Mouse Phenotype	increased liver adenoma incidence	494	1.038653e-8	2.010235087651822e-7	2.02216	80	0.003588892	463	0.02342273604103672	1.454679	25	28	0.002169197