# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	translational initiation	1	3.695084e-126	4.862361035599999e-122	11.52158	182	0.08629682	2	1.18658848085e-34	5.782357	72	143	0.0440367	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	2	2.780783e-124	1.8296161748500003e-120	16.57098	148	0.07017544	1	1.5967630642e-34	7.240168	58	92	0.03547401	
GO Biological Process	cotranslational protein targeting to membrane	3	2.591804e-120	1.1368516278666665e-116	15.51963	148	0.07017544	3	8.684808409999999e-33	6.796892	58	98	0.03547401	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	4	1.882275e-118	6.19221418125e-115	13.59978	156	0.07396871	5	2.8053619464e-31	6.034178	62	118	0.03792049	
GO Biological Process	protein targeting to ER	5	3.651498e-117	9.6100124364e-114	14.7304	148	0.07017544	4	6.784583015e-32	6.595004	58	101	0.03547401	
GO Biological Process	viral gene expression	6	1.336471e-115	2.9311036481666663e-112	12.55373	159	0.07539118	6	5.171763339e-31	5.787416	64	127	0.03914373	
GO Biological Process	viral transcription	7	3.983894e-110	7.489151592285715e-107	12.78084	150	0.07112376	9	8.528176833e-31	6.097913	60	113	0.03669725	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	8	2.911534e-109	4.78910948825e-106	12.91133	148	0.07017544	7	7.349775224e-31	6.343766	58	105	0.03547401	
GO Biological Process	protein localization to endoplasmic reticulum	9	4.323119e-109	6.320880324555556e-106	11.45856	158	0.07491702	8	6.848063675875e-31	5.834818	63	124	0.03853211	
GO Biological Process	multi-organism metabolic process	10	1.286237e-106	1.6925592683e-103	10.04744	167	0.07918445	10	1.8580652749e-27	5.078138	65	147	0.03975535	
GO Biological Process	translation	11	2.384727e-101	2.852783872090909e-98	5.398802	250	0.1185396	22	5.830350354227272e-22	3.056333	99	372	0.06055046	
GO Biological Process	protein targeting to membrane	12	3.482998e-101	3.819397556833333e-98	9.998432	159	0.07539118	11	1.4591536590909092e-26	5.227975	61	134	0.03730887	
GO Biological Process	mRNA metabolic process	13	2.206778e-99	2.2337685924615388e-96	3.674453	359	0.1702229	14	2.0068433727142854e-24	2.561771	147	659	0.08990826	
GO Biological Process	RNA catabolic process	14	4.234883e-96	3.980487528357143e-93	6.697143	199	0.09435752	18	9.508167040000001e-23	3.716944	78	241	0.04770642	
GO Biological Process	mRNA catabolic process	15	5.584257e-95	4.8988825242e-92	7.268366	185	0.0877193	15	1.3470148941333336e-23	3.989887	74	213	0.04525994	
GO Biological Process	nuclear-transcribed mRNA catabolic process	16	1.209692e-94	9.948960642499999e-92	7.690243	177	0.08392603	17	8.378652664117648e-23	4.060143	70	198	0.04281346	
GO Biological Process	DNA replication-dependent nucleosome assembly	17	1.81822e-93	1.407409234117647e-90	74.77293	63	0.02987198	66	2.2805504018181822e-14	7.895528	22	32	0.01345566	
GO Biological Process	peptide biosynthetic process	18	2.038256e-91	1.4900783724444445e-88	4.831587	250	0.1185396	30	3.067263330233333e-20	2.900398	99	392	0.06055046	
GO Biological Process	RNA processing	19	2.851654e-91	1.9749955255789473e-88	3.136503	401	0.1901375	23	1.9557477930434782e-21	2.212002	172	893	0.1051988	
GO Biological Process	chromatin silencing at rDNA	20	1.955171e-85	1.28640475945e-82	37.49083	72	0.0341394	27	1.2399754942222222e-20	8.932314	28	36	0.01712538	
GO Cellular Component	intracellular ribonucleoprotein complex	1	2.132635e-127	3.6851932800000002e-124	3.96336	417	0.197724	12	3.25777536e-22	2.285594	162	814	0.09908257	
GO Cellular Component	ribonucleoprotein complex	2	3.240531e-127	2.7998187839999996e-124	3.958314	417	0.197724	11	1.9133861236363638e-22	2.291258	163	817	0.09969419	
GO Cellular Component	cytosolic ribosome	3	1.08106e-126	6.2269056e-124	12.31951	176	0.08345187	2	1.30995792e-40	6.972674	68	112	0.04159021	
GO Cellular Component	ribosomal subunit	4	2.385123e-123	1.030373136e-120	10.30905	190	0.09009009	5	6.777772415999999e-27	4.469606	72	185	0.0440367	
GO Cellular Component	ribosome	5	1.345298e-104	4.649349888e-102	7.550371	198	0.09388336	7	2.2406432914285715e-25	3.893018	80	236	0.04892966	
GO Cellular Component	cytosolic part	6	1.105739e-97	3.18452832e-95	6.498403	207	0.09815078	9	1.84118976e-23	3.732431	78	240	0.04770642	
GO Cellular Component	nucleosome	7	4.69635e-90	1.159327542857143e-87	15.15604	112	0.05310574	1	1.861527744e-40	7.218768	66	105	0.04036697	
GO Cellular Component	cytosolic large ribosomal subunit	8	1.355593e-82	2.92808088e-80	14.77215	104	0.04931247	6	1.4422512959999997e-25	7.530757	40	61	0.02446483	
GO Cellular Component	DNA packaging complex	9	9.789936e-82	1.879667712e-79	12.4152	113	0.0535799	3	1.4424335999999999e-39	6.870134	67	112	0.04097859	
GO Cellular Component	nuclear nucleosome	10	1.148399e-75	1.984433472e-73	32.63176	67	0.03176861	24	2.1136147199999996e-15	7.177752	25	40	0.01529052	
GO Cellular Component	large ribosomal subunit	11	1.020429e-71	1.6030011927272728e-69	10.07514	112	0.05310574	21	3.001139382857143e-16	4.394033	44	115	0.02691131	
GO Cellular Component	protein-DNA complex	12	1.895141e-65	2.72900304e-63	5.869729	151	0.07159791	4	1.4145507359999999e-30	4.548279	80	202	0.04892966	
GO Cellular Component	small ribosomal subunit	14	1.652522e-55	2.039684297142857e-53	10.95703	82	0.03888099	30	2.3192720640000002e-11	4.625663	29	72	0.017737	
GO Cellular Component	cytosolic small ribosomal subunit	15	5.703679e-54	6.570638208e-52	13.76427	70	0.03319109	26	3.3066296861538462e-15	6.786239	26	44	0.01590214	
GO Cellular Component	nuclear chromatin	17	1.580621e-51	1.6066547576470588e-49	3.494987	202	0.09577999	16	1.0793873159999999e-19	3.089159	85	316	0.05198777	
GO Cellular Component	chromatin	18	4.606489e-50	4.4222294399999995e-48	2.935906	248	0.1175913	8	2.16438048e-25	2.882916	122	486	0.07461774	
GO Cellular Component	chromosome, telomeric region	20	7.696752e-49	6.649993728e-47	6.149761	108	0.0512091	41	8.69932940487805e-9	2.888293	42	167	0.02568807	
GO Cellular Component	nuclear chromosome, telomeric region	21	2.178846e-48	1.7928789942857144e-46	7.046808	96	0.0455192	32	5.20997724e-11	3.480122	40	132	0.02446483	
GO Cellular Component	nuclear chromosome part	22	1.010424e-47	7.936421236363635e-46	2.851726	247	0.1171171	20	2.33188848e-16	2.413065	108	514	0.06605505	
GO Cellular Component	chromosomal part	23	2.382701e-46	1.7901336208695653e-44	2.326584	336	0.1593172	14	2.1542642742857145e-21	2.224092	165	852	0.1009174	
GO Molecular Function	RNA binding	1	1.95066e-140	8.235686519999999e-137	2.779972	685	0.3247985	1	4.883004764e-29	2.005213	286	1638	0.1749235	
GO Molecular Function	structural constituent of ribosome	2	1.310212e-109	2.765857532e-106	10.11086	171	0.08108108	2	5.0764272500000005e-26	4.749723	67	162	0.04097859	
GO Molecular Function	nucleosomal DNA binding	4	1.486373e-65	1.5688667015e-62	14.52141	83	0.03935514	12	1.483754699833333e-9	5.492541	22	46	0.01345566	
GO Molecular Function	structural molecule activity	5	2.088008e-64	1.7631139552e-61	2.977149	310	0.1469891	14	1.4247476759999999e-9	1.90863	117	704	0.07155963	
GO Molecular Function	nucleosome binding	6	7.876114e-54	5.542158884666667e-51	9.306488	88	0.04172594	15	3.390474285333333e-9	4.524159	26	66	0.01590214	
GO Molecular Function	chromatin DNA binding	9	4.51713e-43	2.119035873333333e-40	5.853861	99	0.04694168	13	1.4609581461538462e-9	3.754517	34	104	0.02079511	
GO Molecular Function	structure-specific DNA binding	10	1.375112e-37	5.805722864e-35	4.470987	111	0.05263158	17	6.465133698823529e-9	3.222243	39	139	0.02385321	
GO Molecular Function	histone binding	12	1.854107e-33	6.5233664616666665e-31	3.621016	125	0.0592698	10	3.8212042734e-10	2.958104	51	198	0.03119266	
GO Molecular Function	mRNA binding	13	3.217962e-33	1.0450950433846155e-30	3.427257	133	0.06306306	8	1.6327244515e-10	3.034739	51	193	0.03119266	
GO Molecular Function	miRNA binding	15	4.992879e-32	1.4053290092e-29	10.72646	47	0.02228544	25	0.0025820147639999996	4.785168	10	24	0.006116208	
GO Molecular Function	telomeric DNA binding	17	2.546353e-30	6.3239425682352935e-28	10.48235	45	0.02133713	33	0.011724625777575758	3.715542	11	34	0.006727829	
GO Molecular Function	single-stranded RNA binding	18	4.869646e-29	1.1422025228888888e-26	4.800386	79	0.03745851	24	0.002601088000833333	2.835655	20	81	0.01223242	
GO Molecular Function	rRNA binding	21	1.060528e-24	2.132166293333333e-22	9.330541	39	0.01849218	27	0.005893769702962963	3.062508	16	60	0.009785933	
GO Molecular Function	protein heterodimerization activity	23	5.120267e-23	9.399029249565218e-21	2.048284	220	0.1043148	6	8.962926019999999e-15	2.386954	106	510	0.0648318	
GO Molecular Function	cadherin binding	25	3.120516e-22	5.2699274208e-20	2.497898	142	0.06733049	21	0.000028450811504761904	2.07777	55	304	0.03363914	
GO Molecular Function	mRNA 3'-UTR binding	28	5.099171e-19	7.688821415e-17	4.129464	59	0.02797534	23	0.0016385049660869564	3.13211	18	66	0.01100917	
GO Molecular Function	ribonucleoprotein complex binding	32	1.090807e-15	1.439183485625e-13	3.839366	52	0.02465624	28	0.006758517285714285	2.396745	24	115	0.0146789	
GO Molecular Function	mRNA 5'-UTR binding	38	6.567345e-14	7.296665944736842e-12	8.077708	23	0.01090564	29	0.007148488035172413	4.698165	9	22	0.005504587	
GO Molecular Function	translation factor activity, RNA binding	44	1.142894e-11	1.0966587427272728e-9	3.426797	43	0.02038881	35	0.014763043274285716	2.537252	19	86	0.0116208	
GO Molecular Function	DNA topoisomerase binding	72	1.068728e-8	6.266902244444444e-7	12.87593	10	0.004741584	38	0.029616196726315786	9.187523	4	5	0.002446483	
Mouse Phenotype Single KO	abnormal semilunar valve morphology	201	0.000002142776	0.00009761890463681591	2.09657	49	0.02323376	20	0.032282911930000005	2.71999	18	76	0.01100917	
Mouse Phenotype Single KO	semilunar valve regurgitation	429	0.0003050672	0.006511655828438229	3.044808	14	0.006638217	13	0.028280633764615384	6.18391	7	13	0.004281346	
Mouse Phenotype Single KO	cardiac valve regurgitation	596	0.001643419	0.025249643931208054	2.301304	17	0.008060692	10	0.010627138036	5.439981	9	19	0.005504587	
Mouse Phenotype	decreased myocardial fiber number	376	0.0001150166	0.002924664129255319	3.051347	16	0.007586534	65	0.03457192879384616	4.375011	8	21	0.004892966