# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of Notch signaling pathway 279 0.0005379357 0.02537166980752688 2.019689 28 0.005688744 909 0.043467086745874586 1.807305 18 33 0.003176284 GO Biological Process intrinsic apoptotic signaling pathway in response to oxidative stress 304 0.0007483109 0.032391523464144735 2.34401 19 0.003860219 932 0.047952497289699574 2.14396 11 17 0.001941062 GO Biological Process myoblast fate commitment 351 0.001130329 0.042376066413105415 2.778319 13 0.002641203 866 0.03800185482678984 3.313393 5 5 0.000882301 GO Biological Process positive regulation of cell fate commitment 368 0.001256269 0.04492185807336956 2.886259 12 0.002438033 611 0.009733031736333879 2.945239 8 9 0.001411682 GO Cellular Component heterotrimeric G-protein complex 47 0.0001669412 0.006137753055319149 2.030916 33 0.006704592 76 0.04705639578947368 1.791023 20 37 0.003529204 GO Molecular Function NF-kappaB binding 28 0.0002950263 0.04448575137857143 2.404502 21 0.004266558 80 0.041317077802500005 2.011703 17 28 0.002999824 Mouse Phenotype Single KO arrest of tooth development 79 0.00005055509 0.005859910875063291 2.668524 22 0.004469728 590 0.011707395223728814 3.313393 6 6 0.001058761 Mouse Phenotype Single KO abnormal central nervous system regeneration 94 0.00008522924 0.008302597347659573 3.667729 13 0.002641203 906 0.044946972786975715 2.577084 7 9 0.001235221 Mouse Phenotype Single KO increased muscle cell glucose uptake 110 0.0001158848 0.00964688285090909 2.128948 31 0.006298253 552 0.009985912541847827 2.208929 14 21 0.002470443 Mouse Phenotype Single KO improved central nervous system regeneration 123 0.000141673 0.010547151715447154 3.993011 11 0.002234864 780 0.029360159538461536 3.313393 5 5 0.000882301 Mouse Phenotype Single KO bifid ureter 198 0.0006115229 0.028281389875252524 2.324496 20 0.004063389 906 0.044946972786975715 2.577084 7 9 0.001235221 Mouse Phenotype Single KO abnormal zygomatic arch morphology 244 0.000891311 0.03344973289754098 2.201589 21 0.004266558 722 0.022422829606648202 2.485045 9 12 0.001588142 Mouse Phenotype abnormal ureter development 42 0.000001470443 0.0003347358457857143 2.114931 50 0.01015847 321 0.00008964182126168224 2.518179 19 25 0.003352744 Mouse Phenotype absent nasal bone 48 0.000001937037 0.00038583355743749994 3.115759 24 0.004876067 880 0.01455594888409091 2.899219 7 8 0.001235221 Mouse Phenotype abnormal orbit size 80 0.00001496014 0.00178792373175 3.643779 16 0.003250711 798 0.009037732939849625 3.313393 6 6 0.001058761 Mouse Phenotype decreased molar number 113 0.0000355358 0.0030067060513274337 2.813285 21 0.004266558 1178 0.03609387070033956 2.577084 7 9 0.001235221 Mouse Phenotype double ureter 116 0.00004035082 0.003325811982931035 2.334058 29 0.005891914 1094 0.029681801138939673 2.14396 11 17 0.001941062 Mouse Phenotype ocular hypotelorism 123 0.00005037504 0.003915737865365854 2.485183 25 0.005079236 1159 0.034690310764452115 2.293888 9 13 0.001588142 Mouse Phenotype abnormal foot pigmentation 125 0.0000524638 0.0040128511344 2.136676 34 0.006907761 1222 0.04108781069558102 1.840774 15 27 0.002646903 Mouse Phenotype abnormal thyroid gland development 128 0.00005556626 0.00415053915515625 2.724428 21 0.004266558 1122 0.03257272497860962 2.208929 10 15 0.001764602 Mouse Phenotype abnormal orbit morphology 136 0.00006779454 0.004766055859852941 2.107766 34 0.006907761 776 0.008060044976675257 2.267059 13 19 0.002293983 Mouse Phenotype increased pulmonary respiratory rate 158 0.000103067 0.00623685814556962 2.060702 34 0.006907761 1011 0.023572697513353114 1.798699 19 35 0.003352744 Mouse Phenotype arrest of tooth development 166 0.0001265177 0.007286962227108434 2.181298 29 0.005891914 717 0.0060262983 2.945239 8 9 0.001411682 Mouse Phenotype abnormal external nares morphology 183 0.0001700695 0.008885434368852458 2.446542 22 0.004469728 717 0.0060262983 2.945239 8 9 0.001411682 Mouse Phenotype abnormal sagittal suture morphology 195 0.0001994014 0.009776804027692309 2.090747 30 0.006095083 467 0.0007328375471306209 2.692132 13 16 0.002293983 Mouse Phenotype increased birth body size 206 0.0002366035 0.01098138865776699 3.127729 14 0.002844372 1143 0.03275110093963255 2.840051 6 7 0.001058761 Mouse Phenotype abnormal frontonasal suture morphology 276 0.0005564857 0.019277390498913045 2.74484 15 0.003047542 798 0.009037732939849625 3.313393 6 6 0.001058761 Mouse Phenotype bifid ureter 289 0.0006115229 0.020231039608650518 2.324496 20 0.004063389 1178 0.03609387070033956 2.577084 7 9 0.001235221 Mouse Phenotype abnormal pancreatic epsilon cell morphology 399 0.001625 0.038938909774436085 2.306536 17 0.003453881 798 0.009037732939849625 3.313393 6 6 0.001058761 Mouse Phenotype abnormal philtrum morphology 407 0.001685925 0.03960473937346438 2.449648 15 0.003047542 1015 0.02355792721182266 3.313393 5 5 0.000882301 Mouse Phenotype decreased bone trabecular spacing 477 0.002421657 0.04853975383018868 2.662503 12 0.002438033 1178 0.03609387070033956 2.577084 7 9 0.001235221