# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	1	5.115348e-115	6.731286433200001e-111	9.668821	187	0.04094592	3	4.795043100666667e-20	3.054281	68	92	0.01496479	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	2	1.878521e-113	1.23597289195e-109	8.252904	205	0.04488723	10	7.424951275099999e-19	2.731495	78	118	0.01716549	
GO Biological Process	protein targeting to ER	3	3.000442e-111	1.3160938759333333e-107	8.824696	192	0.04204073	7	2.8940851880000003e-19	2.904858	71	101	0.015625	
GO Biological Process	cotranslational protein targeting to membrane	4	3.247967e-111	1.068499943825e-107	9.103807	188	0.04116488	9	7.684589895777778e-19	2.90945	69	98	0.01518486	
GO Biological Process	viral transcription	5	2.542214e-104	6.6905988052e-101	7.751393	197	0.04313554	12	2.637085531666667e-18	2.742652	75	113	0.01650528	
GO Biological Process	protein localization to endoplasmic reticulum	6	2.55381e-104	5.600930965e-101	7.066442	211	0.04620101	4	1.56649539035e-19	2.732625	82	124	0.01804577	
GO Biological Process	viral gene expression	7	6.338312e-104	1.1915121086857144e-100	7.401456	203	0.04444931	14	1.4778205550714287e-17	2.603	80	127	0.01760563	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	8	2.380505e-103	3.915633161875e-100	7.815497	194	0.04247865	6	2.4787827616666666e-19	2.872906	73	105	0.01606514	
GO Biological Process	translational initiation	9	2.216113e-99	3.2402034407777773e-96	6.372984	218	0.04773374	16	3.9133031964375004e-17	2.485137	86	143	0.01892606	
GO Biological Process	multi-organism metabolic process	10	1.563159e-90	2.0569609281e-87	5.890067	212	0.04641997	30	2.0568389880333335e-14	2.333182	83	147	0.01826585	
GO Biological Process	nuclear-transcribed mRNA catabolic process	11	9.407649e-89	1.1254113926454547e-85	4.915622	245	0.05364572	17	9.940200231764704e-17	2.233091	107	198	0.02354754	
GO Biological Process	mRNA catabolic process	12	5.332399e-87	5.847419870083332e-84	4.626482	255	0.05583534	15	2.0123497249333333e-17	2.211633	114	213	0.02508803	
GO Biological Process	protein targeting to membrane	13	5.522e-86	5.589538307692308e-83	5.86586	202	0.04423035	36	5.978601575555556e-14	2.374509	77	134	0.01694542	
GO Biological Process	RNA catabolic process	14	9.849362e-86	9.257696754142857e-83	4.258265	274	0.05999562	8	4.320025680625e-19	2.194729	128	241	0.02816901	
GO Biological Process	rRNA processing	15	1.240405e-77	1.0881659596666666e-74	4.228569	250	0.05474053	62	5.090525191290322e-12	1.902152	116	252	0.02552817	
GO Biological Process	rRNA metabolic process	16	1.328775e-75	1.0928343890624999e-72	4.11255	251	0.05495949	72	1.7354727045972222e-11	1.866698	117	259	0.02574824	
GO Biological Process	translation	17	3.076507e-75	2.381397389e-72	3.280944	329	0.07203854	61	4.781452082786885e-12	1.732884	156	372	0.03433099	
GO Biological Process	ncRNA metabolic process	18	1.274195e-74	9.31507333611111e-72	2.855451	398	0.08714692	56	4.0588606525e-12	1.593341	214	555	0.04709507	
GO Biological Process	ncRNA processing	19	7.872703e-73	5.45246835668421e-70	3.277519	319	0.06984892	92	1.3838171748152173e-10	1.659166	159	396	0.0349912	
GO Biological Process	peptide biosynthetic process	20	3.428634e-69	2.2558697403e-66	3.025485	339	0.07422816	65	6.5282952943076925e-12	1.707721	162	392	0.03565141	
GO Cellular Component	cytosolic ribosome	1	8.115258e-100	1.4023165824e-96	6.755735	209	0.04576308	17	2.3914615341176473e-21	2.84093	77	112	0.01694542	
GO Cellular Component	ribosomal subunit	2	2.288368e-96	1.977149952e-93	5.762864	230	0.05036129	30	6.530365440000001e-14	2.121973	95	185	0.02090669	
GO Cellular Component	ribonucleoprotein complex	3	1.163201e-92	6.70003776e-90	2.559957	584	0.1278739	23	6.042248013913043e-16	1.542644	305	817	0.06712148	
GO Cellular Component	intracellular ribonucleoprotein complex	4	2.015282e-92	8.706018239999999e-90	2.558831	583	0.1276549	24	1.1944584000000002e-15	1.538176	303	814	0.06668134	
GO Cellular Component	ribosome	5	4.845544e-81	1.6746200064e-78	4.402392	250	0.05474053	34	1.52454528e-11	1.891035	108	236	0.02376761	
GO Cellular Component	cytosolic part	6	1.169102e-69	3.36701376e-67	3.740258	258	0.05649223	33	8.35984930909091e-12	1.893954	110	240	0.02420775	
GO Cellular Component	cytosolic large ribosomal subunit	7	1.164125e-64	2.8737257142857143e-62	7.871134	120	0.02627545	31	2.090986467096774e-13	2.980648	44	61	0.009683099	
GO Cellular Component	large ribosomal subunit	8	6.555817e-58	1.416056472e-55	5.732679	138	0.03021677	42	1.2109071085714287e-8	2.12003	59	115	0.01298415	
GO Cellular Component	nucleosome	9	1.275772e-54	2.44948224e-52	6.936433	111	0.0243048	26	2.7225450830769233e-15	2.597422	66	105	0.01452465	
GO Cellular Component	DNA packaging complex	11	1.931073e-48	3.033540130909091e-46	5.783964	114	0.02496168	25	2.5893146879999996e-15	2.545769	69	112	0.01518486	
GO Cellular Component	cytosolic small ribosomal subunit	14	1.345695e-45	1.6609721142857143e-43	7.718263	85	0.01861178	40	5.23152432e-9	2.911367	31	44	0.006822183	
GO Cellular Component	small ribosomal subunit	18	1.217128e-42	1.16844288e-40	5.985444	97	0.02123933	48	0.000020115810000000002	2.123524	37	72	0.008142606	
GO Cellular Component	nuclear nucleosome	19	2.600484e-41	2.365071764210526e-39	12.59503	56	0.01226188	61	0.00019038534609836066	2.376051	23	40	0.00506162	
GO Cellular Component	protein-DNA complex	20	1.514288e-40	1.308344832e-38	3.231165	180	0.03941318	22	2.6027214545454545e-16	2.168415	106	202	0.02332746	
GO Cellular Component	chromatin	23	1.780201e-38	1.3374727513043479e-36	2.066464	378	0.08276768	14	6.5379312e-22	1.853566	218	486	0.04797535	
GO Cellular Component	nuclear chromatin	26	2.580189e-34	1.7148333046153846e-32	2.245154	281	0.06152836	19	1.1409465600000001e-18	1.98767	152	316	0.0334507	
GO Cellular Component	chromosome, telomeric region	30	8.245566e-31	4.7494460159999996e-29	3.365813	128	0.02802715	50	0.00005604778368	1.682598	68	167	0.01496479	
GO Cellular Component	nuclear chromosome, telomeric region	37	8.234498e-27	3.84573312e-25	3.525333	104	0.02277206	62	0.0001916164428387097	1.721776	55	132	0.01210387	
GO Cellular Component	cortical cytoskeleton	55	1.446779e-14	4.5455165672727273e-13	2.518603	90	0.01970659	76	0.011745532042105263	1.681735	35	86	0.007702465	
GO Cellular Component	nuclear euchromatin	76	2.580273e-7	0.000005866725978947368	2.715607	35	0.007663674	47	0.0000026111804323404253	3.140519	19	25	0.004181338	
GO Molecular Function	structural constituent of ribosome	2	2.051412e-88	4.330530732e-85	5.761296	211	0.04620101	8	1.47436725875e-10	2.091639	82	162	0.01804577	
GO Molecular Function	nucleosomal DNA binding	3	1.036621e-42	1.4588712873333332e-39	6.948241	86	0.01883074	30	0.00008541664711333332	2.425458	27	46	0.005941901	
GO Molecular Function	chromatin DNA binding	6	1.974376e-33	1.3893025786666666e-30	3.549737	130	0.02846508	14	7.98188702142857e-8	2.185331	55	104	0.01210387	
GO Molecular Function	nucleosome binding	7	3.251877e-31	1.961346384857143e-28	4.493001	92	0.02014451	33	0.001973170890909091	2.003521	32	66	0.007042254	
GO Molecular Function	structure-specific DNA binding	11	1.316259e-26	5.052041361818181e-24	2.752883	148	0.03240639	15	1.7421016241333334e-7	1.99181	67	139	0.01474472	
GO Molecular Function	histone binding	20	7.713305e-16	1.6282786854999999e-13	2.046715	153	0.0335012	32	0.001524050963125	1.565251	75	198	0.01650528	
GO Molecular Function	single-stranded DNA binding	28	9.203153e-11	1.3877039987857143e-8	2.173065	86	0.01883074	52	0.03399834513461539	1.63654	40	101	0.008802817	
GO Molecular Function	mRNA 5'-UTR binding	41	9.576718e-9	9.86168375512195e-7	4.05458	25	0.005474053	42	0.009806083545714286	2.629621	14	22	0.003080986	
GO Molecular Function	double-stranded RNA binding	44	2.093119e-8	0.0000020084428222727275	2.294221	57	0.01248084	48	0.029563657825000002	1.815691	29	66	0.006382042	
GO Molecular Function	mRNA 3'-UTR binding	47	2.553536e-8	0.000002293835955744681	2.133198	66	0.0144515	40	0.004816974795	1.940911	31	66	0.006822183	
GO Molecular Function	NF-kappaB binding	77	0.000001422546	0.00007799985989610389	3.085009	25	0.005474053	39	0.004491026922564103	2.508874	17	28	0.003741197	
GO Molecular Function	ligand-dependent nuclear receptor transcription coactivator activity	100	0.00001010767	0.00042674582739999994	2.109956	42	0.009196409	43	0.010093918325581396	2.025619	25	51	0.005501761	
GO Molecular Function	ubiquitin-protein transferase regulator activity	110	0.00002645086	0.0010152320992727272	2.716532	23	0.005036129	54	0.035911143585185185	2.673817	11	17	0.002420775	
Mouse Phenotype Single KO	abnormal mortality induced by ionizing radiation	27	0.000001588587	0.0005387663392222222	2.307884	41	0.008977447	83	0.00940843025819277	2.112045	23	45	0.00506162	
Mouse Phenotype Single KO	abnormal response to radiation	38	0.000005793826	0.0013961595968947367	2.161143	42	0.009196409	78	0.007192924461794872	2.110091	24	47	0.00528169	
Mouse Phenotype Single KO	absent hypoglossal nerve	50	0.00002263166	0.0041447622124	3.704026	15	0.003284432	138	0.039692104723188404	2.754842	10	15	0.002200704	
Mouse Phenotype Single KO	abnormal neural plate morphology	51	0.00002883246	0.0051768399258823525	2.123009	37	0.008101598	32	0.0000203233004790625	3.140519	19	25	0.004181338	
Mouse Phenotype Single KO	increased mortality induced by ionizing radiation	59	0.0000761969	0.011826017174576271	2.094339	34	0.007444712	99	0.01531413905151515	2.116525	21	41	0.004621479	
Mouse Phenotype	macrocytic anemia	8	2.486162e-9	0.0000029712743602499996	3.060091	39	0.008539523	153	0.012107456743137256	2.51529	14	23	0.003080986	
Mouse Phenotype	increased fibroblast apoptosis	21	2.334979e-7	0.00010630825818571429	2.563399	39	0.008539523	251	0.03252149390438247	1.893954	22	48	0.004841549	
Mouse Phenotype	abnormal mortality induced by ionizing radiation	36	0.000003919656	0.001040995306	2.174105	43	0.009415371	160	0.013334744626875	1.94918	25	53	0.005501761	
Mouse Phenotype	abnormal response to radiation	39	0.000004291055	0.0010519686373076922	2.103331	46	0.01007226	123	0.0061535979624390245	1.992341	27	56	0.005941901	
Mouse Phenotype	absent hypoglossal nerve	60	0.00002263166	0.003606355021	3.704026	15	0.003284432	219	0.026114950326027397	2.754842	10	15	0.002200704	
Mouse Phenotype	abnormal intestinal enteroendocrine cell morphology	124	0.0005270686	0.04063953939193548	2.564795	17	0.003722356	180	0.015880555416666668	3.099197	9	12	0.001980634