# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	2.49285e-48	1.929612538235294e-45	2.61611	306	0.01806482	381	0.0003681508281364829	1.387733	81	113	0.008351376	
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	3.205895e-44	2.008874871666667e-41	2.426119	321	0.01895035	339	0.00012968718530973454	1.399106	86	119	0.008866893	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	29	6.59477e-38	2.992433738965517e-35	2.105837	370	0.02184308	406	0.0005243475805172415	1.323956	106	155	0.01092896	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	53	1.070255e-31	2.657261423584906e-29	2.293397	254	0.01499498	558	0.004428206308960574	1.3593	66	94	0.006804825	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	54	3.153028e-31	7.683462120740741e-29	2.537693	205	0.01210225	440	0.0009821315351818182	1.43957	58	78	0.005979998	
GO Biological Process	endoplasmic reticulum unfolded protein response	56	9.217201e-31	2.1658776421249995e-28	2.267795	252	0.01487691	718	0.014792884119359329	1.290649	76	114	0.007835859	
GO Biological Process	cellular response to topologically incorrect protein	61	1.610222e-29	3.473592016065574e-27	2.092675	289	0.01706122	554	0.004361068370036101	1.295291	93	139	0.009588617	
GO Biological Process	cellular response to unfolded protein	75	8.658631e-27	1.5191856710533332e-24	2.091846	261	0.01540823	728	0.015787409026923077	1.279982	80	121	0.008248273	
GO Biological Process	RNA phosphodiester bond hydrolysis	96	7.999499e-25	1.0965146598020834e-22	2.05226	252	0.01487691	263	0.000007584282213307984	1.426506	98	133	0.01010413	
GO Biological Process	translational elongation	100	2.443591e-24	3.2155213969e-22	2.228319	204	0.01204321	276	0.00001523773581195652	1.45198	84	112	0.008660687	
GO Biological Process	protein-lipid complex assembly	119	7.175103e-23	7.934216838403362e-21	3.290221	97	0.00572643	511	0.002635260997260274	1.668942	25	29	0.002577585	
GO Biological Process	liver regeneration	130	2.754726e-22	2.788418418e-20	2.676439	130	0.007674597	834	0.02768132920143885	1.493465	27	35	0.002783792	
GO Biological Process	triglyceride homeostasis	135	6.88385e-22	6.709969048148148e-20	3.159472	98	0.005785465	334	0.00011588776716167664	1.754475	29	32	0.002989999	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	139	1.27016e-21	1.2024485928057553e-19	2.138269	197	0.01162997	349	0.0001779771717191977	1.394557	85	118	0.00876379	
GO Biological Process	regulation of mitochondrial membrane permeability	145	4.16068e-21	3.7758888358620693e-19	2.114419	197	0.01162997	490	0.002088978091	1.432089	54	73	0.005567584	
GO Biological Process	protein-lipid complex subunit organization	150	7.027586e-21	6.165066944933334e-19	2.509682	136	0.008028809	369	0.0002666096490704607	1.606445	39	47	0.004021033	
GO Biological Process	mitochondrial translational termination	167	7.891841e-20	6.218487168802395e-18	2.335475	148	0.008737234	423	0.0007255542847281323	1.424164	64	87	0.006598618	
GO Biological Process	mitochondrial translational elongation	169	1.092382e-19	8.505712862721894e-18	2.342111	146	0.008619163	461	0.001373593223492408	1.412121	62	85	0.006392412	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	172	1.637497e-19	1.2527804083139535e-17	2.062252	192	0.01133479	671	0.01061658314485842	1.30207	76	113	0.007835859	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	179	4.672819e-19	3.435174593351955e-17	2.199807	161	0.009504693	597	0.00583014674840871	1.415861	49	67	0.005052067	
GO Cellular Component	mitochondrial ribosome	45	2.426473e-23	9.31765632e-22	2.629057	141	0.008323986	106	0.00197318200754717	1.389345	61	85	0.006289308	
GO Cellular Component	high-density lipoprotein particle	53	7.278328e-20	2.3730095818867922e-18	3.7985	69	0.00407344	140	0.016314245485714286	1.577459	22	27	0.002268275	
GO Cellular Component	PcG protein complex	54	1.027682e-19	3.2885824e-18	2.256902	158	0.009327587	111	0.0028261393297297293	1.515109	36	46	0.003711723	
GO Cellular Component	proteasome core complex	62	8.843875e-18	2.464873548387096e-16	4.293549	53	0.003128874	184	0.04941171860869566	1.532645	19	24	0.001958965	
GO Cellular Component	endopeptidase complex	68	2.650088e-16	6.734341270588236e-15	2.203654	135	0.007969774	97	0.0008010913583505154	1.458994	52	69	0.005361377	
GO Cellular Component	proteasome complex	71	2.746571e-15	6.684612236619719e-14	2.155901	132	0.007792668	99	0.001157432378181818	1.45198	51	68	0.005258274	
GO Cellular Component	mitochondrial large ribosomal subunit	72	4.626502e-15	1.1103604800000002e-13	2.666497	85	0.005018006	146	0.022294478465753425	1.404529	37	51	0.003814826	
GO Cellular Component	axon cytoplasm	86	1.502697e-13	3.019372576744186e-12	2.228253	107	0.006316784	133	0.009055257888721805	1.500379	31	40	0.003196206	
GO Cellular Component	DNA-directed RNA polymerase III complex	87	2.482269e-13	4.9302998068965525e-12	4.235648	39	0.002302379	165	0.035560606254545456	1.630293	16	19	0.001649655	
GO Cellular Component	very-low-density lipoprotein particle	93	1.092034e-12	2.0290696258064515e-11	3.025844	57	0.003365016	149	0.023658117583892614	1.645577	17	20	0.001752758	
GO Cellular Component	protein-lipid complex	94	1.670777e-12	3.071385804255319e-11	2.130504	108	0.006375819	160	0.0301821012	1.428932	31	42	0.003196206	
GO Cellular Component	spliceosomal snRNP complex	97	1.96215e-12	3.495458969072165e-11	2.168832	103	0.006080642	94	0.00047602061617021274	1.498818	48	62	0.004948964	
GO Cellular Component	zonula adherens	117	1.310138e-10	1.934973046153846e-9	3.630278	36	0.002125273	183	0.047785073311475405	1.935973	8	8	0.0008248273	
GO Cellular Component	U5 snRNP	137	1.818885e-9	2.2941848759124085e-8	2.790514	46	0.002715627	168	0.03546376457142857	1.583978	18	22	0.001855861	
GO Cellular Component	methylosome	157	5.946527e-9	6.544967296815287e-8	3.894281	27	0.001593955	177	0.04298216461016949	1.774642	11	12	0.001134138	
GO Cellular Component	U2 snRNP	214	8.357307e-7	0.000006748330138317757	2.580933	35	0.002066238	165	0.035560606254545456	1.630293	16	19	0.001649655	
GO Cellular Component	U1 snRNP	241	0.000003533019	0.000025332186024896266	2.23534	41	0.00242045	165	0.035560606254545456	1.630293	16	19	0.001649655	
GO Molecular Function	unfolded protein binding	11	9.116982e-24	3.4992634549090915e-21	2.287537	188	0.01109865	96	0.010136700952083333	1.333264	73	106	0.007526549	
GO Molecular Function	ribonuclease activity	14	6.498255e-21	1.9596880435714284e-18	2.092111	200	0.01180707	69	0.000878071979710145	1.40798	72	99	0.007423446	
GO Molecular Function	endoribonuclease activity	19	2.013557e-17	4.474335607368421e-15	2.366458	125	0.00737942	125	0.0270283050272	1.417409	41	56	0.00422724	
GO Molecular Function	rRNA methyltransferase activity	168	6.828893e-7	0.000017161658479761905	2.393858	41	0.00242045	102	0.01400381934509804	1.742376	18	20	0.001855861	
GO Molecular Function	ribosomal small subunit binding	348	0.00005222824	0.0006336426128735632	2.020806	39	0.002302379	144	0.03967041043055555	1.797689	13	14	0.001340344	
Human Phenotype	Increased serum lactate	14	2.549108e-20	1.2150141202857142e-17	2.105146	191	0.01127575	50	0.000019946904907999998	1.490699	77	100	0.007938963	
Human Phenotype	Abnormal CSF metabolite level	20	1.601322e-18	5.342810852999999e-16	2.469516	123	0.00726135	138	0.0026232428555797104	1.475027	48	63	0.004948964	
Human Phenotype	Abnormality of the mitochondrion	23	1.3994e-17	4.060085304347826e-15	2.144964	156	0.009209517	67	0.00005174847757910447	1.554232	57	71	0.005876895	
Human Phenotype	Abnormality of mitochondrial metabolism	27	4.515076e-17	1.1158926721481481e-14	2.138949	152	0.008973375	74	0.00011455503029729731	1.543167	55	69	0.005670688	
Human Phenotype	Increased CSF lactate	29	2.2204e-16	5.1092169655172415e-14	2.438695	110	0.00649389	198	0.012828020170707072	1.43529	43	58	0.004433447	
Human Phenotype	Overgrowth	42	1.535718e-13	2.4399633842857145e-11	3.107058	59	0.003483086	188	0.012008581722340426	1.742376	18	20	0.001855861	
Human Phenotype	Atherosclerosis	90	8.889789e-11	6.591284666333334e-9	2.139559	90	0.005313183	230	0.022914078148695654	1.53739	27	34	0.002783792	
Human Phenotype	External ophthalmoplegia	168	1.679225e-8	6.669921681547619e-7	2.00803	79	0.004663794	274	0.046295617927007295	1.512479	25	32	0.002577585	
Human Phenotype	Non-medullary thyroid carcinoma	190	4.028617e-8	0.0000014148926968947368	2.604213	43	0.002538521	254	0.03544216828740157	1.935973	10	10	0.001031034	
Human Phenotype	Hypolipoproteinemia	198	6.112006e-8	0.0000020598694968686868	2.003949	73	0.004309581	142	0.0031029990419014085	1.834079	18	19	0.001855861	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	314	0.00000325496	0.00006917308305732484	2.389079	36	0.002125273	229	0.02170420349956332	1.806908	14	15	0.001443448	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	388	0.00001393763	0.00023970568296391754	2.202226	37	0.002184308	201	0.013558872019900496	1.814974	15	16	0.001546551	
Mouse Phenotype Single KO	pale liver	62	4.441248e-20	6.559436763870968e-18	2.041797	203	0.01198418	231	0.025227150485281385	1.355181	56	80	0.005773791	
Mouse Phenotype Single KO	increased follicular B cell number	184	1.109609e-12	5.522113920108696e-11	2.476579	80	0.004722829	243	0.02806759173909465	1.806908	14	15	0.001443448	
Mouse Phenotype Single KO	spontaneous skin ulceration	188	1.5863e-12	7.726462287234043e-11	2.355929	87	0.005136077	252	0.028828031062698413	1.626217	21	25	0.002165172	
Mouse Phenotype	decreased circulating free fatty acid level	25	9.643987e-34	3.68824638828e-31	2.041766	353	0.02083948	316	0.005989406757911392	1.317763	81	119	0.008351376	
Mouse Phenotype	dry eyes	85	2.183765e-20	2.4563502547058826e-18	3.000017	98	0.005785465	351	0.011124863623931624	1.814974	15	16	0.001546551	
Mouse Phenotype	increased follicular B cell number	160	4.262328e-15	2.5470073755000004e-13	2.202754	124	0.007320385	369	0.013307080122764228	1.572978	26	32	0.002680689	
Mouse Phenotype	spontaneous skin ulceration	212	2.780438e-13	1.2539513074528302e-11	2.144413	114	0.006730031	499	0.04113123039679358	1.45198	30	40	0.003093102	
Mouse Phenotype	increased liver adenoma incidence	301	2.455745e-11	7.800457789036544e-10	2.428231	73	0.004309581	177	0.00017689151808474577	1.797689	26	28	0.002680689	
Mouse Phenotype	abnormal kidney inner medulla morphology	523	5.40941e-8	9.888980690248567e-7	2.108103	65	0.003837299	523	0.04776708505927342	1.935973	9	9	0.0009279307