# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 19 8.71914e-31 6.038692803157894e-28 3.972184 104 0.02150982 166 0.001442270791807229 1.708261 50 114 0.01037129 GO Biological Process regulation of gene expression, epigenetic 20 1.218256e-29 8.015515352e-27 2.552124 189 0.03908997 122 0.0004209644995491803 1.507678 96 248 0.01991288 GO Biological Process gene silencing 29 4.610059e-24 2.091854013137931e-21 2.755093 133 0.02750776 186 0.00231986166016129 1.536296 71 180 0.01472724 GO Biological Process nucleosome organization 31 1.804137e-23 7.658270575161291e-21 2.676174 136 0.02812823 253 0.006800592004743083 1.50327 66 171 0.01369011 GO Biological Process nucleosome assembly 34 4.372534e-22 1.6922992619411764e-19 2.788207 119 0.0246122 205 0.003379246605658537 1.590848 58 142 0.0120307 GO Biological Process chromatin assembly or disassembly 35 5.292739e-22 1.9899186428857144e-19 2.551863 138 0.02854188 260 0.007564557434230769 1.487915 68 178 0.01410496 GO Biological Process protein-DNA complex subunit organization 40 4.344516e-21 1.4292371511e-18 2.155899 185 0.03826267 209 0.0038267694196172253 1.433299 92 250 0.01908318 GO Biological Process chromatin assembly 41 6.652178e-21 2.135024641512195e-18 2.615603 125 0.02585315 244 0.006430787120901639 1.528353 62 158 0.0128604 GO Biological Process cellular response to topologically incorrect protein 46 1.483837e-20 4.244741539782609e-18 2.790538 110 0.02275078 384 0.027325955412239585 1.485081 53 139 0.01099357 GO Biological Process chromatin silencing 58 2.731082e-19 6.196260006551724e-17 3.82373 66 0.01365047 295 0.0117746865820339 1.646271 41 97 0.00850446 GO Biological Process DNA conformation change 69 1.208592e-18 2.3049075547826086e-16 2.028238 187 0.03867632 444 0.04030566135135135 1.316759 95 281 0.01970546 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 71 6.416466e-18 1.189215156253521e-15 10.94022 25 0.005170631 264 0.007828638012878787 3.186683 9 11 0.001866833 GO Biological Process protein-DNA complex assembly 73 8.42226e-18 1.5181988950684931e-15 2.120845 160 0.03309204 193 0.002842628998031088 1.476125 83 219 0.01721635 GO Biological Process DNA packaging 81 2.800889e-17 4.550234364320988e-15 2.241848 137 0.02833506 359 0.02327733630779944 1.409187 72 199 0.01493466 GO Biological Process platelet aggregation 97 5.238551e-16 7.106607485463918e-14 3.753039 55 0.01137539 247 0.006433333876923077 2.089912 22 41 0.004563369 GO Biological Process endoplasmic reticulum unfolded protein response 105 1.037042e-15 1.2996605407619047e-13 2.711396 86 0.01778697 391 0.02783557597826087 1.537435 45 114 0.009334163 GO Biological Process cellular response to unfolded protein 121 1.222598e-14 1.3296005852892563e-12 2.527103 90 0.01861427 340 0.01920927598235294 1.545059 48 121 0.009956441 GO Biological Process mRNA catabolic process 136 7.613324e-14 7.366450773235294e-12 2.107901 123 0.0254395 258 0.00737810338875969 1.444563 79 213 0.01638664 GO Biological Process regulation of regulatory T cell differentiation 139 9.780749e-14 9.259343603669066e-12 3.534027 50 0.01034126 303 0.01268053354851485 2.336901 15 25 0.003111388 GO Biological Process regulation of megakaryocyte differentiation 144 1.912857e-13 1.7480059210416665e-11 2.7627 70 0.01447777 234 0.005379072474401709 1.793674 35 76 0.007259905 GO Cellular Component nucleosome 27 8.991159e-23 5.75434176e-21 4.190889 71 0.01468459 44 0.0036044041745454548 1.669215 45 105 0.009334163 GO Cellular Component DNA packaging complex 28 3.229453e-20 1.9930338514285715e-18 3.594318 75 0.01551189 40 0.002353121712 1.669215 48 112 0.009956441 GO Cellular Component protein-DNA complex 55 6.184818e-12 1.9431573643636362e-10 2.000798 118 0.02440538 42 0.0025481157942857146 1.484665 77 202 0.01597179 GO Cellular Component ESC/E(Z) complex 60 6.339233e-11 1.8256991040000001e-9 3.723779 36 0.007445708 59 0.045969398237288135 2.380177 11 18 0.002281684 GO Cellular Component clathrin vesicle coat 144 0.00002740979 0.00032891748 2.429845 28 0.005791107 55 0.03794241861818181 2.181108 14 25 0.002903962 GO Molecular Function S100 protein binding 103 0.00002413716 0.0009893892186407767 3.683146 15 0.003102378 49 0.013774662734693877 2.996027 10 13 0.002074258 GO Molecular Function cAMP response element binding 153 0.0001573484 0.004341993103267974 2.856521 17 0.003516029 32 0.0019100776587500001 3.29563 11 13 0.002281684 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 20 1.845506e-28 8.449649221e-26 5.135154 73 0.01509824 441 0.04896268664172335 2.01457 15 29 0.003111388 Mouse Phenotype Single KO abnormal T cell activation 30 4.40927e-24 1.3458561796666667e-21 2.02272 247 0.05108583 170 0.0011108281289411764 1.428555 106 289 0.02198714 Mouse Phenotype Single KO decreased erythroid progenitor cell number 31 2.855453e-23 8.434639716451613e-21 3.179031 103 0.021303 331 0.021766758891842902 1.832864 24 51 0.00497822 Mouse Phenotype Single KO abnormal platelet activation 33 9.234153e-23 2.5623375460909092e-20 3.066463 106 0.02192347 256 0.00915707869296875 1.695399 37 85 0.007674756 Mouse Phenotype Single KO abnormal neutrophil cell number 37 1.041212e-21 2.576858995675676e-19 2.07627 208 0.04301965 162 0.000877829022037037 1.453297 100 268 0.02074258 Mouse Phenotype Single KO abnormal erythropoiesis 38 1.224049e-21 2.9496359718421055e-19 2.460419 145 0.02998966 95 0.00007840928970947368 1.841195 52 110 0.01078614 Mouse Phenotype Single KO abnormal platelet aggregation 39 1.754821e-21 4.1202297171794876e-19 3.038161 101 0.02088935 361 0.0250531360033241 1.647815 33 78 0.006845053 Mouse Phenotype Single KO decreased T cell proliferation 40 2.849342e-21 6.522856173500001e-19 2.317943 160 0.03309204 231 0.006316593737662338 1.531968 59 150 0.01223812 Mouse Phenotype Single KO decreased erythrocyte cell number 49 1.365733e-20 2.552248383877551e-18 2.121638 187 0.03867632 400 0.0351955475975 1.402141 63 175 0.01306783 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 59 4.287205e-19 6.65388748898305e-17 2.023338 193 0.03991727 241 0.008088264112448134 1.387815 93 261 0.0192906 Mouse Phenotype Single KO abnormal platelet physiology 61 6.873378e-19 1.0317954482950819e-16 2.506227 121 0.02502585 134 0.0003691486694253731 1.77038 50 110 0.01037129 Mouse Phenotype Single KO decreased granulocyte number 67 3.285581e-18 4.490457495074627e-16 2.025097 183 0.03784902 159 0.0008763565751572327 1.507678 84 217 0.01742377 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 69 2.883998e-17 3.8273579255072465e-15 2.342387 125 0.02585315 197 0.0020160455595431472 1.787042 39 85 0.008089608 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 89 1.357479e-14 1.3966781126966293e-12 2.034391 142 0.02936918 229 0.006176856349344978 1.491165 67 175 0.01389753 Mouse Phenotype Single KO enlarged axillary lymph nodes 91 4.178377e-14 4.204549251538462e-12 7.80224 24 0.004963806 371 0.02749565725876011 3.894835 5 5 0.001037129 Mouse Phenotype Single KO enlarged lymph nodes 93 6.115343e-14 6.021311381827957e-12 2.11487 123 0.0254395 152 0.0006908546844736842 1.669215 57 133 0.01182327 Mouse Phenotype Single KO joint inflammation 108 4.739748e-13 4.018691892222222e-11 2.266312 98 0.02026887 375 0.028068353842666666 1.495617 48 125 0.009956441 Mouse Phenotype Single KO cortical renal glomerulopathies 114 9.085907e-13 7.298214947280701e-11 2.02262 124 0.02564633 223 0.00585147082600897 1.56956 54 134 0.011201 Mouse Phenotype Single KO extramedullary hematopoiesis 123 3.648478e-12 2.716188052520325e-10 2.225994 94 0.01944157 409 0.03585171476528117 1.50327 44 114 0.009126737 Mouse Phenotype Single KO arthritis 125 6.19479e-12 4.5380553624e-10 2.248516 90 0.01861427 402 0.035316362253731345 1.498013 45 117 0.009334163 Mouse Phenotype abnormal embryonic erythropoiesis 20 1.554189e-28 7.4298005145e-26 4.812973 78 0.01613237 529 0.031616564217391306 2.010237 16 31 0.003318814 Mouse Phenotype abnormal platelet activation 28 7.985641e-25 2.726811200035714e-22 3.089759 115 0.0237849 417 0.012937576058273384 1.596882 41 100 0.00850446 Mouse Phenotype abnormal platelet aggregation 31 1.84394e-24 5.687067851612903e-22 3.093638 113 0.02337125 419 0.013133765432935561 1.615942 39 94 0.008089608 Mouse Phenotype decreased erythroid progenitor cell number 34 7.67948e-24 2.1595149494117647e-21 2.859325 124 0.02564633 259 0.0013427317048262547 1.844922 36 76 0.00746733 Mouse Phenotype decreased erythrocyte cell number 37 1.366261e-23 3.530492275945946e-21 2.061268 231 0.04777663 203 0.0002674476393694581 1.517468 90 231 0.01866833 Mouse Phenotype abnormal erythropoiesis 45 3.923881e-22 8.336939164666666e-20 2.303916 169 0.03495346 152 0.000037072884432236846 1.725229 66 149 0.01369011 Mouse Phenotype abnormal platelet physiology 50 7.14836e-22 1.3669093992e-19 2.532816 139 0.02874871 156 0.000039948977582692305 1.77038 60 132 0.01244555 Mouse Phenotype decreased T cell proliferation 56 1.224392e-20 2.090430698571429e-18 2.026228 209 0.04322647 205 0.0003096248231707317 1.535991 84 213 0.01742377 Mouse Phenotype abnormal erythroid progenitor cell morphology 60 4.604826e-19 7.337790231000001e-17 2.273463 148 0.03061013 184 0.00012819783710869565 1.767404 54 119 0.011201 Mouse Phenotype decreased neutrophil cell number 65 4.347408e-18 6.394702752e-16 2.488038 117 0.02419855 553 0.03619656285352622 1.436393 52 141 0.01078614 Mouse Phenotype abnormal mean corpuscular hemoglobin 75 1.562078e-16 1.9913370344e-14 2.065807 157 0.03247156 266 0.0014195622862781955 1.524066 72 184 0.01493466 Mouse Phenotype abnormal splenic cell ratio 78 2.641878e-16 3.2383327638461535e-14 2.840236 83 0.01716649 242 0.0008764608208264462 1.979342 31 61 0.006430201 Mouse Phenotype atherosclerotic lesions 82 8.673062e-16 1.0112578753902439e-13 2.345286 113 0.02337125 551 0.036326229980036304 1.500762 42 109 0.008711886 Mouse Phenotype extramedullary hematopoiesis 88 2.001983e-15 2.1751090298863636e-13 2.034282 151 0.03123061 185 0.00012764493155675675 1.624703 73 175 0.01514209 Mouse Phenotype arteriosclerosis 95 5.908147e-15 5.946083522842106e-13 2.258655 115 0.0237849 519 0.0294995904566474 1.50327 44 114 0.009126737 Mouse Phenotype abnormal proerythroblast morphology 117 3.24971e-13 2.6555963512820514e-11 2.304358 96 0.01985522 477 0.019797074749685534 1.647815 33 78 0.006845053 Mouse Phenotype abnormal reticulocyte cell number 137 8.329444e-12 5.812979130218978e-10 2.180956 95 0.0196484 551 0.036326229980036304 1.500762 42 109 0.008711886 Mouse Phenotype abnormal liver iron level 140 1.990739e-11 1.359532541357143e-9 3.269081 45 0.009307135 425 0.013684348848705882 1.947418 21 42 0.004355943 Mouse Phenotype increased bleeding time 148 3.245698e-11 2.0967647687837836e-9 2.154823 92 0.01902792 196 0.00019915436170408161 1.844922 45 95 0.009334163 Mouse Phenotype abnormal reticulocyte morphology 164 1.667503e-10 9.72133913597561e-9 2.040081 97 0.02006205 541 0.034609088062846585 1.490198 44 115 0.009126737