# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process androgen biosynthetic process 46 0.0001168572 0.033428780321739134 5.626072 8 0.005475702 183 0.0032600279177049177 5.730935 7 11 0.003357314 Mouse Phenotype Single KO small scala media 7 1.80534e-85 2.3616426257142855e-82 34.56482 74 0.05065024 364 0.03622743156318681 5.003197 5 9 0.002398082 Mouse Phenotype Single KO unidirectional circling 16 8.224558e-78 4.707017350375e-75 27.03061 74 0.05065024 364 0.03622743156318681 5.003197 5 9 0.002398082 Mouse Phenotype Single KO abnormal cranial ganglia morphology 70 2.458023e-33 3.215445230142857e-31 3.671587 121 0.08281999 222 0.010867325486036035 1.855731 34 165 0.01630695 Mouse Phenotype Single KO abnormal sensory ganglion morphology 78 6.121771e-30 7.186802185512821e-28 3.320765 123 0.08418891 223 0.011049932576233183 1.757221 40 205 0.01918465 Mouse Phenotype Single KO altered righting response 86 2.666437e-25 2.8391353033720933e-23 3.461554 98 0.06707734 403 0.042507839215880895 1.86326 24 116 0.01151079 Mouse Phenotype Single KO stereotypic behavior 103 4.030042e-19 3.582824717864078e-17 2.725344 103 0.07049966 378 0.03768614222222222 1.734027 31 161 0.01486811 Mouse Phenotype Single KO impaired coordination 115 1.078617e-16 8.588605103478261e-15 2.081017 149 0.1019849 140 0.0019906036020000003 1.653599 65 354 0.03117506 Mouse Phenotype Single KO decreased neuron number 128 1.362399e-14 9.74647472109375e-13 2.097469 127 0.08692676 297 0.02371679340774411 1.574433 50 286 0.02398082 Mouse Phenotype Single KO abnormal spinal nerve morphology 162 2.673454e-7 0.000015111616220987653 2.277211 48 0.03285421 62 0.00012466930574193548 2.654328 28 95 0.01342926 Mouse Phenotype Single KO paraparesis 179 0.0002102367 0.010754957887709499 2.886658 16 0.0109514 296 0.023579488457094594 3.105433 10 29 0.004796163 Mouse Phenotype Single KO fusion of vertebral arches 193 0.0003856164 0.018295799869430054 2.474075 19 0.01300479 419 0.04614660315513127 2.389282 13 49 0.006235012 Mouse Phenotype Single KO dilated cardiomyopathy 205 0.0005484741 0.024499401627804878 2.47118 18 0.01232033 292 0.022196411202054796 2.660791 13 44 0.006235012 Mouse Phenotype Single KO absent kidney 206 0.0005807745 0.0258162723131068 2.032794 27 0.01848049 89 0.00047482419714606737 3.178502 18 51 0.008633094 Mouse Phenotype Single KO abnormal epidermis stratum granulosum morphology 207 0.0006103659 0.02700058234927536 2.319016 20 0.01368925 313 0.02764428964249201 2.324066 16 62 0.007673861 Mouse Phenotype Single KO abnormal first pharyngeal arch morphology 213 0.0007391281 0.03177556813004695 2.099657 24 0.0164271 81 0.0003871821525679012 3.514441 16 41 0.007673861 Mouse Phenotype Single KO abnormal epidermis stratum corneum morphology 218 0.0008500788 0.0357072090440367 2.010098 26 0.01779603 340 0.034608935364705884 1.912727 24 113 0.01151079 Mouse Phenotype Single KO abnormal hippocampal mossy fiber morphology 230 0.001208614 0.04811860173043478 2.368318 17 0.01163587 150 0.002964351045933333 3.810127 11 26 0.005275779 Mouse Phenotype Single KO abnormal sympathetic postganglionic fiber morphology 231 0.001226718 0.04862795119480519 5.197893 6 0.004106776 349 0.03587662748137536 9.005755 3 3 0.001438849 Mouse Phenotype small scala media 8 7.015175e-83 8.384011021875001e-80 30.71983 75 0.0513347 323 0.007779164086996904 5.403453 6 10 0.002877698 Mouse Phenotype abnormal semicircular canal morphology 70 8.266902e-30 1.1291407146e-27 4.140919 94 0.06433949 325 0.00802273512276923 2.419457 18 67 0.008633094 Mouse Phenotype abnormal inner ear canal morphology 72 4.686385e-29 6.223128747916666e-27 4.042948 94 0.06433949 392 0.01432869021122449 2.283149 18 71 0.008633094 Mouse Phenotype abnormal cranial ganglia morphology 79 5.74333e-28 6.950883307594936e-26 3.15312 123 0.08418891 354 0.01095483445 1.781358 36 182 0.01726619 Mouse Phenotype abnormal myocardial fiber physiology 83 6.768866e-24 7.797244316385543e-22 3.187678 103 0.07049966 491 0.02519403337270876 1.736049 32 166 0.01534772 Mouse Phenotype abnormal sensory ganglion morphology 89 6.512856e-23 6.99656361977528e-21 2.616826 133 0.09103354 334 0.00866693199700599 1.656231 48 261 0.02302158 Mouse Phenotype altered righting response 91 2.703304e-22 2.840251598241758e-20 2.969455 106 0.07255305 364 0.011976289838736264 1.861189 31 150 0.01486811 Mouse Phenotype abnormal postural reflex 93 7.799467e-22 8.018355267419355e-20 2.908022 107 0.07323751 398 0.014552132673618092 1.812479 32 159 0.01534772 Mouse Phenotype impaired righting response 94 8.589081e-22 8.736191855425531e-20 3.08339 98 0.06707734 587 0.04191881188415673 1.773861 26 132 0.01247002 Mouse Phenotype ataxia 95 9.26108e-22 9.320545882105262e-20 2.453751 141 0.09650924 375 0.0129529164512 1.55084 57 331 0.02733813 Mouse Phenotype decreased sensory neuron number 99 4.048934e-20 3.910288684242424e-18 2.580552 119 0.08145106 409 0.015113360231295843 1.711094 38 200 0.01822542 Mouse Phenotype stereotypic behavior 107 1.497373e-16 1.3379797432710282e-14 2.380427 112 0.07665982 474 0.02327923979113924 1.648941 39 213 0.01870504 Mouse Phenotype abnormal piriform cortex morphology 168 0.00001398355 0.0007958138187499999 6.541198 9 0.006160164 496 0.02635757589314516 9.005755 3 3 0.001438849 Mouse Phenotype brachydactyly 169 0.0000229533 0.0012985591792899409 2.733416 23 0.01574264 338 0.00935600989704142 3.001918 12 36 0.005755396 Mouse Phenotype abnormal keratinocyte proliferation 180 0.0001835912 0.009751752573333335 2.370701 23 0.01574264 555 0.033115669097297296 2.126359 17 72 0.008153477 Mouse Phenotype increased body length 197 0.0003923118 0.019040066597969543 2.121683 26 0.01779603 246 0.002844226101585366 2.657436 18 61 0.008633094 Mouse Phenotype paraparesis 200 0.0004224285 0.0201941944425 2.705783 16 0.0109514 540 0.03185231215 2.814299 10 32 0.004796163 Mouse Phenotype Purkinje cell degeneration 207 0.0005256555 0.024279189543478262 2.046634 27 0.01848049 522 0.029081026994252874 2.061558 19 83 0.00911271 Mouse Phenotype abnormal epidermis stratum basale morphology 220 0.0007062928 0.03069484300363636 2.190072 22 0.01505818 380 0.013160575601052632 2.442239 16 59 0.007673861 Mouse Phenotype abnormal metacarpal bone morphology 231 0.0009317076 0.03856301456103896 2.101277 23 0.01574264 301 0.00598854664385382 2.865468 14 44 0.006714628