# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	10	1.900106e-63	2.5003494854e-60	2.71556	380	0.01875154	361	0.000021945410106094182	1.354988	93	113	0.008154318	
GO Biological Process	regulation of DNA-templated transcription in response to stress	14	2.831581e-55	2.661483884214286e-52	2.47016	391	0.01929435	374	0.000029612098803208552	1.34201	97	119	0.008505042	
GO Biological Process	liver regeneration	20	2.279817e-51	1.50000559515e-48	3.545051	206	0.01016531	642	0.005984563572741433	1.458225	31	35	0.002718106	
GO Biological Process	mRNA catabolic process	23	6.970992e-48	3.9883166838260864e-45	2.052574	502	0.02477177	141	1.7233446368085105e-13	1.406769	182	213	0.01595791	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	24	2.018117e-47	1.1065167334583333e-44	2.140803	450	0.02220577	414	0.0000998889836642512	1.285241	121	155	0.01060938	
GO Biological Process	nuclear-transcribed mRNA catabolic process	26	2.380541e-46	1.2048284238076924e-43	2.093523	463	0.02284727	158	1.934273058227848e-12	1.405246	169	198	0.01481806	
GO Biological Process	IRE1-mediated unfolded protein response	39	5.084487e-41	1.7155580623846155e-38	3.206466	187	0.009227733	848	0.0320116572240566	1.305752	46	58	0.004033319	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	40	5.974627e-41	1.9655029173249998e-38	2.362278	313	0.01544535	746	0.01470681238150134	1.261059	72	94	0.006313021	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	44	1.200284e-39	3.589667535454545e-37	2.485924	274	0.01352085	259	1.4561353105791507e-7	1.409192	101	118	0.008855765	
GO Biological Process	endoplasmic reticulum unfolded protein response	46	3.44963e-39	9.868191558695653e-37	2.324357	309	0.01524796	516	0.0015673837911627908	1.285334	89	114	0.007803595	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	52	6.876586e-37	1.7401729841153845e-34	2.535084	245	0.01208981	501	0.001100033828003992	1.350878	64	78	0.005611574	
GO Biological Process	cellular response to topologically incorrect protein	56	2.34136e-35	5.5017778999999995e-33	2.100268	347	0.01712312	495	0.000926252173979798	1.26736	107	139	0.00938185	
GO Biological Process	cellular response to unfolded protein	65	6.445901e-33	1.304947865523077e-30	2.116983	316	0.01559339	510	0.0014100916059607842	1.279008	94	121	0.008241999	
GO Biological Process	regulation of nuclease activity	66	1.017899e-32	2.0294746880303032e-30	3.694632	122	0.006020232	664	0.00708705689879518	1.519738	24	26	0.00210434	
GO Biological Process	multi-organism metabolic process	67	1.813203e-32	3.561184817462687e-30	2.066249	330	0.01628423	189	4.398103327777778e-10	1.422385	127	147	0.01113547	
GO Biological Process	viral gene expression	70	4.638406e-32	8.719540650571429e-30	2.234984	272	0.01342216	209	1.698109765980861e-9	1.438965	111	127	0.009732573	
GO Biological Process	RNA phosphodiester bond hydrolysis	90	7.238363e-29	1.0583290968555555e-26	2.042181	300	0.01480385	294	0.0000014927350283333332	1.36167	110	133	0.009644893	
GO Biological Process	protein targeting to ER	91	9.29759e-29	1.3444723825274725e-26	2.320229	224	0.01105354	266	2.2212807547368422e-7	1.434472	88	101	0.007715914	
GO Biological Process	viral transcription	96	4.618087e-28	6.330146545104166e-26	2.190256	247	0.0121885	234	1.3357627794444445e-8	1.442406	99	113	0.008680403	
GO Biological Process	regulation of cellular amino acid metabolic process	97	6.405267e-28	8.689372005463917e-26	2.851713	149	0.007352578	909	0.04279328514521452	1.289667	47	60	0.004121	
GO Cellular Component	ribosomal subunit	37	1.040104e-32	4.857566789189189e-31	2.010226	356	0.01756723	64	1.7622692099999998e-8	1.343805	151	185	0.01323981	
GO Cellular Component	mitochondrial ribosome	44	5.052074e-26	1.9840872436363636e-24	2.571615	165	0.008142117	102	0.00007611574023529412	1.375214	71	85	0.00622534	
GO Cellular Component	large ribosomal subunit	45	2.580362e-25	9.908590079999999e-24	2.153232	230	0.01134962	65	5.571505329230769e-8	1.417321	99	115	0.008680403	
GO Cellular Component	endopeptidase complex	48	3.228764e-22	1.16235504e-20	2.319528	170	0.008388848	188	0.014080148425531914	1.288474	54	69	0.004734765	
GO Cellular Component	proteasome complex	49	3.856018e-21	1.3598365518367347e-19	2.279883	167	0.008240809	190	0.018175495073684208	1.28321	53	68	0.004647085	
GO Cellular Component	nuclear ubiquitin ligase complex	50	1.470151e-20	5.080841856e-19	2.8381	108	0.005329386	148	0.002344663654054054	1.440585	35	40	0.003068829	
GO Cellular Component	PcG protein complex	51	9.304543e-20	3.1525980988235294e-18	2.137223	179	0.008832963	179	0.011862884111731843	1.360056	38	46	0.003331872	
GO Cellular Component	mitochondrial large ribosomal subunit	53	1.383927e-19	4.5121242566037736e-18	2.779516	106	0.005230693	132	0.0008244394036363638	1.420409	44	51	0.003857957	
GO Cellular Component	endoribonuclease complex	95	3.935142e-12	7.157816185263158e-11	2.460648	77	0.003799655	172	0.006162755274418605	1.476068	26	29	0.002279702	
GO Cellular Component	DNA-directed RNA polymerase III complex	109	4.72947e-11	7.497728587155963e-10	3.540471	39	0.0019245	177	0.009926559457627118	1.559731	18	19	0.001578255	
GO Cellular Component	CCR4-NOT complex	153	1.051506e-8	1.1875832470588234e-7	2.436226	53	0.002615347	159	0.003714126249056604	1.646383	16	16	0.001402893	
GO Cellular Component	spliceosomal tri-snRNP complex	166	5.484746e-8	5.709422342168674e-7	2.215702	58	0.002862077	195	0.02463864812307692	1.419296	25	29	0.002192021	
GO Cellular Component	anaphase-promoting complex	224	0.000004153916	0.00003204449485714285	2.245567	40	0.001973847	196	0.025483433142857146	1.489585	19	21	0.001665936	
GO Cellular Component	INO80-type complex	247	0.000009292772	0.00006501178144129555	2.245133	37	0.001825808	218	0.04956928910091744	1.431638	20	23	0.001753617	
GO Cellular Component	Ino80 complex	268	0.00002926397	0.00018868709014925375	2.470025	27	0.001332346	207	0.032396585739130436	1.543484	15	16	0.001315213	
GO Cellular Component	U2-type prespliceosome	332	0.0002448099	0.001274191286746988	2.039437	31	0.001529731	207	0.032396585739130436	1.543484	15	16	0.001315213	
GO Molecular Function	ribonuclease activity	13	6.638152e-25	2.155867518769231e-22	2.098491	240	0.01184308	64	0.000033493205162500005	1.380301	83	99	0.00727751	
GO Molecular Function	NF-kappaB binding	14	8.724315e-25	2.631004137857143e-22	3.142529	113	0.005576116	121	0.005298027294214877	1.528784	26	28	0.002279702	
GO Molecular Function	unfolded protein binding	15	7.147484e-24	2.0117784965333333e-21	2.166362	213	0.01051073	128	0.0068644013703125	1.273617	82	106	0.007189829	
GO Molecular Function	rRNA binding	21	4.575999e-18	9.199937037142856e-16	2.639235	106	0.005230693	118	0.004827492047457627	1.371986	50	60	0.004384042	
GO Molecular Function	endoribonuclease activity	22	2.293882e-17	4.402168092727273e-15	2.231255	141	0.006957809	142	0.0144487395	1.352386	46	56	0.004033319	
GO Molecular Function	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	27	5.469567e-16	8.552782175555555e-14	2.252634	126	0.006217617	164	0.02723581307317073	1.350034	41	50	0.003594915	
GO Molecular Function	peptide disulfide oxidoreductase activity	173	3.202474e-7	0.00000781551747283237	2.69464	35	0.001727116	173	0.037273768369942194	1.646383	13	13	0.001139851	
GO Molecular Function	ubiquitin protein ligase activity involved in ERAD pathway	391	0.0002521335	0.002722525925831202	2.158502	27	0.001332346	173	0.037273768369942194	1.646383	13	13	0.001139851	
Human Phenotype	Increased serum lactate	9	8.767889e-25	6.500902588555555e-22	2.128149	231	0.01139896	44	8.101800011136363e-9	1.481745	90	100	0.007891276	
Human Phenotype	Abnormal CSF metabolite level	11	1.416766e-20	8.594617743636363e-18	2.416631	144	0.007105848	75	0.0000017681652738666667	1.515718	58	63	0.005085489	
Human Phenotype	Increased CSF lactate	28	1.214384e-15	2.8941372971428574e-13	2.260819	122	0.006020232	92	0.000011610599310869565	1.504454	53	58	0.004647085	
Human Phenotype	Aplasia/hypoplasia of the femur	98	1.708679e-10	1.1634709149999999e-8	2.030268	99	0.00488527	276	0.015187658543115943	1.446822	29	33	0.002542744	
Human Phenotype	Increased intramyocellular lipid droplets	286	0.000002320441	0.000054140918856643354	2.393123	37	0.001825808	354	0.04694417799435028	1.549537	16	17	0.001402893	
Human Phenotype	Glioma	483	0.00006161414	0.0008512446298550725	2.095269	35	0.001727116	273	0.013760173310989011	1.646383	15	15	0.001315213	
Mouse Phenotype Single KO	absent hypoglossal nerve	37	3.953607e-23	9.784643053783784e-21	4.118119	74	0.003651616	230	0.022412525891739133	1.646383	15	15	0.001315213	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	68	1.185498e-18	1.5964125273529412e-16	2.915412	93	0.004589193	199	0.011993272614572864	1.571548	21	22	0.001841298	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	74	3.811912e-18	4.716983538378378e-16	2.252456	145	0.007155194	227	0.02205037064581498	1.514673	23	25	0.002016659	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	124	1.180108e-13	8.714716899999999e-12	2.381401	94	0.004638539	246	0.031010493178048777	1.509185	22	24	0.001928979	
Mouse Phenotype Single KO	thin hypoglossal nerve	155	4.494323e-12	2.6551300458709676e-10	2.769257	62	0.003059462	230	0.022412525891739133	1.646383	15	15	0.001315213	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	279	2.168469e-8	7.117086248387097e-7	2.278942	58	0.002862077	173	0.006665941364739885	1.646383	18	18	0.001578255	
Mouse Phenotype Single KO	reduced sympathetic cervical ganglion size	551	0.00003737714	0.0006211660090381125	2.15021	35	0.001727116	280	0.04994894952857143	1.646383	13	13	0.001139851	
Mouse Phenotype	absent hypoglossal nerve	45	3.953607e-23	8.400097006e-21	4.118119	74	0.003651616	311	0.017306464476848873	1.646383	15	15	0.001315213	
Mouse Phenotype	absent segment of posterior cerebral artery	70	1.185498e-18	1.6192209111428572e-16	2.915412	93	0.004589193	270	0.009229477636666667	1.571548	21	22	0.001841298	
Mouse Phenotype	abnormal vitelline vein morphology	75	3.811912e-18	4.859425417600001e-16	2.252456	145	0.007155194	309	0.016913495636893205	1.514673	23	25	0.002016659	
Mouse Phenotype	abnormal cerebral artery morphology	143	1.180108e-13	7.890218593006992e-12	2.381401	94	0.004638539	339	0.023496013661946903	1.509185	22	24	0.001928979	
Mouse Phenotype	increased neural tube apoptosis	147	1.567743e-13	1.0196728451020407e-11	2.061217	128	0.006316309	273	0.0097759613989011	1.416655	37	43	0.003244191	
Mouse Phenotype	thin hypoglossal nerve	185	4.494323e-12	2.3227147136756757e-10	2.769257	62	0.003059462	311	0.017306464476848873	1.646383	15	15	0.001315213	
Mouse Phenotype	abnormal hypoglossal nerve topology	346	2.168469e-8	5.992119106647398e-7	2.278942	58	0.002862077	224	0.005375386273660715	1.646383	18	18	0.001578255	
Mouse Phenotype	reduced sympathetic cervical ganglion size	630	0.00003737714	0.0005672425960952382	2.15021	35	0.001727116	374	0.03904477209625669	1.646383	13	13	0.001139851