# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process antigen receptor-mediated signaling pathway 90 5.42364e-8 0.000007929964306666666 2.079547 66 0.03166987 165 0.0010578193118787878 1.835409 48 172 0.01681261 GO Biological Process regulation of mRNA stability 137 0.000002204022 0.00021169872626277373 2.094211 49 0.02351248 288 0.010415773426041667 1.742221 40 151 0.01401051 GO Biological Process regulation of RNA stability 155 0.000005255972 0.00044621506805161287 2.009801 50 0.02399232 327 0.016416641235168197 1.685326 41 160 0.01436077 GO Biological Process T cell receptor signaling pathway 169 0.000007030758 0.0005474422752781065 2.003587 49 0.02351248 283 0.010290677437102474 1.772493 38 141 0.01330998 GO Biological Process peptidyl-tyrosine autophosphorylation 181 0.00001023194 0.0007438789970165746 2.618773 27 0.01295585 183 0.0018284416118579236 2.65874 19 47 0.006654991 GO Biological Process positive regulation of multicellular organism growth 205 0.00001905719 0.001223285674195122 2.770947 23 0.01103647 179 0.0016278116732402234 3.082914 15 32 0.00525394 GO Biological Process myelination in peripheral nervous system 272 0.00005672209 0.002744139640845588 3.111204 17 0.00815739 284 0.01041040460809859 3.145466 11 23 0.00385289 GO Biological Process Schwann cell development 279 0.00006509017 0.0030699697026164876 3.075574 17 0.00815739 391 0.027801692394629155 2.782527 11 26 0.00385289 GO Biological Process establishment of epithelial cell polarity 344 0.0001656411 0.006336253589825581 2.509055 21 0.01007678 233 0.005011257820171674 3.053553 13 28 0.004553415 GO Biological Process B cell receptor signaling pathway 394 0.0003376677 0.011277586965228428 2.436472 20 0.009596929 419 0.03877878785680191 2.442842 13 35 0.004553415 GO Biological Process epithelial cell-cell adhesion 400 0.0003538214 0.0116398395065 3.34474 12 0.005758157 415 0.036607164787951806 3.288441 8 16 0.002802102 GO Biological Process Schwann cell differentiation 436 0.0004719609 0.014244342851146789 2.506561 18 0.008637236 472 0.047832853483050844 2.466331 12 32 0.004203152 GO Biological Process regulation of T cell receptor signaling pathway 553 0.00122489 0.02914706602169982 2.631298 14 0.00671785 463 0.047371291574514036 2.374985 13 36 0.004553415 GO Biological Process long-chain fatty acid biosynthetic process 631 0.002316186 0.048302205347068146 3.538964 8 0.003838772 264 0.007291860471212121 4.603818 7 10 0.002451839 GO Cellular Component extrinsic component of cytoplasmic side of plasma membrane 39 3.706435e-7 0.000016422358153846153 2.279589 47 0.02255278 61 0.008286451200000001 1.87049 31 109 0.01085814 GO Cellular Component cell cortex part 41 0.000002111412 0.00008898829112195123 2.045845 52 0.02495202 86 0.03355717730232558 1.6564 34 135 0.01190893 GO Cellular Component ER to Golgi transport vesicle membrane 78 0.00008381333 0.0018567876184615384 2.639548 21 0.01007678 68 0.013885402447058822 2.233658 18 53 0.006304729 GO Cellular Component MHC protein complex 91 0.0002054603 0.0039014878945054943 6.025174 7 0.003358925 59 0.00808254427118644 3.288441 10 20 0.003502627 GO Cellular Component ER to Golgi transport vesicle 97 0.0002831815 0.005044717855670103 2.253987 24 0.01151631 89 0.043563928449438204 1.89198 21 73 0.007355517 GO Cellular Component SNARE complex 158 0.003632015 0.0397222906329114 2.027913 19 0.009117083 87 0.039647450482758625 2.0705 17 54 0.005954466 GO Molecular Function SNAP receptor activity 76 0.00007653162 0.00425153289 2.921401 18 0.008637236 41 0.0184953565902439 2.566588 16 41 0.005604203 GO Molecular Function phosphoprotein binding 82 0.0001102676 0.005677436673170732 2.024281 35 0.01679463 46 0.028750957243478262 2.049937 24 77 0.008406305 Human Phenotype Laryngomalacia 46 0.0002377388 0.03448763070434783 4.073412 10 0.004798464 7 0.03947438888714285 4.227996 9 14 0.003152364 Mouse Phenotype Single KO abnormal interventricular septum thickness 16 6.002569e-8 0.000034353452708124996 3.45589 27 0.01295585 151 0.02072412846423841 2.447212 16 43 0.005604203 Mouse Phenotype Single KO abnormal cell adhesion 68 0.00002664652 0.0035882674064705885 2.30696 31 0.01487524 70 0.0035579274952857146 2.452397 22 59 0.007705779 Mouse Phenotype Single KO decreased body temperature 80 0.00006766967 0.007745639602375 2.224022 30 0.01439539 95 0.007867392700947369 2.257736 23 67 0.008056042 Mouse Phenotype Single KO decreased single-positive T cell number 83 0.0000785045 0.008661032608433735 2.652244 21 0.01007678 179 0.024145893789944136 2.466331 15 40 0.00525394 Mouse Phenotype Single KO decreased IgG3 level 96 0.0001345912 0.012838037691666667 2.136258 30 0.01439539 173 0.022933007815606934 2.044166 23 74 0.008056042 Mouse Phenotype Single KO increased immature B cell number 135 0.0003612384 0.02450266688 2.215174 24 0.01151631 74 0.003858257402432432 2.795175 17 40 0.005954466 Mouse Phenotype Single KO decreased cranium height 148 0.0004470004 0.027656639613513515 2.518506 18 0.008637236 145 0.017451776880000002 2.923059 12 27 0.004203152 Mouse Phenotype Single KO increased B cell apoptosis 162 0.0006149997 0.03476266822777778 2.613309 16 0.007677543 133 0.015469085339097745 3.145466 11 23 0.00385289 Mouse Phenotype Single KO increased transitional stage B cell number 181 0.0009275056 0.04692358441546961 2.711423 14 0.00671785 114 0.010911714141228069 3.288441 11 22 0.00385289 Mouse Phenotype thin myocardium 39 3.948826e-7 0.00009680698816923076 2.084615 57 0.02735125 106 0.0005638667398584906 2.150135 34 104 0.01190893 Mouse Phenotype decreased single-positive T cell number 49 0.000001215558 0.00023718265383673468 2.385911 39 0.01871401 279 0.014575806183870969 1.980989 25 83 0.008756567 Mouse Phenotype abnormal interventricular septum thickness 54 0.000002507311 0.00044393334205555557 2.342612 38 0.01823417 220 0.005912474595 2.192294 23 69 0.008056042 Mouse Phenotype abnormal adipose tissue physiology 57 0.00000361127 0.0006057430257894737 2.022107 51 0.02447217 207 0.0044461837 1.911231 34 117 0.01190893 Mouse Phenotype abnormal cell adhesion 64 0.000005300205 0.000791800937578125 2.237846 39 0.01871401 164 0.0017952077562804877 2.249986 26 76 0.00910683 Mouse Phenotype enlarged liver sinusoidal spaces 71 0.000009347419 0.0012587418740704224 2.824846 24 0.01151631 231 0.007433950671428571 2.566588 16 41 0.005604203 Mouse Phenotype small thymus medulla 90 0.0000201438 0.00213994302 4.231631 13 0.006238004 259 0.01018731933011583 3.288441 10 20 0.003502627