# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transforming growth factor beta production 105 0.000001423516 0.00017840044803809523 4.674019 15 0.01485149 5 0.00250952894062 5.808408 11 28 0.008661417 Mouse Phenotype Single KO abnormal hemopoiesis 5 1.360971e-22 2.4924822894e-19 2.258462 166 0.1643564 4 0.00012090048909749999 1.790297 89 735 0.07007874 Mouse Phenotype Single KO abnormal blood cell morphology/development 6 8.331563e-22 1.2715353731833335e-18 2.128862 180 0.1782178 5 0.00010316635154399999 1.721192 100 859 0.07874016 Mouse Phenotype Single KO abnormal definitive hematopoiesis 9 3.367772e-19 3.4265209115555553e-16 2.168699 153 0.1514851 6 0.0002085367868833333 1.780068 85 706 0.06692913 Mouse Phenotype Single KO abnormal platelet aggregation 22 1.173571e-13 4.884722566818183e-11 4.896022 34 0.03366337 51 0.035985807021568623 2.843277 15 78 0.01181102 Mouse Phenotype Single KO abnormal leukopoiesis 28 2.450011e-12 8.012410973928573e-10 2.051732 109 0.1079208 36 0.02198230946166667 1.668351 58 514 0.04566929 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 45 1.678231e-10 3.415013614888889e-8 4.748309 26 0.02574257 13 0.0016923629295384616 3.642691 17 69 0.01338583 Mouse Phenotype Single KO abnormal erythropoiesis 52 7.409857e-10 1.30484731825e-7 3.167968 39 0.03861386 7 0.00033325567194285717 3.225827 24 110 0.01889764 Mouse Phenotype Single KO decreased erythroid progenitor cell number 56 3.012572e-9 4.926093179285714e-7 3.989298 27 0.02673267 23 0.009815631159565217 3.768736 13 51 0.01023622 Mouse Phenotype Single KO abnormal litter size 69 1.397698e-8 0.0000018548870414492755 2.034588 74 0.07326733 31 0.018707219303225806 1.907747 40 310 0.03149606 Mouse Phenotype Single KO decreased litter size 73 2.030709e-8 0.0000025472879880821916 2.038954 72 0.07128713 30 0.018733662257666664 1.928483 39 299 0.03070866 Mouse Phenotype Single KO anemia 80 5.035422e-8 0.0000057636699067500005 2.188857 58 0.05742574 28 0.016262423205357143 2.008534 36 265 0.02834646 Mouse Phenotype Single KO cervical aortic arch 82 7.382292e-8 0.00000824385949317073 20.67793 7 0.006930693 62 0.04559705995967742 14.78504 3 3 0.002362205 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 86 2.144786e-7 0.000022836983025581393 2.870606 32 0.03168317 19 0.00587394079 3.13095 18 85 0.01417323 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 92 4.860516e-7 0.00004837798370869565 2.537599 37 0.03663366 65 0.043661097244615386 2.112148 25 175 0.01968504 Mouse Phenotype Single KO increased nucleated erythrocyte cell number 222 0.0002517879 0.010385683785135135 2.956135 15 0.01485149 42 0.027214473185714287 3.69626 11 44 0.008661417 Mouse Phenotype Single KO abnormal myelopoiesis 254 0.0005267856 0.018991243067716535 2.148828 24 0.02376238 44 0.028425076154545457 2.55378 19 110 0.01496063 Mouse Phenotype Single KO abnormal nucleated erythrocyte cell number 258 0.0005700869 0.020233665671705425 2.729012 15 0.01485149 46 0.03089665360652174 3.614121 11 45 0.008661417 Mouse Phenotype abnormal hemopoiesis 2 1.834344e-28 8.769081492e-25 2.235256 211 0.2089109 7 0.00011718738772714286 1.649327 112 1004 0.08818898 Mouse Phenotype abnormal blood cell morphology/development 3 4.406908e-27 1.4044815796000002e-23 2.109257 225 0.2227723 6 0.00013557220731 1.602574 124 1144 0.0976378 Mouse Phenotype abnormal definitive hematopoiesis 5 3.468221e-25 6.6319321962e-22 2.169588 199 0.1970297 11 0.00021379317332727272 1.632704 108 978 0.08503937 Mouse Phenotype abnormal pre-B cell morphology 13 2.710051e-21 1.9931382777692305e-18 4.228971 64 0.06336634 56 0.014024703094285714 2.445646 22 133 0.01732283 Mouse Phenotype abnormal leukopoiesis 17 3.875744e-19 2.1797640225882355e-16 2.1447 156 0.1544554 26 0.001532709936230769 1.644958 84 755 0.06614173 Mouse Phenotype abnormal lymphopoiesis 19 4.82512e-17 2.4280511747368423e-14 2.150857 138 0.1366337 62 0.020734601438709678 1.567078 69 651 0.05433071 Mouse Phenotype abnormal platelet physiology 37 1.277101e-13 3.300098016486486e-11 3.838103 44 0.04356436 70 0.02833732887428571 2.352165 21 132 0.01653543 Mouse Phenotype decreased mean corpuscular hemoglobin 67 1.457485e-10 2.0798528485074628e-8 4.302126 29 0.02871287 9 0.00013165677596666664 3.84027 20 77 0.01574803 Mouse Phenotype abnormal erythropoiesis 74 3.900358e-10 5.0393679510810804e-8 2.936754 45 0.04455446 15 0.00045010867864 2.778397 28 149 0.02204724 Mouse Phenotype increased myeloid cell number 78 6.814049e-10 8.352451601153845e-8 2.333564 65 0.06435644 38 0.006147214757368421 2.009117 39 287 0.03070866 Mouse Phenotype decreased T cell proliferation 87 4.804817e-9 5.280328199655173e-7 2.459762 53 0.05247525 74 0.032122686032432436 2.012987 29 213 0.02283465 Mouse Phenotype abnormal blood coagulation 89 5.938114e-9 6.379135725168539e-7 2.237887 63 0.06237624 60 0.019042261260000002 1.906085 37 287 0.02913386 Mouse Phenotype abnormal hemostasis 91 6.595962e-9 6.930109085934066e-7 2.231461 63 0.06237624 64 0.020599054987499997 1.892894 37 289 0.02913386 Mouse Phenotype decreased erythroid progenitor cell number 113 8.79132e-8 0.000007438390311504425 3.201216 29 0.02871287 65 0.021773662449230766 2.9181 15 76 0.01181102 Mouse Phenotype abnormal mean corpuscular hemoglobin 123 2.022962e-7 0.000015724829009756097 2.519563 40 0.03960396 44 0.009828744940227273 2.249897 28 184 0.02204724 Mouse Phenotype extramedullary hematopoiesis 134 7.808237e-7 0.00005571235369925373 2.450716 38 0.03762376 83 0.03570096982771084 2.112148 25 175 0.01968504 Mouse Phenotype abnormal erythroid progenitor cell morphology 142 0.000001917424 0.00012910204833802816 2.500232 34 0.03366337 63 0.020627022809523807 2.484881 20 119 0.01574803 Mouse Phenotype abnormal myelopoiesis 221 0.00009870404 0.0042701779476923074 2.105847 32 0.03168317 53 0.01188491830754717 2.324692 25 159 0.01968504 Mouse Phenotype increased nucleated erythrocyte cell number 227 0.0001046359 0.004407153479735683 3.069346 16 0.01584158 43 0.008729424242790699 3.856967 12 46 0.009448819 Mouse Phenotype abnormal nucleated erythrocyte cell number 275 0.0002791808 0.009706355013818183 2.808348 16 0.01584158 51 0.011618920888235294 3.69626 12 48 0.009448819