# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 91 1.495431e-42 2.1624589592307694e-40 2.14234 403 0.01479333 1028 0.0069533333653696485 1.211656 92 113 0.007291749 GO Biological Process gene silencing by miRNA 110 7.484999e-30 8.954100167363637e-28 2.446366 210 0.007708685 920 0.00338949522 1.352937 40 44 0.003170326 GO Biological Process adherens junction assembly 111 9.221905e-30 1.0932526837387387e-27 2.323609 232 0.008516262 1130 0.013188205992920353 1.356916 31 34 0.002457002 GO Biological Process heterochromatin organization 119 8.120469e-28 8.979600972352941e-26 3.716702 102 0.003744218 1501 0.04980231762025317 1.48823 13 13 0.001030356 GO Biological Process posttranscriptional gene silencing by RNA 139 3.568459e-25 3.3782267612230216e-23 2.187403 221 0.008112473 1015 0.0065134145944827585 1.313144 45 51 0.003566616 GO Biological Process posttranscriptional gene silencing 141 7.721464e-25 7.206152111773051e-23 2.169161 222 0.008149181 987 0.005049908239209726 1.316511 46 52 0.003645875 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to hypoxia 149 5.122788e-24 4.524212569932886e-22 2.001277 260 0.009544086 1520 0.04936785846315789 1.202032 63 78 0.004993263 GO Biological Process intrinsic apoptotic signaling pathway in response to DNA damage 161 4.498674e-23 3.676897587950311e-21 2.023924 242 0.008883342 1354 0.031399745341211226 1.229408 57 69 0.004517714 GO Biological Process positive regulation of branching involved in ureteric bud morphogenesis 215 3.085466e-19 1.8884487020465114e-17 2.159351 170 0.006240364 1480 0.04771953975472973 1.409902 18 19 0.001426647 GO Biological Process regulation of protein kinase C signaling 324 4.642688e-15 1.8855904750617282e-13 2.108086 137 0.005028999 1303 0.025884540722179585 1.48823 15 15 0.001188872 GO Biological Process regulation of mammary gland epithelial cell proliferation 338 7.962383e-15 3.099911180384615e-13 2.118821 133 0.004882167 1210 0.018722331569421487 1.48823 16 16 0.00126813 GO Biological Process pyrimidine nucleotide catabolic process 345 1.498645e-14 5.71613610289855e-13 3.792476 49 0.001798693 1501 0.04980231762025317 1.48823 13 13 0.001030356 GO Biological Process thyroid gland development 430 3.782249e-13 1.1574561532790696e-11 2.127193 115 0.004221423 1492 0.04949030224329759 1.364211 22 24 0.001743679 GO Cellular Component PcG protein complex 37 4.347784e-24 2.0305326356756755e-22 2.087239 235 0.008626386 88 0.000059296614545454546 1.423525 44 46 0.003487358 GO Cellular Component Seh1-associated complex 193 0.0000117524 0.00010522356062176165 2.006008 47 0.001725277 196 0.0225969413877551 1.48823 15 15 0.001188872 Mouse Phenotype Single KO vertebral transformation 11 1.916911e-47 1.595741275181818e-44 2.183515 432 0.01585787 576 0.0016926507831597224 1.26176 78 92 0.006182135 Mouse Phenotype Single KO thoracic vertebral transformation 16 1.223542e-43 7.00248380875e-41 2.799512 246 0.009030174 675 0.00419381239511111 1.333206 43 48 0.0034081 Mouse Phenotype Single KO abnormal cervical atlas morphology 43 1.910692e-30 4.068885266046512e-28 2.080625 304 0.01115924 485 0.0006023027134226804 1.389015 42 45 0.003328842 Mouse Phenotype Single KO lumbar vertebral transformation 53 1.163788e-27 2.0107182483018866e-25 2.697749 162 0.0059467 1163 0.04140494628374893 1.29241 33 38 0.002615519 Mouse Phenotype Single KO cervical vertebral transformation 65 1.371311e-25 1.9318607426153847e-23 2.419827 182 0.00668086 897 0.014899684433667782 1.331574 34 38 0.002694777 Mouse Phenotype Single KO thin interventricular septum 84 6.885189e-23 7.505675675357143e-21 2.749258 128 0.004698627 737 0.006480689698100407 1.48823 19 19 0.001505905 Mouse Phenotype Single KO abnormal interventricular septum thickness 89 2.802118e-22 2.8830330928089885e-20 2.095408 214 0.007855517 880 0.013708330764772727 1.31518 38 43 0.003011809 Mouse Phenotype Single KO abnormal mesangial cell morphology 99 2.42417e-21 2.242234817171717e-19 2.248679 174 0.006387196 1139 0.03747177051887621 1.313144 30 34 0.002377744 Mouse Phenotype Single KO increased embryonic neuroepithelium apoptosis 101 3.065514e-21 2.779298187920792e-19 2.807265 114 0.004184715 858 0.012340626356643356 1.48823 17 17 0.001347388 Mouse Phenotype Single KO increased neural tube apoptosis 138 2.645619e-18 1.7555024045652174e-16 2.293721 141 0.005175831 486 0.0006053688931687243 1.48823 26 26 0.002060712 Mouse Phenotype Single KO abnormal thymus involution 143 5.472824e-18 3.5045209348251745e-16 2.707292 101 0.00370751 1183 0.043971960442941674 1.48823 13 13 0.001030356 Mouse Phenotype Single KO abnormal facial motor nucleus morphology 153 2.67923e-17 1.603510399346405e-15 2.472195 114 0.004184715 1099 0.03179405386169244 1.48823 14 14 0.001109614 Mouse Phenotype Single KO abnormal renal glomerulus basement membrane thickness 198 7.091125e-15 3.2794662436868686e-13 2.030758 148 0.005432788 815 0.010198256514478527 1.426221 23 24 0.001822937 Mouse Phenotype Single KO abnormal white fat cell number 285 2.007675e-12 6.45062455263158e-11 2.084999 113 0.004148007 778 0.009140768099357327 1.48823 18 18 0.001426647 Mouse Phenotype Single KO testis degeneration 654 3.055999e-8 4.2788658781345567e-7 2.274423 57 0.002092357 1183 0.043971960442941674 1.48823 13 13 0.001030356 Mouse Phenotype thoracic vertebral transformation 26 4.676958e-49 1.7198613630000001e-46 2.750865 286 0.01049849 879 0.0009725222955631399 1.331574 51 57 0.004042165 Mouse Phenotype sacral vertebral transformation 35 2.902746e-44 7.929472716e-42 5.216678 115 0.004221423 1450 0.01748152362 1.417362 20 21 0.001585163 Mouse Phenotype abnormal cervical atlas morphology 52 3.659804e-36 6.729112700769231e-34 2.159373 334 0.01226048 548 0.000037004960698905106 1.403991 50 53 0.003962907 Mouse Phenotype abnormal rib development 75 2.00874e-30 2.560741752e-28 2.530339 201 0.007378313 1700 0.03477666398117647 1.307839 29 33 0.002298486 Mouse Phenotype abnormal fourth pharyngeal arch artery morphology 93 1.311701e-27 1.3485132538709675e-25 2.074447 276 0.01013141 1837 0.049460052298856826 1.322871 24 27 0.001902195 Mouse Phenotype abnormal third pharyngeal arch artery morphology 111 5.877476e-25 5.062571895135135e-23 2.336986 190 0.006974525 1450 0.01748152362 1.417362 20 21 0.001585163 Mouse Phenotype ectopic thymus 126 1.700353e-23 1.2902440502380953e-21 2.720984 134 0.004918875 1669 0.03254275679568604 1.48823 13 13 0.001030356 Mouse Phenotype athymia 128 3.57654e-23 2.6715077296875e-21 2.326783 177 0.00649732 780 0.00039383278953846157 1.48823 26 26 0.002060712 Mouse Phenotype abnormal stapedial artery morphology 133 1.346835e-22 9.682022131578948e-21 2.70222 130 0.004772043 1513 0.023861993714474554 1.413819 19 20 0.001505905 Mouse Phenotype absent stapedial artery 136 1.885357e-22 1.3254336968382352e-20 2.715633 128 0.004698627 1638 0.03132741033150183 1.409902 18 19 0.001426647 Mouse Phenotype increased embryonic neuroepithelium apoptosis 138 2.771254e-22 1.9199970647826088e-20 2.600267 137 0.005028999 816 0.0005606208347426471 1.48823 25 25 0.001981454 Mouse Phenotype increased neural tube apoptosis 139 2.79093e-22 1.9197181100719423e-20 2.228098 186 0.006827693 502 0.000015433114795219123 1.45362 42 43 0.003328842 Mouse Phenotype abnormal thymus involution 146 9.474773e-22 6.204678400890411e-20 2.594265 134 0.004918875 1290 0.009632492562790697 1.423525 22 23 0.001743679 Mouse Phenotype cervical vertebral transformation 147 1.256736e-21 8.173913534693878e-20 2.087951 209 0.007671977 1055 0.0029236550181042653 1.34979 39 43 0.003091068 Mouse Phenotype abnormal third pharyngeal arch morphology 171 5.614474e-20 3.1391804628070176e-18 2.012282 210 0.007708685 1727 0.039186121120440065 1.328777 25 28 0.001981454 Mouse Phenotype absent metanephros 209 2.593313e-18 1.1863476360287083e-16 2.692272 104 0.003817635 1797 0.04499542273622704 1.48823 12 12 0.0009510977 Mouse Phenotype absent ureter 231 3.406215e-17 1.4098191175324674e-15 2.016978 177 0.00649732 1099 0.0038347509352138305 1.430991 25 26 0.001981454 Mouse Phenotype colon polyps 241 6.940054e-17 2.753272045394191e-15 2.838798 87 0.003193598 1429 0.017148774191042684 1.48823 15 15 0.001188872 Mouse Phenotype aorta dilation 264 8.142784e-16 2.9489832509090907e-14 2.664411 90 0.003303722 1638 0.03132741033150183 1.409902 18 19 0.001426647 Mouse Phenotype abnormal facial motor nucleus morphology 306 1.109762e-14 3.4674622490196077e-13 2.222617 118 0.004331547 1354 0.012156458435007384 1.48823 16 16 0.00126813