# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process DNA replication-dependent nucleosome assembly 8 1.05879e-31 1.7415772012499999e-28 25.73454 30 0.01028101 131 0.001953964842442748 3.115653 15 32 0.005309735 GO Biological Process negative regulation of megakaryocyte differentiation 16 2.176662e-24 1.790168453625e-21 35.6366 20 0.00685401 239 0.028600833230543934 3.323363 9 18 0.003185841 GO Biological Process negative regulation of gene expression, epigenetic 17 7.216298e-24 5.585839140117647e-21 4.430016 70 0.02398903 85 0.00012625642508235294 2.215575 38 114 0.01345133 GO Biological Process chromatin silencing at rDNA 25 1.167727e-22 6.146447837200001e-20 11.66663 31 0.01062371 134 0.0023282366002238806 2.9541 16 36 0.005663717 GO Biological Process regulation of gene expression, epigenetic 34 1.013292e-20 3.9217380670588234e-18 2.662552 119 0.04078136 72 0.000026647157763888888 1.849291 69 248 0.02442478 GO Biological Process regulation of megakaryocyte differentiation 44 3.037485e-18 9.0841511625e-16 3.923721 60 0.02056203 52 0.0000029665978575 2.798621 32 76 0.01132743 GO Biological Process macromolecular complex disassembly 56 7.984422e-17 1.8761965910357144e-14 2.6965 93 0.03187114 252 0.034044045758730164 1.600782 46 191 0.01628319 GO Biological Process protein heterotetramerization 61 3.066417e-16 6.614914967704917e-14 5.714029 36 0.01233722 172 0.008797602461627906 2.568053 17 44 0.006017699 GO Biological Process response to topologically incorrect protein 66 8.693406e-16 1.733280750818182e-13 2.710044 86 0.02947224 102 0.00042795712700980396 1.883239 51 180 0.0180531 GO Biological Process DNA conformation change 68 9.666781e-16 1.8706642820441175e-13 2.228487 124 0.04249486 118 0.0010330850992457629 1.655768 70 281 0.02477876 GO Biological Process nucleosome organization 69 1.054927e-15 2.01185281057971e-13 2.738835 84 0.02878684 79 0.00010329665087341773 1.982357 51 171 0.0180531 GO Biological Process protein-DNA complex subunit organization 70 1.071566e-15 2.0143909991428571e-13 2.278504 118 0.04043866 106 0.0005291973783396227 1.728149 65 250 0.02300885 GO Biological Process chromatin silencing 76 1.658092e-15 2.87089903e-13 4.319833 45 0.01542152 153 0.004909779431895424 2.055688 30 97 0.01061947 GO Biological Process positive regulation of gene expression, epigenetic 80 2.235726e-15 3.6774898042500007e-13 4.198639 46 0.01576422 196 0.012855174803061226 2.077102 25 80 0.008849558 GO Biological Process gene silencing 87 1.236354e-14 1.8700209524137933e-12 2.711583 79 0.02707334 102 0.00042795712700980396 1.883239 51 180 0.0180531 GO Biological Process nucleosome assembly 94 4.361745e-14 6.105978984574468e-12 2.795257 72 0.02467443 90 0.00016703040364444445 2.059549 44 142 0.01557522 GO Biological Process chromatin assembly or disassembly 100 7.743837e-14 1.0190115108299999e-11 2.543124 83 0.02844414 101 0.0003025182442079208 1.904399 51 178 0.0180531 GO Biological Process regulation of gene silencing 110 2.278612e-13 2.7258413916363636e-11 2.844742 66 0.02261823 98 0.00026367091126530614 2.080273 41 131 0.01451327 GO Biological Process cellular response to topologically incorrect protein 111 2.347612e-13 2.783083451171171e-11 2.816315 67 0.02296093 135 0.0023861994492592594 1.912727 40 139 0.01415929 GO Biological Process regulation of chromatin organization 112 2.367818e-13 2.7819747376785713e-11 2.274645 99 0.03392735 168 0.007850863051190475 1.778105 42 157 0.01486726 GO Cellular Component nuclear nucleosome 20 6.818324e-23 5.891031936e-21 11.26437 32 0.01096642 33 0.0014190922472727273 2.824858 17 40 0.006017699 GO Cellular Component nucleosome 28 4.018379e-17 2.4799138971428576e-15 4.596813 47 0.01610692 20 0.000006266519424 2.405482 38 105 0.01345133 GO Cellular Component ficolin-1-rich granule lumen 30 5.774573e-15 3.326154048e-13 3.121916 65 0.02227553 35 0.002454652635428571 1.929695 36 124 0.01274336 GO Cellular Component DNA packaging complex 35 1.901489e-14 9.387922834285714e-13 3.811603 48 0.01644962 23 0.00001209505335652174 2.314485 39 112 0.01380531 GO Cellular Component COPI-coated vesicle 39 7.021455e-14 3.111044676923077e-12 6.843559 26 0.008910212 64 0.027386802000000002 2.889881 10 23 0.003539823 GO Cellular Component uropod 68 1.945305e-9 4.9433632941176464e-8 7.224942 16 0.005483208 66 0.03364625454545454 3.579006 7 13 0.002477876 GO Cellular Component protein-DNA complex 73 4.500852e-9 1.0654071583561645e-7 2.107141 75 0.02570254 28 0.00006449642742857143 1.875561 57 202 0.02017699 GO Cellular Component sorting endosome 74 5.357966e-9 1.2511574659459458e-7 5.82752 18 0.006168609 58 0.012018129765517242 5.538938 5 6 0.001769912 GO Molecular Function cadherin binding 12 3.845056e-16 1.3528188693333333e-13 2.021505 159 0.05448938 9 0.00009653063522222223 1.749138 80 304 0.02831858 GO Molecular Function nucleosomal DNA binding 39 5.783602e-9 6.261119908717949e-7 3.667078 29 0.009938314 34 0.026980119788235293 2.456399 17 46 0.006017699 GO Molecular Function 1-acylglycerol-3-phosphate O-acyltransferase activity 44 2.935061e-8 0.0000028163244413636364 3.951942 24 0.008224812 15 0.005759345601333333 3.848104 11 19 0.003893805 GO Molecular Function acylglycerol O-acyltransferase activity 45 3.215163e-8 0.0000030165373746666667 3.680053 26 0.008910212 24 0.013953943969166667 3.08598 13 28 0.00460177 GO Molecular Function lysophosphatidic acid acyltransferase activity 46 3.439919e-8 0.000003157247395217391 3.917719 24 0.008224812 20 0.008291623798 3.655699 11 20 0.003893805 GO Molecular Function heat shock protein binding 54 5.638599e-8 0.0000044085490700000006 2.29932 53 0.01816313 26 0.018587322523076922 1.962367 31 105 0.01097345 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 16 1.73319e-25 9.91926301875e-23 6.294127 54 0.01850583 87 0.013054871767816093 2.979567 13 29 0.00460177 Mouse Phenotype Single KO abnormal third pharyngeal arch artery morphology 23 9.163718e-24 3.648355031565217e-21 8.179158 41 0.01405072 70 0.009522584068 4.43115 8 12 0.002831858 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 24 1.055334e-23 4.0265389324999995e-21 5.631232 55 0.01884853 106 0.0257729293754717 2.65869 14 35 0.004955752 Mouse Phenotype Single KO abnormal platelet activation 28 3.171931e-23 1.03733472025e-20 3.834714 80 0.02741604 58 0.004432758451034483 2.18951 28 85 0.009911504 Mouse Phenotype Single KO abnormal platelet aggregation 31 4.96807e-23 1.467503773870968e-20 3.887721 78 0.02673064 64 0.00609325523234375 2.215575 26 78 0.00920354 Mouse Phenotype Single KO abnormal platelet physiology 44 7.021977e-21 1.4613691679318183e-18 3.157433 92 0.03152844 53 0.003310094820566038 2.054442 34 110 0.0120354 Mouse Phenotype Single KO abnormal third pharyngeal arch morphology 49 1.156796e-19 2.161792035102041e-17 6.090756 42 0.01439342 107 0.02564457216542056 3.518855 9 17 0.003185841 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 54 3.695214e-18 6.266124925555556e-16 3.490205 69 0.02364633 91 0.015164857386813188 2.382788 19 53 0.006725664 Mouse Phenotype Single KO abnormal hemostasis 90 4.683679e-14 4.765383178111111e-12 2.077867 128 0.04386566 102 0.02370649445784314 1.601257 53 220 0.01876106 Mouse Phenotype Single KO abnormal platelet cell number 91 5.513112e-14 5.54764467956044e-12 2.108745 123 0.04215216 30 0.00009245279584666667 1.894627 61 214 0.02159292 Mouse Phenotype Single KO abnormal blood coagulation 94 7.746539e-14 7.546282725851063e-12 2.069502 127 0.04352296 111 0.03192060078828829 1.585457 52 218 0.01840708 Mouse Phenotype Single KO abnormal erythropoiesis 105 3.925065e-13 3.423030495714286e-11 2.417969 86 0.02947224 14 0.00001860760612357143 2.416991 40 110 0.01415929 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 106 4.902926e-13 4.235480507735849e-11 2.278917 96 0.03289925 46 0.0014577448327608696 1.861083 49 175 0.01734513 Mouse Phenotype Single KO thrombocytopenia 136 3.556995e-11 2.3949561187500005e-9 2.143746 92 0.03152844 56 0.0038253253037499996 1.868034 43 153 0.01522124 Mouse Phenotype Single KO extramedullary hematopoiesis 140 8.589425e-11 5.618097480357143e-9 2.511235 64 0.02193283 82 0.011937109868292682 1.924052 33 114 0.01168142 Mouse Phenotype Single KO abnormal dorsal aorta morphology 163 1.710929e-9 9.611642241104295e-8 2.132371 77 0.02638794 79 0.011192485188607595 2.158028 25 77 0.008849558 Mouse Phenotype Single KO abnormal cell chemotaxis 193 6.248351e-9 2.964567363056995e-7 2.277659 62 0.02124743 90 0.014939798116666665 1.916173 32 111 0.01132743 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 288 5.801616e-7 0.00001844631865 2.46528 39 0.01336532 108 0.028078745002777777 2.119246 22 69 0.007787611 Mouse Phenotype Single KO increased interleukin-12b secretion 655 0.001056172 0.014765445807633589 3.637195 9 0.003084304 130 0.048006988313076926 3.877257 7 12 0.002477876 Mouse Phenotype abnormal platelet activation 26 8.191122e-25 3.012127593923077e-22 3.828569 86 0.02947224 82 0.004799262879512195 2.060485 31 100 0.01097345 Mouse Phenotype abnormal platelet aggregation 27 9.741378e-25 3.449530187333333e-22 3.855859 85 0.02912954 74 0.003799032341351351 2.121295 30 94 0.01061947 Mouse Phenotype abnormal embryonic erythropoiesis 34 6.449561e-23 1.8136544917941177e-20 5.521077 54 0.01850583 132 0.020332632652272725 2.787337 13 31 0.00460177 Mouse Phenotype abnormal embryonic erythrocyte morphology 43 1.769087e-21 3.933544373720931e-19 4.933856 56 0.01919123 137 0.021262659048175182 2.556433 15 39 0.005309735 Mouse Phenotype abnormal platelet physiology 45 9.613168e-21 2.0424777610666667e-18 2.989064 99 0.03392735 81 0.004516134808888889 1.913451 38 132 0.01345133 Mouse Phenotype abnormal third pharyngeal arch artery morphology 57 5.026572e-19 8.431413138947368e-17 5.282191 46 0.01576422 92 0.007406132466847826 3.481618 11 21 0.003893805 Mouse Phenotype decreased pre-B cell number 67 2.854315e-17 4.073150106716417e-15 2.691488 96 0.03289925 160 0.032277858316875005 1.853414 29 104 0.01026549 Mouse Phenotype abnormal erythropoiesis 71 3.444269e-17 4.6381205505633804e-15 2.484757 110 0.03769705 19 6.87005655e-7 2.319663 52 149 0.01840708 Mouse Phenotype abnormal third pharyngeal arch morphology 86 1.062586e-15 1.1813238076744185e-13 4.204564 47 0.01610692 145 0.024880544143448275 2.848597 12 28 0.004247788 Mouse Phenotype extramedullary hematopoiesis 87 1.196721e-15 1.3151551127586207e-13 2.388522 107 0.03666895 67 0.002347478081641791 1.823102 48 175 0.01699115 Mouse Phenotype decreased erythroid progenitor cell number 101 1.117849e-14 1.058193493960396e-12 2.827384 74 0.02535984 93 0.007808228132903225 2.186423 25 76 0.008849558 Mouse Phenotype abnormal pre-B cell morphology 105 2.299188e-14 2.0935749017142857e-12 2.332872 102 0.03495545 155 0.031382440403225804 1.749138 35 133 0.01238938 Mouse Phenotype decreased fibroblast proliferation 116 5.993999e-13 4.940398658534483e-11 2.581298 75 0.02570254 112 0.012324521683928572 1.840632 36 130 0.01274336 Mouse Phenotype lung inflammation 121 1.164419e-12 9.200834759504133e-11 2.026282 121 0.04146676 134 0.020636790613432834 1.588156 54 226 0.01911504 Mouse Phenotype abnormal mean corpuscular hemoglobin 134 9.863031e-12 7.037346223208955e-10 2.13662 98 0.03358465 65 0.0021506822293846156 1.806175 50 184 0.01769912 Mouse Phenotype abnormal fibroblast proliferation 185 2.071816e-9 1.0707369068108107e-7 2.026319 86 0.02947224 79 0.00428186480392405 1.798526 46 170 0.01628319 Mouse Phenotype abnormal liver development 192 3.261648e-9 1.6241987774999997e-7 2.337756 61 0.02090473 142 0.02305274255915493 2.255139 19 56 0.006725664 Mouse Phenotype interstitial pneumonia 228 2.560226e-8 0.0000010736105607894736 4.132641 23 0.007882111 170 0.037233430420588236 3.021239 10 22 0.003539823 Mouse Phenotype abnormal cell chemotaxis 234 3.406307e-8 0.0000013917821037179489 2.059787 70 0.02398903 156 0.03122970718461538 1.719782 37 143 0.01309735 Mouse Phenotype abnormal phospholipid level 390 0.00001052494 0.0002580229521538461 2.254313 36 0.01233722 129 0.019450046062790695 2.150411 22 68 0.007787611