# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process multi-organism metabolic process 159 3.121971e-38 2.5837746156603774e-36 2.243818 324 0.01768366 653 0.009974006118836141 1.224367 107 147 0.009585237 GO Biological Process viral gene expression 198 4.34649e-32 2.8886596924242423e-30 2.30841 254 0.01386312 909 0.04054538340814082 1.205266 91 127 0.00815193 GO Biological Process cellular response to epidermal growth factor stimulus 264 7.057855e-26 3.517966437310606e-24 2.3799 190 0.01037005 930 0.045487719911827956 1.372219 31 38 0.002777031 GO Biological Process positive regulation of mRNA catabolic process 282 1.211935e-24 5.65526690248227e-23 2.869867 129 0.007040716 858 0.030575734015151512 1.480226 22 25 0.001970796 GO Biological Process regulation of membrane permeability 327 2.927213e-22 1.1779570601529054e-20 2.024551 232 0.01266237 371 0.00021070158877897573 1.391346 67 81 0.006001971 GO Biological Process regulation of mitochondrial membrane permeability 330 5.332824e-22 2.1265039701818186e-20 2.093738 211 0.01151621 457 0.0007770323273085339 1.382527 60 73 0.005374899 GO Biological Process mitochondrial transmembrane transport 397 7.099066e-19 2.3530632114357683e-17 2.096688 178 0.009715097 896 0.03851264797209821 1.25649 62 83 0.005554063 GO Biological Process tRNA transport 425 5.407371e-18 1.6742492938588235e-16 2.646362 105 0.005730815 712 0.01406017341544944 1.441778 30 35 0.00268745 GO Biological Process posttranscriptional gene silencing by RNA 549 2.555193e-14 6.124550944808742e-13 2.045585 139 0.007586508 945 0.046961282205291006 1.319274 40 51 0.003583266 GO Biological Process tRNA export from nucleus 692 7.373227e-12 1.4020851747543352e-10 2.337696 83 0.004530073 626 0.007967566394408945 1.478187 29 33 0.002597868 GO Biological Process positive regulation of transcription from RNA polymerase I promoter 700 8.675905e-12 1.6309461985e-10 2.777532 60 0.003274752 779 0.022307562482670087 1.529159 20 22 0.001791633 GO Biological Process cytoplasmic mRNA processing body assembly 945 2.016471e-9 2.8079091946031748e-8 2.563226 53 0.002892697 757 0.0200866311664465 1.682075 13 13 0.001164561 GO Biological Process regulation of endoplasmic reticulum unfolded protein response 948 2.104796e-9 2.921625586919831e-8 2.010667 89 0.004857548 727 0.015457339717744155 1.535807 21 23 0.001881215 GO Biological Process glutamine metabolic process 998 5.183016e-9 6.833998751903808e-8 2.189747 69 0.003765964 727 0.015457339717744155 1.535807 21 23 0.001881215 GO Cellular Component ficolin-1-rich granule lumen 68 2.872938e-25 7.300642447058823e-24 2.027058 265 0.01446349 74 0.004641889037837838 1.261556 93 124 0.008331094 GO Molecular Function peptide disulfide oxidoreductase activity 275 7.866741e-7 0.000012077592909818183 2.724937 32 0.001746534 116 0.04205719822413793 1.682075 13 13 0.001164561 GO Molecular Function CoA hydrolase activity 276 8.65402e-7 0.000013238142188405795 2.431927 39 0.002128589 108 0.02778767157037037 1.593544 18 19 0.00161247 Mouse Phenotype Single KO decreased circulating free fatty acid level 75 1.490443e-31 1.8197315401333336e-29 2.132061 297 0.01621002 409 0.004335899949633252 1.302251 72 93 0.006449879 Mouse Phenotype Single KO abnormal cell adhesion 81 1.995252e-29 2.2556200696296296e-27 2.192315 259 0.01413601 436 0.005916715741284403 1.368468 48 59 0.004299919 Mouse Phenotype Single KO increased circulating tumor necrosis factor level 139 5.728195e-22 3.7736029938848923e-20 2.292507 172 0.009387621 533 0.015142544347467169 1.329382 49 62 0.004389501 Mouse Phenotype Single KO abnormal lactate dehydrogenase level 297 8.106826e-14 2.499468204781145e-12 2.007238 140 0.007641087 237 0.000228864610164557 1.525603 39 43 0.003493684 Mouse Phenotype Single KO renal glomerulus hypertrophy 462 2.359098e-10 4.675813936363636e-9 2.059705 94 0.005130444 690 0.04142529921594203 1.513867 18 20 0.00161247 Mouse Phenotype Single KO pancytopenia 639 2.131319e-8 3.054223487167449e-7 2.279935 58 0.003165593 672 0.039402898035714284 1.576945 15 16 0.001343725 Mouse Phenotype Single KO increased osteosarcoma incidence 734 1.827136e-7 0.0000022794392850136243 2.327678 48 0.002619801 699 0.04286569861945637 1.682075 11 11 0.0009853982 Mouse Phenotype decreased circulating free fatty acid level 93 5.383639e-38 5.534728223548387e-36 2.06946 387 0.02112215 281 0.000020909675630604983 1.356968 96 119 0.008599839 Mouse Phenotype abnormal cell adhesion 122 1.129346e-32 8.850555004918031e-31 2.095055 321 0.01751992 336 0.00007987635010714285 1.416484 64 76 0.005733226 Mouse Phenotype increased circulating tumor necrosis factor level 186 1.118413e-23 5.749003598387097e-22 2.0513 240 0.01309901 1129 0.04258549004428698 1.218646 71 98 0.006360297 Mouse Phenotype increased susceptibility to endotoxin shock 192 3.337518e-23 1.6619796665624997e-21 2.212213 197 0.0107521 721 0.007980422157836339 1.313401 57 73 0.005106154 Mouse Phenotype early cellular replicative senescence 206 3.36257e-22 1.560656882038835e-20 2.155959 199 0.01086126 1021 0.03050206218805093 1.267317 55 73 0.004926991 Mouse Phenotype abnormal lactate dehydrogenase level 285 3.498036e-17 1.1734990244210526e-15 2.047574 170 0.009278463 310 0.0000371672463483871 1.517165 46 51 0.004120756 Mouse Phenotype increased liver adenoma incidence 360 5.052271e-15 1.3417989730833334e-13 2.644725 86 0.004693811 982 0.02603376568228106 1.441778 24 28 0.00214996 Mouse Phenotype increased lactate dehydrogenase level 441 8.981214e-13 1.947151633877551e-11 2.249696 98 0.005348761 1110 0.04092093357027027 1.401729 25 30 0.002239541 Mouse Phenotype polyploidy 498 1.074384e-11 2.062687836144578e-10 2.168778 96 0.005239603 832 0.014245257962740386 1.457798 26 30 0.002329123 Mouse Phenotype abnormal circulating lactate dehydrogenase level 686 2.86443e-9 3.9922471180758015e-8 3.912112 28 0.001528217 1023 0.030581694970674488 1.682075 11 11 0.0009853982 Mouse Phenotype abnormal primordial ovarian follicle number 736 9.391761e-9 1.2200356918614132e-7 2.708941 44 0.002401485 1023 0.030581694970674488 1.682075 11 11 0.0009853982 Mouse Phenotype increased cellular sensitivity to ultraviolet irradiation 798 3.504737e-8 4.199096548496241e-7 2.106929 67 0.003656806 832 0.014245257962740386 1.457798 26 30 0.002329123 Mouse Phenotype peritoneal inflammation 892 2.398917e-7 0.000002571305542264574 2.165088 55 0.003001856 746 0.009110079657908847 1.593544 18 19 0.00161247 Mouse Phenotype decreased primordial ovarian follicle number 978 9.221526e-7 0.00000901503170613497 2.458314 38 0.002074009 1155 0.04557831346233766 1.682075 10 10 0.0008958165 Mouse Phenotype joint swelling 1007 0.000001578931 0.000014991220745779543 2.017221 56 0.003056435 916 0.02029657302510917 1.682075 12 12 0.00107498 Mouse Phenotype increased circulating lactate dehydrogenase level 1036 0.000002242486 0.00002069537514092664 3.286675 22 0.001200742 1155 0.04557831346233766 1.682075 10 10 0.0008958165 Mouse Phenotype decreased liver function 1167 0.000009923852 0.00008130415507455013 2.297547 35 0.001910272 1023 0.030581694970674488 1.682075 11 11 0.0009853982