# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process multi-organism metabolic process 197 2.524666e-31 1.6863999946192894e-29 2.049822 324 0.01615477 775 0.01109487926 1.228559 104 147 0.009618052 GO Biological Process viral gene expression 210 1.475561e-28 9.246146285238096e-27 2.158645 260 0.0129637 978 0.033069212840490796 1.216932 89 127 0.008230833 GO Biological Process cotranslational protein targeting to membrane 211 1.852243e-28 1.1551500301895734e-26 2.359748 214 0.01067012 719 0.006702220943810849 1.293531 73 98 0.006751133 GO Biological Process translational initiation 218 1.095689e-27 6.613840161009174e-26 2.003732 301 0.01500798 734 0.00820651891825613 1.238637 102 143 0.00943309 GO Biological Process protein targeting to ER 220 1.721668e-27 1.029792236909091e-25 2.292078 219 0.01091943 901 0.022962922356270808 1.255109 73 101 0.006751133 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 228 2.005924e-26 1.1577172770175439e-24 2.02179 280 0.01396091 786 0.011367492555343514 1.26013 82 113 0.007583464 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 230 3.18071e-26 1.8197809952173912e-24 2.342997 199 0.009922218 911 0.02527784677277717 1.26464 67 92 0.006196245 GO Biological Process establishment of protein localization to endoplasmic reticulum 237 6.752978e-26 3.749469936793249e-24 2.155805 235 0.01171719 762 0.010026206476509186 1.273449 77 105 0.007121058 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 249 1.611522e-24 8.516473091566266e-23 2.117637 231 0.01151775 1012 0.03725106152865612 1.221451 83 118 0.007675946 GO Biological Process postreplication repair 604 5.632292e-13 1.2270750070860926e-11 2.003508 131 0.006531711 951 0.029071095261829657 1.343346 41 53 0.003791732 GO Biological Process histone H2A ubiquitination 638 2.588032e-12 5.3379174119122256e-11 2.374531 84 0.004188273 797 0.012480023668130488 1.578655 20 22 0.001849625 GO Biological Process global genome nucleotide-excision repair 888 2.141478e-9 3.1733906533783786e-8 2.047337 85 0.004238133 856 0.018434636795560747 1.465189 27 32 0.002496994 GO Biological Process peptidyl-lysine dimethylation 944 6.671715e-9 9.300116280190678e-8 2.496012 52 0.00259274 875 0.019949404932571427 1.736521 12 12 0.001109775 GO Biological Process regulation of Golgi organization 976 1.149673e-8 1.5500560457991803e-7 2.362764 56 0.002792182 1021 0.039321618115572964 1.620753 14 15 0.001294738 GO Biological Process histone H2A monoubiquitination 980 1.23058e-8 1.6523675734693877e-7 2.168347 67 0.003340646 845 0.017663925252071003 1.634373 16 17 0.0014797 GO Biological Process histone H3-K9 methylation 1644 0.00002328089 0.00018634624787712895 2.148675 37 0.001844834 1080 0.04877891433611111 1.736521 10 10 0.0009248127 GO Cellular Component telomerase holoenzyme complex 74 1.584899e-24 3.700953340540541e-23 4.065301 80 0.003988831 153 0.04545829270588236 1.499723 19 22 0.001757144 GO Cellular Component cytoplasmic side of endoplasmic reticulum membrane 317 0.00001766265 0.00009628094384858044 2.263636 34 0.001695253 151 0.04581416646357616 1.736521 10 10 0.0009248127 Human Phenotype Tarsal synostosis 368 1.094631e-9 1.984911049728261e-8 2.039616 89 0.004437575 232 0.038154718327586205 1.736521 12 12 0.001109775 Mouse Phenotype Single KO abnormal conotruncus morphology 95 8.186048e-21 7.890488582736843e-19 2.390303 149 0.007429198 489 0.0047364648040899805 1.736521 15 15 0.001387219 Mouse Phenotype Single KO abnormal conotruncal ridge morphology 98 1.377299e-20 1.2869313207142856e-18 2.392265 147 0.007329477 543 0.007411090628913443 1.736521 14 14 0.001294738 Mouse Phenotype Single KO increased fibroblast apoptosis 135 1.566065e-17 1.0622560892592594e-15 2.365988 126 0.006282409 884 0.04785261745248869 1.389217 28 35 0.002589476 Mouse Phenotype Single KO delayed intramembranous bone ossification 144 4.502876e-17 2.863391356388889e-15 2.145935 151 0.007528919 868 0.04246139933294931 1.499723 19 22 0.001757144 Mouse Phenotype Single KO abnormal neural fold formation 160 4.961146e-16 2.8393258701250003e-14 2.03959 159 0.007927802 501 0.005413996743113772 1.550465 25 28 0.002312032 Mouse Phenotype Single KO increased osteosarcoma incidence 178 9.882086e-15 5.083722556292134e-13 3.012445 68 0.003390507 759 0.02780314936363636 1.736521 11 11 0.001017294 Mouse Phenotype Single KO disorganized myocardium 186 1.765471e-14 8.691622552150538e-13 2.08767 134 0.006681292 582 0.010012430576975945 1.504985 26 30 0.002404513 Mouse Phenotype Single KO lordosis 191 2.529392e-14 1.2126514420942408e-12 2.117384 128 0.00638213 705 0.02307009384539007 1.456437 26 31 0.002404513 Mouse Phenotype Single KO increased body temperature 204 6.741451e-14 3.0260522944607844e-12 2.153019 119 0.005933387 802 0.033910985654613465 1.42079 27 33 0.002496994 Mouse Phenotype Single KO abnormal chondrocyte physiology 241 7.880874e-13 2.994405112780083e-11 2.050512 122 0.006082968 824 0.036536096614077675 1.469364 22 26 0.002034588 Mouse Phenotype Single KO abnormal response to stress-induced hyperthermia 356 3.760308e-10 9.672230437078652e-9 2.790323 50 0.00249302 864 0.042429945149305565 1.736521 10 10 0.0009248127 Mouse Phenotype Single KO enlarged esophagus 587 3.01248e-7 0.000004699366160136287 2.132319 56 0.002792182 864 0.042429945149305565 1.736521 10 10 0.0009248127 Mouse Phenotype increased fibroblast apoptosis 117 2.804546e-26 2.291817462051282e-24 2.544411 170 0.008476266 924 0.014651725477272727 1.374746 38 48 0.003514288 Mouse Phenotype increased pulmonary respiratory rate 193 8.340511e-20 4.131794076217617e-18 2.290627 154 0.0076785 1165 0.037912475402575106 1.389217 28 35 0.002589476 Mouse Phenotype abnormal neural fold formation 194 9.639904e-20 4.750882584742268e-18 2.141565 178 0.00887515 777 0.006629644159073359 1.48115 29 34 0.002681957 Mouse Phenotype increased body temperature 288 7.720082e-15 2.5629063889583333e-13 2.092442 137 0.006830874 921 0.014627011599348533 1.438832 29 35 0.002681957 Mouse Phenotype decreased classified tumor incidence 324 1.194214e-13 3.524037053703704e-12 2.267144 104 0.005185481 1214 0.04399023975617792 1.426428 23 28 0.002127069 Mouse Phenotype persistent right dorsal aorta 397 1.297506e-11 3.1247997143576826e-10 2.012282 114 0.005684085 891 0.012171571494949494 1.634373 16 17 0.0014797 Mouse Phenotype abnormal circulating lactate dehydrogenase level 402 1.850946e-11 4.4022126134328355e-10 4.212072 33 0.001645393 1020 0.021601589108823527 1.736521 11 11 0.001017294 Mouse Phenotype abnormal response to stress-induced hyperthermia 479 3.760308e-10 7.505700373277662e-9 2.790323 50 0.00249302 1132 0.03381348158745583 1.736521 10 10 0.0009248127 Mouse Phenotype increased liver adenoma incidence 691 5.314136e-8 7.352887741823444e-7 2.022754 72 0.003589948 1214 0.04399023975617792 1.426428 23 28 0.002127069 Mouse Phenotype abnormal ceramide level 797 2.94476e-7 0.0000035326035583437893 2.00687 65 0.003240925 679 0.0035420055154639176 1.649695 19 20 0.001757144 Mouse Phenotype increased circulating lactate dehydrogenase level 1087 0.000009045127 0.00007955884015363385 3.002516 22 0.001096929 1132 0.03381348158745583 1.736521 10 10 0.0009248127