# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of adaptive immune response 197 5.343915e-31 3.5695724611675133e-29 2.005807 337 0.02277489 433 0.0010550059583833717 1.341398 90 131 0.009358428 GO Biological Process tumor necrosis factor-mediated signaling pathway 266 7.078734e-24 3.501844387443609e-22 2.117451 224 0.0151382 794 0.020396383707808562 1.266061 83 128 0.00863055 GO Biological Process nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 270 1.660389e-23 8.092244018888889e-22 2.862708 123 0.008312496 588 0.005869296685204081 1.627067 25 30 0.002599563 GO Biological Process regulation of antigen receptor-mediated signaling pathway 289 2.33667e-22 1.0639529595155709e-20 2.318542 171 0.0115564 583 0.005775193931732417 1.47357 40 53 0.004159301 GO Biological Process nucleotide-binding oligomerization domain containing signaling pathway 302 1.167346e-21 5.086458945033113e-20 2.796001 117 0.007907008 641 0.008846865498127925 1.615846 24 29 0.002495581 GO Biological Process B cell receptor signaling pathway 308 1.976498e-21 8.444395188961039e-20 2.470688 144 0.009731702 816 0.024010820919117645 1.506199 27 35 0.002807528 GO Biological Process cytoplasmic pattern recognition receptor signaling pathway 339 6.41459e-20 2.489958401474926e-18 2.600359 121 0.008177333 816 0.024010820919117645 1.506199 27 35 0.002807528 GO Biological Process Fc receptor mediated stimulatory signaling pathway 342 7.516306e-20 2.892019609766082e-18 2.026691 204 0.01378658 866 0.030954116275981523 1.337315 50 73 0.005199127 GO Biological Process Fc-gamma receptor signaling pathway 348 9.955968e-20 3.76467192275862e-18 2.037366 200 0.01351625 891 0.03474777945791246 1.327686 51 75 0.005303109 GO Biological Process negative regulation of antigen receptor-mediated signaling pathway 404 2.872749e-17 9.357055468069309e-16 2.923029 85 0.005744408 937 0.04289352299146212 1.597484 18 22 0.001871686 GO Biological Process organelle transport along microtubule 448 1.292437e-15 3.796245197098214e-14 2.009464 160 0.010813 437 0.001116430337368421 1.479152 50 66 0.005199127 GO Biological Process regulation of interferon-gamma-mediated signaling pathway 458 2.912452e-15 8.367894294323143e-14 2.900423 75 0.005068595 775 0.019291331710967745 1.627067 20 24 0.002079651 GO Biological Process regulation of B cell receptor signaling pathway 519 1.229603e-13 3.117600361657033e-12 2.40436 92 0.006217477 541 0.00403695499168207 1.76653 19 21 0.001975668 GO Biological Process mitotic recombination 539 3.015999e-13 7.363178263636364e-12 2.842942 66 0.004460364 933 0.04280095211682744 1.644194 16 19 0.00166372 GO Biological Process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 558 8.363257e-13 1.9722598362544805e-11 2.21083 102 0.006893289 863 0.03102883051216686 1.477552 28 37 0.002911511 GO Biological Process regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 573 1.365754e-12 3.1364671703315884e-11 2.104409 112 0.007569102 652 0.00961711589064417 1.485583 35 46 0.003639389 GO Biological Process response to cadmium ion 693 1.770097e-10 3.361140897979798e-9 2.01986 100 0.006758127 859 0.03062877503958091 1.380201 41 58 0.004263284 GO Biological Process somatic recombination of immunoglobulin gene segments 710 2.510304e-10 4.652547934647887e-9 2.726831 53 0.003581807 687 0.012035399534934496 1.686233 19 22 0.001975668 GO Biological Process vesicle transport along microtubule 766 8.171131e-10 1.4037064337989556e-8 2.080774 86 0.005811989 863 0.03102883051216686 1.477552 28 37 0.002911511 GO Biological Process cellular response to osmotic stress 788 1.361943e-9 2.2743411087563453e-8 2.087892 83 0.005609245 914 0.039550742229759295 1.534091 22 28 0.002287616 GO Cellular Component clathrin coat 93 6.31537e-15 1.1734364903225805e-13 2.109964 135 0.009123471 109 0.01939500858715596 1.434475 36 49 0.003743371 GO Cellular Component AP-type membrane coat adaptor complex 120 1.805309e-12 2.5996449599999996e-11 2.180935 102 0.006893289 91 0.009048402356043957 1.485583 35 46 0.003639389 GO Molecular Function tumor necrosis factor receptor binding 122 3.196444e-10 1.106179226885246e-8 2.271835 74 0.005001014 89 0.004530030004269663 1.647405 27 32 0.002807528 GO Molecular Function tumor necrosis factor receptor superfamily binding 133 7.506114e-10 2.3827679178947367e-8 2.019387 93 0.006285058 87 0.0045405547528735634 1.537059 37 47 0.003847354 Mouse Phenotype Single KO abnormal T cell physiology 26 7.634167e-135 2.6886948930384612e-132 2.061389 1376 0.09299182 26 2.517539645076923e-17 1.376034 370 525 0.03847354 Mouse Phenotype Single KO abnormal T cell activation 53 6.132954e-79 1.0596124486415095e-76 2.097865 784 0.05298371 148 3.770563040810811e-7 1.324173 196 289 0.02038058 Mouse Phenotype Single KO autoimmune response 55 2.350163e-74 3.912807743818182e-72 2.074771 758 0.0512266 159 6.199542401257862e-7 1.297721 220 331 0.02287616 Mouse Phenotype Single KO abnormal immune tolerance 59 4.612034e-72 7.158033108135593e-70 2.039811 765 0.05169967 161 6.580345326708074e-7 1.293951 224 338 0.02329209 Mouse Phenotype Single KO abnormal self tolerance 61 6.30187e-72 9.460036654098361e-70 2.04379 760 0.05136176 162 6.824502958641976e-7 1.29579 221 333 0.02298014 Mouse Phenotype Single KO abnormal T cell proliferation 65 7.506934e-69 1.0575537636615386e-66 2.064864 710 0.0479827 206 0.0000059539747480582525 1.309134 175 261 0.01819694 Mouse Phenotype Single KO decreased immunoglobulin level 68 4.351476e-67 5.859774372352941e-65 2.064634 692 0.04676624 237 0.00002125634501308017 1.283058 184 280 0.01913279 Mouse Phenotype Single KO abnormal B cell activation 69 2.01007e-66 2.6675668101449273e-64 2.4333 483 0.03264175 181 0.0000014760901871823205 1.425824 111 152 0.01154206 Mouse Phenotype Single KO abnormal tumor necrosis factor secretion 74 7.928887e-61 9.811461926891892e-59 2.226288 529 0.03575049 236 0.000020978132147881357 1.333872 138 202 0.01434959 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 76 1.52081e-59 1.8323759434210525e-57 2.075901 606 0.04095425 329 0.00029868464030395137 1.256769 168 261 0.01746907 Mouse Phenotype Single KO abnormal interleukin-6 secretion 79 3.369291e-58 3.9053921122784807e-56 2.342753 455 0.03074948 444 0.0019279488093918917 1.293363 104 157 0.01081418 Mouse Phenotype Single KO decreased mature B cell number 80 5.098042e-58 5.83534632425e-56 2.020671 630 0.0425762 174 0.0000010502894807471266 1.371498 144 205 0.01497348 Mouse Phenotype Single KO decreased IgG level 81 8.884101e-57 1.0043421340370372e-54 2.089129 569 0.03845374 434 0.0017921076083870968 1.246449 143 224 0.0148695 Mouse Phenotype Single KO abnormal B cell proliferation 83 7.064312e-56 7.793723492048194e-54 2.338855 438 0.02960059 242 0.00002495726349628099 1.400692 99 138 0.01029427 Mouse Phenotype Single KO abnormal marginal zone B cell morphology 91 7.172729e-49 7.217657082747253e-47 2.783793 278 0.01878759 874 0.029476362045766587 1.294341 59 89 0.006134969 Mouse Phenotype Single KO abnormal IgM level 92 1.118398e-48 1.113170705e-46 2.060258 503 0.03399338 393 0.0009547600805597965 1.280992 124 189 0.01289383 Mouse Phenotype Single KO abnormal immune organ physiology 96 1.408872e-47 1.3438584275e-45 2.192169 426 0.02878962 188 0.0000020460936581914894 1.446281 100 135 0.01039825 Mouse Phenotype Single KO abnormal double-positive T cell morphology 99 2.501486e-47 2.3137482123232324e-45 2.106027 464 0.03135771 209 0.000007231699127272728 1.427933 98 134 0.01019029 Mouse Phenotype Single KO abnormal IgG1 level 102 5.512953e-47 4.9492265314705876e-45 2.073072 478 0.03230385 281 0.00010672910392170818 1.322648 126 186 0.0131018 Mouse Phenotype Single KO increased T cell proliferation 106 8.767954e-46 7.574354224339622e-44 2.486458 317 0.02142326 438 0.0018419656727397258 1.34773 78 113 0.008110637 Mouse Phenotype abnormal lymphopoiesis 24 2.220238e-182 8.8448731325e-180 2.025569 1904 0.1286747 36 4.942898896666666e-22 1.376633 459 651 0.04772798 Mouse Phenotype abnormal B cell differentiation 59 3.143121e-98 5.093454217118644e-96 2.004234 1083 0.07319051 94 6.633602848723404e-14 1.410751 250 346 0.02599563 Mouse Phenotype abnormal B cell activation 63 4.24482e-93 6.442019685714286e-91 2.44261 673 0.04548219 163 7.120991740490798e-10 1.447692 152 205 0.01580534 Mouse Phenotype abnormal spleen white pulp morphology 65 1.888111e-91 2.7772660416923077e-89 2.05521 951 0.06426978 341 0.000009120762212903226 1.253245 233 363 0.02422793 Mouse Phenotype decreased mature B cell number 68 8.980746e-87 1.2627193015588238e-84 2.051515 907 0.06129621 171 1.084538895614035e-9 1.373469 204 290 0.02121244 Mouse Phenotype abnormal B cell proliferation 69 2.338878e-86 3.2408713852173913e-84 2.431057 630 0.0425762 197 1.1635042978172588e-8 1.435951 139 189 0.01445357 Mouse Phenotype decreased immunoglobulin level 70 9.33737e-85 1.2753513510000001e-82 2.045905 892 0.06028249 253 3.999385195256917e-7 1.290432 230 348 0.02391598 Mouse Phenotype abnormal lymph node size 77 3.236607e-80 4.0188570814285714e-78 2.051837 839 0.05670068 233 1.2221920678969956e-7 1.333736 194 284 0.02017261 Mouse Phenotype decreased IgG level 79 1.006289e-77 1.2178644467088608e-75 2.155614 726 0.049064 431 0.00006573251831554524 1.268031 176 271 0.01830093 Mouse Phenotype abnormal interleukin-6 secretion 80 3.264761e-76 3.901797490125e-74 2.437565 553 0.03737244 533 0.0003325852148780488 1.291484 127 192 0.01320578 Mouse Phenotype abnormal double-positive T cell morphology 81 2.717541e-74 3.207704876666667e-72 2.063655 767 0.05183483 118 5.955216316271187e-12 1.456225 179 240 0.01861287 Mouse Phenotype abnormal IgG1 level 82 2.999029e-74 3.4967946669512195e-72 2.189813 670 0.04527945 261 5.089269014942529e-7 1.347946 165 239 0.01715712 Mouse Phenotype abnormal IgM level 85 7.052997e-73 7.933376978470588e-71 2.134525 696 0.04703656 494 0.0001688777042368421 1.265207 162 250 0.01684517 Mouse Phenotype altered susceptibility to autoimmune disorder 89 1.186363e-70 1.2744737801123595e-68 2.020053 768 0.05190241 506 0.00019730975235177862 1.226111 211 336 0.02194031 Mouse Phenotype abnormal marginal zone B cell morphology 92 6.765169e-69 7.030628348804349e-67 2.650652 429 0.02899236 619 0.0009475937991760905 1.320382 94 139 0.009774358 Mouse Phenotype enlarged lymph nodes 93 8.430853e-67 8.66746081e-65 2.115536 651 0.0439954 317 0.000004792799608201892 1.334047 151 221 0.01570136 Mouse Phenotype decreased double-positive T cell number 94 2.618542e-66 2.6633914959574464e-64 2.115804 646 0.0436575 168 8.675702619642857e-10 1.452096 148 199 0.01538941 Mouse Phenotype abnormal spleen marginal zone morphology 98 8.495794e-64 8.288600656530612e-62 2.424222 467 0.03156045 508 0.00021460774931102364 1.325758 110 162 0.01143808 Mouse Phenotype abnormal immature B cell morphology 100 3.353913e-63 3.2066762193e-61 2.160727 587 0.0396702 258 4.686980079069767e-7 1.404031 128 178 0.01330976 Mouse Phenotype abnormal tumor necrosis factor secretion 101 3.914229e-63 3.705340937524752e-61 2.121722 611 0.04129215 424 0.00005572730322877358 1.278683 167 255 0.01736508