# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of G1/S transition of mitotic cell cycle 92 0.000123289 0.01763434729347826 2.146073 30 0.01683502 292 0.035180618045547944 1.963591 24 97 0.0101437 GO Biological Process mesodermal cell differentiation 115 0.0004191508 0.04796178588869565 2.458408 19 0.01066218 291 0.034888917943298965 3.052377 10 26 0.004226543 GO Molecular Function chromatin DNA binding 11 0.00001444565 0.005544503118181818 2.309351 33 0.01851852 45 0.038090959057777776 1.984045 26 104 0.01098901 GO Molecular Function histone acetyltransferase activity (H4-K5 specific) 25 0.0001849795 0.031239337960000002 7.486307 6 0.003367003 40 0.025089361659999997 5.290786 6 9 0.002535926 GO Molecular Function histone acetyltransferase activity (H4-K8 specific) 25 0.0001849795 0.031239337960000002 7.486307 6 0.003367003 40 0.025089361659999997 5.290786 6 9 0.002535926 GO Molecular Function histone acetyltransferase activity (H4-K16 specific) 25 0.0001849795 0.031239337960000002 7.486307 6 0.003367003 40 0.025089361659999997 5.290786 6 9 0.002535926 GO Molecular Function H4 histone acetyltransferase activity 32 0.0002184816 0.0288259161 5.12653 8 0.004489338 48 0.04666252913333333 3.734673 8 17 0.003381234 Human Phenotype Abnormal number of teeth 9 1.21623e-7 0.00009017669766666666 2.128803 59 0.03310887 5 0.0035538329369999995 2.329887 32 109 0.01352494 Human Phenotype Abnormal number of incisors 11 3.336065e-7 0.00020237783404545453 4.178419 19 0.01066218 30 0.009979335815666669 4.883803 8 13 0.003381234 Human Phenotype Reduced number of teeth 14 5.335976e-7 0.00025433548462857144 2.203639 49 0.02749719 25 0.0097520076144 2.23205 27 96 0.01141167 Human Phenotype Upper limb undergrowth 19 0.000002126267 0.0007467673521578947 3.089943 24 0.01346801 51 0.022170453705882352 2.848885 14 39 0.00591716 Human Phenotype Agenesis of incisor 21 0.00000269604 0.0008566988057142856 5.595428 12 0.006734007 76 0.0467801884736842 5.668699 5 7 0.002113271 Human Phenotype Abnormality of the incisor 23 0.000002853103 0.0008277720138695653 2.813335 27 0.01515152 14 0.008846186377142858 3.557598 13 29 0.005494505 Human Phenotype Forearm undergrowth 30 0.000006983944 0.0015534619437333334 3.043311 22 0.01234568 55 0.02355599331818182 2.947724 13 35 0.005494505 Human Phenotype Hypoplasia of the ulna 34 0.00002495531 0.004897846577352941 3.192499 18 0.01010101 41 0.01513710318512195 3.779133 10 21 0.004226543 Human Phenotype Dental malocclusion 37 0.00003152122 0.005684894623243244 2.159052 35 0.01964085 53 0.022949932686792452 2.462952 18 58 0.007607777 Human Phenotype Neoplasm of the stomach 71 0.0002154601 0.020250214750704227 2.597598 19 0.01066218 57 0.02537651755964912 3.072069 12 31 0.005071851 Human Phenotype Abnormality of the vagina 104 0.0006949837 0.04459255990480769 2.040608 26 0.01459035 69 0.03980855518115942 2.645393 14 42 0.00591716 Mouse Phenotype Single KO small basisphenoid bone 1 4.713883e-9 0.000043165026631 4.959993 21 0.01178451 58 0.0005525892692758621 5.494278 9 13 0.003803888 Mouse Phenotype Single KO abnormal presphenoid bone morphology 8 6.243091e-7 0.0007145998035874999 3.056273 27 0.01515152 123 0.007561210354471545 3.283936 12 29 0.005071851 Mouse Phenotype Single KO abnormal palatine bone horizontal plate morphology 16 0.0000042774 0.0024480094875 2.885142 25 0.01402918 156 0.013690924193589743 3.233258 11 27 0.004649197 Mouse Phenotype Single KO decreased circulating alanine transaminase level 17 0.000009304789 0.005011997227823529 2.361543 33 0.01851852 120 0.007204764228 2.327946 22 75 0.009298394 Mouse Phenotype Single KO abnormal basisphenoid bone morphology 22 0.00003061017 0.01274078757681818 2.221116 33 0.01851852 71 0.0010147858334507043 3.137559 17 43 0.007185123 Mouse Phenotype Single KO abnormal palatine bone morphology 23 0.00003567297 0.014202495056086957 2.344092 29 0.01627385 155 0.01362842808516129 2.777663 14 40 0.00591716 Mouse Phenotype small basisphenoid bone 1 3.093078e-8 0.00029572918758 4.434802 21 0.01178451 240 0.0029448883905 4.201507 9 17 0.003803888 Mouse Phenotype abnormal presphenoid bone morphology 9 0.000002951817 0.003135813593 2.689256 29 0.01627385 214 0.001900460521682243 3.174472 14 35 0.00591716 Mouse Phenotype abnormal palatine bone horizontal plate morphology 14 0.00000876438 0.005985445512857144 2.763926 25 0.01402918 367 0.012681616613623978 3.010275 11 29 0.004649197 Mouse Phenotype decreased circulating alanine transaminase level 19 0.00001572615 0.007913564218421052 2.26643 34 0.01907969 341 0.008509702160410556 2.122467 23 86 0.009721048 Mouse Phenotype midface hypoplasia 20 0.00002601721 0.0124375272405 4.125065 13 0.007295174 321 0.00707994134953271 5.290786 6 9 0.002535926 Mouse Phenotype abnormal thymus involution 24 0.00005236117 0.02085938109875 3.84755 13 0.007295174 460 0.025426045350000002 3.105461 9 23 0.003803888 Mouse Phenotype decreased circulating serum albumin level 25 0.00005273802 0.0201691283688 2.10287 35 0.01964085 518 0.036049916617760615 1.820225 25 109 0.01056636 Mouse Phenotype small hair follicles 27 0.00006327833 0.022407559745555552 3.774735 13 0.007295174 399 0.018301848314285715 3.96809 7 14 0.00295858 Mouse Phenotype increased cranium height 29 0.00007514999 0.024776174289310345 6.005414 8 0.004489338 519 0.03681460286705202 7.936179 3 3 0.001267963 Mouse Phenotype abnormal interventricular groove morphology 30 0.00007656271 0.024400535677 4.694448 10 0.005611672 552 0.04445845947282608 4.408988 5 9 0.002113271 Mouse Phenotype small first pharyngeal arch 32 0.00008059435 0.0240800806359375 2.809909 19 0.01066218 73 0.000042060214212328764 4.68956 13 22 0.005494505 Mouse Phenotype abnormal palatine bone morphology 37 0.0001191188 0.030780941805405405 2.119646 31 0.01739618 396 0.017463381381060607 2.429443 15 49 0.006339814