# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ribosome biogenesis	14	6.996036e-19	6.575774123142857e-16	2.096149	175	0.03821795	100	0.0000017107950105	1.592325	120	323	0.02739101	
GO Biological Process	rRNA metabolic process	17	2.396551e-18	1.855071447588235e-15	2.287841	140	0.03057436	172	0.00011850811786046512	1.555539	94	259	0.02145629	
GO Biological Process	rRNA processing	18	5.840793e-18	4.2699441714999994e-15	2.294313	136	0.02970081	171	0.00011466198536842106	1.564733	92	252	0.02099977	
GO Biological Process	tRNA metabolic process	39	1.237429e-11	4.175212361794872e-9	2.09806	102	0.02227561	286	0.008948193616783217	1.496701	66	189	0.01506505	
GO Biological Process	positive regulation of gene expression, epigenetic	43	2.908253e-11	8.899930517906978e-9	2.96644	51	0.0111378	399	0.047337243373433584	1.660828	31	80	0.00707601	
GO Biological Process	chaperone-mediated protein folding	63	4.119478e-10	8.604477936825396e-8	2.88345	47	0.01026425	243	0.002369157190452675	1.978157	30	65	0.006847752	
GO Biological Process	ERAD pathway	64	5.348518e-10	1.09970544315625e-7	2.553372	57	0.01244813	197	0.0005322096764771573	1.938908	38	84	0.008673819	
GO Biological Process	cotranslational protein targeting to membrane	67	7.292256e-10	1.432220846328358e-7	2.60807	54	0.01179297	369	0.033284841762330625	1.618187	37	98	0.00844556	
GO Biological Process	negative regulation of protein ubiquitination	75	1.379446e-9	2.4202839885333335e-7	2.080597	83	0.01812623	203	0.0006776158986206896	1.708191	55	138	0.01255421	
GO Biological Process	cytoplasmic translation	83	2.446669e-9	3.879002092891566e-7	3.716088	30	0.006551649	252	0.0034596238128968256	2.192841	22	43	0.005021685	
GO Biological Process	viral gene expression	91	4.146261e-9	5.995675659230769e-7	2.290984	63	0.01375846	258	0.004197850039806201	1.653657	49	127	0.01118466	
GO Biological Process	spliceosomal snRNP assembly	95	6.365269e-9	8.816902607473684e-7	3.559023	30	0.006551649	302	0.013240202358940398	2.143004	19	38	0.004336909	
GO Biological Process	telomere organization	113	2.510584e-8	0.000002923608394336283	2.2105	61	0.01332169	398	0.047182288819095475	1.538567	42	117	0.009586852	
GO Biological Process	termination of RNA polymerase II transcription	115	2.591016e-8	0.000002964798221217391	2.79847	39	0.008517143	319	0.017832590040752352	1.801366	29	69	0.006619493	
GO Biological Process	multi-organism metabolic process	122	3.841917e-8	0.000004143916869098361	2.022868	73	0.01594235	259	0.004253508047027027	1.603608	55	147	0.01255421	
GO Biological Process	DNA-templated transcription, termination	139	9.459328e-8	0.000008955057349064748	2.226143	55	0.01201136	330	0.022227943545454546	1.612168	41	109	0.009358594	
GO Biological Process	blastocyst growth	143	1.08329e-7	0.000009968540636363636	5.045252	17	0.003712601	275	0.006986524617818182	2.94663	11	16	0.002510842	
GO Biological Process	ribonucleoprotein complex export from nucleus	159	2.553105e-7	0.000021129753896226415	2.076586	60	0.0131033	367	0.03303739773923706	1.542963	45	125	0.01027163	
GO Biological Process	ribonucleoprotein complex localization	172	3.836956e-7	0.000029354944188372094	2.03654	61	0.01332169	346	0.026627008309248554	1.552412	46	127	0.01049989	
GO Biological Process	regulation of megakaryocyte differentiation	175	4.558769e-7	0.000034279337869142855	2.167029	52	0.01135619	288	0.009813072949652779	1.804635	32	76	0.007304268	
GO Cellular Component	condensed chromosome, centromeric region	34	4.392394e-12	2.2323696564705882e-10	2.186025	97	0.02118366	36	1.7080411199999998e-7	2.069107	56	116	0.01278247	
GO Cellular Component	chromosome, telomeric region	42	1.884952e-9	7.755231085714286e-8	2.09812	80	0.01747106	71	0.00709372232112676	1.514218	59	167	0.01346724	
GO Cellular Component	nuclear chromosome, telomeric region	43	2.11569e-9	8.502121674418605e-8	2.265176	67	0.01463202	79	0.010722837144303797	1.558548	48	132	0.0109564	
GO Cellular Component	DNA packaging complex	45	2.969001e-9	1.1400963839999999e-7	2.580782	51	0.0111378	63	0.0013908927085714287	1.722057	45	112	0.01027163	
GO Cellular Component	large ribosomal subunit	46	3.251757e-9	1.2215295860869564e-7	2.403072	58	0.01266652	76	0.010913543242105264	1.602594	43	115	0.009815111	
GO Cellular Component	ribosomal subunit	47	3.345479e-9	1.2299973855319148e-7	2.049202	82	0.01790784	73	0.007662200547945205	1.482727	64	185	0.01460854	
GO Cellular Component	nucleosome	51	6.220878e-9	2.10777984e-7	2.742371	44	0.009609085	77	0.010786889641558441	1.632765	40	105	0.009130336	
GO Cellular Component	signal recognition particle	58	3.125939e-8	9.3131424e-7	7.675383	13	0.002839048	96	0.040996242	3.000205	7	10	0.001597809	
GO Cellular Component	mitochondrial nucleoid	70	6.317324e-7	0.000015594765531428572	2.922674	29	0.006333261	60	0.0011939688	2.245052	22	42	0.005021685	
GO Cellular Component	Fanconi anaemia nuclear complex	77	0.000001698909	0.000038126165610389606	3.592796	20	0.004367766	80	0.01232191008	2.967236	9	13	0.002054325	
GO Cellular Component	nuclear pore	86	0.000005000726	0.00010047970381395347	2.036591	49	0.01070103	65	0.001626177467076923	1.885843	33	75	0.007532527	
GO Cellular Component	catalytic step 2 spliceosome	88	0.000005116183	0.00010046322981818182	2.002507	51	0.0111378	81	0.012661984000000001	1.651899	37	96	0.00844556	
GO Cellular Component	PcG protein complex	101	0.00001554871	0.00026602149386138616	2.113648	40	0.008735532	93	0.03680303690322581	1.863482	20	46	0.004565168	
GO Cellular Component	outer mitochondrial membrane protein complex	118	0.00004600291	0.000673669732881356	4.18881	12	0.00262066	64	0.00156295494	3.143072	11	15	0.002510842	
GO Cellular Component	sex chromosome	136	0.0003208129	0.004076210964705882	2.518456	19	0.004149378	84	0.015017920457142857	2.30785	14	26	0.003195617	
GO Cellular Component	pre-autophagosomal structure membrane	147	0.0005409802	0.006359277453061225	3.016509	13	0.002839048	87	0.018266390068965518	2.678755	10	16	0.002282584	
GO Cellular Component	mitochondrial outer membrane translocase complex	152	0.0006294106	0.007155404715789474	3.921341	9	0.001965495	83	0.015002254496385542	3.117097	8	11	0.001826067	
GO Molecular Function	ribonucleoprotein complex binding	8	1.199424e-12	6.329960160000001e-10	2.550488	75	0.01637912	55	0.0036808140607272727	1.714403	46	115	0.01049989	
GO Molecular Function	proteasome binding	10	2.019935e-10	8.52816557e-8	5.383741	23	0.005022931	62	0.01509058564516129	3.214506	9	12	0.002054325	
GO Molecular Function	unfolded protein binding	12	4.509305e-10	1.5865238091666666e-7	2.565678	57	0.01244813	56	0.0042562570064285715	1.738664	43	106	0.009815111	
GO Molecular Function	rRNA binding	14	6.853921e-10	2.0669467472857141e-7	3.63632	33	0.007206814	72	0.028028784908333333	1.85727	26	60	0.005934718	
GO Molecular Function	ubiquitin-protein transferase regulator activity	66	0.00007645865	0.004891036671212121	2.591613	22	0.004804542	67	0.02055893447761194	2.773299	11	17	0.002510842	
GO Molecular Function	ubiquitin ligase inhibitor activity	115	0.0003852952	0.014145359429565216	6.519074	6	0.00131033	77	0.03784446724415585	4.286008	5	5	0.001141292	
Human Phenotype	Exercise intolerance	1	7.262995e-12	4.8465965635000005e-8	3.219593	48	0.01048264	58	0.026479626022413792	1.83686	30	70	0.006847752	
Human Phenotype	Abnormal CNS myelination	3	1.661519e-10	3.695772095666666e-7	2.229919	79	0.01725268	17	0.001649939680529412	1.782979	52	125	0.01186944	
Human Phenotype	Increased serum lactate	8	5.660192e-9	0.000004721307652	2.364797	58	0.01266652	35	0.004925774091714285	1.800123	42	100	0.009586852	
Human Phenotype	Leukodystrophy	9	6.490395e-9	0.000004812267315000001	2.903948	40	0.008735532	49	0.015815350459183673	2.057284	24	50	0.005478201	
Human Phenotype	Lactic acidosis	10	9.169561e-9	0.000006118848055299999	2.021245	80	0.01747106	2	0.0000050969074665	2.002223	64	137	0.01460854	
Human Phenotype	Increased CSF lactate	12	7.194098e-8	0.00004000517996166667	2.87045	35	0.00764359	45	0.012834094892444445	1.995211	27	58	0.006162976	
Human Phenotype	Abnormal CSF metabolite level	13	9.00384e-8	0.000046217403323076923	2.748055	37	0.008080367	42	0.009844824659285715	1.972924	29	63	0.006619493	
Human Phenotype	Abnormality of the mitochondrion	18	2.657311e-7	0.00009851242390555556	2.339755	46	0.01004586	18	0.0018845745725555555	2.052454	34	71	0.007760785	
Human Phenotype	Abnormality of mitochondrial metabolism	20	3.444853e-7	0.00011493752034499999	2.342537	45	0.009827473	22	0.0021887130615454546	2.04983	33	69	0.007532527	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	72	0.00002162274	0.0027499920858333336	2.913482	21	0.004586154	62	0.049873231266129026	2.532641	13	22	0.002967359	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	116	0.0001519072	0.011991501986206896	2.466627	22	0.004804542	52	0.042265278125	2.500171	14	24	0.003195617	
Mouse Phenotype	absent segment of posterior cerebral artery	70	0.00002162274	0.002953357387714286	2.913482	21	0.004586154	87	0.03710992253448276	2.532641	13	22	0.002967359	
Mouse Phenotype	abnormal cerebral artery morphology	107	0.0001519072	0.013573689151401868	2.466627	22	0.004804542	78	0.02941999375	2.500171	14	24	0.003195617