# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	99	3.089231e-107	4.106180881717171e-105	2.195287	978	0.03362442	926	0.020197345519438446	1.13916	183	248	0.01504563	
GO Biological Process	negative regulation of translation	178	4.800034e-64	3.548519517191011e-62	2.00962	716	0.02461665	345	0.000010446342712753624	1.29548	120	143	0.009865987	
GO Biological Process	nuclear-transcribed mRNA catabolic process	181	3.288949e-63	2.391120435966851e-61	2.069783	657	0.02258819	216	1.162219937962963e-8	1.309874	168	198	0.01381238	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	190	2.676044e-61	1.853371736631579e-59	2.365004	475	0.01633088	958	0.02435831172129436	1.202236	88	113	0.007235057	
GO Biological Process	cell cycle G2/M phase transition	196	1.352088e-57	9.077615302040815e-56	2.036009	622	0.02138486	400	0.0000561092193575	1.2827	113	136	0.009290471	
GO Biological Process	G2/M transition of mitotic cell cycle	214	3.345854e-54	2.057387513364486e-52	2.00294	609	0.02093791	416	0.00008985657945432692	1.278803	111	134	0.009126038	
GO Biological Process	regulation of DNA-templated transcription in response to stress	225	1.630833e-53	9.537836198666668e-52	2.174392	494	0.01698412	1102	0.04773895337840291	1.180538	91	119	0.007481707	
GO Biological Process	RNA 3'-end processing	226	3.593317e-53	2.092232672699115e-51	2.476874	375	0.0128928	931	0.020456138997851772	1.21194	84	107	0.006906191	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	227	8.682129e-53	5.032957511497797e-51	2.433664	385	0.01323661	380	0.00003599817594736842	1.308288	100	118	0.008221656	
GO Biological Process	viral gene expression	237	4.212306e-50	2.3388073693670886e-48	2.312861	404	0.01388984	499	0.00042610793434869743	1.264198	104	127	0.008550522	
GO Biological Process	multi-organism metabolic process	247	1.795405e-48	9.565074653846153e-47	2.102705	482	0.01657155	479	0.00033140240968684755	1.249727	119	147	0.00978377	
GO Biological Process	mitochondrial membrane organization	252	6.616111e-48	3.4548176448015874e-46	2.005055	535	0.01839373	486	0.0003590270693209877	1.269884	102	124	0.008386089	
GO Biological Process	cotranslational protein targeting to membrane	309	2.701442e-40	1.1504296206472493e-38	2.357078	310	0.01065805	469	0.0002546850097441365	1.307487	83	98	0.006823974	
GO Biological Process	multi-organism transport	326	2.738978e-39	1.1055893098773007e-37	2.405075	290	0.009970433	595	0.0012805443103361344	1.326346	61	71	0.00501521	
GO Biological Process	transport of virus	328	3.21681e-39	1.2905488655487804e-37	2.428546	284	0.009764148	686	0.0034935878973760934	1.313365	57	67	0.004686344	
GO Biological Process	protein localization to endoplasmic reticulum	338	1.418061e-38	5.520788372485207e-37	2.071866	394	0.01354604	440	0.0001500665519	1.282334	103	124	0.008468306	
GO Biological Process	snRNA metabolic process	344	7.16902e-38	2.742358551744186e-36	2.383914	284	0.009764148	913	0.018775471628696607	1.238614	69	86	0.005672943	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	347	1.014316e-37	3.846508427665706e-36	2.354382	290	0.009970433	576	0.0010512517206076389	1.292077	77	92	0.006330675	
GO Biological Process	histone ubiquitination	349	1.778615e-37	6.706244924068769e-36	2.608346	237	0.00814825	944	0.02214159267690678	1.34586	34	39	0.002795363	
GO Biological Process	organelle transport along microtubule	354	3.017042e-37	1.1215043976836159e-35	2.172345	340	0.01168947	702	0.004520770700997151	1.309874	56	66	0.004604127	
GO Cellular Component	ribonucleoprotein granule	47	1.96475e-75	7.223591489361702e-74	2.01735	837	0.02877673	100	0.001442294208	1.19544	151	195	0.0124147	
GO Cellular Component	cytoplasmic stress granule	49	9.911187e-71	3.4952104359183677e-69	3.344249	310	0.01065805	190	0.04698633903157895	1.292467	36	43	0.002959796	
GO Cellular Component	chromosome, telomeric region	70	1.082394e-52	2.671966902857143e-51	2.122219	514	0.01767173	195	0.04848335556923077	1.14628	124	167	0.01019485	
GO Cellular Component	methyltransferase complex	72	3.242303e-51	7.781527200000001e-50	2.358744	397	0.01364918	159	0.022983899773584907	1.221453	72	91	0.005919592	
GO Cellular Component	nuclear chromosome, telomeric region	77	9.385463e-47	2.106244164155844e-45	2.208828	415	0.01426803	188	0.04011746859574468	1.169531	100	132	0.008221656	
GO Cellular Component	histone methyltransferase complex	79	2.69567e-45	5.896351594936709e-44	2.384806	342	0.01175823	139	0.010943212661870504	1.275297	57	69	0.004686344	
GO Cellular Component	PML body	84	1.062298e-39	2.1852987428571428e-38	2.003973	441	0.01516193	167	0.027385509556886227	1.20956	76	97	0.006248458	
GO Cellular Component	P-body	86	1.165493e-38	2.341827795348837e-37	2.093897	385	0.01323661	143	0.013526638993006993	1.246184	67	83	0.005508509	
GO Cellular Component	catalytic step 2 spliceosome	87	1.313415e-36	2.608713931034483e-35	2.138782	346	0.01189576	154	0.01748955927272727	1.222159	76	96	0.006248458	
GO Cellular Component	PcG protein complex	101	4.356837e-32	7.4540736000000004e-31	2.246069	270	0.009282816	66	0.000017957046109090908	1.476659	44	46	0.003617529	
GO Cellular Component	host cell	103	1.248463e-31	2.0945088000000005e-30	2.230442	270	0.009282816	130	0.0055142487138461534	1.294051	57	68	0.004686344	
GO Cellular Component	axon cytoplasm	119	1.121034e-27	1.6278544134453782e-26	2.413446	199	0.00684178	120	0.00400431456	1.389402	36	40	0.002959796	
GO Cellular Component	cleavage furrow	132	5.407013e-24	7.078271563636363e-23	2.035249	249	0.00856082	176	0.03582225490909091	1.276588	43	52	0.003535312	
GO Cellular Component	BLOC-1 complex	143	9.868058e-22	1.1924478478321678e-20	3.453647	86	0.002956749	186	0.040277255225806455	1.458015	17	18	0.001397681	
GO Cellular Component	small nuclear ribonucleoprotein complex	144	1.069078e-21	1.2828936e-20	2.103992	206	0.007082445	189	0.04722236342857143	1.23055	55	69	0.004521911	
GO Cellular Component	ESC/E(Z) complex	154	2.817383e-20	3.1613232623376625e-19	2.424449	141	0.004847693	186	0.040277255225806455	1.458015	17	18	0.001397681	
GO Cellular Component	Cul2-RING ubiquitin ligase complex	165	2.833941e-19	2.9679091200000002e-18	3.579025	72	0.002475418	193	0.04876743693264249	1.54378	12	12	0.0009865987	
GO Cellular Component	clathrin adaptor complex	211	3.435225e-15	2.813302748815166e-14	2.09147	141	0.004847693	124	0.004437229470967742	1.440862	28	30	0.002302064	
GO Cellular Component	exon-exon junction complex	234	3.153833e-13	2.328984369230769e-12	2.525697	81	0.002784845	152	0.015399913263157894	1.470267	20	21	0.001644331	
GO Cellular Component	INO80-type complex	258	1.487281e-11	9.961323906976744e-11	2.663444	63	0.002165991	133	0.008022794778947368	1.476659	22	23	0.001808764	
GO Molecular Function	ribonucleoprotein complex binding	38	5.151373e-69	5.723446527894736e-67	2.526915	472	0.01622774	76	0.00004276653234473684	1.315569	98	115	0.008057223	
GO Molecular Function	protein transporter activity	57	5.898606e-44	4.3691078126315794e-42	2.165333	407	0.01399299	132	0.022613681292424245	1.23824	77	96	0.006330675	
GO Molecular Function	DNA helicase activity	112	1.913338e-24	7.212600925e-23	2.202177	211	0.007254349	136	0.029628685938235297	1.32324	42	49	0.003453095	
GO Molecular Function	NF-kappaB binding	224	4.928236e-13	9.288844817857143e-12	2.150733	111	0.003816269	103	0.0034565280355339807	1.488645	27	28	0.002219847	
GO Molecular Function	miRNA binding	248	4.416182e-12	7.518193711290322e-11	2.002334	121	0.004160077	123	0.014274094582113822	1.479456	23	24	0.001890981	
GO Molecular Function	ATPase activator activity	270	3.296798e-11	5.155215242962963e-10	2.023272	108	0.003713127	130	0.02005434411076923	1.476659	22	23	0.001808764	
Human Phenotype	Cafe-au-lait spot	65	1.920737e-30	1.971858154e-28	2.200965	267	0.009179674	104	0.03402202101346154	1.331889	44	51	0.003617529	
Human Phenotype	Abnormality of the distal phalanx of the thumb	448	5.965493e-13	8.885655086830356e-12	2.002789	131	0.004503885	110	0.03760652259181818	1.54378	17	17	0.001397681	
Mouse Phenotype Single KO	abnormal DNA repair	57	4.062374e-39	6.52616819614035e-37	2.2412	334	0.01148319	594	0.04503076535016835	1.211785	73	93	0.006001809	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	66	2.806786e-36	3.89420293969697e-34	2.417876	264	0.009076532	485	0.02327898204123711	1.286484	50	60	0.004110828	
Mouse Phenotype Single KO	enlarged liver sinusoidal spaces	93	4.87528e-31	4.800316017204301e-29	2.360256	235	0.008079488	595	0.04497479787394958	1.335161	32	37	0.00263093	
Mouse Phenotype Single KO	large lymphoid organs	116	7.595714e-28	5.996030439482758e-26	2.397128	203	0.006979303	448	0.018021284639955358	1.399051	29	32	0.00238428	
Mouse Phenotype Single KO	increased cellular sensitivity to ionizing radiation	132	1.455159e-25	1.0094614365909091e-23	2.004436	277	0.009523482	550	0.03708340258363636	1.252923	56	69	0.004604127	
Mouse Phenotype Single KO	increased cellular sensitivity to gamma-irradiation	158	4.838505e-24	2.8041892585443034e-22	2.180052	212	0.00728873	356	0.006903392850842697	1.354746	43	49	0.003535312	
Mouse Phenotype Single KO	lymphoid hyperplasia	161	1.755707e-23	9.98571987515528e-22	2.356421	175	0.00601664	566	0.039566474828621905	1.384079	26	29	0.002137631	
Mouse Phenotype	abnormal cell adhesion	82	7.169112e-51	8.359009735609756e-49	2.096763	510	0.01753421	565	0.006634943098938054	1.279713	63	76	0.005179643	
Mouse Phenotype	abnormal DNA repair	103	6.454136e-43	5.99106740737864e-41	2.132897	411	0.01413051	682	0.016703725895894427	1.202124	95	122	0.007810573	
Mouse Phenotype	early cellular replicative senescence	117	2.729211e-37	2.2302552453846154e-35	2.217991	325	0.01117376	639	0.012547922234741785	1.268861	60	73	0.004932994	
Mouse Phenotype	abnormal cellular replicative senescence	121	1.057012e-36	8.352141927272727e-35	2.125473	352	0.01210204	652	0.012998808590337424	1.249727	68	84	0.005590726	
Mouse Phenotype	enlarged liver sinusoidal spaces	123	6.198365e-36	4.818094940243903e-34	2.344456	278	0.009557863	643	0.012674509167807154	1.355514	36	41	0.002959796	
Mouse Phenotype	large lymphoid organs	166	3.967497e-29	2.285134868493976e-27	2.358586	220	0.007563776	672	0.014912712839285715	1.372249	32	36	0.00263093	
Mouse Phenotype	lymphoid hyperplasia	208	6.40756e-25	2.9453212096153846e-23	2.323602	192	0.006601114	647	0.01302895498469861	1.399051	29	32	0.00238428	
Mouse Phenotype	increased fibroblast apoptosis	220	7.016006e-24	3.049092425727273e-22	2.177615	211	0.007254349	290	0.00008984854140000001	1.447294	45	48	0.003699745