# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	chromosome organization	33	1.666588e-46	6.645645906666667e-44	2.058836	465	0.08345298	221	0.0009265388848868779	1.275369	214	578	0.03925885	
GO Biological Process	regulation of gene expression, epigenetic	62	1.628926e-36	3.45726407e-34	2.624662	224	0.04020101	368	0.01368030379728261	1.347318	97	248	0.0177949	
GO Biological Process	DNA conformation change	63	2.471847e-35	5.163021376666667e-33	2.399953	255	0.04576454	454	0.028067689043612332	1.29942	106	281	0.01944597	
GO Biological Process	protein-DNA complex subunit organization	97	5.260075e-25	7.135806899484536e-23	2.184217	216	0.03876525	255	0.0021053780752941175	1.405433	102	250	0.01871216	
GO Biological Process	nucleosome organization	105	6.867548e-24	8.60667277447619e-22	2.56125	150	0.02692032	514	0.0412414836536965	1.369818	68	171	0.01247478	
GO Biological Process	double-strand break repair	106	7.043699e-24	8.744154258584907e-22	2.464058	161	0.02889447	162	0.00005533862303765432	1.603562	81	174	0.01485966	
GO Biological Process	gene silencing	111	2.106986e-23	2.497822412072072e-21	2.588407	144	0.0258435	517	0.04230458148549323	1.358738	71	180	0.01302513	
GO Biological Process	nucleic acid phosphodiester bond hydrolysis	124	4.260421e-22	4.521199995080645e-20	2.132174	200	0.03589375	261	0.0024057798059770115	1.380363	111	277	0.02036324	
GO Biological Process	cell cycle checkpoint	131	8.383436e-21	8.421193459847329e-19	2.187865	177	0.03176597	188	0.000304217741393617	1.515663	88	200	0.01614383	
GO Biological Process	regulation of cellular response to heat	136	3.788935e-20	3.666073210661764e-18	2.963455	98	0.01758794	247	0.0015424026172064776	1.766507	40	78	0.007338103	
GO Biological Process	protein-DNA complex assembly	149	4.068799e-19	3.593377586644295e-17	2.081867	181	0.03248385	338	0.009580581250591715	1.384167	88	219	0.01614383	
GO Biological Process	regulation of chromosome organization	161	3.153762e-18	2.5776617489441e-16	2.129983	163	0.02925341	269	0.00276864724063197	1.511218	68	155	0.01247478	
GO Biological Process	RNA catabolic process	163	6.439014e-18	5.198219952515338e-16	2.101774	165	0.02961235	253	0.001985684778102767	1.415038	99	241	0.01816181	
GO Biological Process	regulation of gene silencing	171	5.200403e-17	4.001877372923977e-15	2.482938	110	0.01974156	529	0.045716256517958416	1.419948	54	131	0.009906439	
GO Biological Process	mitotic cell cycle checkpoint	176	1.571584e-16	1.1750269236363636e-14	2.224426	133	0.02386935	290	0.004536542562068965	1.502717	65	149	0.01192442	
GO Biological Process	mRNA catabolic process	178	1.865831e-16	1.3793522544382022e-14	2.141377	144	0.0258435	258	0.0022276845598062016	1.43933	89	213	0.01632728	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	186	4.377658e-16	3.097075356021505e-14	2.775467	85	0.01525485	511	0.03931087728180039	1.463231	48	113	0.008805724	
GO Biological Process	DNA integrity checkpoint	194	7.303263e-16	4.953795763762886e-14	2.217134	128	0.022972	194	0.00041000201730927833	1.58637	70	152	0.01284168	
GO Biological Process	regulation of telomere maintenance via telomerase	197	1.147024e-15	7.661770972588832e-14	2.851415	79	0.01417803	334	0.009125104610179641	1.819836	28	53	0.005136672	
GO Biological Process	posttranscriptional gene silencing by RNA	199	1.493883e-15	9.878395174371858e-14	3.193805	66	0.01184494	536	0.04937588230037314	1.688573	25	51	0.004586314	
GO Cellular Component	mitotic spindle	40	1.060636e-21	4.58194752e-20	2.985296	105	0.01884422	51	0.0071169984	1.658554	39	81	0.007154651	
GO Cellular Component	clathrin-coated pit	68	1.571407e-13	3.993222494117647e-12	2.456175	87	0.01561378	42	0.0009880420114285714	1.820764	37	70	0.006787745	
GO Cellular Component	clathrin vesicle coat	79	1.822806e-12	3.9870997063291144e-11	3.463887	46	0.008255564	69	0.03054064695652174	2.066813	15	25	0.002751789	
GO Cellular Component	vesicle coat	88	9.464803e-11	1.8585431345454546e-9	2.603708	60	0.01076813	75	0.04633820928000001	1.688573	25	51	0.004586314	
GO Cellular Component	tethering complex	102	2.460241e-9	4.167937694117647e-8	2.145356	75	0.01346016	68	0.027922370823529413	1.604376	34	73	0.006237388	
GO Cellular Component	site of double-strand break	134	2.620082e-7	0.0000033787326089552237	2.670504	36	0.006460876	64	0.025510860899999998	1.924973	19	34	0.003485599	
GO Cellular Component	cAMP-dependent protein kinase complex	162	0.000003486433	0.00003718861866666667	4.65231	14	0.002512563	67	0.026680010507462684	3.014103	7	8	0.001284168	
GO Cellular Component	clathrin coat of coated pit	175	0.000009899254	0.0000977480623542857	2.63002	27	0.004845657	66	0.026987249454545458	2.296459	12	18	0.002201431	
GO Cellular Component	aminoacyl-tRNA synthetase multienzyme complex	179	0.00001182528	0.00011415689296089386	3.922153	15	0.002692032	71	0.03161989318309859	2.583517	9	12	0.001651073	
GO Molecular Function	nuclease activity	35	1.435511e-15	1.731636412e-13	2.039524	152	0.02727925	107	0.036836480450467286	1.348628	83	212	0.01522656	
GO Molecular Function	ATPase regulator activity	45	2.921575e-12	2.741086588888889e-10	3.260841	49	0.00879397	114	0.045314318614035086	1.861994	20	37	0.003669052	
GO Molecular Function	protein transporter activity	76	3.800938e-9	2.11152108368421e-7	2.110653	76	0.01363963	84	0.007897733514285715	1.614698	45	96	0.008255366	
GO Molecular Function	protein phosphorylated amino acid binding	77	3.83459e-9	2.102550516883117e-7	2.280218	64	0.011486	108	0.038976866790740736	1.800633	23	44	0.004219409	
GO Molecular Function	RNA polymerase II core binding	124	0.000001571719	0.000053514496919354836	2.544079	34	0.006101938	94	0.021351911617021276	2.091418	17	28	0.003118694	
GO Molecular Function	RNA polymerase binding	154	0.000007384406	0.00020244780605194806	2.040759	47	0.008435032	120	0.049614903366666664	1.722345	25	50	0.004586314	
GO Molecular Function	mannosyl-oligosaccharide mannosidase activity	195	0.00009192165	0.001990221570769231	2.441188	24	0.004307251	62	0.0002877928342903226	3.444689	10	10	0.001834526	
GO Molecular Function	Ran GTPase binding	202	0.0001364476	0.0028518899366336637	2.080994	32	0.005743001	112	0.04361231758928571	1.937638	18	32	0.003302146	
GO Molecular Function	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	311	0.001535261	0.020842031967845658	2.319546	17	0.003050969	73	0.0029067723920547946	3.444689	8	8	0.001467621	
Human Phenotype	Open mouth	55	1.491327e-11	1.8093863765454546e-9	2.234444	88	0.01579325	98	0.043286130414285716	1.754842	27	53	0.00495322	
Human Phenotype	Cafe-au-lait spot	77	8.807475e-10	7.632763724025974e-8	2.495759	58	0.01040919	37	0.0015723896497297296	2.026288	30	51	0.005503577	
Human Phenotype	Limb hypertonia	239	0.00002026884	0.000565916189623431	2.522142	27	0.004845657	89	0.03502288060786517	2.431545	12	17	0.002201431	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	6	1.700815e-34	2.5957271591666665e-31	3.584151	133	0.02386935	168	0.03594811455238095	1.629245	35	74	0.00642084	
Mouse Phenotype Single KO	abnormal notochord morphology	97	4.514285e-10	4.2615781180412375e-8	2.035443	93	0.0166906	126	0.013552381802380954	1.779756	31	60	0.00568703	
Mouse Phenotype Single KO	decreased brain weight	110	9.619663e-10	8.007932190090909e-8	2.132672	80	0.0143575	126	0.013552381802380954	1.779756	31	60	0.00568703	
Mouse Phenotype Single KO	abnormal subclavian artery morphology	133	4.903569e-9	3.376088822030076e-7	2.086052	77	0.0138191	183	0.048544779692896174	1.757494	25	49	0.004586314	
Mouse Phenotype	embryonic lethality between somite formation and embryo turning, complete penetrance	7	4.907306e-36	6.702678952285714e-33	3.214912	161	0.02889447	136	0.0015290028531617648	1.722345	45	90	0.008255366	
Mouse Phenotype	embryonic lethality between somite formation and embryo turning	12	1.726216e-30	1.3753625979999998e-27	2.718052	175	0.03140704	167	0.00354340335502994	1.589856	54	117	0.009906439	
Mouse Phenotype	aneuploidy	52	9.316354e-17	1.7129550114230768e-14	2.853762	85	0.01525485	269	0.017427122596282527	1.722345	30	60	0.005503577	
Mouse Phenotype	decreased brain weight	89	1.171881e-12	1.2589162068539327e-10	2.079545	115	0.02063891	171	0.004194485063333333	1.665564	44	91	0.008071913	
Mouse Phenotype	subcutaneous edema	108	1.119427e-11	9.910038469444444e-10	3.385555	44	0.007896626	366	0.0369803545	1.95199	17	30	0.003118694	
Mouse Phenotype	abnormal hair follicle orientation	122	5.398087e-11	4.230418836639344e-9	2.617885	61	0.0109476	182	0.005180960383681319	2.181636	19	30	0.003485599	
Mouse Phenotype	decreased mean corpuscular volume	140	3.195001e-10	2.1819574686428575e-8	2.015346	97	0.01740847	284	0.018777804	1.527362	47	106	0.008622271	
Mouse Phenotype	abnormal DNA repair	147	4.757587e-10	3.094373422244898e-8	2.16716	80	0.0143575	265	0.01705688533471698	1.496463	53	122	0.009722987	
Mouse Phenotype	increased skin tumor incidence	165	2.825686e-9	1.6373565967272726e-7	2.125892	76	0.01363963	335	0.02881248733432836	1.548175	40	89	0.007338103	
Mouse Phenotype	thin myocardium compact layer	191	1.606379e-8	8.041146397382199e-7	2.07071	73	0.01310122	275	0.018431014361454546	1.791238	26	50	0.004769767	
Mouse Phenotype	decreased mean corpuscular hemoglobin	203	2.924841e-8	0.0000013775568867487685	2.016771	75	0.01346016	378	0.040316814682539684	1.565768	35	77	0.00642084	
Mouse Phenotype	abnormal spermatocyte morphology	241	1.335932e-7	0.000005299936038174274	2.076445	63	0.01130653	263	0.016710984816730036	1.695847	32	65	0.005870482	
Mouse Phenotype	abnormal thymus development	312	0.000002351746	0.00007206744713461538	2.154933	46	0.008255564	319	0.025153198687147337	2.0193	17	29	0.003118694	
Mouse Phenotype	hypochromic anemia	577	0.0002466136	0.004086434366724437	2.196699	26	0.004666188	386	0.04286419224870467	1.968394	16	28	0.002935241	
Mouse Phenotype	abnormal second pharyngeal arch artery morphology	605	0.0003287865	0.005195913597520661	2.776531	16	0.0028715	291	0.01962734977628866	3.444689	6	6	0.001100715