# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process chromatin assembly 38 2.482252e-15 8.595777386315789e-13 2.841067 77 0.02808169 467 0.04768483467237687 1.546202 43 158 0.01301059 GO Biological Process chromatin assembly or disassembly 40 2.864564e-15 9.423699419e-13 2.706359 83 0.03026988 415 0.03721958147710844 1.532061 48 178 0.01452345 GO Biological Process protein-DNA complex subunit organization 46 6.773161e-15 1.9375657738913043e-12 2.280913 111 0.0404814 450 0.04395430588666666 1.431711 63 250 0.01906203 GO Biological Process production of molecular mediator of immune response 72 6.58357e-13 1.2032388559722222e-10 3.294401 51 0.01859956 390 0.03154098592743589 1.921647 23 68 0.006959153 GO Biological Process cytokine production 94 4.789681e-11 6.705043859468085e-9 2.284802 79 0.02881109 376 0.03011948111170213 1.648037 38 131 0.01149773 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 190 2.471303e-7 0.00001711572430368421 4.269628 19 0.006929249 424 0.040082686424528294 2.603971 11 24 0.00332829 GO Biological Process negative regulation of cytokine secretion 215 9.374903e-7 0.00005737876678 2.483183 37 0.0134938 306 0.01827245839019608 2.093144 21 57 0.006354009 GO Biological Process regulation of receptor catabolic process 250 0.000003241244 0.00017060611918399998 5.043885 13 0.004741065 451 0.044575397654102 3.787595 6 9 0.001815431 GO Biological Process positive regulation of neuron death 251 0.000003247313 0.0001702445887131474 2.001855 53 0.01932896 439 0.041488498528473805 1.820959 25 78 0.007564297 GO Biological Process regulation of regulatory T cell differentiation 254 0.000003738216 0.0001936660800944882 2.991164 24 0.008752735 314 0.01940308379522293 2.727068 12 25 0.003630862 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell differentiation 262 0.000004782475 0.0002402007195610687 2.870451 25 0.009117433 247 0.008512892734412955 2.840696 13 26 0.003933434 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 308 0.00001231469 0.0005261331354220779 2.236882 36 0.0131291 277 0.012951838385559565 2.248884 19 48 0.005748865 GO Biological Process regulation of alpha-beta T cell proliferation 337 0.00001938915 0.0007570974031157271 3.028939 20 0.007293946 370 0.029549537429189192 2.717187 11 23 0.00332829 GO Biological Process regulation of monooxygenase activity 343 0.00002198051 0.0008432697699416909 2.297484 32 0.01167031 184 0.003929765141195652 2.314641 22 54 0.006656581 GO Biological Process regulation of CD4-positive, alpha-beta T cell differentiation 363 0.00002794594 0.0010130595715151516 2.340607 30 0.01094092 361 0.025939680572576177 2.272557 16 40 0.00484115 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 369 0.00002911564 0.0010383000183197832 2.418322 28 0.01021152 264 0.01135378457878788 2.651316 14 30 0.004236006 GO Biological Process positive regulation of memory T cell differentiation 379 0.00003310406 0.0011493834446965698 5.856 9 0.003282276 377 0.030121868988594164 4.734493 5 6 0.001512859 GO Biological Process activation of signaling protein activity involved in unfolded protein response 389 0.00003795434 0.0012839104371722364 5.118219 10 0.003646973 163 0.002845567551349693 4.971218 7 8 0.002118003 GO Biological Process negative regulation of chemokine production 391 0.00003986933 0.0013417915945524298 3.718077 14 0.005105762 288 0.014159134260069447 3.156329 10 18 0.003025719 GO Biological Process erythrocyte differentiation 394 0.00004194741 0.0014009796146954314 2.131542 35 0.01276441 413 0.03733871029297821 1.893797 23 69 0.006959153 GO Cellular Component nuclear envelope lumen 129 0.0003847531 0.005153901990697674 3.12879 13 0.004741065 26 0.03979574695384615 4.261044 6 8 0.001815431 Mouse Phenotype Single KO abnormal interleukin secretion 28 8.727297e-19 2.8541378081785716e-16 2.006052 190 0.06929249 117 0.00020323711052136755 1.508695 111 418 0.03358548 Mouse Phenotype Single KO abnormal platelet physiology 33 1.723403e-17 4.782182203333334e-15 2.99487 82 0.02990518 378 0.023578213950793653 1.704418 33 110 0.009984871 Mouse Phenotype Single KO abnormal platelet morphology 43 3.255687e-16 6.933099036976745e-14 2.130723 141 0.05142232 65 0.000024974534133846153 1.730048 81 266 0.02450832 Mouse Phenotype Single KO abnormal neutrophil cell number 44 3.271932e-16 6.809336664545455e-14 2.23539 127 0.04631656 165 0.0008537365233939395 1.589942 75 268 0.02269289 Mouse Phenotype Single KO abnormal T cell activation 45 4.881112e-16 9.932520574222223e-14 2.093803 145 0.05288111 213 0.0031984988290140845 1.513727 77 289 0.02329803 Mouse Phenotype Single KO decreased inflammatory response 49 1.726657e-14 3.226734316122449e-12 2.27747 108 0.03938731 269 0.00824099022788104 1.511983 66 248 0.01996974 Mouse Phenotype Single KO abnormal neutrophil morphology 50 2.350062e-14 4.3039035467999996e-12 2.083191 130 0.04741065 155 0.000742851286451613 1.582673 78 280 0.02360061 Mouse Phenotype Single KO abnormal T cell proliferation 56 2.100713e-13 3.435040882321429e-11 2.024553 129 0.04704595 304 0.011415429465789472 1.480209 68 261 0.02057489 Mouse Phenotype Single KO decreased T cell proliferation 57 2.766907e-13 4.445011824385965e-11 2.350172 92 0.03355215 326 0.015136535044478528 1.628666 43 150 0.01301059 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 60 4.607039e-13 7.031109353833334e-11 2.107391 114 0.04157549 304 0.011415429465789472 1.480209 68 261 0.02057489 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 67 1.756733e-12 2.400955832985075e-10 2.404501 82 0.02990518 447 0.034968903192393735 1.563336 41 149 0.01240545 Mouse Phenotype Single KO abnormal platelet cell number 69 2.216842e-12 2.941974231014493e-10 2.061651 113 0.0412108 62 0.00001926427505967742 1.831851 69 214 0.02087746 Mouse Phenotype Single KO abnormal blood coagulation 70 2.435376e-12 3.185819718857143e-10 2.028925 117 0.04266958 441 0.034779282680272104 1.45944 56 218 0.01694402 Mouse Phenotype Single KO abnormal hemostasis 71 3.077224e-12 3.968752136338028e-10 2.021211 117 0.04266958 466 0.041049946740343346 1.446172 56 220 0.01694402 Mouse Phenotype Single KO decreased granulocyte number 72 4.115724e-12 5.234400648333333e-10 2.08789 107 0.03902261 194 0.001958847975618557 1.623255 62 217 0.01875946 Mouse Phenotype Single KO abnormal NK cell morphology 73 5.129453e-12 6.434301523424658e-10 2.310704 85 0.03099927 270 0.008224936101851852 1.684827 43 145 0.01301059 Mouse Phenotype Single KO thrombocytopenia 77 1.702551e-11 2.024709026883117e-9 2.206954 89 0.03245806 74 0.00003626648411486486 1.968064 53 153 0.01603631 Mouse Phenotype Single KO decreased pre-B cell number 79 1.855627e-11 2.1508830935443037e-9 2.888899 54 0.01969365 178 0.0013551027605056179 2.311075 24 59 0.007261725 Mouse Phenotype Single KO abnormal circulating cytokine level 80 2.858684e-11 3.2721211735e-9 2.075294 100 0.03646973 197 0.0020100460976649748 1.561299 72 262 0.02178517 Mouse Phenotype Single KO abnormal interleukin-1 beta secretion 91 1.992486e-10 2.004966406813187e-8 3.029669 45 0.01641138 432 0.030923930886574077 1.866743 23 70 0.006959153 Mouse Phenotype abnormal platelet physiology 32 4.280557e-19 1.2789501711562499e-16 2.956009 92 0.03355215 417 0.011442302149640288 1.678593 39 132 0.0118003 Mouse Phenotype decreased inflammatory response 34 2.003855e-18 5.63495813382353e-16 2.338239 133 0.04850474 255 0.0014339550305882353 1.523817 81 302 0.02450832 Mouse Phenotype decreased neutrophil cell number 50 3.220088e-15 6.157452273600001e-13 2.849795 76 0.02771699 615 0.030596086141463412 1.571449 39 141 0.0118003 Mouse Phenotype embryonic lethality between somite formation and embryo turning, complete penetrance 58 4.557535e-14 7.512860712931034e-12 2.840435 70 0.02552881 429 0.012108759117482517 1.830671 29 90 0.008774584 Mouse Phenotype abnormal NK cell number 77 5.186931e-12 6.440551596233767e-10 2.202251 94 0.03428155 333 0.0047164728828828825 1.668909 47 160 0.01422088 Mouse Phenotype abnormal NK cell morphology 82 7.95557e-12 9.276000581707317e-10 2.153728 97 0.03537564 318 0.0037447249999999995 1.666995 49 167 0.01482602 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 84 1.159267e-11 1.319494260357143e-9 2.138621 97 0.03537564 315 0.0037058435999999997 1.641291 52 180 0.01573374 Mouse Phenotype decreased susceptibility to autoimmune disorder 86 1.492008e-11 1.6587312195348838e-9 2.236347 87 0.03172867 677 0.040267980376661745 1.448198 52 204 0.01573374 Mouse Phenotype abnormal T-helper 2 physiology 88 1.768422e-11 1.921350311590909e-9 2.964044 52 0.01896426 501 0.01783949585688623 1.921647 23 68 0.006959153 Mouse Phenotype decreased pre-B cell number 92 2.746639e-11 2.854414725978261e-9 2.3272 78 0.02844639 192 0.00042954146975 2.021264 37 104 0.01119516 Mouse Phenotype abnormal interleukin-6 secretion 103 1.326609e-10 1.2314280241747576e-8 2.117031 89 0.03245806 623 0.03245319542215088 1.479529 50 192 0.01512859 Mouse Phenotype abnormal vascular wound healing 108 2.835169e-10 2.5099121119444445e-8 2.497548 61 0.02224654 545 0.022625834581651377 1.783693 27 86 0.00816944 Mouse Phenotype abnormal interleukin-1 beta secretion 110 3.296035e-10 2.864853694090909e-8 2.662772 54 0.01969365 369 0.007182966833333333 1.853928 31 95 0.009379728 Mouse Phenotype abnormal pre-B cell morphology 113 4.583537e-10 3.878159049292036e-8 2.093183 86 0.03136397 173 0.000253615030734104 1.922275 45 133 0.01361573 Mouse Phenotype joint inflammation 119 1.139319e-9 9.15380584789916e-8 2.232981 71 0.02589351 519 0.01927202848554913 1.572209 44 159 0.01331316 Mouse Phenotype increased respiratory quotient 121 2.332386e-9 1.8429704583471074e-7 3.174513 37 0.0134938 649 0.03558632190600924 1.927615 19 56 0.005748865 Mouse Phenotype arthritis 132 4.924363e-9 3.566805654772727e-7 2.225027 66 0.02407002 470 0.015820810468085107 1.612287 42 148 0.01270802 Mouse Phenotype abnormal circulating tumor necrosis factor level 135 5.353268e-9 3.7913033591111113e-7 2.304706 61 0.02224654 373 0.007332674378284183 1.673287 43 146 0.01301059 Mouse Phenotype abnormal interleukin-1 secretion 136 5.744547e-9 4.038501019632353e-7 2.446182 54 0.01969365 484 0.01778314590929752 1.743794 31 101 0.009379728 Mouse Phenotype absent segment of posterior cerebral artery 139 6.714352e-9 4.618411472805756e-7 4.865366 21 0.007658643 305 0.0030423456227213113 3.098941 12 22 0.003630862