# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	10	7.00457e-42	9.217313663e-39	3.601551	162	0.02486951	336	0.005203620808035715	1.576959	51	113	0.009490138	
GO Biological Process	regulation of DNA-templated transcription in response to stress	13	2.64676e-38	2.679131910769231e-35	3.282189	167	0.02563709	302	0.0031220241659602648	1.585533	54	119	0.01004838	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	15	2.463615e-32	2.161247319e-29	3.766266	117	0.01796131	383	0.011054157824020888	1.657432	37	78	0.006885002	
GO Biological Process	liver regeneration	18	6.217613e-30	4.5454205259444446e-27	4.604182	86	0.01320233	216	0.0003447361313287037	2.296087	23	35	0.004279866	
GO Biological Process	cellular response to decreased oxygen levels	29	3.156827e-22	1.432437465275862e-19	2.051717	221	0.03392693	310	0.0035068285047096777	1.452787	79	190	0.01470041	
GO Biological Process	mRNA catabolic process	30	5.522881e-22	2.4225197026333335e-19	2.251475	177	0.02717224	205	0.00022928190247804877	1.509165	92	213	0.01711946	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	35	1.31371e-21	4.939174254285714e-19	2.960646	106	0.01627264	501	0.028806232946107783	1.484196	48	113	0.008931894	
GO Biological Process	cellular response to hypoxia	36	1.987203e-21	7.263778965833333e-19	2.041994	215	0.03300583	297	0.0027921191541414145	1.470172	77	183	0.01432825	
GO Biological Process	regulation of hematopoietic stem cell differentiation	39	2.177075e-21	7.345674339743589e-19	3.096214	98	0.01504452	530	0.03745778869245283	1.492602	44	103	0.00818757	
GO Biological Process	negative regulation of mitotic cell cycle phase transition	41	5.032566e-21	1.6152081949756098e-18	2.086761	200	0.0307031	206	0.00023030204686407766	1.527547	87	199	0.01618906	
GO Biological Process	RNA catabolic process	42	5.11071e-21	1.6012341164285715e-18	2.113815	194	0.02978201	189	0.00006275780532592592	1.507804	104	241	0.01935244	
GO Biological Process	mitochondrial transport	43	6.151688e-21	1.882559590511628e-18	2.057206	206	0.03162419	529	0.03707178852741021	1.315749	90	239	0.0167473	
GO Biological Process	negative regulation of cell cycle phase transition	51	2.456883e-20	6.339239881764706e-18	2.05151	201	0.03085662	232	0.0006944350290948275	1.485391	88	207	0.01637514	
GO Biological Process	regulation of mitochondrial membrane permeability	53	3.645633e-20	9.051487669245284e-18	2.874764	103	0.0158121	389	0.012117443161953725	1.675227	35	73	0.00651284	
GO Biological Process	rRNA processing	54	5.109952e-20	1.2452195994074073e-17	2.134564	180	0.02763279	291	0.0025036969089003436	1.400391	101	252	0.01879419	
GO Biological Process	rRNA metabolic process	55	5.258384e-20	1.2580922737454545e-17	2.113677	184	0.02824685	276	0.0018874902482971015	1.403014	104	259	0.01935244	
GO Biological Process	nuclear-transcribed mRNA catabolic process	56	5.320957e-20	1.2503298779107144e-17	2.25069	160	0.02456248	230	0.0006253814750000001	1.499969	85	198	0.0158169	
GO Biological Process	regulation of membrane permeability	57	6.366383e-20	1.4697409455614036e-17	2.724512	111	0.01704022	262	0.0011983825962213741	1.768591	41	81	0.007629326	
GO Biological Process	regulation of mRNA stability	65	6.772635e-19	1.371093907153846e-16	2.187733	160	0.02456248	318	0.004215733933018867	1.504059	65	151	0.01209527	
GO Biological Process	negative regulation of G2/M transition of mitotic cell cycle	67	1.30617e-18	2.5653568701492535e-16	2.844414	96	0.01473749	264	0.0012970482371590908	1.727393	44	89	0.00818757	
GO Cellular Component	catalytic step 2 spliceosome	40	6.40722e-19	2.7679190400000003e-17	2.787713	101	0.01550507	63	0.00021126599314285716	1.747023	48	96	0.008931894	
GO Cellular Component	endopeptidase complex	44	7.351567e-17	2.8871608581818184e-15	3.141096	74	0.01136015	87	0.01096198311724138	1.671065	33	69	0.006140677	
GO Cellular Component	proteasome complex	46	2.275784e-16	8.549032069565217e-15	3.1004	73	0.01120663	95	0.017149816117894737	1.644257	32	68	0.005954596	
GO Cellular Component	spliceosomal complex	47	2.624792e-16	9.650299097872341e-15	2.046704	159	0.02440897	57	0.00003246930189473684	1.577956	84	186	0.01563082	
GO Cellular Component	ribosomal subunit	48	6.468055e-16	2.3284998e-14	2.23099	127	0.01949647	72	0.00232613976	1.454278	77	185	0.01432825	
GO Cellular Component	mitochondrial ribosome	54	4.567767e-14	1.46168544e-12	3.05465	63	0.009671477	111	0.03615794854054054	1.520937	37	85	0.006885002	
GO Cellular Component	large ribosomal subunit	63	7.593028e-12	2.0826591085714285e-10	2.359102	81	0.01243476	105	0.0281968128	1.458384	48	115	0.008931894	
GO Cellular Component	PcG protein complex	80	1.98529e-9	4.2882264e-8	2.340109	63	0.009671477	68	0.0004946260235294117	2.050853	27	46	0.005024191	
GO Cellular Component	methyltransferase complex	88	1.178408e-8	2.3139647999999998e-7	2.04276	77	0.01182069	113	0.038683405592920356	1.497448	39	91	0.007257164	
GO Cellular Component	nucleosome	114	5.657842e-7	0.000008576097347368421	2.190617	50	0.007675775	112	0.03666991885714286	1.464171	44	105	0.00818757	
GO Cellular Component	intercellular bridge	126	0.000001694591	0.000023240105142857143	2.276934	42	0.006447651	76	0.006132219536842104	1.905843	24	44	0.004465947	
GO Cellular Component	Fanconi anaemia nuclear complex	131	0.000003090755	0.00004076965374045802	3.030657	24	0.003684372	83	0.008877006650602409	2.687727	10	13	0.001860811	
GO Cellular Component	Sin3 complex	301	0.003101815	0.017807097408637874	2.224429	16	0.002456248	116	0.04186873986206896	2.418955	9	13	0.00167473	
GO Cellular Component	platelet dense tubular network	310	0.004235262	0.02360817011612903	2.376992	13	0.001995702	121	0.04404397804958678	2.541124	8	11	0.001488649	
GO Cellular Component	R2TP complex	317	0.004718424	0.025720620416403786	3.472681	7	0.001074609	107	0.030969926579439255	3.494045	5	5	0.0009304057	
GO Molecular Function	unfolded protein binding	12	5.483007e-19	1.9291046295e-16	2.942613	93	0.01427694	44	0.001554580700909091	1.681097	51	106	0.009490138	
GO Molecular Function	structural constituent of ribosome	23	1.784976e-12	3.276595074782609e-10	2.105783	110	0.01688671	58	0.012984972100000002	1.466636	68	162	0.01265352	
Human Phenotype	Increased serum lactate	15	1.859077e-13	8.270413880666666e-11	2.464832	86	0.01320233	8	0.004188484450375	1.747023	50	100	0.009304057	
Human Phenotype	Hypoglycemia	26	1.686583e-11	4.328680138076923e-9	2.048747	107	0.01642616	44	0.042124904920454544	1.546038	50	113	0.009304057	
Human Phenotype	Abnormal CSF metabolite level	30	5.054993e-11	1.1243989429666667e-8	2.819294	54	0.008289837	32	0.034792500671875	1.774753	32	63	0.005954596	
Human Phenotype	Death in infancy	113	0.000003120849	0.0001842957997964602	2.131731	46	0.007061713	42	0.034375022102380956	1.809416	29	56	0.005396353	
Mouse Phenotype Single KO	abnormal adrenal chromaffin cell morphology	21	9.9714e-16	4.3480052285714286e-13	4.80816	41	0.006294136	95	0.03754349758210527	2.858764	9	11	0.00167473	
Mouse Phenotype	pancytopenia	11	1.487329e-18	1.2927593244545455e-15	3.841311	63	0.009671477	187	0.03585273254598931	2.048234	17	29	0.003163379	
Mouse Phenotype	interstitial pneumonia	625	0.0010861	0.01661472336	2.012229	25	0.003837888	182	0.034959775486813185	2.223483	14	22	0.002605136