# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	16	4.280765e-82	3.5206616646875e-79	2.697869	501	0.01862938	240	7.92298455375e-9	1.382187	104	113	0.008318004	
GO Biological Process	endoplasmic reticulum unfolded protein response	19	1.034759e-80	7.1665229899999995e-78	2.732114	482	0.01792288	284	1.2828977840140847e-7	1.356889	103	114	0.008238023	
GO Biological Process	IRE1-mediated unfolded protein response	22	6.75491e-75	4.04035730409091e-72	3.708295	287	0.01067192	536	0.0011293210922388058	1.346441	52	58	0.004159002	
GO Biological Process	cellular response to topologically incorrect protein	24	5.32597e-74	2.9201849679166666e-71	2.449214	537	0.01996802	326	0.0000010948300109509202	1.307322	121	139	0.009677677	
GO Biological Process	regulation of DNA-templated transcription in response to stress	25	1.530758e-73	8.0572978088e-71	2.480238	521	0.01937307	217	1.2071326785253457e-9	1.388218	110	119	0.008797889	
GO Biological Process	cellular response to unfolded protein	27	1.669022e-70	8.134318702962963e-68	2.493818	494	0.01836909	256	1.5880430266796875e-8	1.365272	110	121	0.008797889	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	28	9.523514e-69	4.4757114545e-66	2.20827	616	0.02290559	521	0.0008439068757581575	1.220818	126	155	0.01007758	
GO Biological Process	response to topologically incorrect protein	30	6.757037e-67	2.9638616627666668e-64	2.157513	631	0.02346335	279	8.449120343727599e-8	1.293216	155	180	0.01239702	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	32	2.347377e-65	9.6528543571875e-63	4.536593	198	0.007362511	791	0.012453015491024021	1.439225	23	24	0.001839559	
GO Biological Process	rRNA processing	33	5.535332e-65	2.2072555693333338e-62	2.030788	707	0.02628937	63	1.0295975482698413e-26	1.430285	240	252	0.01919539	
GO Biological Process	rRNA metabolic process	34	6.524729e-65	2.525262026794118e-62	2.01172	723	0.02688432	60	8.396810536e-28	1.432218	247	259	0.01975526	
GO Biological Process	response to unfolded protein	40	1.289643e-60	4.24260305925e-58	2.14389	579	0.02152977	233	3.95139186193133e-9	1.332847	142	160	0.01135727	
GO Biological Process	positive regulation of nuclease activity	51	5.527482e-56	1.426198738e-53	5.442603	141	0.005243	927	0.0317500266828479	1.5018	15	15	0.001199712	
GO Biological Process	nuclear-transcribed mRNA catabolic process	52	1.398909e-55	3.540046832884616e-53	2.037536	598	0.02223627	103	1.516668012815534e-18	1.410781	186	198	0.01487643	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	53	1.808207e-55	4.489470926981132e-53	2.3886	420	0.01561745	893	0.023742534666293395	1.214221	76	94	0.006078541	
GO Biological Process	liver regeneration	72	5.217347e-47	9.535426274027777e-45	3.034439	234	0.008701149	977	0.0380067612272262	1.330165	31	35	0.002479405	
GO Biological Process	protein targeting to ER	75	2.457123e-46	4.3111042076000005e-44	2.4977	320	0.01189901	163	2.3451235156441717e-12	1.457192	98	101	0.007838119	
GO Biological Process	regulation of cellular amino acid metabolic process	78	3.380727e-45	5.7034598196153845e-43	3.115163	216	0.00803183	500	0.0006563130204000001	1.35162	54	60	0.004318963	
GO Biological Process	regulation of nuclease activity	89	1.910461e-43	2.8246917189887637e-41	3.719686	163	0.006061057	960	0.033459361885416664	1.386277	24	26	0.001919539	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	93	1.693971e-42	2.3968778912903228e-40	2.317631	339	0.01260551	194	4.157290989948454e-11	1.41271	111	118	0.008877869	
GO Cellular Component	ribosomal subunit	38	3.860271e-45	1.7554074442105265e-43	2.042413	480	0.01784851	40	3.2034869279999996e-16	1.396268	172	185	0.0137567	
GO Cellular Component	large ribosomal subunit	43	1.725537e-38	6.934251013953488e-37	2.264516	321	0.01193619	45	8.8044288e-13	1.436504	110	115	0.008797889	
GO Cellular Component	mitochondrial ribosome	44	4.798416e-36	1.8844688290909091e-34	2.630737	224	0.008329305	66	2.8283458909090905e-8	1.413458	80	85	0.006398464	
GO Cellular Component	endopeptidase complex	47	4.596301e-32	1.689874069787234e-30	2.40588	234	0.008701149	69	1.1268991721739131e-7	1.436504	66	69	0.005278733	
GO Cellular Component	proteasome complex	49	5.998358e-31	2.1153393110204082e-29	2.376377	231	0.008589596	71	1.5778745239436619e-7	1.435544	65	68	0.005198752	
GO Cellular Component	catalytic step 2 spliceosome	51	6.585781e-28	2.231417562352941e-26	2.012341	301	0.0111925	78	7.522730584615384e-7	1.361006	87	96	0.00695833	
GO Cellular Component	peptidase complex	53	1.712633e-27	5.583829856603774e-26	2.073651	275	0.01022571	58	1.2893165131034483e-9	1.433536	84	88	0.006718388	
GO Cellular Component	proteasome core complex	55	3.928744e-27	1.234339933090909e-25	4.28616	84	0.003123489	228	0.03595498105263158	1.37665	22	24	0.001759578	
GO Cellular Component	mitochondrial large ribosomal subunit	59	1.811183e-26	5.304617328813559e-25	2.825574	143	0.005317369	90	0.00000639198912	1.442905	49	51	0.003919059	
GO Cellular Component	nuclear ubiquitin ligase complex	61	1.195664e-25	3.387061298360655e-24	2.792096	141	0.005243	206	0.020218623378640773	1.314075	35	40	0.002799328	
GO Cellular Component	cleavage furrow	74	3.383904e-23	7.901873124324325e-22	2.059771	233	0.008663965	212	0.023899560452830187	1.270753	44	52	0.003519155	
GO Cellular Component	MLL1 complex	102	6.371044e-17	1.0793298070588236e-15	2.590584	102	0.003792809	138	0.0014584845913043478	1.450013	28	29	0.002239463	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	121	8.189791e-15	1.1695833758677686e-13	2.942016	71	0.002640092	238	0.04780625263865546	1.371208	21	23	0.001679597	
GO Cellular Component	proton-transporting ATP synthase complex	122	1.299694e-14	1.8408780590163935e-13	2.887864	72	0.002677277	228	0.03595498105263158	1.37665	22	24	0.001759578	
GO Cellular Component	DNA-directed RNA polymerase III complex	138	3.53627e-13	4.428025043478261e-12	3.420375	50	0.00185922	156	0.004861891938461539	1.5018	19	19	0.001519635	
GO Cellular Component	proteasome accessory complex	169	1.940624e-11	1.984259332544379e-10	2.442458	73	0.002714461	175	0.007391520987428572	1.439225	23	24	0.001839559	
GO Cellular Component	cytoplasmic exosome (RNase complex)	171	3.05746e-11	3.0896437894736837e-10	3.834629	36	0.001338638	231	0.03776333049350649	1.5018	13	13	0.00103975	
GO Cellular Component	spliceosomal tri-snRNP complex	230	1.003037e-8	7.535860591304349e-8	2.101423	73	0.002714461	223	0.03374761528251121	1.346441	26	29	0.002079501	
GO Cellular Component	intraciliary transport particle	235	1.478903e-8	1.087465695319149e-7	2.005217	80	0.002974752	193	0.015244648787564766	1.361006	29	32	0.002319443	
GO Cellular Component	mitochondrial small ribosomal subunit	244	2.149415e-8	1.5222086557377047e-7	2.150109	66	0.00245417	188	0.011423955063829788	1.394528	26	28	0.002079501	
GO Molecular Function	unfolded protein binding	9	2.126137e-46	9.973944904444444e-44	2.483155	324	0.01204774	89	0.00026114901114606743	1.289281	91	106	0.007278253	
GO Molecular Function	structural constituent of ribosome	11	1.581202e-39	6.068940767272726e-37	2.012423	434	0.01613803	14	1.7536671095714286e-14	1.409096	152	162	0.01215708	
GO Molecular Function	protein phosphatase 2A binding	16	4.111986e-30	1.08505030575e-27	2.578894	192	0.007139404	169	0.043567217715976325	1.390555	25	27	0.00199952	
GO Molecular Function	rRNA binding	17	8.152908e-30	2.0247986809411765e-27	2.908113	155	0.005763582	64	0.000007744203499999999	1.42671	57	60	0.004558906	
GO Molecular Function	ribonuclease activity	20	3.653953e-28	7.713494783e-26	2.00957	305	0.01134124	68	0.00001614017204117647	1.334933	88	99	0.007038311	
GO Molecular Function	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	42	8.418125e-18	8.462219940476191e-16	2.142025	159	0.005912319	106	0.0010050419220754717	1.381656	46	50	0.003679117	
GO Molecular Function	mRNA 5'-UTR binding	57	3.934011e-16	2.913928849473684e-14	2.616503	95	0.003532518	127	0.004300981319685039	1.5018	22	22	0.001759578	
GO Molecular Function	snRNA binding	62	8.266731e-16	5.6293771422580647e-14	2.554476	97	0.003606887	160	0.0302183053125	1.343715	34	38	0.002719347	
GO Molecular Function	NF-kappaB binding	64	1.573745e-15	1.0381799046875001e-13	2.347071	112	0.004164653	164	0.0319966844390244	1.394528	26	28	0.002079501	
GO Molecular Function	RNA polymerase III activity	110	1.845642e-11	7.083909567272727e-10	3.285346	45	0.001673298	167	0.03763713276646706	1.5018	16	16	0.001279693	
Human Phenotype	Increased serum lactate	5	3.4891e-36	4.6565528599999995e-33	2.207621	318	0.01182464	47	4.273211726595744e-8	1.396674	93	100	0.007438215	
Human Phenotype	Abnormal CSF metabolite level	11	1.11043e-26	6.736272172727272e-24	2.415397	191	0.00710222	114	0.00011323454674561404	1.382609	58	63	0.004638887	
Human Phenotype	Abnormality of mitochondrial metabolism	13	2.653133e-24	1.3618735776153846e-21	2.091787	236	0.008775518	164	0.0011500256337804878	1.327678	61	69	0.004878829	
Human Phenotype	Abnormality of the mitochondrion	14	5.13966e-24	2.449782227142857e-21	2.069864	239	0.008887071	153	0.0006871052895424837	1.332583	63	71	0.005038791	
Human Phenotype	Increased CSF lactate	20	8.340609e-23	2.78284419285e-20	2.359935	169	0.006284163	145	0.00045377039687586213	1.372334	53	58	0.004238983	
Human Phenotype	Exercise intolerance	30	3.562424e-20	7.924018450666666e-18	2.124242	186	0.006916298	211	0.007822919190521327	1.287257	60	70	0.004798848	
Human Phenotype	Abnormality of transition element cation homeostasis	35	2.423575e-19	4.6207188500000005e-17	3.057257	90	0.003346596	256	0.023036840790234374	1.398227	27	29	0.002159482	
Human Phenotype	Global brain atrophy	453	0.000001612095	0.000023747262549668877	2.030781	55	0.002045142	314	0.04753269281847134	1.5018	15	15	0.001199712	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	152	1.249628e-18	7.52818657631579e-17	2.622089	111	0.004127468	301	0.047459240325581395	1.433536	21	22	0.001679597	
Mouse Phenotype Single KO	increased skin tumor incidence	221	6.321341e-15	2.619209028823529e-13	2.007212	153	0.005689213	191	0.008449326904188483	1.365272	40	44	0.003199232	
Mouse Phenotype	pancytopenia	126	1.901358e-24	1.4427685585714287e-22	2.466402	167	0.006209794	363	0.023277613584297523	1.398227	27	29	0.002159482	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	182	3.340807e-20	1.755025039945055e-18	2.613778	122	0.004536496	331	0.018113360716314197	1.40168	28	30	0.002239463	
Mouse Phenotype	absent segment of posterior cerebral artery	212	1.249628e-18	5.635704390566038e-17	2.622089	111	0.004127468	399	0.03738216810526316	1.433536	21	22	0.001679597