# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of epithelial to mesenchymal transition 153 6.379955e-22 5.487178290522875e-20 2.009071 232 0.01707389 474 0.0006491515150421942 1.639005 35 44 0.003840667 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 183 4.726125e-19 3.3984196106557375e-17 2.192014 162 0.01192228 821 0.021008559878197317 1.292155 74 118 0.008120268 GO Biological Process heterochromatin organization 307 1.176958e-13 5.0448176944625406e-12 3.579621 49 0.003606123 811 0.01982118589889026 1.901966 12 13 0.0013168 GO Biological Process gene silencing by miRNA 359 1.772471e-12 6.496920860445682e-11 2.242109 96 0.007065057 959 0.03638006571220021 1.45169 31 44 0.003401734 GO Biological Process posttranscriptional gene silencing by RNA 368 2.505062e-12 8.957638820108697e-11 2.123263 107 0.007874595 976 0.03946726557581968 1.414043 35 51 0.003840667 GO Biological Process nuclear-transcribed mRNA catabolic process, deadenylation-independent decay 438 5.308439e-11 1.5948344475114155e-9 3.937266 34 0.002502208 997 0.04056224134002006 2.060463 8 8 0.0008778668 GO Biological Process positive regulation of focal adhesion assembly 485 2.050231e-10 5.5626782946391756e-9 2.122492 88 0.006476303 904 0.030899879372787608 1.6312 19 24 0.002084934 GO Biological Process positive regulation of adherens junction organization 518 4.591762e-10 1.1664671072972972e-8 2.076749 89 0.006549897 985 0.03997518504467005 1.584972 20 26 0.002194667 GO Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activity 546 8.697445e-10 2.096147962545788e-8 2.415583 62 0.00456285 904 0.030899879372787608 1.6312 19 24 0.002084934 GO Biological Process negative regulation of cyclin-dependent protein kinase activity 694 2.225122e-8 4.2190749853025933e-7 2.19128 63 0.004636444 985 0.03997518504467005 1.584972 20 26 0.002194667 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 723 4.491358e-8 8.174520044536652e-7 2.228442 58 0.004268472 834 0.022771444383693044 1.802905 14 16 0.001536267 GO Biological Process regulation of anoikis 827 2.002315e-7 0.0000031860293935912937 2.00493 67 0.004930821 761 0.014064323637450723 1.702122 19 23 0.002084934 GO Biological Process entrainment of circadian clock by photoperiod 1273 0.00002866962 0.000296357839418696 2.102362 38 0.002796585 944 0.036107808113347455 1.717053 15 18 0.001646 GO Biological Process peptidyl-lysine monomethylation 1766 0.0003429338 0.0025553034395243493 2.082279 28 0.002060642 849 0.023107250498233218 2.060463 9 9 0.0009876001 GO Cellular Component telomerase holoenzyme complex 102 2.830713e-9 4.7955608470588235e-8 3.000209 40 0.002943774 92 0.02630160626086957 1.685833 18 22 0.0019752 GO Cellular Component Sin3 complex 188 0.00001722266 0.00015830189617021276 2.266051 34 0.002502208 67 0.0021281960310447763 2.060463 13 13 0.001426534 GO Cellular Component NuA4 histone acetyltransferase complex 223 0.0000661637 0.0005126945004484305 2.039711 37 0.002722991 79 0.009330012273417721 1.831523 16 18 0.001755734 GO Cellular Component nucleotide-activated protein kinase complex 359 0.006096731 0.029345824980501395 2.01696 17 0.001251104 85 0.014701854494117646 2.060463 10 10 0.001097333 GO Molecular Function DNA polymerase binding 304 0.0002030672 0.0028202293368421055 2.617027 19 0.001398293 127 0.04797867502362205 1.802905 14 16 0.001536267 Human Phenotype Limb hypertonia 287 1.118624e-7 0.0000026008982411149824 2.183414 57 0.004194878 172 0.03053951213255814 1.818056 15 17 0.001646 Mouse Phenotype Single KO dilated brain ventricles 34 6.961119e-26 1.8747931377352942e-23 2.128582 241 0.01773624 631 0.018263411565768623 1.383454 47 70 0.005157467 Mouse Phenotype Single KO dilated lateral ventricles 64 1.003501e-21 1.43579041515625e-19 2.290016 170 0.01251104 739 0.03116400942625169 1.429709 34 49 0.003730934 Mouse Phenotype Single KO abnormal pulmonary valve cusp morphology 92 3.490076e-19 3.47376368826087e-17 2.709889 108 0.00794819 815 0.04542811294723927 1.64837 16 20 0.001755734 Mouse Phenotype Single KO abnormal thyroid cartilage morphology 189 1.668815e-14 8.085364526455027e-13 2.375586 101 0.007433029 518 0.007540306901351351 1.831523 16 18 0.001755734 Mouse Phenotype Single KO fusion of vertebral arches 204 5.096291e-14 2.2875851317156863e-12 2.002119 143 0.01052399 404 0.002400416886633663 1.55586 37 49 0.004060134 Mouse Phenotype Single KO abnormal facial nerve morphology 213 1.024737e-13 4.4054069056338025e-12 2.161425 116 0.008536944 285 0.0002237813363859649 1.839699 25 28 0.002743334 Mouse Phenotype Single KO abnormal fourth pharyngeal arch morphology 219 1.677071e-13 7.012300980365296e-12 2.177953 112 0.008242567 532 0.008054096150939851 1.766111 18 21 0.0019752 Mouse Phenotype Single KO abnormal metanephros morphology 300 1.042723e-11 3.1827381703333337e-10 2.139976 99 0.00728584 815 0.04542811294723927 1.64837 16 20 0.001755734 Mouse Phenotype Single KO iris synechia 310 1.937945e-11 5.724439472580646e-10 2.143486 96 0.007065057 597 0.01279423555795645 1.751394 17 20 0.001865467 Mouse Phenotype Single KO uveal coloboma 313 2.032952e-11 5.947521234504793e-10 2.743309 59 0.004342067 839 0.04853732789392134 1.873148 10 11 0.001097333 Mouse Phenotype Single KO thin interventricular septum 400 3.555297e-10 8.13896365725e-9 2.540628 59 0.004342067 458 0.004594128879694323 1.843572 17 19 0.001865467 Mouse Phenotype Single KO abnormal patella morphology 543 1.716755e-8 2.8950875755064457e-7 2.134184 68 0.005004416 745 0.03228554164832215 1.785735 13 15 0.001426534 Mouse Phenotype Single KO abnormal mammary gland embryonic development 580 3.880694e-8 6.126812923793103e-7 2.027653 73 0.005372387 661 0.02065308014977307 2.060463 9 9 0.0009876001 Mouse Phenotype Single KO enlarged allantois 627 1.046922e-7 0.0000015289736449760765 2.109237 62 0.00456285 655 0.020176491859541984 1.802905 14 16 0.001536267 Mouse Phenotype Single KO abnormal rib development 633 1.148353e-7 0.0000016612114409162716 2.075658 64 0.004710038 588 0.012258725070068028 1.818056 15 17 0.001646 Mouse Phenotype Single KO abnormal thymus development 670 2.113634e-7 0.0000028887382892537315 2.292205 49 0.003606123 655 0.020176491859541984 1.802905 14 16 0.001536267 Mouse Phenotype Single KO increased histiocytic sarcoma incidence 750 6.839672e-7 0.000008350783533866667 2.074602 56 0.004121283 729 0.030027461057613166 1.667994 17 21 0.001865467 Mouse Phenotype Single KO abnormal liver bud morphology 874 0.000003920869 0.000041079402097254 2.010649 52 0.003826906 766 0.036738266537859006 2.060463 8 8 0.0008778668 Mouse Phenotype Single KO abnormal type I pneumocyte morphology 992 0.00001404282 0.00012962711969758065 2.043473 44 0.003238151 839 0.04853732789392134 1.873148 10 11 0.001097333 Mouse Phenotype abnormal liver sinusoid morphology 81 1.353126e-26 1.597189837777778e-24 2.232191 223 0.01641154 941 0.009278608092242296 1.373642 52 78 0.005706134 Mouse Phenotype abnormal keratinocyte proliferation 133 1.348028e-20 9.69059827669173e-19 2.116786 191 0.01405652 1012 0.013402679712450594 1.373642 48 72 0.005267201 Mouse Phenotype abnormal pulmonary valve cusp morphology 147 1.01672e-19 6.61282987755102e-18 2.659043 115 0.00846335 1073 0.016392187476234856 1.602582 21 27 0.0023044 Mouse Phenotype increased squamous cell carcinoma incidence 180 8.014929e-18 4.2572631205e-16 2.251484 142 0.0104504 646 0.0013217940417027865 1.545347 39 52 0.004279601 Mouse Phenotype fusion of vertebral arches 207 3.374216e-17 1.5584965785507245e-15 2.077123 164 0.01206947 800 0.0041207670975 1.488112 39 54 0.004279601 Mouse Phenotype increased keratinocyte proliferation 212 5.500974e-17 2.480887378018868e-15 2.323759 126 0.009272888 672 0.0015067766080357145 1.55586 37 49 0.004060134 Mouse Phenotype abnormal aortic valve cusp morphology 225 1.834634e-16 7.795971410666668e-15 2.294076 125 0.009199293 1015 0.013447824381280789 1.518236 28 38 0.003072534 Mouse Phenotype increased lung adenoma incidence 247 1.524493e-15 5.901084037651822e-14 2.202542 128 0.009420077 824 0.004910246483009709 1.471759 40 56 0.004389334 Mouse Phenotype abnormal lung adenoma incidence 250 2.165352e-15 8.2811721888e-14 2.191659 128 0.009420077 909 0.007952100373927393 1.445939 40 57 0.004389334 Mouse Phenotype abnormal thyroid cartilage morphology 263 5.308163e-15 1.929708990228137e-13 2.171398 127 0.009346482 1180 0.024245164619491524 1.584972 20 26 0.002194667 Mouse Phenotype abnormal paraxial mesoderm morphology 278 1.061115e-14 3.6493958687050356e-13 2.017264 148 0.01089196 1056 0.015524049025568183 1.442324 35 50 0.003840667 Mouse Phenotype abnormal fourth ventricle morphology 309 4.498324e-14 1.3918600570873785e-12 2.14143 122 0.00897851 891 0.007268610215151515 1.63416 23 29 0.002523867 Mouse Phenotype abnormal fourth pharyngeal arch artery morphology 345 3.508272e-13 9.722489446956522e-12 2.004142 133 0.009788048 833 0.005100280442737095 1.678896 22 27 0.002414134 Mouse Phenotype increased skin papilloma incidence 383 2.023214e-12 5.050639439686684e-11 2.166791 103 0.007580218 1109 0.01898796495311091 1.471759 30 42 0.003292 Mouse Phenotype abnormal third pharyngeal arch morphology 406 3.54974e-12 8.359375403940886e-11 2.094013 109 0.008021784 1245 0.030685365221686748 1.545347 21 28 0.0023044 Mouse Phenotype mesangial cell hyperplasia 478 4.404212e-11 8.809345383263598e-10 2.091577 98 0.007212246 1205 0.026713973541908714 1.488112 26 36 0.002853067 Mouse Phenotype abnormal rib development 483 5.126067e-11 1.0147065545962734e-9 2.195763 87 0.006402708 639 0.001256875593802817 1.685833 27 33 0.0029628 Mouse Phenotype decreased B cell apoptosis 557 4.052371e-10 6.955963937342908e-9 2.288178 72 0.005298793 1125 0.020316258136 1.667994 17 21 0.001865467 Mouse Phenotype increased hamartoma incidence 587 1.286798e-9 2.0959243063032368e-8 3.037328 41 0.003017368 720 0.0022592948420833334 2.060463 12 12 0.0013168 Mouse Phenotype increased sternebra number 699 1.645862e-8 2.2512284094420602e-7 3.946188 25 0.001839859 1382 0.04382543091968162 2.060463 7 7 0.0007681334