# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	15	1.666659e-39	1.4621043854e-36	2.690136	236	0.0176475	290	0.0001719384434310345	1.45728	77	114	0.008847524	
GO Biological Process	IRE1-mediated unfolded protein response	18	8.500193e-38	6.214113315944444e-35	3.689701	142	0.01061841	452	0.004356339353097345	1.525152	41	58	0.004711019	
GO Biological Process	mRNA catabolic process	19	9.123621e-37	6.31882782836842e-34	2.137627	345	0.02579825	132	1.0187448576515151e-8	1.468742	145	213	0.01666092	
GO Biological Process	RNA catabolic process	20	1.476712e-36	9.716026604e-34	2.038053	384	0.02871457	119	1.7893165880672268e-9	1.459244	163	241	0.01872917	
GO Biological Process	nuclear-transcribed mRNA catabolic process	21	1.75977e-36	1.1027054014285715e-33	2.199478	321	0.02400359	138	1.4123211421739132e-8	1.481941	136	198	0.0156268	
GO Biological Process	cellular response to topologically incorrect protein	22	3.355011e-36	2.0067540794999997e-33	2.41223	263	0.01966649	375	0.00140775403088	1.365919	88	139	0.01011146	
GO Biological Process	cellular response to unfolded protein	24	8.689122e-34	4.76417318325e-31	2.436461	240	0.01794661	315	0.00036325674325079365	1.426467	80	121	0.009192233	
GO Biological Process	response to topologically incorrect protein	36	2.620928e-31	9.580219875555556e-29	2.097173	305	0.02280715	381	0.001557372485328084	1.318492	110	180	0.01263932	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	42	2.735359e-30	8.570140257380951e-28	2.105061	292	0.02183504	404	0.0021044393948514853	1.336278	96	155	0.01103068	
GO Biological Process	regulation of DNA-templated transcription in response to stress	44	1.765865e-29	5.281140348863637e-27	2.278468	238	0.01779705	768	0.04013409329427083	1.287267	71	119	0.008158106	
GO Biological Process	response to unfolded protein	48	1.74267e-28	4.7774571937500004e-26	2.084934	280	0.02093771	361	0.0009850995077008312	1.348457	100	160	0.01149029	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	55	4.493736e-27	1.0751467640727273e-24	2.344544	205	0.0153294	731	0.03476780613132695	1.331243	58	94	0.006664369	
GO Biological Process	liver regeneration	57	4.215362e-26	9.73156992245614e-24	3.129351	120	0.008973304	600	0.016133712574166667	1.602738	26	35	0.002987476	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	59	6.86758e-25	1.531703139322034e-22	2.419735	176	0.01316085	224	0.000017206091571875	1.499302	82	118	0.009422038	
GO Biological Process	protein targeting to ER	62	9.752536e-25	2.0698971165161288e-22	2.527124	161	0.01203918	180	7.443512629444444e-7	1.602128	75	101	0.008617718	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	79	5.433434e-23	9.05045038050633e-21	2.544105	147	0.0109923	309	0.0003237408267605178	1.577896	49	67	0.005630242	
GO Biological Process	RNA phosphodiester bond hydrolysis	83	6.05757e-22	9.603802846987952e-20	2.11468	205	0.0153294	190	0.000002047104075263158	1.50865	93	133	0.01068597	
GO Biological Process	protein-lipid complex assembly	85	2.433235e-21	3.7669340429411773e-19	3.523109	82	0.006131758	500	0.007748656095600001	1.711146	23	29	0.002642767	
GO Biological Process	cotranslational protein targeting to membrane	88	7.620849e-21	1.1395767271704545e-18	2.414461	146	0.01091752	194	0.0000028837833189175256	1.585125	72	98	0.008273009	
GO Biological Process	DNA-templated transcription, elongation	92	1.401237e-20	2.0042258351086957e-18	2.252561	166	0.01241307	467	0.005325337406852248	1.372975	70	110	0.008043203	
GO Cellular Component	catalytic step 2 spliceosome	51	1.468835e-14	4.976758588235294e-13	2.003235	149	0.01114185	59	0.00008064394413559321	1.505777	67	96	0.007698495	
GO Cellular Component	peptidase complex	56	1.107641e-13	3.4178636571428575e-12	2.031974	134	0.01002019	133	0.021343801263157894	1.348457	55	88	0.00631966	
GO Cellular Component	chylomicron	72	1.37904e-11	3.3096959999999997e-10	3.857312	37	0.002766769	150	0.0337427136	1.849313	12	14	0.001378835	
GO Cellular Component	spliceosomal snRNP complex	73	1.829492e-11	4.3306331178082185e-10	2.267079	85	0.006356091	112	0.008332925142857142	1.461554	42	62	0.004825922	
GO Cellular Component	very-low-density lipoprotein particle	80	7.541861e-11	1.6290419759999997e-9	3.093061	46	0.003439767	107	0.00687789541682243	1.833902	17	20	0.001953349	
GO Cellular Component	DNA-directed RNA polymerase III complex	88	2.347689e-10	4.610007490909091e-9	4.127009	30	0.002243326	118	0.011547029044067797	1.816869	16	19	0.001838447	
GO Cellular Component	ESCRT complex	139	7.424203e-7	0.000009229512794244605	2.356718	42	0.003140657	70	0.00046061814857142853	1.849313	24	28	0.00275767	
GO Cellular Component	DNA-directed RNA polymerase I complex	164	0.000002942886	0.00003100796956097561	2.96065	25	0.001869438	103	0.006069385258252427	2.003422	13	14	0.001493738	
GO Cellular Component	ESCRT III complex	169	0.000004400851	0.000044998050461538456	2.968041	24	0.001794661	88	0.0019222340727272727	2.157532	12	12	0.001378835	
GO Cellular Component	methylosome	170	0.000004992635	0.00005074866635294118	3.471171	19	0.001420773	130	0.01939830203076923	1.977738	11	12	0.001263932	
GO Cellular Component	U1 snRNP	230	0.000107097	0.0008046244173913043	2.140821	31	0.002318104	158	0.042874479797468355	1.703315	15	19	0.001723544	
GO Molecular Function	ribonuclease activity	15	3.038411e-17	8.552114161333333e-15	2.106739	159	0.01188963	39	0.0000028679775358974363	1.590907	73	99	0.008387912	
GO Molecular Function	endoribonuclease activity	36	2.581307e-11	3.027299487222222e-9	2.182173	91	0.006804756	67	0.002539723305074627	1.579622	41	56	0.004711019	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	43	1.287958e-10	1.2645950409302325e-8	2.519244	63	0.004710985	80	0.0090051829625	1.605605	32	43	0.003676893	
GO Molecular Function	5'-3' RNA polymerase activity	47	1.776914e-10	1.5961980655319147e-8	2.477564	64	0.004785762	83	0.011035636549397591	1.58219	33	45	0.003791796	
GO Molecular Function	RNA polymerase III activity	79	1.655341e-8	8.846645192405063e-7	3.817265	26	0.001944216	106	0.03243559466037736	1.88784	14	16	0.001608641	
Human Phenotype	Increased serum lactate	10	3.624221e-18	2.4184426733000002e-15	2.177872	156	0.0116653	48	0.000023147316302083335	1.553423	72	100	0.008273009	
Human Phenotype	Abnormal CSF metabolite level	13	5.446838e-17	2.7959038441538463e-14	2.593975	102	0.007627309	78	0.0003990424057051282	1.609587	47	63	0.005400437	
Human Phenotype	Exercise intolerance	15	1.323335e-16	5.887076303333334e-14	2.48042	108	0.008075974	150	0.015711698614	1.448629	47	70	0.005400437	
Human Phenotype	Increased CSF lactate	16	3.116486e-16	1.299769442375e-13	2.639682	94	0.007029088	86	0.0012034414090697674	1.59955	43	58	0.004940825	
Human Phenotype	Abnormality of transition element cation homeostasis	21	2.112673e-15	6.713269966190476e-13	3.688872	54	0.004037987	139	0.01413447975971223	1.711146	23	29	0.002642767	
Human Phenotype	Increased serum ferritin	30	4.833657e-13	1.0751664387e-10	3.966004	41	0.003065879	154	0.018454233497402595	1.833902	17	20	0.001953349	
Human Phenotype	Abnormality of mitochondrial metabolism	35	1.616545e-12	3.08205851e-10	2.067635	116	0.008674194	74	0.0002656188551756757	1.594697	51	69	0.005860048	
Human Phenotype	Abnormality of the mitochondrion	41	6.551794e-12	1.0663444234634146e-9	2.020284	116	0.008674194	85	0.0009144357325882354	1.549776	51	71	0.005860048	
Human Phenotype	Abnormality of iron homeostasis	42	8.928338e-12	1.4185428446190477e-9	3.359102	45	0.003364989	189	0.03760161355555556	1.708046	19	24	0.002183155	
Human Phenotype	Glycosuria	58	1.030787e-10	1.1859382156896551e-8	2.471658	66	0.004935317	139	0.01413447975971223	1.711146	23	29	0.002642767	
Human Phenotype	Decreased circulating low-density lipoprotein levels	69	1.317235e-9	1.2738998775362317e-7	3.465307	34	0.002542436	186	0.03533693607741935	2.157532	9	9	0.001034126	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	132	1.853253e-7	0.000009368755506818182	3.112928	29	0.002168549	198	0.04879455999494949	1.797943	15	18	0.001723544	
Mouse Phenotype Single KO	abnormal vertebral transverse process morphology	243	0.000001179291	0.00004443937319753087	2.465807	37	0.002766769	222	0.04062757961081081	2.157532	9	9	0.001034126	
Mouse Phenotype	absent hypoglossal nerve	28	1.631888e-20	5.572314702857143e-18	4.722511	56	0.004187542	396	0.037445704787878786	1.869861	13	15	0.001493738	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	73	2.967975e-13	3.8872341061643837e-11	2.843565	66	0.004935317	321	0.021068697041121496	1.654108	23	30	0.002642767	
Mouse Phenotype	abnormal hypoglossal nerve topology	276	1.648076e-7	0.0000057091502304347824	2.500762	42	0.003140657	386	0.03586175052590673	1.797943	15	18	0.001723544	
Mouse Phenotype	abnormal vertebral transverse process morphology	409	0.00001080184	0.0002525095164792176	2.15193	40	0.002991101	240	0.00841955603125	2.157532	11	11	0.001263932	
Mouse Phenotype	tachypnea	537	0.00006886309	0.00122607077	2.082626	35	0.002617214	386	0.03586175052590673	1.797943	15	18	0.001723544	
Mouse Phenotype	abnormal lipoprotein lipase activity	683	0.0004106397	0.00574835457057101	2.160178	25	0.001869438	293	0.014888744882252558	2.157532	10	10	0.001149029