# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	16	1.017288e-35	8.366557995e-33	2.932098	184	0.01923479	347	0.006685534236023054	1.468008	60	114	0.008912656	
GO Biological Process	cellular response to topologically incorrect protein	18	9.337859e-34	6.826493698944444e-31	2.641366	206	0.0215346	341	0.006223971604398826	1.424707	71	139	0.01054664	
GO Biological Process	cellular response to unfolded protein	19	1.174214e-33	8.132358961052631e-31	2.739075	193	0.02017562	318	0.0037301271077358486	1.475288	64	121	0.009506833	
GO Biological Process	mitochondrial transport	21	2.353729e-33	1.4748914243333335e-30	2.128493	313	0.03272005	192	0.0001243627619322917	1.412113	121	239	0.01797386	
GO Biological Process	regulation of DNA-templated transcription in response to stress	26	2.149217e-31	1.087751788576923e-28	2.609751	195	0.0203847	397	0.013230380117128465	1.429766	61	119	0.0090612	
GO Biological Process	response to topologically incorrect protein	33	4.174075e-29	1.664444028030303e-26	2.268532	236	0.02467071	361	0.007770152565096953	1.363617	88	180	0.0130719	
GO Biological Process	response to unfolded protein	35	4.073437e-28	1.5314959280857144e-25	2.300515	221	0.02310266	342	0.006214395464912281	1.394608	80	160	0.01188354	
GO Biological Process	cellular response to insulin stimulus	36	7.437834e-28	2.7187349335000002e-25	2.094988	269	0.02812043	339	0.005765897274041297	1.413454	75	148	0.01114082	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	43	2.355839e-26	7.209415209534884e-24	2.227269	221	0.02310266	315	0.0032734194721269843	1.4216	79	155	0.011735	
GO Biological Process	cellular response to epidermal growth factor stimulus	52	1.241895e-24	3.142710827884615e-22	2.950888	123	0.01285804	291	0.0020096578547766325	1.908411	26	38	0.003862151	
GO Biological Process	response to epidermal growth factor	53	3.132312e-24	7.7769987939622645e-22	2.845587	128	0.01338072	294	0.002108411069455782	1.859477	28	42	0.004159239	
GO Biological Process	mitochondrial membrane organization	55	4.920284e-24	1.1772003119272727e-21	2.244876	197	0.02059377	365	0.00819043199041096	1.439595	64	124	0.009506833	
GO Biological Process	mRNA catabolic process	62	1.31595e-23	2.7929977499999996e-21	2.052861	237	0.02477525	154	0.00001630636791103896	1.479725	113	213	0.0167855	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	69	4.808419e-22	9.17014284362319e-20	2.586645	136	0.01421702	424	0.016274349800471696	1.431633	58	113	0.008615567	
GO Biological Process	nuclear-transcribed mRNA catabolic process	81	1.932686e-20	3.1397796387654323e-18	2.021136	211	0.02205729	157	0.000020927017527388535	1.493216	106	198	0.01574569	
GO Biological Process	regulation of hematopoietic stem cell differentiation	88	1.404797e-19	2.100650423068182e-17	2.581687	120	0.01254443	536	0.039349117106343284	1.408148	52	103	0.007724302	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	92	3.879093e-19	5.548367911630435e-17	2.460161	128	0.01338072	215	0.0003956657912744186	1.56007	66	118	0.009803922	
GO Biological Process	protein targeting to ER	105	1.013409e-17	1.2700427648571427e-15	2.50152	114	0.01191721	290	0.0020007356520344824	1.546496	56	101	0.008318479	
GO Biological Process	macroautophagy	112	3.027979e-17	3.557604969732143e-15	2.004562	179	0.01871211	331	0.005394100705135951	1.413203	76	150	0.01128936	
GO Biological Process	negative regulation of protein ubiquitination	121	1.717158e-16	1.8674448034710746e-14	2.015856	168	0.0175622	409	0.014136852046454767	1.394608	69	138	0.01024955	
GO Cellular Component	catalytic step 2 spliceosome	43	1.108347e-14	4.4540084093023256e-13	2.217819	118	0.01233535	73	0.0019273359254794523	1.539879	53	96	0.007872846	
GO Cellular Component	ESCRT III complex	46	1.881162e-13	7.066625947826086e-12	5.359433	31	0.003240644	101	0.01797730788118812	2.324346	10	12	0.001485443	
GO Cellular Component	peptidase complex	49	5.584359e-13	1.969341296326531e-11	2.204678	104	0.01087184	75	0.002580309504	1.553086	49	88	0.007278669	
GO Cellular Component	proteasome complex	50	7.768437e-13	2.6847718272e-11	2.429358	84	0.0087811	88	0.011352967854545455	1.558679	38	68	0.005644682	
GO Cellular Component	endopeptidase complex	51	7.992147e-13	2.707927454117647e-11	2.427986	84	0.0087811	95	0.015379480117894738	1.53609	38	69	0.005644682	
GO Cellular Component	spliceosomal snRNP complex	52	9.982155e-13	3.317146892307692e-11	2.647308	71	0.00742212	80	0.00634868928	1.619545	36	62	0.005347594	
GO Cellular Component	ESCRT complex	54	1.766697e-12	5.6534304e-11	3.529956	45	0.004704161	86	0.011434503516279068	1.892682	19	28	0.002822341	
GO Cellular Component	large ribosomal subunit	66	4.984875e-11	1.305130909090909e-9	2.042755	103	0.0107673	115	0.025783698365217392	1.382481	57	115	0.008467023	
GO Cellular Component	mitochondrial ribosome	68	7.958047e-11	2.0222801788235293e-9	2.377227	72	0.007526657	96	0.0165803652	1.476644	45	85	0.006684492	
GO Cellular Component	axon cytoplasm	128	7.751784e-7	0.0000104649084	2.065029	56	0.005854066	110	0.024794113745454545	1.673529	24	40	0.003565062	
GO Cellular Component	pre-autophagosomal structure	141	0.00000221511	0.000027146879999999998	2.161916	46	0.004808697	89	0.011304886651685393	1.830423	21	32	0.00311943	
GO Cellular Component	fibrinogen complex	144	0.000002359662	0.000028315944	2.853933	27	0.002822496	114	0.025314320842105265	2.479303	8	9	0.001188354	
GO Cellular Component	retromer complex	151	0.000004372338	0.000050035762013245036	2.388968	35	0.003658792	98	0.017198768130612246	1.992297	15	21	0.002228164	
GO Molecular Function	cadherin binding	3	1.202632e-49	1.6925041013333331e-46	2.032188	524	0.05477734	8	8.8284183775e-12	1.596459	174	304	0.0258467	
GO Molecular Function	SUMO transferase activity	84	7.012835e-7	0.00003524784448809524	2.738687	32	0.003345181	80	0.04669283957499999	2.055212	14	19	0.00207962	
Human Phenotype	Increased CSF lactate	49	2.169081e-8	0.0000029539341863265307	2.276933	58	0.00606314	131	0.043437806903816795	1.586968	33	58	0.004901961	
Human Phenotype	Abnormal CSF metabolite level	57	5.125129e-8	0.000005999997511754386	2.168672	61	0.006376751	99	0.030373042492929294	1.593838	36	63	0.005347594	
Human Phenotype	Progressive macrocephaly	77	4.243835e-7	0.00003677806617532467	2.860671	31	0.003240644	103	0.033522534629126216	1.975694	17	24	0.002525253	
Human Phenotype	Acute necrotizing encephalopathy	99	0.000001690623	0.000113954821	2.841114	28	0.002927033	50	0.0092591651918	2.231373	16	20	0.002376708	
Human Phenotype	Abnormal mitochondria in muscle tissue	143	0.000005633655	0.00026289076793706295	2.660709	28	0.002927033	141	0.04914319018439716	1.940324	16	23	0.002376708	
Human Phenotype	Acute encephalopathy	251	0.0002165145	0.005756180312749003	2.081813	30	0.003136107	59	0.012114435644067797	2.091912	18	24	0.002673797	
Human Phenotype	Laryngomalacia	307	0.000638741	0.013883774244299674	2.129791	24	0.002508886	67	0.01823072563731343	2.390756	12	14	0.001782531	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	69	1.421741e-11	1.886794541594203e-9	2.995663	52	0.005435919	107	0.0033381184538317753	2.574661	12	13	0.001782531	
Mouse Phenotype	dry eyes	28	2.573847e-21	8.788768273928571e-19	3.902901	72	0.007526657	393	0.040212033320610685	2.091912	12	16	0.001782531	
Mouse Phenotype	expanded mesangial matrix	69	7.19912e-14	9.97547627826087e-12	2.188281	114	0.01191721	409	0.04409217616870416	1.593838	28	49	0.004159239	
Mouse Phenotype	abnormal cellular replicative senescence	98	1.054144e-11	1.0284357942857142e-9	2.037932	111	0.0116036	47	0.0000017770652328510637	1.859477	56	84	0.008318479	
Mouse Phenotype	early cellular replicative senescence	119	1.806492e-10	1.4514176480672268e-8	2.033556	98	0.01024462	63	0.000008031224823809524	1.872213	49	73	0.007278669	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	297	0.000001922131	0.00006187708582828283	2.348996	39	0.004076939	412	0.04617893381067961	1.766503	19	30	0.002822341	
Mouse Phenotype	abnormal lipoprotein lipase activity	401	0.00001904088	0.00045398966004987534	2.778279	23	0.002404349	307	0.020583173060912053	2.510294	9	10	0.001336898	
Mouse Phenotype	absent embryonic cilia	433	0.00003133496	0.0006919019689607391	2.688149	23	0.002404349	406	0.04348451126600985	2.014434	13	18	0.001931075