# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	11	1.032844e-38	1.2355631087272727e-35	2.845945	210	0.01965188	360	0.005127711393333333	1.415006	67	113	0.008515506	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	14	8.367884e-35	7.865213254000001e-32	2.363724	262	0.02451806	262	0.00042030604400381677	1.416505	92	155	0.01169293	
GO Biological Process	regulation of DNA-templated transcription in response to stress	16	3.05402e-33	2.51174057375e-30	2.563855	214	0.0200262	362	0.005147219186740331	1.403825	70	119	0.008896797	
GO Biological Process	cellular response to topologically incorrect protein	21	3.249103e-31	2.0359498274761902e-28	2.467829	215	0.02011978	330	0.0027838646064848485	1.390696	81	139	0.01029487	
GO Biological Process	mRNA catabolic process	25	3.323601e-30	1.74941062236e-27	2.147861	277	0.02592177	192	0.000017681206861979165	1.411734	126	213	0.01601423	
GO Biological Process	endoplasmic reticulum unfolded protein response	27	5.773244e-30	2.8137080665185186e-27	2.624785	184	0.01721879	380	0.006989122355526315	1.402593	67	114	0.008515506	
GO Biological Process	RNA catabolic process	30	1.079525e-28	4.7351564916666664e-26	2.019164	304	0.02844844	187	0.00000922266459090909	1.396252	141	241	0.01792069	
GO Biological Process	response to topologically incorrect protein	32	3.535177e-28	1.4537310669687498e-25	2.168446	252	0.02358226	332	0.003157909107018072	1.339093	101	180	0.01283681	
GO Biological Process	nuclear-transcribed mRNA catabolic process	35	1.257913e-27	4.729393476285714e-25	2.152296	251	0.02348868	210	0.00004608217258238095	1.410206	117	198	0.01487036	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	38	3.393634e-27	1.1751797317368423e-24	2.533328	177	0.01656373	573	0.03835609663001745	1.370969	54	94	0.006863244	
GO Biological Process	rRNA metabolic process	40	3.536398e-27	1.1633865320499999e-24	2.016721	288	0.02695115	138	7.66238080942029e-8	1.446644	157	259	0.01995425	
GO Biological Process	rRNA processing	43	4.588847e-26	1.404293899372093e-23	2.00962	278	0.02601535	149	2.1493822284563757e-7	1.439478	152	252	0.01931876	
GO Biological Process	cellular response to unfolded protein	45	6.740025e-26	1.9709330883333338e-23	2.388469	188	0.01759311	401	0.009303829756359102	1.380621	70	121	0.008896797	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	56	8.551748e-23	2.009508070214286e-20	2.529217	147	0.01375632	296	0.0009393614388513513	1.456171	72	118	0.009150991	
GO Biological Process	response to unfolded protein	59	3.05332e-22	6.809938623728814e-20	2.059398	221	0.02068127	408	0.009884286092647058	1.327492	89	160	0.01131164	
GO Biological Process	negative regulation of endoplasmic reticulum unfolded protein response	68	5.317015e-21	1.0289205938970587e-18	6.13528	45	0.004211117	429	0.01218298868811189	2.386502	9	9	0.001143874	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	75	9.007719e-20	1.58043432428e-17	3.253771	84	0.007860752	270	0.000517332926	2.075219	20	23	0.002541942	
GO Biological Process	mitochondrial membrane organization	79	1.554823e-19	2.589862766708861e-17	2.029992	199	0.0186225	179	0.0000030698638451396648	1.578171	82	124	0.01042196	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	80	1.605878e-19	2.6414685752500002e-17	3.195239	85	0.007954333	397	0.008931500547607054	1.770631	23	31	0.002923233	
GO Biological Process	positive regulation of endoplasmic reticulum unfolded protein response	92	3.258519e-18	4.660744730543478e-16	3.482024	70	0.006550627	600	0.0453564412	2.019348	11	13	0.001398068	
GO Cellular Component	ribosomal subunit	38	1.989382e-22	9.046452884210527e-21	2.152397	201	0.01880966	47	0.0000016666832068085109	1.470601	114	185	0.01448907	
GO Cellular Component	catalytic step 2 spliceosome	39	9.706712e-21	4.300820086153846e-19	2.422823	144	0.01347558	80	0.0041024664	1.441845	58	96	0.007371632	
GO Cellular Component	large ribosomal subunit	41	1.478203e-19	6.23008483902439e-18	2.414534	136	0.01272693	54	0.0000043055744	1.577167	76	115	0.00965938	
GO Cellular Component	mitochondrial ribosome	44	1.713708e-18	6.73019869090909e-17	2.837427	96	0.008983717	71	0.00016432381926760563	1.572284	56	85	0.007117438	
GO Cellular Component	azurophil granule lumen	50	3.012774e-15	1.0412146944e-13	2.179924	128	0.01197829	129	0.03161033079069767	1.363716	52	91	0.006609049	
GO Cellular Component	mitochondrial large ribosomal subunit	52	5.031694e-15	1.6720706215384617e-13	3.182547	64	0.005989145	56	0.000016421310514285712	1.824972	39	51	0.004956787	
GO Cellular Component	proteasome complex	53	5.253656e-15	1.7128901071698115e-13	2.485414	96	0.008983717	78	0.0026983872	1.544207	44	68	0.005592272	
GO Cellular Component	endopeptidase complex	54	5.429301e-15	1.73737632e-13	2.48401	96	0.008983717	82	0.004222161482926829	1.521828	44	69	0.005592272	
GO Cellular Component	spliceosomal snRNP complex	55	9.292811e-15	2.9196322559999997e-13	2.703625	81	0.007580011	87	0.005340457489655172	1.539679	40	62	0.005083884	
GO Cellular Component	peptidase complex	60	3.303948e-13	9.515370240000001e-12	2.144398	113	0.01057458	76	0.001728992917894737	1.491564	55	88	0.006990341	
GO Cellular Component	methyltransferase complex	62	4.665291e-13	1.3002617496774193e-11	2.037651	126	0.01179113	108	0.01916088	1.389941	53	91	0.006736146	
GO Cellular Component	small nuclear ribonucleoprotein complex	68	2.334971e-12	5.933573364705881e-11	2.363005	85	0.007954333	94	0.00901368	1.487241	43	69	0.005465175	
GO Cellular Component	spliceosomal tri-snRNP complex	82	7.570929e-11	1.5954347941463414e-9	3.187627	44	0.004117537	132	0.03861061527272727	1.645864	20	29	0.002541942	
GO Cellular Component	small-subunit processome	99	6.405835e-9	1.1181093818181818e-7	2.673521	46	0.004304698	74	0.0005531538162162163	1.841016	27	35	0.003431622	
GO Cellular Component	outer mitochondrial membrane protein complex	119	1.714913e-7	0.0000024902266084033616	3.589849	24	0.002245929	93	0.008916836748387098	2.068302	13	15	0.001652262	
GO Cellular Component	prespliceosome	139	0.000001033383	0.000012846660604316548	2.85292	29	0.002713831	115	0.02273331255652174	1.818287	16	21	0.002033554	
GO Cellular Component	U2-type prespliceosome	184	0.00003404446	0.0003197218852173913	2.744749	22	0.002058768	119	0.022814972773109246	1.939033	13	16	0.001652262	
GO Cellular Component	exon-exon junction complex	210	0.00009883108	0.000813238601142857	2.291547	27	0.00252667	115	0.02273331255652174	1.818287	16	21	0.002033554	
GO Cellular Component	death-inducing signaling complex	228	0.0002520467	0.0019102486736842104	2.84695	16	0.001497286	92	0.007460091547826087	2.386502	9	9	0.001143874	
GO Molecular Function	ribonucleoprotein complex binding	10	4.894054e-18	2.0662695988e-15	2.200364	151	0.01413064	49	0.0011689649575510204	1.473406	71	115	0.009023894	
GO Molecular Function	protein phosphatase activator activity	133	0.0000109625	0.00034799755639097746	2.673644	26	0.00243309	86	0.0465614629627907	2.386502	8	8	0.001016777	
GO Molecular Function	mismatch repair complex binding	224	0.0001857752	0.0035015307785714283	3.205987	14	0.001310125	86	0.0465614629627907	2.386502	8	8	0.001016777	
GO Molecular Function	nucleoside-triphosphate diphosphatase activity	253	0.0003355427	0.005599451697233202	2.673488	17	0.001590867	65	0.010802948316923076	2.386502	10	10	0.001270971	
Human Phenotype	Increased serum lactate	12	2.711721e-13	1.50794285275e-10	2.096538	120	0.01122965	67	0.0016286900656716419	1.503496	63	100	0.008007117	
Human Phenotype	Hemolytic anemia	41	2.085578e-9	3.394405364390244e-7	2.027561	87	0.008141494	117	0.028778025427350428	1.478959	44	71	0.005592272	
Human Phenotype	CNS hypomyelination	67	3.77958e-8	0.0000037643488567164182	2.644235	42	0.003930376	55	0.0004676546381272727	1.988752	25	30	0.003177428	
Human Phenotype	Broad femoral neck	167	0.00001882603	0.0007522520849700599	4.267129	13	0.001216545	130	0.048683815986153844	2.386502	8	8	0.001016777	
Mouse Phenotype Single KO	pale liver	16	6.848676e-20	3.91958288325e-17	2.343724	147	0.01375632	98	0.014837797234693875	1.491564	50	80	0.006354855	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	89	4.078411e-10	4.1961808457303374e-8	2.017965	96	0.008983717	71	0.003591908053661972	1.645864	40	58	0.005083884	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	95	4.078411e-10	4.1045986916842105e-8	2.017965	96	0.008983717	103	0.0025852136420388347	1.645864	40	58	0.005083884	
Mouse Phenotype	increased neural tube apoptosis	186	2.025537e-7	0.000010411913579032258	2.015529	66	0.006176305	209	0.028879814786124402	1.609502	29	43	0.003685816	
Mouse Phenotype	decreased abdominal adipose tissue amount	225	8.971028e-7	0.00003812088831466667	2.427183	39	0.003649635	201	0.026895307052238804	1.813742	19	25	0.002414845