# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	12	3.693477e-33	4.0502053202499994e-30	2.012297	350	0.06141428	66	1.0533143481666667e-8	1.486436	209	555	0.04393525	
GO Biological Process	rRNA processing	19	1.865637e-26	1.292100909631579e-23	2.453377	181	0.03175996	137	0.000016183091881751825	1.582027	101	252	0.02123187	
GO Biological Process	rRNA metabolic process	22	2.37987e-25	1.4234867877272724e-22	2.389688	182	0.03193543	148	0.00003543835174932432	1.55451	102	259	0.02144209	
GO Biological Process	ncRNA processing	23	3.052885e-25	1.7466484223913044e-22	2.058386	250	0.04386735	139	0.000018059629338848922	1.455294	146	396	0.03069161	
GO Biological Process	regulation of DNA-templated transcription in response to stress	25	1.012336e-24	5.328531769600001e-22	2.875452	128	0.02246008	386	0.030934620378756477	1.525822	46	119	0.00966996	
GO Biological Process	ribosome biogenesis	30	8.196789e-22	3.5953848817e-19	2.059538	214	0.03755045	136	0.000012317791573529412	1.515347	124	323	0.02606685	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	31	1.624737e-21	6.896746510645161e-19	3.129371	97	0.01702053	160	0.00009461395019375	1.806362	54	118	0.01135169	
GO Biological Process	regulation of gene expression, epigenetic	39	6.189358e-20	2.088352869794872e-17	2.107927	184	0.03228637	211	0.000858669029099526	1.480213	93	248	0.01955014	
GO Biological Process	viral gene expression	41	3.593502e-19	1.1533388492195122e-16	2.863384	98	0.017196	132	0.000007375720186287878	1.864836	60	127	0.01261299	
GO Biological Process	RNA catabolic process	42	4.877062e-19	1.528029972809524e-16	2.129661	171	0.03000526	143	0.000021355603068531468	1.588721	97	241	0.020391	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	44	4.927542e-19	1.4736710267727272e-16	3.12747	85	0.0149149	463	0.04825027298488121	1.619379	32	78	0.006726929	
GO Biological Process	cotranslational protein targeting to membrane	46	7.623316e-19	2.1807655487826088e-16	3.182082	82	0.01438849	159	0.00008944478515723271	1.893062	47	98	0.009880177	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	49	1.376064e-18	3.695433913469388e-16	2.937843	91	0.01596771	154	0.00005565832323181818	1.879636	50	105	0.01051083	
GO Biological Process	protein targeting to ER	50	1.473098e-18	3.8768993164e-16	3.093928	84	0.01473943	161	0.00009508889559006211	1.875914	48	101	0.01009039	
GO Biological Process	nuclear-transcribed mRNA catabolic process	53	1.871375e-18	4.646306344339623e-16	2.283143	142	0.02491665	199	0.000574031750718593	1.554972	78	198	0.01639689	
GO Biological Process	viral transcription	54	1.943735e-18	4.73659423425926e-16	2.900906	92	0.01614318	123	0.000002657074908536585	1.956152	56	113	0.01177213	
GO Biological Process	protein localization to endoplasmic reticulum	58	3.806887e-18	8.637038971206896e-16	2.710641	101	0.01772241	222	0.0009957219693243241	1.687125	53	124	0.01114148	
GO Biological Process	mRNA catabolic process	61	9.960184e-18	2.1486239550163936e-15	2.180893	150	0.02632041	195	0.0005023797132205128	1.538125	83	213	0.01744797	
GO Biological Process	multi-organism metabolic process	72	1.307107e-16	2.388919585138889e-14	2.449116	110	0.01930163	138	0.000018129716894927535	1.772228	66	147	0.01387429	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	74	2.438273e-16	4.3358424874324326e-14	3.066168	74	0.01298473	175	0.0001945937881142857	1.887808	44	92	0.009249527	
GO Cellular Component	ribosomal subunit	29	2.009723e-22	1.1975177048275863e-20	2.650433	132	0.02316196	32	0.000009333873	1.685576	79	185	0.01660711	
GO Cellular Component	ribosome	36	2.221409e-18	1.0662763199999999e-16	2.187322	155	0.02719775	31	0.000008265358451612903	1.605655	96	236	0.02018079	
GO Cellular Component	mitochondrial ribosome	40	1.206849e-16	5.21358768e-15	3.491488	63	0.01105457	65	0.011779177846153845	1.67177	36	85	0.007567795	
GO Cellular Component	large ribosomal subunit	41	1.230443e-15	5.1858670829268285e-14	2.763051	83	0.01456396	49	0.0005806182269387756	1.716189	50	115	0.01051083	
GO Cellular Component	catalytic step 2 spliceosome	44	5.643306e-14	2.2162801745454546e-12	2.586959	82	0.01438849	55	0.0019964683636363636	1.726916	42	96	0.008829094	
GO Cellular Component	mitochondrial large ribosomal subunit	46	3.613176e-13	1.3572974191304349e-11	3.916162	42	0.007369714	82	0.03561165658536585	1.780126	23	51	0.00483498	
GO Cellular Component	proteasome complex	54	2.979388e-11	9.5340416e-10	2.767062	57	0.01000175	69	0.014248687304347828	1.741427	30	68	0.006306496	
GO Cellular Component	endopeptidase complex	55	3.042419e-11	9.558727330909091e-10	2.765499	57	0.01000175	73	0.018113835747945204	1.716189	30	69	0.006306496	
GO Cellular Component	peptidase complex	57	4.813779e-11	1.459335107368421e-9	2.455232	69	0.01210739	64	0.011904327	1.659633	37	88	0.007778011	
GO Cellular Component	cytosolic ribosome	63	1.557796e-9	4.2728118857142856e-8	2.098185	81	0.01421302	57	0.002578455814736842	1.656429	47	112	0.009880177	
GO Cellular Component	small ribosomal subunit	64	2.410747e-9	6.5090169e-8	2.571345	52	0.009124408	74	0.01798325163243243	1.699504	31	72	0.006516712	
GO Cellular Component	proteasome regulatory particle	93	8.063537e-7	0.000014982571974193547	3.501943	22	0.003860326	84	0.03905757257142857	2.255563	12	21	0.002522598	
GO Cellular Component	pre-autophagosomal structure	107	0.000003649655	0.00005894022280373832	2.524427	32	0.00561502	54	0.00146029696	2.343671	19	32	0.003994114	
GO Cellular Component	pre-autophagosomal structure membrane	119	0.0000134839	0.00019579982521008402	3.355875	18	0.003158449	61	0.009112109429508197	2.713725	11	16	0.002312382	
GO Cellular Component	U2 snRNP	127	0.00002361526	0.0003213162935433071	3.506855	16	0.00280751	58	0.002860397131034483	2.70074	13	19	0.002732815	
GO Cellular Component	axon cytoplasm	138	0.00003156902	0.0003952990330434782	2.166396	35	0.006141428	86	0.04013474902325581	1.874937	19	40	0.003994114	
GO Cellular Component	U12-type spliceosomal complex	155	0.00007795734	0.0008690986033548388	2.823399	19	0.003333918	83	0.036293995951807226	2.125435	14	26	0.002943031	
GO Molecular Function	structural constituent of ribosome	7	4.070947e-18	2.4553626048571425e-15	2.516332	115	0.02017898	20	0.0005324273427	1.656864	68	162	0.01429472	
GO Molecular Function	enoyl-CoA hydratase activity	33	2.408929e-7	0.000030819691630303035	5.06543	16	0.00280751	44	0.03989966556363636	3.453831	7	8	0.001471516	
Human Phenotype	Lactic acidosis	11	2.715908e-12	1.6475685530909091e-9	2.131524	105	0.01842428	22	0.0013104191712272728	1.699904	59	137	0.01240277	
Human Phenotype	Increased serum lactate	14	6.970792e-12	3.3225782154285713e-9	2.456966	75	0.0131602	23	0.0016984929063913043	1.815728	46	100	0.00966996	
Human Phenotype	Increased CSF lactate	28	1.259659e-9	3.002037323928572e-7	2.89939	44	0.007720653	59	0.042271916816949154	1.837506	27	58	0.005675846	
Mouse Phenotype Single KO	abnormal mammary gland duct morphology	19	8.115279e-13	3.911137358052631e-10	2.268369	96	0.01684506	140	0.031078629075	1.861904	25	53	0.005255413	
Mouse Phenotype Single KO	abnormal mammary gland epithelium morphology	30	9.358595e-11	2.8565551471666665e-8	2.03926	100	0.01754694	133	0.02796887917142857	1.788591	29	64	0.006096279	
Mouse Phenotype Single KO	decreased creatinine clearance	90	1.082875e-7	0.000011017651527777777	3.811575	23	0.004035796	152	0.04231848511447368	2.554094	11	17	0.002312382	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	119	8.8346e-7	0.00006798187579831934	3.009739	27	0.004737673	74	0.0035823644170270273	2.691297	15	22	0.003153248	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	239	0.00003720017	0.0014252801535146445	2.432296	27	0.004737673	101	0.011787724502970295	2.467022	15	24	0.003153248	
Mouse Phenotype Single KO	disorganized yolk sac vascular plexus	300	0.0001929285	0.005888820914999999	2.095361	30	0.005264081	144	0.03490102159513889	2.492991	12	19	0.002522598	
Mouse Phenotype Single KO	decreased hepatocyte proliferation	324	0.0002729058	0.007712958057407408	2.024247	31	0.005439551	117	0.01948413937606838	2.368341	15	25	0.003153248	
Mouse Phenotype	pancreatic islet hypoplasia	77	1.652689e-8	0.0000020521246141558443	3.941772	25	0.004386735	268	0.03717245449253731	3.947236	5	5	0.001051083	
Mouse Phenotype	decreased creatinine clearance	109	1.082875e-7	0.000009498502637614677	3.811575	23	0.004035796	232	0.028949150216379307	2.554094	11	17	0.002312382	
Mouse Phenotype	absent segment of posterior cerebral artery	157	8.8346e-7	0.000053801025859872615	3.009739	27	0.004737673	115	0.002406876163304348	2.691297	15	22	0.003153248	
Mouse Phenotype	interstitial pneumonia	168	0.000001295339	0.00007371866773214285	2.759991	30	0.005264081	246	0.0309929259402439	2.332457	13	22	0.002732815	
Mouse Phenotype	abnormal cerebral artery morphology	296	0.00003720017	0.00120159062625	2.432296	27	0.004737673	167	0.0074436335353293415	2.467022	15	24	0.003153248	
Mouse Phenotype	abnormal locus ceruleus morphology	429	0.0004040401	0.009004725865034965	2.124349	26	0.004562204	274	0.03814668018613139	2.732702	9	13	0.001891949	
Mouse Phenotype	symmetric azygos veins	652	0.003119973	0.04575162860889571	2.292515	15	0.002632041	303	0.0460283894950495	3.070072	7	9	0.001471516