# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	15	5.585923e-38	4.900344050466666e-35	2.952983	194	0.020391	397	0.009475066685894207	1.443476	60	113	0.008686839	
GO Biological Process	liver regeneration	16	1.30909e-36	1.076644706875e-33	4.252033	116	0.01219256	282	0.0015178640520212765	1.941819	25	35	0.003619516	
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	9.958253e-35	6.240031010809524e-32	2.71821	202	0.02123187	386	0.007758761171243523	1.43923	63	119	0.009121181	
GO Biological Process	mitochondrial transport	23	2.021235e-33	1.156410059347826e-30	2.133289	312	0.03279378	142	3.847600784366197e-7	1.501457	132	239	0.01911105	
GO Biological Process	nuclear-transcribed mRNA catabolic process	33	1.375837e-29	5.486254267575757e-27	2.282594	237	0.02491066	193	0.000034530388719170984	1.469113	107	198	0.01549153	
GO Biological Process	cellular response to topologically incorrect protein	34	1.931899e-29	7.477017335588235e-27	2.513988	195	0.02049611	464	0.020124064371982754	1.369052	70	139	0.01013465	
GO Biological Process	mRNA catabolic process	38	2.953764e-28	1.0228573809473685e-25	2.177301	250	0.02627707	191	0.000029071434630890052	1.454997	114	213	0.01650499	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	40	5.566571e-28	1.8312626947249998e-25	2.860108	148	0.01555602	225	0.00018488535362666666	1.56662	68	118	0.009845085	
GO Biological Process	endoplasmic reticulum unfolded protein response	41	8.151228e-28	2.616146567121951e-25	2.65972	166	0.01744797	529	0.03548410169565218	1.38312	58	114	0.008397278	
GO Biological Process	response to topologically incorrect protein	43	1.286364e-27	3.9365729944186046e-25	2.232606	231	0.02428001	373	0.00658577963002681	1.359273	90	180	0.01303026	
GO Biological Process	RNA catabolic process	48	8.316175e-27	2.2798447255208335e-24	2.044092	274	0.02879966	169	0.00000583762906147929	1.455156	129	241	0.0186767	
GO Biological Process	cellular response to unfolded protein	49	1.126533e-26	3.0253158667346937e-24	2.511461	176	0.01849905	423	0.012896896362647754	1.415442	63	121	0.009121181	
GO Biological Process	rRNA processing	59	8.01746e-25	1.7881653583050847e-22	2.046076	252	0.02648728	141	3.6564950630496453e-7	1.488728	138	252	0.01997973	
GO Biological Process	response to unfolded protein	62	4.268168e-24	9.058842372903225e-22	2.187491	209	0.02196763	348	0.00469587233908046	1.393255	82	160	0.01187201	
GO Biological Process	protein targeting to ER	68	4.792324e-23	9.273851693529413e-21	2.77995	126	0.01324364	175	0.000011197218682857143	1.695727	63	101	0.009121181	
GO Biological Process	cotranslational protein targeting to membrane	72	1.352638e-22	2.472133811388889e-20	2.812668	121	0.0127181	181	0.000018929061556353593	1.692156	61	98	0.00883162	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	74	1.700622e-22	3.0241195808108105e-20	2.117844	209	0.02196763	243	0.00038145574546090535	1.473277	84	155	0.01216158	
GO Biological Process	multi-organism metabolic process	75	1.808341e-22	3.1727945625333333e-20	2.30727	173	0.01818373	200	0.000058120236953	1.534962	83	147	0.01201679	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	78	3.707276e-22	6.254364728717949e-20	2.443508	152	0.01597646	284	0.0016498397424295774	1.561718	54	94	0.007818155	
GO Biological Process	viral transcription	80	8.619206e-22	1.4177516469250001e-19	2.568741	136	0.01429472	157	0.0000013310906825477706	1.708113	71	113	0.01027943	
GO Cellular Component	ribosomal subunit	38	1.049926e-23	4.774400336842105e-22	2.273214	189	0.01986546	45	1.5953118719999998e-7	1.572348	107	185	0.01549153	
GO Cellular Component	large ribosomal subunit	42	8.414039e-21	3.461776045714286e-19	2.572386	129	0.01355897	56	0.0000038856672	1.654767	70	115	0.01013465	
GO Cellular Component	catalytic step 2 spliceosome	45	5.725528e-19	2.198602752e-17	2.437816	129	0.01355897	67	0.00014150444991044777	1.614137	57	96	0.008252497	
GO Cellular Component	mitochondrial ribosome	49	6.772147e-17	2.388218370612245e-15	2.854985	86	0.00903931	72	0.0006927108	1.599145	50	85	0.007239033	
GO Cellular Component	methyltransferase complex	57	9.467e-15	2.869995789473684e-13	2.197843	121	0.0127181	61	0.00003839811462295082	1.672952	56	91	0.008107717	
GO Cellular Component	mitochondrial large ribosomal subunit	58	1.321601e-14	3.9374595310344827e-13	3.295329	59	0.006201387	78	0.0010386626953846152	1.759059	33	51	0.004777762	
GO Cellular Component	peptidase complex	59	1.452469e-14	4.254010901694915e-13	2.301986	108	0.01135169	119	0.030774024605042014	1.421058	46	88	0.00665991	
GO Cellular Component	CCR4-NOT complex	62	7.874862e-14	2.1948002477419355e-12	4.112202	42	0.004414547	120	0.0307818288	2.03891	12	16	0.001737368	
GO Cellular Component	spliceosomal snRNP complex	64	1.031159e-13	2.7841293e-12	2.736757	73	0.007672903	79	0.001640160729113924	1.666206	38	62	0.005501665	
GO Cellular Component	nuclear chromosome, telomeric region	67	3.038623e-13	7.836926185074626e-12	2.050242	126	0.01324364	84	0.0020224298057142857	1.441653	70	132	0.01013465	
GO Cellular Component	spliceosomal tri-snRNP complex	69	1.960268e-12	4.9091929043478265e-11	3.5803	44	0.004624764	101	0.007390247097029702	1.87486	20	29	0.002895613	
GO Cellular Component	PcG protein complex	74	1.505722e-11	3.5160643459459457e-10	2.238014	88	0.009249527	106	0.012418651833962263	1.654767	28	46	0.004053858	
GO Cellular Component	small nuclear ribonucleoprotein complex	77	2.635506e-11	5.914486192207792e-10	2.373074	76	0.007988228	85	0.002189565063529412	1.615368	41	69	0.005936007	
GO Cellular Component	intercellular bridge	89	3.566667e-10	6.92494446741573e-9	2.412677	65	0.006832037	121	0.030554895867768595	1.606414	26	44	0.003764297	
GO Cellular Component	cytosolic large ribosomal subunit	95	1.332256e-9	2.423303545263158e-8	2.235539	71	0.007462687	86	0.0025492440558139537	1.648954	37	61	0.005356884	
GO Cellular Component	U4/U6 x U5 tri-snRNP complex	101	4.326334e-9	7.401886289108911e-8	3.168137	36	0.003783897	127	0.038467620283464565	1.812364	16	24	0.002316491	
GO Cellular Component	methylosome	105	6.506806e-9	1.0708343588571429e-7	5.135918	20	0.002102165	87	0.002623767393103448	2.492001	11	12	0.001592587	
GO Cellular Component	mitochondrial nucleoid	117	2.990285e-8	4.416420923076923e-7	2.425269	50	0.005255413	109	0.012894045886238532	1.68291	26	42	0.003764297	
GO Cellular Component	zona pellucida receptor complex	127	8.396641e-8	0.0000011424720982677165	7.841331	12	0.001261299	117	0.02992129476923077	2.416486	8	9	0.001158245	
GO Cellular Component	high-density lipoprotein particle	150	0.000001107626	0.000012759851520000002	2.842403	29	0.00304814	100	0.006973454592	1.913051	19	27	0.002750832	
GO Molecular Function	structural constituent of ribosome	9	7.99508e-23	3.7505808622222224e-20	2.306844	176	0.01849905	24	0.000005035438666666667	1.577428	94	162	0.01360938	
GO Molecular Function	unfolded protein binding	10	1.175857e-20	4.964468254e-18	2.642985	122	0.01282321	86	0.012770033025581396	1.46186	57	106	0.008252497	
GO Molecular Function	ribonuclease activity	21	4.492443e-14	9.031949688571428e-12	2.17904	117	0.01229767	62	0.0031996590432258063	1.537764	56	99	0.008107717	
GO Molecular Function	protein transporter activity	25	6.493025e-13	1.0965420620000001e-10	2.033112	125	0.01313853	42	0.0005515312191904762	1.614137	57	96	0.008252497	
GO Molecular Function	snRNA binding	27	7.839404e-13	1.225850506962963e-10	3.498679	47	0.004940088	52	0.001486543466153846	1.931599	27	38	0.003909078	
GO Molecular Function	endoribonuclease activity	54	5.896612e-9	4.6102770118518524e-7	2.224628	66	0.006937145	84	0.011554297138095238	1.650546	34	56	0.004922542	
GO Molecular Function	tRNA-specific ribonuclease activity	75	8.025005e-8	0.000004517542814666667	3.16655	30	0.003153248	87	0.017491736294252876	2.208819	13	16	0.001882149	
GO Molecular Function	protein binding involved in protein folding	92	3.785896e-7	0.00001737397055652174	2.630234	36	0.003783897	88	0.01936153546363636	1.913051	19	27	0.002750832	
GO Molecular Function	Hsp70 protein binding	100	8.79869e-7	0.00003714806918	2.121097	52	0.00546563	80	0.007330816925	1.836856	25	37	0.003619516	
GO Molecular Function	xenobiotic-transporting ATPase activity	385	0.001045483	0.011465010976623377	2.407461	17	0.00178684	98	0.039183192946938776	2.718546	7	7	0.001013465	
Human Phenotype	Hypoglycemia	8	6.721318e-17	5.60641937675e-14	2.084425	159	0.01671221	150	0.04830949490666666	1.39536	58	113	0.008397278	
Human Phenotype	Increased serum lactate	12	7.736466e-15	4.3021198015000005e-12	2.256687	115	0.01208745	37	0.0003489748150270271	1.631128	60	100	0.008686839	
Human Phenotype	Abnormal CSF metabolite level	13	1.684944e-14	8.648947163076923e-12	2.752466	77	0.008093336	75	0.003906557485066667	1.68291	39	63	0.005646446	
Human Phenotype	Increased CSF lactate	17	5.890163e-13	2.3120622175882355e-10	2.72357	69	0.00725247	85	0.006209359174941176	1.687374	36	58	0.005212104	
Human Phenotype	Glycosuria	40	1.120048e-10	1.868520076e-8	2.789883	53	0.005570738	119	0.02422204232184874	1.87486	20	29	0.002895613	
Human Phenotype	Leukodystrophy	78	4.161039e-8	0.000003559822211153846	2.166347	62	0.006516712	104	0.01618898673557692	1.685499	31	50	0.0044882	
Human Phenotype	Abnormal shape of the occiput	147	0.000002165084	0.00009828303082993196	2.124063	48	0.005045197	106	0.01630124506981132	1.812364	24	36	0.003474736	
Human Phenotype	Increased serum pyruvate	292	0.0001484706	0.0033929599787671234	2.872412	17	0.00178684	76	0.003965977260394737	2.718546	10	10	0.001447807	
Human Phenotype	Abnormality of glycolysis	304	0.0001881749	0.0041305628542763154	2.717565	18	0.001891949	60	0.0018461966666666668	2.718546	11	11	0.001592587	
Human Phenotype	Abnormality of monocarboxylic acid metabolism	409	0.0009494699	0.015490984456479217	2.104983	23	0.00241749	77	0.00454144361	2.509427	12	13	0.001737368	
Mouse Phenotype Single KO	decreased sensitivity to induced cell death	45	2.42331e-15	4.931166593333333e-13	2.13512	135	0.01418962	128	0.00967436334609375	1.568392	45	78	0.00651513	
Mouse Phenotype Single KO	pale liver	93	2.149188e-11	2.1161413458064517e-9	2.005668	112	0.01177213	150	0.018292621457333333	1.529182	45	80	0.00651513	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	161	4.790116e-9	2.724415665341615e-7	3.096638	37	0.003889006	99	0.006455602679494949	2.265455	15	18	0.00217171	
Mouse Phenotype Single KO	reduced sympathetic cervical ganglion size	199	4.157383e-8	0.000001913022921155779	3.533133	27	0.002837923	176	0.029678289647159087	2.300308	11	13	0.001592587	
Mouse Phenotype Single KO	abnormal infrahyoid muscle morphology	248	5.245209e-7	0.00001936708823104839	3.476405	23	0.00241749	90	0.004595718212333334	2.718546	10	10	0.001447807	
Mouse Phenotype Single KO	abnormal pharyngeal muscle morphology	273	0.000001457092	0.00004887396133333333	3.268502	23	0.00241749	154	0.019673368542207793	2.471406	10	11	0.001447807	
Mouse Phenotype Single KO	abnormal infrahyoid muscle connection	356	0.000009733459	0.00025036315748033707	3.186964	20	0.002102165	122	0.00922424390409836	2.718546	9	9	0.001303026	
Mouse Phenotype Single KO	subcutaneous edema	370	0.00001347901	0.0003335872826216216	2.027858	45	0.004729872	195	0.03984419197846154	1.812364	20	30	0.002895613	
Mouse Phenotype	pancytopenia	49	5.690648e-16	1.1103731740408164e-13	3.047518	73	0.007672903	313	0.0478262602428115	1.781117	19	29	0.002750832	
Mouse Phenotype	abnormal hypoglossal nerve topology	180	4.790116e-9	2.544349948666667e-7	3.096638	37	0.003889006	177	0.0037700648910169486	2.265455	15	18	0.00217171	
Mouse Phenotype	reduced sympathetic cervical ganglion size	234	4.157383e-8	0.0000016986640539743588	3.533133	27	0.002837923	254	0.02147177384527559	2.300308	11	13	0.001592587	
Mouse Phenotype	abnormal infrahyoid muscle morphology	304	5.245209e-7	0.000016496527384539474	3.476405	23	0.00241749	160	0.0026991438001875002	2.718546	10	10	0.001447807	
Mouse Phenotype	abnormal pharyngeal muscle morphology	391	0.000007239259	0.0001770193230153453	2.957571	23	0.00241749	303	0.0417993036039604	2.265455	10	12	0.001447807	
Mouse Phenotype	abnormal infrahyoid muscle connection	407	0.000009733459	0.00022865258353562654	3.186964	20	0.002102165	199	0.00590456130603015	2.718546	9	9	0.001303026	
Mouse Phenotype	subcutaneous edema	426	0.00001347901	0.0003025183441549296	2.027858	45	0.004729872	277	0.02928666842382671	1.812364	20	30	0.002895613	
Mouse Phenotype	abnormal apolipoprotein level	465	0.00003043304	0.0006257425708387097	2.846203	21	0.002207273	254	0.02147177384527559	2.300308	11	13	0.001592587	
Mouse Phenotype	decreased spongiotrophoblast size	489	0.00004920137	0.000961992430613497	2.27179	30	0.003153248	296	0.03837620666554054	2.003139	14	19	0.002026929	
Mouse Phenotype	impaired placental function	601	0.0002230601	0.0035485484460898503	3.00267	15	0.001576624	279	0.031167845643010752	2.718546	7	7	0.001013465	
Mouse Phenotype	abnormal tricuspid valve cusp morphology	674	0.0004577996	0.006494097886646884	2.517915	18	0.001891949	279	0.031167845643010752	2.718546	7	7	0.001013465