# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	19	1.376062e-60	9.530315714736842e-58	2.981095	311	0.02058512	257	0.000003741951098638133	1.473547	86	113	0.008867808	
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	3.989369e-54	2.4998146033809525e-51	2.72015	321	0.02124702	270	0.000008659177602222222	1.448062	89	119	0.00917715	
GO Biological Process	mRNA catabolic process	24	6.809835e-51	3.7337757818749995e-48	2.287024	417	0.02760127	112	1.8921666824107144e-12	1.490762	164	213	0.0169107	
GO Biological Process	mitochondrial transport	30	3.788367e-47	1.6617040451000001e-44	2.071078	481	0.03183744	256	0.000003196301567109375	1.328587	164	239	0.0169107	
GO Biological Process	rRNA metabolic process	31	9.590024e-47	4.0708105101935485e-44	2.154521	435	0.02879269	130	1.9733388234615386e-11	1.427834	191	259	0.01969478	
GO Biological Process	RNA catabolic process	32	1.197836e-46	4.92572622625e-44	2.118764	451	0.02985173	113	1.8914525342477878e-12	1.462172	182	241	0.01876676	
GO Biological Process	nuclear-transcribed mRNA catabolic process	33	1.780129e-46	7.098399245757575e-44	2.2926	378	0.02501986	104	8.138917417307691e-13	1.515691	155	198	0.01598268	
GO Biological Process	rRNA processing	35	7.148394e-46	2.6875919041714285e-43	2.162807	423	0.02799841	136	3.397846347132353e-11	1.42908	186	252	0.01917921	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	41	2.37012e-44	7.60692904390244e-42	3.039555	219	0.01449563	279	0.000015155616484946237	1.539009	62	78	0.006393071	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	42	7.179251e-43	2.2493277121190474e-40	2.847691	234	0.01548848	172	1.199093983488372e-9	1.575191	96	118	0.009898948	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	44	2.572036e-42	7.69214130090909e-40	2.258952	354	0.02343129	499	0.003354859360721443	1.286618	103	155	0.01062075	
GO Biological Process	multi-organism metabolic process	53	1.020229e-37	2.533055360566038e-35	2.376812	283	0.0187318	94	2.030227915638298e-13	1.606891	122	147	0.01257991	
GO Biological Process	mitochondrial translational termination	55	1.009427e-36	2.4150999805454542e-34	3.096224	175	0.01158327	209	7.88629573492823e-8	1.60235	72	87	0.007424211	
GO Biological Process	endoplasmic reticulum unfolded protein response	57	3.810377e-36	8.79662297245614e-34	2.492189	247	0.01634895	362	0.00027404144587016575	1.392685	82	114	0.008455352	
GO Biological Process	mitochondrial membrane organization	58	3.974042e-36	9.016279082413793e-34	2.229503	309	0.02045274	322	0.00005955031890372671	1.405286	90	124	0.009280264	
GO Biological Process	mitochondrial translational elongation	61	1.391024e-35	3.000735215737705e-33	3.075612	171	0.01131851	226	1.8923742465044247e-7	1.594495	70	85	0.007217983	
GO Biological Process	regulation of mRNA stability	62	2.523177e-35	5.355239700483871e-33	2.081085	353	0.0233651	373	0.000420404296461126	1.333523	104	151	0.01072386	
GO Biological Process	translational elongation	63	2.931718e-35	6.123567803492063e-33	2.645341	216	0.01429706	225	1.8974313006666666e-7	1.521278	88	112	0.009074036	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	73	1.724488e-33	3.1085667934246572e-31	4.28239	105	0.00694996	552	0.0059154687302536224	1.694151	21	24	0.002165395	
GO Biological Process	mitochondrial translation	74	1.828816e-33	3.2520796951351348e-31	2.679212	200	0.01323802	220	1.336910137909091e-7	1.538081	85	107	0.008764694	
GO Cellular Component	ribosomal subunit	36	1.021967e-38	4.9054416e-37	2.317694	306	0.02025417	33	2.091332421818182e-12	1.517541	145	185	0.01495154	
GO Cellular Component	mitochondrial ribosome	38	7.91524e-35	3.599351242105263e-33	3.24036	155	0.01025947	52	1.0800229292307692e-7	1.594495	70	85	0.007217983	
GO Cellular Component	large ribosomal subunit	43	9.012326e-29	3.621697518139535e-27	2.473824	197	0.01303945	50	3.0714795648e-8	1.532102	91	115	0.009383378	
GO Cellular Component	mitochondrial large ribosomal subunit	45	1.04494e-26	4.0125696e-25	3.587593	102	0.00675139	71	0.00002539417690140845	1.632459	43	51	0.004433904	
GO Cellular Component	ficolin-1-rich granule lumen	46	7.033387e-24	2.642107116521739e-22	2.105775	227	0.01502515	103	0.001583646906407767	1.327215	85	124	0.008764694	
GO Cellular Component	peptidase complex	51	6.331435e-22	2.1452391529411763e-20	2.295257	171	0.01131851	60	0.0000015196826880000001	1.540137	70	88	0.007217983	
GO Cellular Component	catalytic step 2 spliceosome	56	2.508104e-20	7.739292342857143e-19	2.154002	181	0.01198041	88	0.00031753747636363637	1.411792	70	96	0.007217983	
GO Cellular Component	endopeptidase complex	57	3.411959e-20	1.034362307368421e-18	2.470723	135	0.008935663	73	0.000029944346301369864	1.543326	55	69	0.005671272	
GO Cellular Component	proteasome complex	60	2.017473e-19	5.81032224e-18	2.435495	133	0.008803283	74	0.00004595858854054054	1.537549	54	68	0.005568158	
GO Cellular Component	DNA-directed RNA polymerase III complex	63	2.061993e-18	5.655752228571428e-17	5.357827	44	0.002912364	136	0.007530048423529412	1.732365	17	19	0.001752939	
GO Cellular Component	spliceosomal snRNP complex	67	2.19308e-17	5.656182447761194e-16	2.549725	108	0.007148531	83	0.00015761922853012048	1.530201	49	62	0.005052588	
GO Cellular Component	small nuclear ribonucleoprotein complex	80	3.187355e-15	6.8846868e-14	2.28093	116	0.007678051	80	0.000097186608	1.515265	54	69	0.005568158	
GO Cellular Component	integral component of mitochondrial membrane	101	3.349133e-13	5.730001805940594e-12	2.084167	121	0.008009002	181	0.03884424662983425	1.331119	44	64	0.004537018	
GO Cellular Component	small ribosomal subunit	103	4.610306e-13	7.734571619417476e-12	2.126442	114	0.007545671	79	0.00009309685306329114	1.505912	56	72	0.005774386	
GO Cellular Component	MLL1 complex	112	2.721933e-12	4.1995537714285716e-11	2.802989	62	0.004103786	158	0.02212168101265823	1.535585	23	29	0.002371623	
GO Cellular Component	axon cytoplasm	119	9.255166e-12	1.343943432605042e-10	2.194772	94	0.006221869	161	0.02299210255900621	1.452129	30	40	0.003093421	
GO Cellular Component	serine C-palmitoyltransferase complex	123	1.438753e-11	2.0212725073170733e-10	3.309728	45	0.002978554	191	0.04574584159162304	1.936172	8	8	0.0008249124	
GO Cellular Component	CCR4-NOT complex	129	4.133144e-11	5.536490567441861e-10	3.021186	49	0.003243315	129	0.005462889823255814	1.815162	15	16	0.001546711	
GO Cellular Component	proteasome accessory complex	136	1.29695e-10	1.6478894117647061e-9	2.918318	49	0.003243315	151	0.01489806071523179	1.613477	20	24	0.002062281	
GO Cellular Component	cytosolic proteasome complex	153	1.577802e-9	1.7819881411764707e-8	3.696041	31	0.002051893	124	0.005004536051612904	1.936172	12	12	0.001237369	
GO Molecular Function	structural constituent of ribosome	10	7.541377e-37	3.1839693693999996e-34	2.344121	284	0.01879799	12	1.481402694e-10	1.529815	128	162	0.0131986	
GO Molecular Function	unfolded protein binding	11	2.329368e-35	8.940537905454544e-33	2.755766	202	0.0133704	67	0.0012241997773134328	1.388199	76	106	0.007836667	
GO Molecular Function	ribonuclease activity	12	1.637187e-23	5.760169595e-21	2.251836	192	0.0127085	57	0.0004039249618947368	1.427683	73	99	0.007527325	
GO Molecular Function	rRNA binding	14	6.614454e-22	1.994730342e-19	3.206144	96	0.006354249	88	0.008475856909090909	1.452129	45	60	0.004640132	
GO Molecular Function	RNA polymerase III activity	22	6.302157e-18	1.2094412206363636e-15	5.458209	42	0.002779984	97	0.017750676472164946	1.815162	15	16	0.001546711	
GO Molecular Function	exonuclease activity	25	2.336435e-17	3.945771427999999e-15	2.161741	151	0.009994705	101	0.01835157093069307	1.375701	54	76	0.005568158	
GO Molecular Function	snRNA binding	27	6.458251e-17	1.0098791008148148e-14	3.28141	70	0.004633307	105	0.019391312260952382	1.528557	30	38	0.003093421	
GO Molecular Function	endoribonuclease activity	63	5.967616e-12	3.9992499606349207e-10	2.143833	101	0.0066852	117	0.028798630071794874	1.417555	41	56	0.004227676	
GO Molecular Function	poly(A)-specific ribonuclease activity	102	1.986425e-9	8.222241519607844e-8	2.679999	49	0.003243315	89	0.0087935816	1.936172	13	13	0.001340483	
GO Molecular Function	exoribonuclease activity	104	2.093121e-9	8.497266213461538e-8	2.12227	78	0.005162828	116	0.028685629231034484	1.537549	27	34	0.002784079	
Human Phenotype	Abnormal CSF metabolite level	2	5.13766e-21	1.714180259e-17	2.701274	120	0.007942812	75	0.038248301400000004	1.413713	46	63	0.004743246	
Human Phenotype	Abnormality of mitochondrial metabolism	24	1.472811e-14	4.09502825125e-12	2.098405	133	0.008803283	64	0.013174128543750002	1.431084	51	69	0.005258816	
Human Phenotype	Abnormality of the mitochondrion	29	3.573708e-14	8.223225339310346e-12	2.065766	134	0.008869473	66	0.016368434243939394	1.418042	52	71	0.00536193	
Human Phenotype	Leukodystrophy	56	4.18168e-11	4.982919757142857e-9	2.11234	96	0.006354249	62	0.011956993524193549	1.510214	39	50	0.004021448	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	91	3.401799e-13	3.423106971758242e-11	2.098235	119	0.007876622	235	0.04844999872765957	1.38759	43	60	0.004433904	
Mouse Phenotype Single KO	spontaneous chromosome breakage	245	5.964759e-8	0.0000022293591086938776	2.245284	56	0.003706645	100	0.0017458287507	1.781279	23	25	0.002371623	
Mouse Phenotype Single KO	abnormal DNA replication	316	7.778677e-7	0.000022540932053481014	2.187824	49	0.003243315	127	0.00438943606992126	1.76781	21	23	0.002165395	
Mouse Phenotype	pancytopenia	47	3.139775e-19	6.38710399468085e-17	2.76038	105	0.00694996	272	0.017797393751470585	1.60235	24	29	0.002474737	
Mouse Phenotype	early cellular replicative senescence	84	5.156944e-15	5.869707331428571e-13	2.010226	153	0.01012708	240	0.008142573861249999	1.405714	53	73	0.005465044