# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	6	3.731511e-38	8.1838255415e-35	2.803525	212	0.01935896	213	0.000003941364528403756	1.605593	75	113	0.009662458	
GO Biological Process	regulation of DNA-templated transcription in response to stress	17	4.594284e-33	3.556246068e-30	2.536885	217	0.01981554	229	0.000012317806615283842	1.565295	77	119	0.009920124	
GO Biological Process	rRNA processing	24	2.833798e-28	1.5537478284166666e-25	2.045637	290	0.0264816	127	5.253538027637795e-10	1.516733	158	252	0.02035558	
GO Biological Process	rRNA metabolic process	26	9.222572e-28	4.667685574923077e-25	2.01575	295	0.02693818	131	8.77282303442748e-10	1.503761	161	259	0.02074208	
GO Biological Process	mRNA catabolic process	33	1.042207e-25	4.155879367575758e-23	2.027789	268	0.02447265	209	0.0000031115475479904305	1.44237	127	213	0.01636176	
GO Biological Process	nuclear-transcribed mRNA catabolic process	34	1.599644e-25	6.191092763529411e-23	2.083478	249	0.02273765	215	0.000004257713187023256	1.453899	119	198	0.0153311	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	35	7.302598e-25	2.745568202342857e-22	2.718989	142	0.01296685	272	0.0000867256957242647	1.643743	53	78	0.006828137	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	36	9.050066e-25	3.3080505137222226e-22	2.095241	238	0.02173318	326	0.0007472439062576687	1.404635	90	155	0.01159495	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	39	7.130675e-24	2.4059628801282052e-21	2.551959	152	0.01388001	208	0.000002895736009855769	1.599061	78	118	0.01004896	
GO Biological Process	cellular response to epidermal growth factor stimulus	46	4.290037e-22	1.2272303670217392e-19	2.682466	128	0.01168843	463	0.005693367824190065	1.718829	27	38	0.003478485	
GO Biological Process	endoplasmic reticulum unfolded protein response	51	1.17001e-21	3.0188552137254905e-19	2.310709	166	0.01515843	382	0.002029862902539267	1.442968	68	114	0.008760629	
GO Biological Process	regulation of hematopoietic stem cell differentiation	56	3.567563e-21	8.383135985178572e-19	2.537071	135	0.01232764	456	0.005298684895175439	1.432667	61	103	0.007858799	
GO Biological Process	response to epidermal growth factor	57	4.195297e-21	9.685247933859648e-19	2.563376	132	0.01205369	477	0.007151872360796645	1.670326	29	42	0.00373615	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	62	2.875275e-20	6.10253931048387e-18	2.392418	144	0.01314948	405	0.002802631762567901	1.434329	67	113	0.008631796	
GO Biological Process	protein localization to endoplasmic reticulum	63	5.709921e-20	1.1926484196666668e-17	2.248648	161	0.01470185	177	1.7564885971751412e-7	1.63874	84	124	0.01082195	
GO Biological Process	protein targeting to ER	65	7.868719e-20	1.592991897246154e-17	2.491834	130	0.01187106	204	0.0000023726167237254902	1.652648	69	101	0.008889461	
GO Biological Process	mitochondrial translation	70	5.50912e-19	1.0356358582857142e-16	2.421038	131	0.01196238	172	1.1902828088953487e-7	1.695626	75	107	0.009662458	
GO Biological Process	mitochondrial translational elongation	73	7.203372e-19	1.2984818102465756e-16	2.679862	108	0.009862113	206	0.000002812481374223301	1.707595	60	85	0.007729967	
GO Biological Process	cellular response to unfolded protein	74	1.061802e-18	1.8881422321621622e-16	2.119919	171	0.01561501	327	0.0007475905566972478	1.459453	73	121	0.009404793	
GO Biological Process	cellular response to topologically incorrect protein	75	1.746625e-18	3.0645117833333335e-16	2.049694	183	0.0167108	400	0.0026309476257749998	1.392284	80	139	0.01030662	
GO Cellular Component	ribosomal subunit	26	8.195813e-27	5.44706340923077e-25	2.267501	217	0.01981554	37	5.884311697297297e-11	1.621446	124	185	0.01597526	
GO Cellular Component	mitochondrial ribosome	32	1.57494e-23	8.504676e-22	3.11486	108	0.009862113	52	4.113912738461538e-7	1.736055	61	85	0.007858799	
GO Cellular Component	large ribosomal subunit	40	3.041521e-20	1.3139370719999999e-18	2.425402	140	0.01278422	43	2.718541841860465e-9	1.724918	82	115	0.01056429	
GO Cellular Component	endopeptidase complex	41	7.810591e-20	3.2918783531707317e-18	2.752137	109	0.009953429	71	0.00014989041938028169	1.647788	47	69	0.00605514	
GO Cellular Component	mitochondrial large ribosomal subunit	46	9.232376e-19	3.468162114782609e-17	3.493725	72	0.006574742	58	0.00001041658063448276	1.849895	39	51	0.005024478	
GO Cellular Component	proteasome complex	47	1.577587e-18	5.80014965106383e-17	2.677902	106	0.009679481	74	0.00023974902486486487	1.636445	46	68	0.005926308	
GO Cellular Component	peptidase complex	53	1.158302e-15	3.77650161509434e-14	2.259166	122	0.01114054	81	0.0004173877333333333	1.539423	56	88	0.007214635	
GO Cellular Component	catalytic step 2 spliceosome	54	1.795509e-14	5.745628799999999e-13	2.117924	129	0.01177975	118	0.008260683498305086	1.411138	56	96	0.007214635	
GO Cellular Component	proteasome accessory complex	82	7.474015e-10	1.5750119414634146e-8	3.204456	39	0.003561319	122	0.012150603383606557	1.81432	18	24	0.00231899	
GO Cellular Component	small ribosomal subunit	84	4.726884e-9	9.723875657142857e-8	2.058694	80	0.007305269	130	0.016437360738461537	1.444736	43	72	0.005539809	
GO Cellular Component	mitochondrial small ribosomal subunit	134	0.000002799327	0.000036098784000000004	2.560071	32	0.002922108	155	0.04610039783225806	1.641527	19	28	0.002447823	
GO Cellular Component	ESCRT complex	167	0.00002352132	0.00024338228119760477	2.261243	33	0.003013423	155	0.04610039783225806	1.641527	19	28	0.002447823	
GO Cellular Component	prespliceosome	199	0.00008725192	0.0007576448128643218	2.399899	25	0.002282897	131	0.01676547810687023	1.843118	16	21	0.002061324	
GO Cellular Component	U2-type prespliceosome	230	0.0003494886	0.002625723046956522	2.434845	20	0.001826317	109	0.0030415273100917435	2.116706	14	16	0.001803659	
GO Cellular Component	preribosome, small subunit precursor	262	0.0007852475	0.005179036946564886	2.400269	18	0.001643686	152	0.04261676589473684	2.015911	10	12	0.001288328	
GO Cellular Component	very-low-density lipoprotein particle	266	0.0008331945	0.0054126319398496246	2.052796	25	0.002282897	143	0.02873690584615385	1.81432	15	20	0.001932492	
GO Molecular Function	structural constituent of ribosome	8	1.633405e-21	8.6202948875e-19	2.163558	190	0.01735001	19	4.3981907263157895e-9	1.627661	109	162	0.01404277	
GO Molecular Function	rRNA binding	11	1.461075e-16	5.6078715000000004e-14	3.225248	70	0.00639211	118	0.04172734984745763	1.491774	37	60	0.004766813	
GO Molecular Function	ribonucleoprotein complex binding	12	3.59662e-15	1.2654108033333331e-12	2.061802	145	0.0132408	76	0.004791965000263157	1.43042	68	115	0.008760629	
GO Molecular Function	telomeric DNA binding	37	5.484012e-10	6.257702341621621e-8	2.557076	57	0.005205004	69	0.0020344924649275363	1.849895	26	34	0.003349652	
GO Molecular Function	nucleoside-diphosphatase activity	133	0.000004412007	0.0001400563425112782	3.250926	21	0.001917633	114	0.032038887728070176	2.073508	12	14	0.001545993	
GO Molecular Function	CDP-alcohol phosphatidyltransferase activity	181	0.00003666004	0.0008551308777900553	3.379126	16	0.001461054	109	0.032957307719266055	2.419093	8	8	0.001030662	
GO Molecular Function	RNA polymerase I CORE element sequence-specific DNA binding	444	0.002983712	0.028372144288288288	2.731047	11	0.001004474	109	0.032957307719266055	2.419093	8	8	0.001030662	
Human Phenotype	Increased serum lactate	14	6.221747e-15	2.9655512665000002e-12	2.165143	127	0.01159711	79	0.010499923265822785	1.451456	60	100	0.007729967	
Human Phenotype	Telangiectasia	99	3.31163e-7	0.000022321724232323234	2.078131	59	0.005387636	132	0.037293733805303035	1.632888	27	40	0.003478485	
Human Phenotype	Aplasia/Hypoplasia involving the femoral head and neck	100	3.321037e-7	0.000022161279900999998	2.463579	41	0.00374395	157	0.04448489570063695	1.767799	19	26	0.002447823	
Human Phenotype	Aplasia/hypoplasia of the femur	140	0.000003141609	0.00014974254897857144	2.011346	53	0.004839741	149	0.0412439006704698	1.686035	23	33	0.002963154	
Human Phenotype	Tethered cord	152	0.000004626987	0.00020313081744078947	2.882149	25	0.002282897	152	0.04379145274671052	2.199175	10	11	0.001288328	
Human Phenotype	Obstructive sleep apnea	153	0.000004652244	0.0002029047334117647	2.747871	27	0.002465528	152	0.04379145274671052	2.199175	10	11	0.001288328	
Human Phenotype	Basal cell carcinoma	236	0.00005474592	0.0015479640854237288	2.133911	34	0.003104739	80	0.01037296996875	1.979258	18	22	0.00231899	
Mouse Phenotype Single KO	extramedullary hematopoiesis	1	7.043293e-40	6.4495434001e-36	2.61384	250	0.02282897	115	0.004692049188782609	1.442968	68	114	0.008760629	
Mouse Phenotype Single KO	abnormal vertebral transverse process morphology	292	0.00001354489	0.00042476218400684933	2.441483	30	0.002739476	150	0.021458861766000002	2.419093	9	9	0.001159495	
Mouse Phenotype	extramedullary hematopoiesis	3	2.827451e-34	9.011086337e-31	2.063985	347	0.0316866	185	0.0057321140821621624	1.340869	97	175	0.01249678	
Mouse Phenotype	decreased circulating free fatty acid level	19	3.803444e-21	1.9139330570526316e-18	2.004072	224	0.02045475	317	0.03819577274763406	1.341682	66	119	0.008502963	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	54	5.731738e-14	1.0148360558888888e-11	2.493932	88	0.008035796	314	0.03751535436305733	1.727924	20	28	0.002576656	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	341	0.00001757922	0.000492888335542522	2.104526	40	0.003652634	182	0.004718889336263737	1.854638	23	30	0.002963154	
Mouse Phenotype	abnormal vertebral transverse process morphology	434	0.0001155371	0.0025452769887096775	2.102293	32	0.002922108	301	0.031684629892026576	2.199175	10	11	0.001288328