# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of catenin import into nucleus 1 0 0 50.62494 278 0.122467 212 0.01213825885283019 5.869341 6 11 0.003438395 GO Biological Process regulation of catenin import into nucleus 20 2.255143e-305 1.48377133685e-302 28.82927 284 0.1251101 134 0.0026616345954477614 4.483524 10 24 0.005730659 GO Biological Process negative regulation of cellular response to growth factor stimulus 34 1.151963e-226 4.458435622647058e-224 8.802428 380 0.1674009 147 0.004120800826394558 2.252189 27 129 0.01547278 GO Biological Process liver development 43 2.086441e-199 6.384994678837209e-197 9.328958 324 0.1427313 303 0.038468330078217816 2.012118 23 123 0.01318052 GO Biological Process hepaticobiliary system development 48 3.589491e-196 9.840440014374999e-194 9.09511 324 0.1427313 336 0.04872558383333334 1.964211 23 126 0.01318052 GO Biological Process regulation of cellular response to growth factor stimulus 62 1.280598e-168 2.7179659809677424e-166 5.17138 424 0.1867841 181 0.008471633337016574 1.823053 41 242 0.0234957 GO Biological Process regulation of dendrite development 63 9.757035e-167 2.037981326428571e-164 6.814247 337 0.1484581 258 0.02265590130387597 2.037966 25 132 0.01432665 GO Biological Process regulation of cell morphogenesis involved in differentiation 98 2.938093e-120 3.945139366020408e-118 4.205938 374 0.1647577 131 0.002438133673129771 1.884127 45 257 0.02578797 GO Biological Process gland development 99 5.927216e-120 7.87840761050505e-118 3.546786 448 0.1973568 7 2.2102326364285715e-7 2.119484 78 396 0.04469914 GO Biological Process regulation of epithelial cell proliferation 108 6.76714e-116 8.24525882037037e-114 4.003981 380 0.1674009 189 0.009619702445502646 1.731992 47 292 0.0269341 GO Biological Process response to wounding 125 2.454038e-106 2.5834148833600002e-104 3.393246 422 0.1859031 30 0.00004026701811033333 1.745458 91 561 0.052149 GO Biological Process kidney development 134 1.35708e-97 1.3326728149253732e-95 3.682621 354 0.1559471 274 0.029005653711678833 1.701258 40 253 0.02292264 GO Biological Process urogenital system development 137 5.250731e-94 5.0433846152554745e-92 3.34338 383 0.1687225 104 0.00121378616 1.852794 52 302 0.02979943 GO Biological Process regulation of neuron projection development 138 2.071937e-93 1.9756970277536234e-91 2.966319 444 0.1955947 138 0.0029611011143478258 1.661353 65 421 0.03724928 GO Biological Process chordate embryonic development 141 6.337207e-92 5.914277086028368e-90 2.886921 454 0.2 121 0.0017612005599999998 1.589834 82 555 0.0469914 GO Biological Process embryo development ending in birth or egg hatching 143 1.13213e-91 1.0417971097902098e-89 2.877092 455 0.2004405 117 0.0014388894125641027 1.594854 83 560 0.04756447 GO Biological Process negative regulation of signal transduction 144 1.514602e-90 1.3840727581944444e-88 2.274314 644 0.2837004 242 0.01736381707231405 1.319504 142 1158 0.08137536 GO Biological Process renal system development 146 2.512001e-89 2.2640699423972604e-87 3.420648 355 0.1563877 321 0.04468902983800624 1.64007 41 269 0.0234957 GO Biological Process regulation of cell migration 147 1.070274e-88 9.58077249387755e-87 2.535968 531 0.2339207 62 0.0003476117521129032 1.575799 105 717 0.06017192 GO Biological Process regulation of cell morphogenesis 150 4.398583e-88 3.858730246466667e-86 3.062658 403 0.177533 244 0.017800885787295082 1.551508 62 430 0.03553009 GO Cellular Component protein-DNA complex 46 5.396491e-14 2.027203575652174e-12 2.708651 75 0.03303965 17 0.00005092285891764706 2.237323 42 202 0.02406877 GO Cellular Component nucleosome 66 8.581004e-8 0.0000022466628654545453 3.394549 27 0.01189427 14 0.000026121176228571432 2.869456 28 105 0.01604585 GO Cellular Component nuclear nucleosome 67 9.489822e-8 0.0000024475242411940294 6.334968 14 0.006167401 30 0.0455143968 2.959126 11 40 0.006303725 GO Cellular Component DNA packaging complex 81 0.000004195723 0.00008950875733333333 2.756066 27 0.01189427 19 0.00008096759545263158 2.690115 28 112 0.01604585 GO Cellular Component microvillus membrane 104 0.0001962175 0.003260229230769231 3.183753 14 0.006167401 27 0.0079198144 4.210614 9 23 0.005157593 Mouse Phenotype Single KO decreased embryo size 38 2.155531e-128 5.1942624649999994e-126 3.572401 473 0.20837 7 0.0004200684796285714 1.75419 82 503 0.0469914 Mouse Phenotype Single KO abnormal embryo size 44 1.37347e-115 2.8583783613636366e-113 3.205939 488 0.214978 9 0.001353944863 1.635168 93 612 0.05329513 Mouse Phenotype Single KO abnormal prenatal body size 56 8.076887e-96 1.320715254625e-93 2.737007 508 0.2237885 13 0.002282790793076923 1.545462 107 745 0.06131805 Mouse Phenotype Single KO abnormal embryonic growth/weight/body size 59 2.311205e-91 3.587068505932203e-89 2.583233 530 0.2334802 26 0.011563198977692306 1.454824 111 821 0.06361032 Mouse Phenotype Single KO embryonic lethality during organogenesis 66 3.507309e-75 4.8661255322727273e-73 2.446487 485 0.2136564 20 0.007064932259499999 1.502131 104 745 0.05959885 Mouse Phenotype Single KO abnormal prenatal growth/weight/body size 69 3.074296e-73 4.0799026771014495e-71 2.225926 557 0.2453744 29 0.016800887847241378 1.396478 129 994 0.0739255 Mouse Phenotype Single KO postnatal lethality, incomplete penetrance 79 1.284846e-65 1.4892828888607595e-63 2.418331 437 0.192511 27 0.016671335944444445 1.537208 83 581 0.04756447 Mouse Phenotype Single KO neonatal lethality 101 6.947144e-51 6.298514614653465e-49 2.049267 473 0.20837 22 0.008163561232272727 1.507067 100 714 0.05730659 Mouse Phenotype Single KO abnormal mammary gland duct morphology 193 4.092838e-12 1.9418713764766838e-10 3.084741 52 0.02290749 52 0.044514695175 2.842385 14 53 0.008022923 Mouse Phenotype Single KO abnormal mammary gland epithelium morphology 198 1.001533e-11 4.6318372126262624e-10 2.867037 56 0.0246696 28 0.017284161265357142 2.858247 17 64 0.00974212 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 212 5.822471e-11 2.5149229691981134e-9 3.056041 47 0.02070485 14 0.002174397019357143 3.451468 17 53 0.00974212 Mouse Phenotype Single KO increased keratinocyte apoptosis 234 2.209976e-9 8.648183859829059e-8 10.95939 12 0.005286344 39 0.028957063702564102 7.686042 5 7 0.00286533 Mouse Phenotype Single KO abnormal mammary gland development 240 5.833123e-9 2.225579471291667e-7 2.077988 76 0.03348018 10 0.0014421698108999998 2.619938 28 115 0.01604585 Mouse Phenotype Single KO decreased uterus weight 277 7.269036e-8 0.0000024029806011552344 4.04341 22 0.00969163 19 0.005454294757894738 5.380229 9 18 0.005157593 Mouse Phenotype Single KO abnormal uterus weight 388 0.0000164476 0.00038817183814432996 2.798527 23 0.01013216 46 0.03573383885652174 3.710503 10 29 0.005730659 Mouse Phenotype Single KO abnormal neural fold morphology 390 0.00001668889 0.00039184657879487184 2.3296 32 0.01409692 8 0.0005543518457375 3.892081 17 47 0.00974212 Mouse Phenotype Single KO abnormal neural fold formation 612 0.001915716 0.028663744137254903 2.153366 19 0.008370044 40 0.029354892502499997 3.843021 10 28 0.005730659 Mouse Phenotype Single KO abnormal dermomyotome development 629 0.002547192 0.037082094028616855 3.188168 9 0.003964758 35 0.025246191733428573 6.456275 6 10 0.003438395 Mouse Phenotype sacral vertebral fusion 1 0 0 62.14064 276 0.1215859 132 0.04466390728636363 4.966365 6 13 0.003438395 Mouse Phenotype abnormal radius morphology 57 3.834412e-155 6.431721602105263e-153 7.551975 292 0.1286344 86 0.017984819106976746 2.35385 21 96 0.01203438 Mouse Phenotype increased cell proliferation 64 2.095381e-146 3.13030277203125e-144 5.65587 344 0.1515419 96 0.02183451545625 1.771802 41 249 0.0234957 Mouse Phenotype abnormal forelimb zeugopod morphology 67 2.710626e-141 3.868103759104478e-139 6.193727 309 0.1361233 74 0.013941643475675676 2.223235 25 121 0.01432665 Mouse Phenotype prenatal lethality, incomplete penetrance 87 4.106644e-117 4.513060147586207e-115 3.598955 431 0.1898678 45 0.007813642263333333 1.638524 67 440 0.03839542 Mouse Phenotype decreased embryo size 91 2.814079e-111 2.956638386703297e-109 3.068882 498 0.2193833 14 0.0003012814515 1.660778 96 622 0.05501433 Mouse Phenotype abnormal embryo size 103 1.791757e-101 1.6632027841747573e-99 2.81923 513 0.2259912 17 0.000701945561117647 1.577218 107 730 0.06131805 Mouse Phenotype neonatal lethality, incomplete penetrance 108 9.319316e-96 8.250183358888889e-94 3.203101 411 0.1810573 20 0.0009907538445000001 1.784531 67 404 0.03839542 Mouse Phenotype abnormal prenatal body size 126 1.203824e-83 9.134731161904762e-82 2.447702 533 0.2348018 29 0.0018384708430344825 1.481688 122 886 0.06991404 Mouse Phenotype abnormal embryonic growth/weight/body size 131 1.483605e-78 1.0828051454198473e-76 2.281496 567 0.2497797 42 0.006520554195 1.411031 131 999 0.07507163 Mouse Phenotype abnormal postnatal growth 151 7.952577e-65 5.035403224966888e-63 2.075477 571 0.2515419 24 0.001383288268625 1.455827 138 1020 0.07908309 Mouse Phenotype abnormal prenatal growth/weight/body size 154 1.67856e-62 1.0421241662337661e-60 2.006432 592 0.260793 67 0.013191965272835822 1.345057 149 1192 0.08538682 Mouse Phenotype postnatal growth retardation 155 8.341337e-62 5.145259552064516e-60 2.063696 554 0.2440529 33 0.0028099077860000003 1.438333 133 995 0.07621777 Mouse Phenotype embryonic lethality during organogenesis 161 1.393096e-59 8.272913575155281e-58 2.082326 527 0.2321586 26 0.0015503915348076924 1.466826 131 961 0.07507163 Mouse Phenotype postnatal lethality, incomplete penetrance 175 4.381418e-52 2.393756428457143e-50 2.033178 491 0.2162996 28 0.0018525806771785714 1.5086 113 806 0.06475645 Mouse Phenotype abnormal pancreas size 265 6.491065e-24 2.3419272628301887e-22 3.594604 89 0.03920705 136 0.046750119403676474 2.424892 16 71 0.009169054 Mouse Phenotype abnormal mammary gland epithelium morphology 292 8.273807e-16 2.709105093390411e-14 2.85016 79 0.03480176 59 0.011626432040338983 2.483183 21 91 0.01203438 Mouse Phenotype abnormal hair follicle outer root sheath morphology 293 8.801994e-16 2.87221381003413e-14 5.195334 38 0.01674009 77 0.015922082302597403 3.843021 10 28 0.005730659 Mouse Phenotype incomplete rostral neuropore closure 298 6.861247e-15 2.2013551196979865e-13 2.75751 78 0.03436123 82 0.016127623057317075 2.378628 21 95 0.01203438 Mouse Phenotype abnormal neuropore morphology 300 1.739483e-14 5.543732321e-13 2.7073 78 0.03436123 97 0.021626597588659795 2.305813 21 98 0.01203438