# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	40	3.719286e-69	1.22355211185e-66	2.378022	532	0.01642077	282	0.000006718528101418439	1.251871	106	113	0.00753376	
GO Biological Process	regulation of DNA-templated transcription in response to stress	60	2.318017e-61	5.083797617166666e-59	2.197108	556	0.01716155	244	0.000001951713218319672	1.256039	112	119	0.007960199	
GO Biological Process	endoplasmic reticulum unfolded protein response	76	2.27952e-56	3.9468689052631573e-54	2.258469	480	0.01481573	318	0.00002210353644842767	1.24089	106	114	0.00753376	
GO Biological Process	IRE1-mediated unfolded protein response	91	1.248758e-52	1.8057589584615384e-50	2.949485	275	0.008488178	636	0.007313201149056604	1.242504	54	58	0.003837953	
GO Biological Process	cellular response to unfolded protein	102	9.174193e-50	1.1835608400686272e-47	2.095216	500	0.01543305	315	0.000020608021655238095	1.235278	112	121	0.007960199	
GO Biological Process	cellular response to topologically incorrect protein	104	1.127532e-49	1.4266532296153846e-47	2.033049	537	0.0165751	440	0.0005879740268181817	1.190526	124	139	0.008813077	
GO Biological Process	liver regeneration	119	2.024452e-46	2.2386356191596636e-44	2.809468	261	0.008056053	895	0.047561595544134076	1.258282	33	35	0.002345416	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	136	1.976317e-43	1.9122320149264707e-41	2.081871	441	0.01361195	727	0.01884806829986245	1.178372	83	94	0.005899076	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	152	4.441941e-41	3.845493527565789e-39	2.25234	348	0.0107414	438	0.0005350139953196347	1.248994	73	78	0.005188344	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	167	4.515697e-39	3.5582069953892217e-37	2.128124	375	0.01157479	421	0.00038404400845605703	1.210135	107	118	0.007604833	
GO Biological Process	regulation of mitochondrial membrane permeability	172	1.994585e-38	1.525973489244186e-36	2.109999	376	0.01160565	600	0.004838138825666667	1.224853	67	73	0.004761905	
GO Biological Process	cotranslational protein targeting to membrane	184	1.380626e-36	9.873726920652176e-35	2.204857	323	0.009969751	234	0.0000014233865359829059	1.28007	94	98	0.006680881	
GO Biological Process	protein targeting to ER	209	2.813446e-34	1.7713940628708133e-32	2.125128	328	0.01012408	224	7.010944837946428e-7	1.281688	97	101	0.006894101	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	244	8.343507e-32	4.499680680860656e-30	2.15014	295	0.0091055	273	0.00000542511828974359	1.276518	88	92	0.006254442	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	250	1.373305e-31	7.228528198e-30	2.098563	310	0.009568492	709	0.016220145318899856	1.294101	32	33	0.002274343	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	255	2.031969e-31	1.0485756890588236e-29	2.128848	298	0.009198099	591	0.004559377523181049	1.234949	62	67	0.004406539	
GO Biological Process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	415	4.315075e-22	1.368242696987952e-20	2.177885	194	0.005988024	812	0.030900816217980295	1.290057	29	30	0.002061123	
GO Biological Process	lipid storage	665	1.026284e-15	2.030807692631579e-14	2.132122	140	0.004321254	893	0.04704982030347144	1.286879	27	28	0.001918977	
GO Biological Process	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	830	2.212287e-13	3.5074077871084336e-12	2.254765	103	0.003179209	752	0.022824810460106384	1.334542	23	23	0.001634684	
GO Cellular Component	high-density lipoprotein particle	63	1.465917e-28	4.0208009142857145e-27	3.396367	118	0.0036422	171	0.04168689852631579	1.285114	26	27	0.001847903	
GO Cellular Component	mitochondrial ribosome	91	4.99385e-23	9.482827252747254e-22	2.115486	217	0.006697944	77	0.0000801672610909091	1.256039	80	85	0.005685856	
GO Cellular Component	nuclear ubiquitin ligase complex	120	2.721184e-18	3.9185049600000004e-17	2.301232	140	0.004321254	177	0.044342159186440674	1.234451	37	40	0.002629709	
GO Cellular Component	mitochondrial large ribosomal subunit	130	1.999332e-16	2.6575736123076923e-15	2.214244	135	0.004166924	80	0.00015518414159999998	1.308374	50	51	0.00355366	
GO Cellular Component	very-low-density lipoprotein particle	162	4.647377e-13	4.957202133333333e-12	2.414685	87	0.002685351	166	0.032308894843373494	1.334542	20	20	0.001421464	
GO Cellular Component	INO80-type complex	223	1.304982e-8	1.0112147515695068e-7	2.277299	60	0.001851966	144	0.015652488000000003	1.334542	23	23	0.001634684	
GO Molecular Function	unfolded protein binding	18	5.579898e-31	1.3087960753333332e-28	2.048499	322	0.009938885	108	0.01327090705	1.183461	94	106	0.006680881	
GO Molecular Function	rRNA binding	64	7.47613e-18	4.931909509375e-16	2.242658	144	0.004444719	66	0.000039607074566666666	1.312299	59	60	0.004193319	
Human Phenotype	Abnormal CSF metabolite level	38	1.108351e-20	1.9463226902631577e-18	2.088956	199	0.006142354	275	0.04072199463272727	1.207442	57	63	0.004051173	
Human Phenotype	Exercise intolerance	45	9.007053e-20	1.3356458815333333e-17	2.000297	211	0.006512748	156	0.00455080206474359	1.239217	65	70	0.004619758	
Mouse Phenotype Single KO	ruffled hair	277	3.020629e-18	9.985523376534295e-17	2.338869	135	0.004166924	399	0.016793993079699247	1.334542	25	25	0.00177683	
Mouse Phenotype	spontaneous skin ulceration	200	1.491799e-26	7.1315451195e-25	2.222704	226	0.006975739	399	0.00330469614962406	1.301178	39	40	0.002771855	
Mouse Phenotype	ruffled hair	413	7.243356e-17	1.6768456831961258e-15	2.037569	169	0.005216371	755	0.040964997282119206	1.258282	33	35	0.002345416	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	582	9.56504e-13	1.5713289938144328e-11	2.08073	117	0.003611334	409	0.004031315000977995	1.334542	30	30	0.002132196