# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	18	4.954199e-30	3.621794702277778e-27	2.085286	295	0.02699488	148	4.9078313199324324e-8	1.444778	157	252	0.0193899	
GO Biological Process	rRNA metabolic process	20	3.625205e-29	2.38520362975e-26	2.047382	299	0.02736091	152	8.104995166842104e-8	1.432591	160	259	0.01976041	
GO Biological Process	IRE1-mediated unfolded protein response	27	1.173292e-25	5.718277565925926e-23	3.37052	106	0.009699854	513	0.012242807831384017	1.519349	38	58	0.004693096	
GO Biological Process	cellular response to topologically incorrect protein	30	5.538416e-24	2.4293338714666665e-21	2.233594	199	0.0182101	562	0.01769279998683274	1.317997	79	139	0.0097567	
GO Biological Process	response to topologically incorrect protein	33	2.856653e-23	1.139112025060606e-20	2.027868	241	0.02205344	406	0.002974222136724138	1.326987	103	180	0.01272076	
GO Biological Process	cellular response to unfolded protein	38	6.79214e-22	2.3520465857894735e-19	2.236191	180	0.01647145	563	0.017695246208525757	1.341574	70	121	0.008645177	
GO Biological Process	response to unfolded protein	43	8.222713e-21	2.516341403883721e-18	2.00468	220	0.02013177	402	0.0029375460916169155	1.347923	93	160	0.01148574	
GO Biological Process	regulation of DNA-templated transcription in response to stress	53	2.131074e-18	5.291094861509435e-16	2.073612	177	0.01619693	411	0.0030976948752554747	1.403097	72	119	0.008892182	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	59	6.084339e-18	1.357013845779661e-15	2.133573	161	0.0147328	558	0.017519534146953404	1.354464	66	113	0.008151167	
GO Biological Process	regulation of nuclease activity	66	1.980243e-17	3.948184490454546e-15	3.594158	64	0.005856515	661	0.03832143674130106	1.694659	19	26	0.002346548	
GO Biological Process	mitochondrial translational elongation	68	3.209684e-17	6.211210552352942e-15	2.586039	104	0.009516837	604	0.02727610156125828	1.391404	51	85	0.006298629	
GO Biological Process	mitochondrial transmembrane transport	72	7.181818e-17	1.3125769869722223e-14	2.369885	120	0.01098097	301	0.0002766130656843854	1.564631	56	83	0.006916142	
GO Biological Process	mitochondrial translational termination	73	9.239576e-17	1.6655285011506848e-14	2.543865	104	0.009516837	698	0.047894574759312324	1.359418	51	87	0.006298629	
GO Biological Process	mitochondrial translation	77	2.140209e-16	3.6575337962337667e-14	2.296493	124	0.011347	553	0.01724917175533454	1.365397	63	107	0.00778066	
GO Biological Process	viral gene expression	87	1.799937e-15	2.722456434827586e-13	2.118002	139	0.01271962	268	0.00010111022074626866	1.479052	81	127	0.01000371	
GO Biological Process	regulation of triglyceride biosynthetic process	89	2.025333e-15	2.9945344884269665e-13	4.148374	47	0.004300878	674	0.04214829652373887	1.884193	13	16	0.001605533	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	91	3.235188e-15	4.678224054065934e-13	2.170366	129	0.01180454	388	0.0022327353500773196	1.414987	72	118	0.008892182	
GO Biological Process	spliceosomal snRNP assembly	97	5.122381e-15	6.94901150298969e-13	3.181409	64	0.005856515	627	0.030150605971291867	1.586689	26	38	0.003211066	
GO Biological Process	translational elongation	98	1.002146e-14	1.345636654489796e-12	2.150295	127	0.01162152	588	0.02290467177210884	1.345852	65	112	0.008027665	
GO Biological Process	protein targeting to ER	99	1.402422e-14	1.86408798969697e-12	2.228162	116	0.01061493	267	0.00010054170913483146	1.538351	67	101	0.00827467	
GO Cellular Component	ribosomal subunit	34	4.590949e-20	2.333282315294118e-18	2.062847	197	0.01802709	66	0.00003301736727272727	1.403939	112	185	0.01383228	
GO Cellular Component	mitochondrial ribosome	35	2.969779e-19	1.4662223177142856e-17	2.861298	99	0.009059297	106	0.009687321237735849	1.418687	52	85	0.006422132	
GO Cellular Component	mitochondrial large ribosomal subunit	43	1.189677e-16	4.7808415255813955e-15	3.306574	68	0.006222548	104	0.009677281846153844	1.546005	34	51	0.004199086	
GO Cellular Component	large ribosomal subunit	45	7.745867e-16	2.974412928e-14	2.222178	128	0.01171303	83	0.0019170806746987951	1.41157	70	115	0.008645177	
GO Cellular Component	MLL1 complex	49	1.944018e-14	6.855638987755101e-13	3.437627	55	0.005032943	130	0.01789043593846154	1.679281	21	29	0.002593553	
GO Cellular Component	methyltransferase complex	52	2.316363e-13	7.69745243076923e-12	2.039968	129	0.01180454	65	0.00003252138535384615	1.579983	62	91	0.007657157	
GO Cellular Component	preribosome	59	1.733573e-12	5.077312108474576e-11	2.231278	97	0.008876281	114	0.011570299957894737	1.434123	47	76	0.005804619	
GO Cellular Component	DNA-directed RNA polymerase III complex	62	4.916842e-11	1.3703714477419354e-9	4.713683	28	0.002562225	96	0.0052225577999999995	1.952848	16	19	0.001976041	
GO Cellular Component	spliceosomal snRNP complex	64	5.429848e-11	1.46605896e-9	2.382642	73	0.006680088	155	0.03313892624516129	1.421327	38	62	0.004693096	
GO Cellular Component	small nuclear ribonucleoprotein complex	78	2.126638e-9	4.711321107692308e-8	2.120385	78	0.007137628	172	0.046414100093023256	1.377961	41	69	0.005063604	
GO Cellular Component	spliceosomal tri-snRNP complex	84	1.299649e-8	2.673563657142857e-7	2.83367	40	0.003660322	130	0.01789043593846154	1.679281	21	29	0.002593553	
GO Cellular Component	endoplasmic reticulum chaperone complex	108	5.770717e-7	0.0000092331472	4.236952	18	0.001647145	136	0.018840447529411764	2.108188	10	11	0.001235025	
GO Cellular Component	COPI-coated vesicle	127	0.000002355653	0.000032051719559055124	2.459922	35	0.003202782	152	0.031252573894736846	1.714049	17	23	0.002099543	
GO Cellular Component	mitochondrial nucleoid	142	0.000007254979	0.00008828594163380282	2.026999	48	0.004392387	140	0.02169626194285714	1.546005	28	42	0.003458071	
GO Cellular Component	ripoptosome	152	0.00001323969	0.0001505143705263158	4.7737	12	0.001098097	153	0.031267776	2.319007	7	7	0.0008645177	
GO Cellular Component	DNA polymerase complex	261	0.0009654786	0.006392134179310345	2.188426	21	0.001921669	157	0.033293387006369426	1.803672	14	18	0.001729035	
GO Molecular Function	unfolded protein binding	8	1.707431e-18	9.0109671025e-16	2.414167	128	0.01171303	108	0.02001411344259259	1.378278	63	106	0.00778066	
GO Molecular Function	ribonucleoprotein complex binding	9	6.883252e-17	3.229009993777778e-14	2.137388	150	0.01372621	50	0.000045605072939999995	1.532561	76	115	0.009386192	
GO Molecular Function	RNA polymerase III activity	22	2.833119e-10	5.437012917272728e-8	4.671329	26	0.002379209	98	0.014145604208163265	2.029131	14	16	0.001729035	
GO Molecular Function	endoribonuclease activity	26	9.167851e-10	1.4887179585384614e-7	2.200884	75	0.006863104	122	0.03905398449180328	1.49079	36	56	0.004446091	
Human Phenotype	Increased serum lactate	1	2.543065e-13	1.6969872745e-9	2.084278	122	0.01116398	118	0.0275773091720339	1.391404	60	100	0.007410152	
Mouse Phenotype Single KO	extramedullary hematopoiesis	5	2.537072e-27	4.6463936608000005e-24	2.284065	218	0.01994876	210	0.04478889281904762	1.342583	66	114	0.008151167	
Mouse Phenotype Single KO	pale liver	26	1.529617e-15	5.387193411153846e-13	2.135916	137	0.0125366	132	0.01088521725909091	1.478367	51	80	0.006298629	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	69	2.529899e-9	3.35743262942029e-7	2.047636	84	0.007686676	144	0.012426856596527779	1.546005	40	60	0.004940101	
Mouse Phenotype Single KO	absent hypoglossal nerve	95	3.965522e-8	0.000003822345784631579	3.199151	31	0.00283675	112	0.0056010033235714286	2.164407	14	15	0.001729035	
Mouse Phenotype Single KO	embryo tumor	320	0.0001294336	0.0037038233599999996	2.804035	18	0.001647145	173	0.027220098200000004	2.319007	9	9	0.001111523	
Mouse Phenotype	absent hypoglossal nerve	116	3.965522e-8	0.0000032684789518965515	3.199151	31	0.00283675	161	0.004068254195776398	2.164407	14	15	0.001729035	
Mouse Phenotype	absent hypoglossal canal	188	0.000002680902	0.00013634097884042553	3.978442	17	0.001555637	271	0.042098141413284135	2.319007	8	8	0.0009880203	
Mouse Phenotype	embryo tumor	356	0.0001294336	0.0034761647460674156	2.804035	18	0.001647145	229	0.021470908068995636	2.319007	9	9	0.001111523